CN114502714A - 评估靶分子的系统和方法 - Google Patents

评估靶分子的系统和方法 Download PDF

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Publication number
CN114502714A
CN114502714A CN202080068980.2A CN202080068980A CN114502714A CN 114502714 A CN114502714 A CN 114502714A CN 202080068980 A CN202080068980 A CN 202080068980A CN 114502714 A CN114502714 A CN 114502714A
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sensing electrode
sensor
target molecule
signals
sequence
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Chinese (zh)
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伊戈尔·康斯坦汀·伊万诺夫
田晖
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An Xuyuan Co ltd
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An Xuyuan Co ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
CN202080068980.2A 2019-07-31 2020-07-29 评估靶分子的系统和方法 Pending CN114502714A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962881254P 2019-07-31 2019-07-31
US62/881,254 2019-07-31
PCT/US2020/044089 WO2021021944A1 (en) 2019-07-31 2020-07-29 Systems and methods for assessing a target molecule

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Publication Number Publication Date
CN114502714A true CN114502714A (zh) 2022-05-13

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CN202080068980.2A Pending CN114502714A (zh) 2019-07-31 2020-07-29 评估靶分子的系统和方法

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US (1) US20220396831A1 (ja)
EP (1) EP4003382A4 (ja)
JP (1) JP2022544464A (ja)
CN (1) CN114502714A (ja)
CA (1) CA3146453A1 (ja)
WO (1) WO2021021944A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN116482365A (zh) * 2023-03-14 2023-07-25 南京芯原生物科技有限公司 用于检测血清抗体的蛋白组合物及其应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112534063A (zh) 2018-05-22 2021-03-19 安序源有限公司 用于核酸测序的方法、系统和组合物
JP2022544464A (ja) * 2019-07-31 2022-10-19 エーエックスバイオ インコーポレイテッド 標的分子を評価するためのシステム及び方法
WO2023186363A1 (en) * 2022-03-30 2023-10-05 Bayer Aktiengesellschaft Biosensors for the identification of nematode species

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US20060019247A1 (en) * 2002-05-20 2006-01-26 Xing Su Method and apparatus for nucleic acid sequencing and identification
US20100127271A1 (en) * 2008-11-26 2010-05-27 Palo Alto Research Center Incorporated Electronic circuit structure and method for forming same
WO2013112541A2 (en) * 2012-01-23 2013-08-01 The Ohio State University Devices and methods for the rapid and accurate detection of analytes
US20140134616A1 (en) * 2012-11-09 2014-05-15 Genia Technologies, Inc. Nucleic acid sequencing using tags
WO2014182630A1 (en) * 2013-05-06 2014-11-13 Pacific Biosciences Of California , Inc. Real-time electronic sequencing
CN104312914A (zh) * 2014-10-23 2015-01-28 北京大学 一种基于纳米孔结构的蛋白质分子电子器件
US20150268195A1 (en) * 2014-03-20 2015-09-24 Agency For Science, Technology And Research Sensor device and method of operating thereof
CN105612260A (zh) * 2013-10-17 2016-05-25 吉尼亚科技公司 在纳米孔单元阵列中的非法拉第的、电容性耦合的测量
CN106796214A (zh) * 2014-07-31 2017-05-31 伊鲁米那股份有限公司 混合纳米孔传感器
CN107083421A (zh) * 2010-12-17 2017-08-22 纽约哥伦比亚大学理事会 使用经修饰的核苷酸和纳米孔检测的dna边合成边测序
CN107250780A (zh) * 2014-12-19 2017-10-13 豪夫迈·罗氏有限公司 利用变化的电压刺激的基于纳米孔的测序
US20180073071A1 (en) * 2012-06-20 2018-03-15 The Trustees Of Columbia University In The City Of New York Nucleic acid sequencing by nanopore detection of tag molecules
WO2018102350A1 (en) * 2016-11-29 2018-06-07 University Of Georgia Research Foundation, Inc. Bacteriophage-based electrochemical bacterial sensors, systems, and methods
CN109891233A (zh) * 2016-04-27 2019-06-14 量子生物有限公司 用于生物分子的测量和测序的系统和方法
WO2019121845A1 (en) * 2017-12-21 2019-06-27 F. Hoffmann-La Roche Ag Compositions and methods for unidirectional nucleic acid sequencing
CN109952382A (zh) * 2016-08-08 2019-06-28 豪夫迈·罗氏有限公司 随机测序方法的碱基识别
US20210018486A1 (en) * 2017-12-28 2021-01-21 Roche Sequencing Solutions, Inc. Measuring and removing noise in stochastic signals from a nanopore dna sequencing system driven by an alternating signal
US20220396831A1 (en) * 2019-07-31 2022-12-15 Axbio Inc. Systems and methods for assessing a target molecule

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Publication number Priority date Publication date Assignee Title
EP2710359B1 (en) * 2011-02-16 2020-09-16 Centrul International de Biodinamica Systems and method for detection and quantitation of analytes using impedance analysis
EP3375892B1 (en) * 2013-12-12 2020-07-01 Altratech Limited Capacitive sensor
US10190158B2 (en) * 2015-08-06 2019-01-29 Pacific Biosciences Of California, Inc. Systems and methods for selectively addressing sparsely arranged electronic measurement devices

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060019247A1 (en) * 2002-05-20 2006-01-26 Xing Su Method and apparatus for nucleic acid sequencing and identification
US20040185445A1 (en) * 2003-03-19 2004-09-23 Ye Fang Universal readout for target identification using biological microarrays
US20100127271A1 (en) * 2008-11-26 2010-05-27 Palo Alto Research Center Incorporated Electronic circuit structure and method for forming same
CN107083421A (zh) * 2010-12-17 2017-08-22 纽约哥伦比亚大学理事会 使用经修饰的核苷酸和纳米孔检测的dna边合成边测序
WO2013112541A2 (en) * 2012-01-23 2013-08-01 The Ohio State University Devices and methods for the rapid and accurate detection of analytes
US20180073071A1 (en) * 2012-06-20 2018-03-15 The Trustees Of Columbia University In The City Of New York Nucleic acid sequencing by nanopore detection of tag molecules
US20140134616A1 (en) * 2012-11-09 2014-05-15 Genia Technologies, Inc. Nucleic acid sequencing using tags
WO2014182630A1 (en) * 2013-05-06 2014-11-13 Pacific Biosciences Of California , Inc. Real-time electronic sequencing
CN105612260A (zh) * 2013-10-17 2016-05-25 吉尼亚科技公司 在纳米孔单元阵列中的非法拉第的、电容性耦合的测量
US20150268195A1 (en) * 2014-03-20 2015-09-24 Agency For Science, Technology And Research Sensor device and method of operating thereof
CN106796214A (zh) * 2014-07-31 2017-05-31 伊鲁米那股份有限公司 混合纳米孔传感器
CN104312914A (zh) * 2014-10-23 2015-01-28 北京大学 一种基于纳米孔结构的蛋白质分子电子器件
CN107250780A (zh) * 2014-12-19 2017-10-13 豪夫迈·罗氏有限公司 利用变化的电压刺激的基于纳米孔的测序
CN109891233A (zh) * 2016-04-27 2019-06-14 量子生物有限公司 用于生物分子的测量和测序的系统和方法
CN109952382A (zh) * 2016-08-08 2019-06-28 豪夫迈·罗氏有限公司 随机测序方法的碱基识别
WO2018102350A1 (en) * 2016-11-29 2018-06-07 University Of Georgia Research Foundation, Inc. Bacteriophage-based electrochemical bacterial sensors, systems, and methods
WO2019121845A1 (en) * 2017-12-21 2019-06-27 F. Hoffmann-La Roche Ag Compositions and methods for unidirectional nucleic acid sequencing
US20210018486A1 (en) * 2017-12-28 2021-01-21 Roche Sequencing Solutions, Inc. Measuring and removing noise in stochastic signals from a nanopore dna sequencing system driven by an alternating signal
US20220396831A1 (en) * 2019-07-31 2022-12-15 Axbio Inc. Systems and methods for assessing a target molecule

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116482365A (zh) * 2023-03-14 2023-07-25 南京芯原生物科技有限公司 用于检测血清抗体的蛋白组合物及其应用
CN116482365B (zh) * 2023-03-14 2023-10-20 南京芯原生物科技有限公司 用于检测血清抗体的蛋白组合物及其应用

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CA3146453A1 (en) 2021-02-04
WO2021021944A1 (en) 2021-02-04
EP4003382A1 (en) 2022-06-01
JP2022544464A (ja) 2022-10-19
EP4003382A4 (en) 2023-10-11
US20220396831A1 (en) 2022-12-15

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