CN114470508A

CN114470508A - Physiotherapy salt pillow material with drug slow-release effect, preparation method and application

Info

Publication number: CN114470508A
Application number: CN202210094268.0A
Authority: CN
Inventors: 邵志超; 米立伟; 卫武涛; 刘宁
Original assignee: Zhongyuan University of Technology
Current assignee: Zhongyuan University of Technology
Priority date: 2022-01-26
Filing date: 2022-01-26
Publication date: 2022-05-13
Anticipated expiration: 2042-01-26
Also published as: CN114470508B

Abstract

The invention discloses a physiotherapeutic salt pillow material with a drug slow-release effect, a preparation method and application thereof, and the physiotherapeutic salt pillow material is synthesized by processes of pulverization, extraction, aging, molding and the like. The method is simple and easy to implement, and is green and environment-friendly. The traditional Chinese medicine salt pillow particle material disclosed by the invention fuses double functions of salt warming and traditional Chinese medicine components, adopts a mixed biological binder with rich hydroxyl and carboxyl on the surface, can form hydrogen bonds with electronegative atoms in medicine molecules on the basis of fusing with salt lattices to generate an organic combination, realizes the effects of slow release and ion slow release of medicines, and enables the effective components of the medicines to be uniformly and slowly released and utilized.

Description

Physiotherapy salt pillow material with drug slow-release effect, preparation method and application

Technical Field

The invention belongs to the technical field of health care and rehabilitation, and particularly relates to a preparation method of a spherical functional salt material with a drug slow-release effect and application of the spherical functional salt material in a physiotherapy salt pillow.

Background

With the pace of life of modern society becoming faster, sub-health populations are increasing. The insomnia problem is continuously increased, the rest of people is seriously influenced, and the life quality is reduced; long-term reading with a low head and sitting lead to the fact that the head, the neck, the waist and the knees bear excessive pressure, which can cause various health hazards such as inflammation of the shoulders of the cervical vertebrae, soreness and swelling of the knees and the like. At present, the effective physiotherapy method for the chronic health problem becomes a problem to be solved, and some physiotherapy pillow products are produced at the same time. However, the effect of directly filling the medicine in the pillow core is not obvious, the medicine smell greatly influences the sleep, the medicine cannot be effectively absorbed, and the health care effect is rapidly reduced along with the increase of time. On the other hand, although researches show that the coarse-particle salt hot compress has the effects of promoting blood circulation, diminishing inflammation, dispelling cold and eliminating dampness and plays roles of improving tissue fibrosis and promoting repair and regeneration of damaged tissues, most of the currently marketed physiotherapy salt pillows are prepared by simply filling salt crystals into the pillows or mixing common salt, wormwood and semen cassiae, cannot effectively exert curative effects, are not safe enough in use, are not easy to control the temperature, are quick in heat dissipation, and are easy to solidify after being cooled or moistened, so that the using effect is influenced. Simultaneously, large granule crystal salt edges and corners are sharp, and user experience feels relatively poor, hardly reaches the effect of long-term use. According to the invention, the functional pillow core salt spherical particles are prepared by processes of dry frying, nano pulverization, homogeneous fusion and the like, and research shows that the spherical particle material has good drug slow release and ion slow release functions, and the half-life period of drug ingredients in the material reaches more than 500 days. Simultaneously the outward appearance is mellow and smooth, compares with the sharp crystal salt in edges and corners, laminates human skin more easily to direct effect can reach and condition blood vessel and nerve in the skin receptor and the nerve trunk of neck and waist, realizes the very big promotion of functional salt material physiotherapy effect. Through the feedback of an experiencer, the physiotherapy product serving as the filler has the effects of soothing nerves, helping sleep, diminishing inflammation and easing pain, and the effective rate reaches 99.7%.

Disclosure of Invention

The invention aims to provide a preparation method and application of a functional salt pillow material based on traditional Chinese medicine components. The material has good drug slow release and anion slow release functions, effectively improves double physical therapy effects of salt and traditional Chinese medicines, has mellow and smooth appearance, is more fit with human body structure, and has the effects of calming nerves, helping sleep, diminishing inflammation, relieving pain, sterilizing and purifying.

In order to solve the technical problems, the technical scheme adopted by the invention is as follows:

a physiotherapy salt pillow material with a drug slow-release effect comprises the following raw materials in parts by weight: 5-20 parts of traditional Chinese medicine extract, 90-95 parts of sodium chloride, 5-20 parts of biological binder and 20-30 parts of dispersing agent.

Further, the mass ratio of the traditional Chinese medicine extract to the biological adhesive is (1-5) to 1.

Further, the dispersing agent is selected from one or more of water, alcohols, fatty acids, fatty acid amides, esters or high molecular polymer dispersing agents; the biological adhesive is a compound containing a plurality of hydroxyl groups or amino groups in the molecule, and is selected from one or more of the following mixtures: sodium carboxymethyl cellulose, sodium carboxyethyl cellulose, dopamine.

Further, the traditional Chinese medicine extract comprises traditional Chinese medicine extracts of tranquilization and sleep aiding, channels dredging and collaterals dredging, and blood sugar reducing and pressure suppressing, wherein the traditional Chinese medicine for tranquilization and sleep aiding comprises angelica sinensis, spina date seed, poria cocos, polygonum multiflorum, coptis chinensis and lavender; the Chinese medicinal materials with meridian dredging effect comprise folium Artemisiae Argyi, caulis et folium Gaultheriae Yunnanensis, rhizoma Ligustici Chuanxiong, radix Clematidis, Carthami flos, and radix Angelicae Dahuricae; the Chinese medicinal composition for lowering blood sugar and suppressing blood pressure comprises Saviae Miltiorrhizae radix, herba Leonuri, radix Angelicae sinensis, Ginseng radix, radix Paeoniae Rubra, and radix astragali; further, the specific form of the Chinese medicinal extract is not particularly required. For example, the Chinese medicinal extract is obtained by oven drying and pulverizing one or more Chinese medicinal materials, squeezing to obtain juice, crystallizing, microwave extracting, ultrasonic extracting, solution extracting, leaching and centrifuging, enzyme treating, supercritical extracting, fermenting, and lyophilizing.

The preparation method of the physiotherapy salt pillow material with the drug slow-release effect comprises the following steps:

(1) pretreatment: fully pulverizing sodium chloride, the traditional Chinese medicine extract and the biological binder to respectively obtain sodium chloride superfine powder, traditional Chinese medicine extract superfine powder and biological binder superfine powder; parching the sodium chloride superfine powder, and cooling in a vacuum box to room temperature;

(2) uniformly mixing the traditional Chinese medicine extract superfine powder and the biological binder superfine powder according to a weight ratio, adding a dispersing agent, and fully stirring to form a uniform colloidal solution, so that a combination of hydrogen bond interaction is formed between the traditional Chinese medicine extract and the biological binder in a system; the mechanism is as follows:

；

(3) adding salt into the colloidal solution obtained in the step (2) according to the weight ratio, mechanically mixing to obtain uniform salt mass, and standing and aging;

(4) and (3) putting the salt mass after standing and aging into a forming machine to prepare spherical particles with the diameter, and drying the spherical particles and then carrying out surface treatment to obtain the physical therapy salt pillow material with the drug slow release effect.

Further, the pulverization time in the step (1) is 1 hour, and the mesh number of the sodium chloride superfine powder, the traditional Chinese medicine extract superfine powder and the biological binder superfine powder is 20-2000 meshes.

Further, in the step (1), the sodium chloride superfine powder is dried and fried for 2 hours, evenly stirred and fried until the water content of the sodium chloride superfine powder is less than 1 percent.

Further, uniformly mixing the traditional Chinese medicine extract superfine powder and the biological binder superfine powder according to the weight ratio in the step (2), adding a dispersing agent, and fully stirring for 1 hour at the temperature of 60 ℃ to form a uniform colloidal solution.

Further, putting the salt mass into a molding machine in the step (4), and selecting molds with the interval of 3-6 mm to uniformly prepare the salt mass into spherical particles with the diameter of 3-6 mm; placing the spherical particles in an oven at 80 ℃ for 4 h or naturally airing for 2 days; the surface treatment mode comprises powder coating and polishing.

The physiotherapy salt pillow material with the drug slow-release function is applied to physiotherapy salt pillows.

The invention also provides a physiotherapy salt pillow which is composed of a heating layer with a temperature controller, a heat preservation layer of cotton velvet, a physiotherapy layer made of physiotherapy salt pillow materials with a drug slow-release effect and a non-woven cotton layer with magnetic sheets.

Compared with the existing physical therapy pillow material, the invention has the following beneficial effects:

1. the traditional Chinese medicine salt pillow particle material disclosed by the invention integrates the dual functions of salt warming and traditional Chinese medicine components. The nanometer ion components in the salt particles can effectively adjust the osmotic pressure of human epidermis, pores can be fully opened in a heating state, a substance exchange channel is formed, and effective absorption of traditional Chinese medicine components and discharge of vivotoxin through the pores are greatly promoted.

2. According to the traditional Chinese medicine salt pillow particle material, the mixed biological adhesive is rich in hydroxyl and carboxyl on the surface, and can form hydrogen bonds with electronegative atoms in medicine molecules on the basis of fusion with salt lattices, so that the traditional Chinese medicine salt pillow particle material is organically combined together, the slow-release effect of medicines is realized, the effective ingredients of the medicines are uniformly and slowly released and utilized, and experimental results show that the half-life period of the effective ingredients is more than 500 days.

3. The traditional Chinese medicine salt pillow granular material is mellow and smooth in appearance, and is more easily attached to human skin compared with crystal salt with sharp edges and corners, so that the traditional Chinese medicine salt pillow granular material is directly applied to skin receptors and nerve trunks at the neck and waist, and the aims of conditioning blood vessels and nerves and improving partial microcirculation are fulfilled. By selecting 1000 experients for feedback, the physiotherapy product serving as the filler has the effects of soothing nerves, helping sleep, diminishing inflammation and easing pain, and the effective rate reaches 99.7%. Meanwhile, the spherical particles have isotropy, good high-temperature resistance, and better heat gathering and heat dissipation delaying functions.

4. The traditional Chinese medicine salt pillow granular material can slowly release negative ions, effectively captures dust particles in the air, enables the dust particles to be condensed and precipitated, and reduces the harm of PM2.5 to human health.

Drawings

FIG. 1 UV and fluorescence spectroscopy analysis of the combination of biological binders and Chinese medicinal molecules;

FIG. 2 is a high-resolution photograph of granular salt pillow material containing different Chinese medicinal materials;

FIG. 3 is a schematic diagram of the combination of biological binder and Chinese medicinal molecules in salt ball through hydrogen bond;

FIG. 4 shows the drug release profile of the granular material of salt pillow;

FIG. 5 comparison of PXRD diffraction patterns during salt pillow particle material aging experiments;

FIG. 6 comparison of solid UV absorption spectra during aging experiments of salt pillow granular materials;

FIG. 7 is a high resolution FEMS and areal elemental scan analysis image of a cross-section of a granular material of the salt pillow;

FIG. 8 is an elemental content analysis image of a cross-section of a salt pillow particulate material;

FIG. 9 is an infrared absorption image contrast during an aging experiment of a salt pillow particulate material;

FIG. 10 photoelectron spectroscopy images of salt pillow particulate material;

FIG. 11 is a design drawing of the functional salt pillow;

figure 12 feedback of experience effect of the traditional Chinese medicine salt pillow.

Detailed Description

The present invention is further illustrated by the following examples, which are illustrative of the present invention and are not to be construed as being limited thereto.

Example 1

A preparation method of a physiotherapy salt pillow material with a drug slow-release effect comprises the following steps:

1) fully pulverizing salt, traditional Chinese medicine extract and biological binder for 1 h to 20-2000 meshes to obtain ultrafine powder. Parching salt powder for 2 hr, stirring, parching until the water content of salt granule is less than 1%, and cooling in vacuum oven to room temperature.

2) Weighing 5 parts of a nerve-soothing and sleep-aiding traditional Chinese medicine mixture (1 part of Chinese angelica, 1 part of spina date seed, 1 part of poria cocos, 1 part of polygonum multiflorum, 0.5 part of coptis chinensis and 0.5 part of lavender) and 5 parts of a biological adhesive carboxymethylcellulose sodium, uniformly mixing, adding into 20 parts of water, and fully stirring for 1 hour at the temperature of 60 ℃ to obtain a colloidal solution, so that a combination of hydrogen bond interaction is formed between the traditional Chinese medicine extract and the biological adhesive in a system.

3) Weighing 90 parts of salt powder, adding the salt powder into the colloidal solution obtained in the step 2), mechanically mixing to obtain uniform salt groups, and standing and aging for 1 hour.

4) Putting the salt mass obtained in the step 3) after standing and aging into a molding machine, selecting molds with the interval of 3-6 mm, and adjusting the proper rotating speed to uniformly prepare the salt mass into spherical particles with the diameter of 3-6 mm. Then the mixture is placed in an oven at 80 ℃ for 4 h or naturally aired for 2 days. Performing surface treatment such as powder coating and polishing to obtain pillow core salt material, wherein the salt ball particles are shown in figure 2.

Example 2

weighing 5 parts of a nerve-soothing and sleep-aiding traditional Chinese medicine mixture (1 part of Chinese angelica, 1 part of spina date seed, 1 part of poria cocos, 1 part of polygonum multiflorum, 0.5 part of coptis chinensis and 0.5 part of lavender) and 10 parts of a biological adhesive carboxymethylcellulose sodium, mechanically stirring, adding the mixture into 25 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 92 parts of dried salt powder, and carrying out mixing, aging, forming, drying, powder coating, polishing and other steps to obtain the physical therapy salt pillow material with the drug slow-release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 3

weighing 5 parts of a nerve-soothing and sleep-aiding traditional Chinese medicine mixture (1 part of Chinese angelica, 1 part of spina date seed, 1 part of poria cocos, 1 part of polygonum multiflorum, 0.5 part of coptis chinensis and 0.5 part of lavender) and 20 parts of a biological adhesive carboxymethylcellulose sodium, mechanically stirring, adding the mixture into 30 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 92 parts of dried salt powder, and carrying out mixing, aging, forming, drying, powder coating, polishing and other steps to obtain the physical therapy salt pillow material with the drug slow-release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 4

weighing 10 parts of a nerve-soothing and sleep-aiding traditional Chinese medicine mixture (2 parts of angelica sinensis, 2 parts of spina date seed, 2 parts of poria cocos, 2 parts of polygonum multiflorum, 1 part of coptis chinensis and 1 part of lavender) and 5 parts of a biological adhesive carboxymethylcellulose sodium, mechanically stirring the mixture, adding the mixture into 20 parts of water, uniformly mixing the mixture at 60 ℃ to obtain a hydrogen bond combination, then adding 92 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to obtain the physical therapy salt pillow material with the drug slow release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 5

weighing 20 parts of a nerve-calming sleep-aiding traditional Chinese medicine mixture (4 parts of Chinese angelica, 4 parts of spina date seed, 4 parts of poria cocos, 4 parts of polygonum multiflorum, 2 parts of coptis chinensis and 2 parts of lavender) and 5 parts of a biological adhesive carboxymethylcellulose sodium, mechanically stirring, adding the mixture into 20 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 95 parts of dried salt powder, mixing, aging, forming, drying, powder packaging, polishing and the like to obtain the physical therapy salt pillow material with the drug slow release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 6

weighing 5 parts of a channel-dredging collateral-dredging traditional Chinese medicine mixture (1 part of folium artemisiae argyi, 1 part of garden balsam stem, 1 part of ligusticum chuanxiong hort, 1 part of radix clematidis, 0.5 part of safflower and 0.5 part of radix angelicae dahuricae) and 5 parts of biological binder carboxymethylcellulose sodium, mechanically stirring, adding into 20 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 90 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to obtain the physiotherapy salt pillow material with the drug slow-release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 7

weighing 5 parts of a channel-dredging collateral-dredging traditional Chinese medicine mixture (1 part of folium artemisiae argyi, 1 part of garden balsam stem, 1 part of ligusticum chuanxiong hort, 1 part of radix clematidis, 0.5 part of safflower and 0.5 part of radix angelicae dahuricae) and 10 parts of biological binder carboxymethylcellulose sodium, mechanically stirring, adding into 25 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 90 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to obtain the physiotherapy salt pillow material with the drug slow-release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 8

weighing 5 parts of a channel-dredging collateral-dredging traditional Chinese medicine mixture (1 part of folium artemisiae argyi, 1 part of garden balsam stem, 1 part of ligusticum chuanxiong hort, 1 part of radix clematidis, 0.5 part of safflower and 0.5 part of radix angelicae dahuricae) and 20 parts of biological binder carboxymethylcellulose sodium, mechanically stirring, adding into 30 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 90 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to obtain the physiotherapy salt pillow material with the drug slow-release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 9

weighing 10 parts of a channel-dredging collateral-dredging traditional Chinese medicine mixture (2 parts of folium artemisiae argyi, 2 parts of garden balsam stem, 2 parts of ligusticum chuanxiong hort, 2 parts of radix clematidis, 1 part of safflower and 1 part of radix angelicae) and 5 parts of biological adhesive carboxymethylcellulose sodium, mechanically stirring, adding into 25 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 92 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to obtain the physical therapy salt pillow material with the drug slow-release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 10

weighing 20 parts of a channel-dredging collateral-dredging traditional Chinese medicine mixture (4 parts of folium artemisiae argyi, 4 parts of garden balsam stem, 4 parts of ligusticum chuanxiong hort, 4 parts of radix clematidis, 2 parts of safflower and 2 parts of radix angelicae formosanae) and 5 parts of biological adhesive carboxymethylcellulose sodium, mechanically stirring, adding the mixture into 25 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 95 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to obtain the physical therapy salt pillow material with the drug slow release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 11

weighing 5 parts of a blood sugar-reducing and pressure-suppressing traditional Chinese medicine mixture (1 part of salvia miltiorrhiza, 1 part of motherwort, 1 part of angelica, 0.5 part of ginseng, 0.5 part of red paeony root and 1 part of astragalus root) and 5 parts of biological adhesive carboxymethylcellulose sodium, mechanically stirring, adding the mixture into 20 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 90 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to obtain the physical therapy salt pillow material with the drug slow-release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 12

weighing 5 parts of a blood sugar-reducing and pressure-suppressing traditional Chinese medicine mixture (1 part of salvia miltiorrhiza, 1 part of motherwort, 1 part of angelica, 0.5 part of ginseng, 0.5 part of red paeony root and 1 part of astragalus root) and 10 parts of biological adhesive carboxymethylcellulose sodium, mechanically stirring, adding into 25 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 90 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to obtain the physical therapy salt pillow material with the drug slow-release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 13

weighing 5 parts of a blood sugar-reducing and pressure-suppressing traditional Chinese medicine mixture (1 part of salvia miltiorrhiza, 1 part of motherwort, 1 part of angelica, 0.5 part of ginseng, 0.5 part of red paeony root and 1 part of astragalus root) and 20 parts of biological adhesive carboxymethylcellulose sodium, mechanically stirring, adding the mixture into 30 parts of water, uniformly mixing at 60 ℃ to obtain a hydrogen bond combination, then adding 90 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to obtain the physical therapy salt pillow material with the drug slow-release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 14

weighing 10 parts of a blood sugar-reducing and pressure-inhibiting traditional Chinese medicine mixture (2 parts of salvia miltiorrhiza, 2 parts of motherwort, 2 parts of angelica, 1 part of ginseng, 1 part of red paeony root and 2 parts of astragalus mongholicus) and 5 parts of a biological binder carboxymethylcellulose sodium, mechanically stirring the mixture, adding the mixture into 25 parts of water, uniformly mixing the mixture at the temperature of 60 ℃ to obtain a hydrogen bond combination, then adding 92 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to prepare the physical therapy salt pillow material with the drug slow release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

Example 15

weighing 20 parts of a blood sugar-reducing and pressure-inhibiting traditional Chinese medicine mixture (4 parts of salvia miltiorrhiza, 4 parts of motherwort, 4 parts of angelica, 2 parts of ginseng, 2 parts of red paeony root and 4 parts of astragalus mongholicus) and 5 parts of biological binder carboxymethylcellulose sodium, mechanically stirring the mixture, adding the mixture into 25 parts of water, uniformly mixing the mixture at the temperature of 60 ℃ to obtain a hydrogen bond combination, then adding 95 parts of dried salt powder, and carrying out steps of mixing, aging, forming, drying, powder coating, polishing and the like to prepare the physical therapy salt pillow material with the drug slow release effect. The specific operation method is the same as that of example 1, and the salt ball particles are shown in figure 2.

The parts in examples 1 to 15 are parts by weight.

Example 16

As shown in figure 11, a physiotherapy salt pillow comprises a heating layer with temperature controller, a thermal insulation layer of cotton velvet, a physiotherapy layer made of physiotherapy salt pillow material with drug slow release effect, and a non-woven cotton layer with magnetic sheets.

Trial feedback for making traditional Chinese medicine physiotherapy salt pillow by using the granular material of example 2

1000 persons are selected to try the traditional Chinese medicine physiotherapy salt pillow made of the granular material in the embodiment 2 for 1 month, and the feedback result shows that the effective rate of the physiotherapy effect of the product reaches 99.7%. This shows that the traditional Chinese medicine salt pillow has very obvious effect and is worthy of clinical popularization and use, as shown in fig. 12.

Test example 1

Example 1 binding assay of Chinese medicinal molecules with binding Agents

Dissolving 20 mg of biological adhesive sodium carboxymethyl cellulose or dopamine in water, adding 10mg of traditional Chinese medicine spina date seed components after complete dissolution, fully stirring at 50 ℃, carrying out ultraviolet absorption spectroscopy on a single component and a combined body after 1 hour, and analyzing fluorescence emission spectra, wherein as shown in figure 1, characteristic peaks shift to a certain degree, which indicates that hydrogen bond weak interaction is generated between the two, so that electron transition and emission are influenced.

Test example 2

Example 2 drug sustained release test of salt material of spherical pillow core

The granular material of example 2 was placed in an oven and heat treated. Sampling regularly within 0-500 days, selecting C element in drug molecules for reference calculation, utilizing an element analyzer to represent the content of organic carbon element to monitor the amount of the residual traditional Chinese medicine components in the granular salt balls, drawing a drug slow-release curve according to the percentage of the traditional Chinese medicine, and comparing and analyzing the drug slow-release curve with a simple mixture of the traditional Chinese medicine and salt, wherein as shown in figure 4, the spherical pillow core material has an obvious drug slow-release effect, and the half-life period of the traditional Chinese medicine components reaches more than 500 days.

Test example 3

Example 2 PXRD diffraction analysis of salt material of spherical pillow core in aging experiment process

The granular material of example 2 was subjected to an aging test in which balls of Chinese medicinal salt for 100 days, 300 days and 500 days were crushed and placed in a mortar and ground for 0.5 hour to obtain a uniform powder. And a PANalyticalX' Pert PRO type powder single crystal diffractometer is adopted, Cu-Kalpha ray radiation is carried out, a powder X-ray diffraction pattern is obtained after testing for 5 min, and the comparison analysis is carried out on the powder X-ray diffraction pattern and pure salt powder data, as shown in figure 5, the spherical pillow core salt material keeps good structural stability in the aging process.

Test example 4

Example 2 solid ultraviolet absorption spectrum of spherical pillow core salt material in aging experiment process

The granular material of example 2 was subjected to an aging test in which the balls of traditional Chinese medicine salt were crushed during 100 days, 300 days, and 500 days, and were put in a mortar and ground for 0.5 h to obtain a uniform powder. And testing with Lambda-950 ultraviolet-visible spectrophotometer, selecting 250-800 nm wavelength to obtain ultraviolet-visible spectrum, and comparing with pure salt powder data for analysis, as shown in FIG. 6, the characteristic absorption peak of the traditional Chinese medicine components of the spherical pillow core salt material is slightly reduced in the aging process.

Test example 5

Example 2 high resolution field emission scanning electron microscope image of salt material of spherical pillow core

The granular material of example 2 was cut after drying and fixed on a conductive gel, and gold sprayed for 120 s, and subjected to top-down procedure on a zeiss Merlin compact field emission scanning electron microscope (FE-SEM), to obtain a high-resolution scanning electron micrograph of the cross section of the salt sphere. And a regional energy spectrometer (Mapping) is added to characterize the crystal powder sample to obtain a regional element analysis image, as shown in fig. 7, the spherical pillow core salt material particles and the traditional Chinese medicine particles are tightly combined and uniformly distributed under the action of hydrogen bonds.

Test example 6

Example 2 analysis image of element content of salt material of spherical pillow core

The particle material of example 2 was cut into a section after drying, and fixed on a conductive adhesive, and sprayed with gold for 120 s, and operated on a zeiss Merlin compact field emission scanning electron microscope (FE-SEM), and the cross section of the salt sphere was characterized by an energy spectrometer (EDS), to obtain an image of the content of the regional elements, as shown in fig. 8, the C, O, Cl, and Na elements in the particle of the salt material of the spherical pillow core were uniformly distributed.

Test example 7

Example 2 solid infrared absorption analysis image of salt material of spherical pillow core

The granular material of example 2 was subjected to an aging test in which 100, 300, and 500-day-old traditional Chinese medicine salt balls were placed in a mortar and ground for 0.5 h to obtain a uniform powder. Adding potassium bromide powder, mixing, tabletting, and making sample at 400-4000 cm^-1In this range, FI-IR spectrum analysis was performed on the sample powder using Thermo iS50 FT-IR. The obtained solid infrared absorption analysis image shows that the characteristic absorption peak intensity of the traditional Chinese medicine components of the spherical pillow core salt material is reduced in the aging process as shown in fig. 9, which indicates that the traditional Chinese medicine components are slowly released in the aging process.

Test example 8

Example 2 photoelectron spectroscopy image of spherical pillow core salt material powder

The particle material of example 2 was subjected to an aging test, in which salt balls of a Chinese medicine aged for 500 days were selected, crushed, put in a mortar and ground for 0.5 hour to obtain a uniform powder, and pressed into a sheet shape to be coated on a conductive paste, and an X-ray photoelectron spectroscopy (XPS) was measured using a Thermo scientific K-Alpha X-ray photoelectron spectrometer. An X-ray photoelectron spectroscopy analysis image is obtained, and as shown in FIG. 10, characteristic peaks of C and O elements in the material are obvious, which means that organic molecules of the traditional Chinese medicine components exist.

The invention adopts the characteristic adhesives of sodium carboxymethyl cellulose and dopamine which are rich in polycarboxyl and hydroxyl, and combines the traditional Chinese medicine components and the salt crystal lattice through the action of hydrogen bonds to realize the effect of slow release of the medicine. The granular material of the traditional Chinese medicine salt pillow is spherical, has mellow and smooth appearance, and is more easily attached to the skin of a human body, so that the traditional Chinese medicine salt pillow directly acts on skin receptors and nerve trunks at the neck and waist, and the aims of conditioning blood vessels and nerves and improving partial microcirculation are fulfilled. The invention adopts double physical therapy functions of salt and traditional Chinese medicine components. The pore is fully opened by utilizing osmotic pressure to form a substance exchange channel, and the effective absorption of the traditional Chinese medicine components and the discharge of vivotoxin through the pore are promoted.

What has been described above is merely a preferred embodiment of the present patent. It should be noted that, for those skilled in the art, which may be conceivably carried out without inventive step without departing from the patentable principle, several variations and modifications are possible, which obviously should be regarded as equivalent features, and which still fall within the scope of protection of the patent of the invention.

Claims

1. A physiotherapy salt pillow material with medicine slow release effect is characterized in that: the physiotherapy salt pillow material is prepared from the following raw materials in parts by weight: 5-20 parts of traditional Chinese medicine extract, 90-95 parts of sodium chloride, 5-20 parts of biological binder and 20-30 parts of dispersing agent.

2. The physiotherapy saline pillow material with the drug slow-release effect according to claim 1, which is characterized in that: the mass ratio of the traditional Chinese medicine extract to the biological adhesive is (1-5) to 1.

3. The physiotherapy saline pillow material with the drug slow-release effect according to claim 1, which is characterized in that: the dispersing agent is selected from one or more of water, alcohols, fatty acids, aliphatic amides, esters or high molecular polymer dispersing agents; the biological adhesive is a compound containing a plurality of hydroxyl groups or amino groups in the molecule, and is selected from one or more of the following mixtures: sodium carboxymethylcellulose, sodium carboxyethyl cellulose, dopamine; the traditional Chinese medicine extract comprises traditional Chinese medicine extracts for soothing nerves and helping sleep, dredging channels and collaterals, and reducing blood sugar and suppressing pressure, wherein the traditional Chinese medicine for soothing nerves and helping sleep comprises angelica sinensis, spina date seed, poria cocos, polygonum multiflorum, coptis chinensis and lavender; dredging channels and collaterals, and comprises folium Artemisiae Argyi, herba speranskiae tuberculatae, rhizoma Ligustici Chuanxiong, radix Clematidis, Carthami flos, and radix Angelicae Dahuricae; the Chinese medicinal composition for lowering blood sugar and suppressing blood pressure comprises Saviae Miltiorrhizae radix, herba Leonuri, radix Angelicae sinensis, Ginseng radix, radix Paeoniae Rubra, and radix astragali.

4. The preparation method of the physiotherapy saline pillow material with the drug slow-release effect according to any one of claims 1 to 3, which is characterized by comprising the following steps:

(2) uniformly mixing the traditional Chinese medicine extract superfine powder and the biological binder superfine powder according to a weight ratio, adding a dispersing agent, and fully stirring to form a uniform colloidal solution, so that a combination of hydrogen bond interaction is formed between the traditional Chinese medicine extract and the biological binder in a system;

5. The preparation method of the physiotherapy saline pillow material with the drug slow-release effect according to claim 4, which is characterized in that: in the step (1), the pulverization time is 1 h, and the mesh number of the sodium chloride superfine powder, the traditional Chinese medicine extract superfine powder and the biological binder superfine powder is 20-2000 meshes.

6. The preparation method of the physiotherapy saline pillow material with the drug slow-release effect according to claim 4, which is characterized in that: in the step (1), the sodium chloride superfine powder is dried and fried for 2 hours, evenly stirred and fried until the water content of the sodium chloride superfine powder is less than 1 percent.

7. The preparation method of the physiotherapy saline pillow material with the drug slow-release effect according to claim 4, which is characterized in that: and (2) uniformly mixing the traditional Chinese medicine extract superfine powder and the biological binder superfine powder according to the weight ratio, adding a dispersing agent, and fully stirring for 1 hour at the temperature of 60 ℃ to form a uniform colloidal solution.

8. The preparation method of the physiotherapy saline pillow material with the drug slow-release effect according to claim 4, which is characterized in that: putting the salt mass into a molding machine in the step (4), and selecting molds with the interval of 3-6 mm to uniformly prepare the salt mass into spherical particles with the diameter of 3-6 mm; placing the spherical particles in an oven at 80 ℃ for 4 h or naturally airing for 2 days; the surface treatment method comprises powder coating and polishing.

9. Use of a physiotherapy saline pillow material with a drug sustained-release effect as claimed in any one of claims 1 to 4 in a physiotherapy saline pillow.

10. A physiotherapy salt pillow which is characterized in that: the physiotherapy salt pillow is composed of a heating layer with a temperature controller, a thermal insulation layer of cotton velvet, a physiotherapy layer made of physiotherapy salt pillow material with drug slow release function according to any one of claims 1 to 4, and a non-woven cotton layer with magnetic sheets.