CN114470047A - Composition for treating dysmenorrhea and preparation method and application thereof - Google Patents
Composition for treating dysmenorrhea and preparation method and application thereof Download PDFInfo
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- CN114470047A CN114470047A CN202210244675.5A CN202210244675A CN114470047A CN 114470047 A CN114470047 A CN 114470047A CN 202210244675 A CN202210244675 A CN 202210244675A CN 114470047 A CN114470047 A CN 114470047A
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- 206010013935 Dysmenorrhoea Diseases 0.000 title claims abstract description 56
- 208000005171 Dysmenorrhea Diseases 0.000 title claims abstract description 46
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 108010010803 Gelatin Proteins 0.000 claims abstract description 66
- 239000008273 gelatin Substances 0.000 claims abstract description 66
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- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 16
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- -1 compound amino acid Chemical class 0.000 claims abstract description 15
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- 238000000034 method Methods 0.000 claims description 12
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- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims description 2
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims description 2
- 108010038807 Oligopeptides Proteins 0.000 claims description 2
- 102000015636 Oligopeptides Human genes 0.000 claims description 2
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- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 5
- 238000000265 homogenisation Methods 0.000 description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
The invention relates to a composition for treating dysmenorrhea and a preparation method and application thereof, wherein the composition comprises the following raw materials in parts by weight: 16-24 parts of donkey-hide gelatin, 9-12 parts of rose, 19-26 parts of food-grade compound amino acid, 3-5 parts of sodium alginate and 2-4 parts of chitosan oligosaccharide. The invention defines that the difficulty in inner membrane shedding is the root cause of dysmenorrhea, and takes the inner membrane shedding as the treatment target, and provides the composition for treating the dysmenorrhea, wherein the short peptide donkey-hide gelatin freeze-dried powder, the rose probiotic freeze-dried powder and the food-grade compound amino acid are used for helping the inner membrane shedding; the anticoagulant function of the sodium alginate is utilized to help the discharge of menstrual blood; the chitosan oligosaccharide is used for promoting the healing of endometrial wounds, has remarkable effect and no toxic or side effect, has the advantages of simple and convenient preparation, convenient use, low cost, convenient production and wide application range, and has good application prospect.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines and foods, and particularly relates to a composition for treating dysmenorrhea as well as a preparation method and application thereof.
Background
The periodic shedding of endometrium and the bleeding accompanying the periodic change of the ovary are the menstruation, and the duration of the shedding of endometrium is the period time of the menstruation. Unfortunately, some people have difficulty in the stripping of the endometrium during this process to stimulate uterine contraction and cause dysmenorrhea.
Dysmenorrhea is classified into primary dysmenorrhea and secondary dysmenorrhea, the former refers to dysmenorrhea of a female who is not born, and the latter refers to dysmenorrhea of a female who is born later. For primary dysmenorrhea, the cause of the formation is currently believed to be: the first is a physiological factor, because the increase of endometrial prostaglandin can cause the excessive or uncoordinated contraction of the uterus, and the local hypoxia of the uterus can cause the release of peroxide, histamine and the like to cause dysmenorrheal; secondly, psychological factors, namely the fear and tension psychology caused by lack of correct understanding of menstruation, and the dysmenorrhea is aggravated; thirdly, diet factors, some girls eat snacks and eat cold foods such as cold drinks and pears during the menstrual period, which easily causes stagnation of qi and blood, and dysmenorrheal is aggravated naturally as the traditional Chinese medicine says that obstruction causes pain; fourthly, the physical labor is a fatigue factor, and the bleeding and the dysmenorrheal are aggravated by the heavy physical labor; and fifthly, a cooling factor. For secondary dysmenorrhea, the conventional theory suggests that the cause is adenomyosis or endometriosis.
For primary dysmenorrhea, the traditional treatment method suggests exercise, warmth retention, good lifestyle and finally taking analgesic (such as ibuprofen). The ibuprofen regimen is centered on reducing the concentration of prostaglandins at the expense of a prolonged process of intimal detachment, i.e. a longer period of menstruation. Ibuprofen has the problem that even though the intima slowly falls off, the process is not guaranteed to be painless and the menstrual period becomes longer, and the fact that ibuprofen only relieves pain, does not eliminate pain and even does not heal. For secondary dysmenorrhea, the traditional treatment method is to take Chinese patent medicines, mainly including cassia twig and poria cocos pills, dysmenorrhea granules, ease pills and motherwort herb granules. The Chinese patent medicine takes the blood vessel obstruction as a target point, and hopes to accelerate the bleeding process to solve the problem of dysmenorrhea. The traditional Chinese medicine helps to accelerate the discharge of the fallen intimal part and blood, but has no effect on the more difficult-to-fall intimal part, and has no feasible method except for surgical removal of the uterus. Regardless of primary dysmenorrhea and secondary dysmenorrhea, the final result of the current treatment scheme is not ideal, and the problem of dysmenorrhea cannot be solved practically. According to statistics, at present, the number of dysmenorrhea patients is 11346 ten thousands only in China. Therefore, a technical method for solving the difficult problem of treating dysmenorrhea is urgently needed.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention provides a composition for treating dysmenorrhea.
It is a further object of the present invention to provide a process for the preparation of said composition.
It is another object of the present invention to provide the use of said composition.
In order to achieve the first purpose, the invention adopts the technical scheme that:
the composition for treating dysmenorrhea comprises the following raw materials in parts by weight: 16-24 parts of donkey-hide gelatin, 9-12 parts of rose, 19-26 parts of food-grade compound amino acid, 3-5 parts of sodium alginate and 2-4 parts of chitosan oligosaccharide.
Preferably, the composition comprises the following raw materials in parts by weight: 20 parts of donkey-hide gelatin, 10 parts of rose, 24 parts of food-grade compound amino acid, 4 parts of sodium alginate and 3 parts of chitosan oligosaccharide.
More preferably, the roses in the composition are rose with red petals.
More preferably, the moisture content in the double-petal red rose is less than or equal to 12.0 wt%, and the total ash content is less than or equal to 7.0 wt%.
As another preferable example of the invention, the composition further comprises conventional auxiliary materials for preparing medicines, health products or foods.
As another preferred example of the present invention, the composition is further formulated into tablets, granules, capsules, mixtures or QQ sugar.
In order to achieve the second object, the invention adopts the technical scheme that:
a process for the preparation of a composition as described above, comprising the steps of:
s1 preparation of short peptide donkey-hide gelatin freeze-dried powder: grinding and crushing donkey-hide gelatin to obtain donkey-hide gelatin powder, adding the donkey-hide gelatin powder and a solution with an equal proportion (1ml/mg) into an ultrasonic extractor for processing for 30 minutes to obtain an extracted solution, filtering the extracted solution by using a microporous membrane to obtain a subsequent filtrate, adding a trypsin solution into the subsequent filtrate for homogenizing, performing enzymolysis to obtain a short-peptide donkey-hide gelatin solution, cooling the short-peptide donkey-hide gelatin solution to room temperature, and performing low-temperature freezing spray drying to obtain a short-peptide donkey-hide gelatin freeze-dried powder;
s2 preparation of rose probiotic freeze-dried powder: adding 9 times of distilled water by mass into sterile water-washed rose, crushing to obtain rose pulp, adding 10 wt% of sugar into the rose pulp for sterilization, adding lactic acid and bifidobacterium, fermenting for 16 hours to obtain a fermentation solution, filtering the fermentation solution with a microporous filter membrane, homogenizing the obtained filtrate to obtain a rose probiotic solution, cooling the rose probiotic solution to room temperature, and performing low-temperature freeze spray drying to obtain rose probiotic freeze-dried powder;
preparation of S3 product: adding sodium alginate powder, chitosan oligosaccharide powder and adjuvants into the lyophilized powder of oligopeptide donkey-hide gelatin obtained in S1 and the lyophilized powder of rose probiotics obtained in S2, and making into tablet, granule, capsule, mixture or QQ sugar.
Preferably, the donkey-hide gelatin powder in the S1 is 500 meshes.
Preferably, the solution in S1 is sodium bicarbonate or ammonium bicarbonate solution.
Preferably, the concentration of the trypsin solution in the S1 is 1mg/1ml, and the mass of the trypsin in the added trypsin solution is ten thousandth of the mass of the donkey-hide gelatin.
Preferably, the sugar in S2 is white sugar, black sugar or brown sugar.
Preferably, the amount of lactic acid added in S2 is 0.015-0.03 wt% of the amount of fermented liquid, and the amount of bifidobacterium added is 0.015-0.03 wt% of the amount of fermented liquid.
In order to achieve the third object, the invention adopts the technical scheme that:
the composition can be applied to the preparation of medicines, health-care products or foods for treating dysmenorrhea.
The mechanism and thought of the composition for treating dysmenorrhea provided by the invention are as follows:
the appearance of the endometrium can be observed under a microscope, and the endometrium is uneven and takes on a concave-convex shape like a hilly land. It is the unevenness of endometrium that causes the endometrium to strip and stimulate the uterine contraction unsmoothly to cause dysmenorrheal. The smoother the intima, the more it is likely to fall off, the less pain and irritation; the greater the degree of irregularity of the inner membrane, the more difficult it is to fall off, and dysmenorrhea is likely to occur. In real life, dysmenorrhea disappears in some women after childbirth. The reason is that the uterus before pregnancy is equivalent to a pear, about 50g, the uterus can weigh about 1000g and the foot is increased by 20 times when the pregnant woman is in full term, and 5000 ml of contents such as fetus, amniotic fluid and the like are contained in the uterus. Just like a blown up balloon! During this process, the endometrium is stretched and the flatness is greatly improved. For primary dysmenorrhea, the endometrium is relaxed during menstruation, so that the endometrium can be smooth and easy to fall off, and the pain caused by uterine contraction during dysmenorrhea is counteracted. For secondary dysmenorrhea, adenomyosis and endometriosis are caused by unsmooth shedding of the intima during each dysmenorrhea, and the intima growing next time shifts in the original position, and is increasingly poor in smoothness just like hyperosteogeny caused by bony spur. Even if the fertility is not improved, the endometriosis and the adenomyosis can be obtained after a long time. It can relax endometrium during menstruation, and can also eliminate endometriosis and treat adenomyosis. It was clarified that the difficulty in the exfoliation of the intima is the root cause of dysmenorrhea.
The invention provides a composition for treating dysmenorrhea by targeting inner membrane exfoliation as treatment, wherein short peptide donkey-hide gelatin freeze-dried powder, rose probiotic freeze-dried powder and food-grade compound amino acid are used for helping the inner membrane exfoliation; the anticoagulant function of the sodium alginate is utilized to help the menstrual blood to be discharged; chitosan oligosaccharides are used to promote the healing of endometrial wounds.
The invention has the beneficial effects that:
the invention defines that the difficulty in inner membrane shedding is the root cause of dysmenorrhea, and takes the inner membrane shedding as the treatment target, and provides the composition for treating the dysmenorrhea, wherein the short peptide donkey-hide gelatin freeze-dried powder, the rose probiotic freeze-dried powder and the food-grade compound amino acid are used for helping the inner membrane shedding; the anticoagulant function of the sodium alginate is utilized to help the menstrual blood to be discharged; chitosan oligosaccharides are used to promote the healing of endometrial wounds.
The product prepared from the composition for treating dysmenorrhea has an obvious effect and no toxic or side effect, and after the trial of more than one hundred volunteers, the pain is obviously relieved and disappears by 50 percent after the product is taken for one month no matter primary pain or secondary pain; after 3 months of administration, the pain completely disappeared.
The composition for treating dysmenorrhea has the advantages of simple preparation, convenient use, low cost, convenient production and wide application range, and has good application prospect.
Detailed Description
The principles and features of this invention are described below in conjunction with examples, which are set forth to illustrate, but are not to be construed to limit the scope of the invention.
Example 1:
a composition for treating dysmenorrhea comprises the following raw materials in parts by weight: 200g of donkey-hide gelatin, 100g of double-petal red rose, 240g of food-grade compound amino acid, 40g of sodium alginate, 30g of chitosan oligosaccharide and auxiliary materials: 500g of gelatin and 100g of pectin, wherein the donkey-hide gelatin is raw-grade donkey-hide gelatin produced by Dong-E donkey-hide gelatin company; the rose is red rose with multiple petals and flat yin in Shandong, the water content is less than or equal to 12.0 wt%, and the total ash content is less than or equal to 7.0 wt%.
A method of making a QQ saccharide from a composition as described above, comprising the steps of:
s1 preparation of short peptide donkey-hide gelatin freeze-dried powder: the donkey-hide gelatin blocks enter a water-cooling medicinal material crusher to be crushed into small particles with the diameter of below 6 mm, then enter a medicinal material universal crusher to crush the particles into 60 meshes, and finally enter a fluidized bed jet mill meeting the GMP-268 requirement to obtain 198 g of donkey-hide gelatin powder with the particle size of about 500 meshes. Adding colla Corii Asini powder and 198 ml 1% sodium bicarbonate solution into traditional Chinese medicine ultrasonic extractor, and processing for 30 min; filtering the obtained solution with microporous membrane to obtain continuous filtrate; adding 19 ml of trypsin solution with the concentration of 1mg/1ml into the subsequent filtrate, adding into a production type micro-jet high-pressure homogenizer for homogenizing, and simultaneously carrying out enzymolysis for 2.5 hours to obtain the short peptide donkey-hide gelatin solution. After the short peptide donkey-hide gelatin solution is cooled to room temperature, low-temperature freeze spray drying is carried out through a freeze spray dryer, and finally 170 g of short peptide donkey-hide gelatin freeze-dried powder is obtained.
S2 preparation of rose probiotic freeze-dried powder: after removing impurities and bad flowers from 100g of fresh Shandong Pingyin double-petal red rose petals, 99 g of usable rose flowers are obtained. Washing with sterile water for 2 times, adding 891 g of distilled water, and injecting into a pump type liquid pulverizer together to pulverize to obtain flos Rosae Rugosae slurry; adding 89 g of brown sugar (manufactured by Nanjing Ganyuan sugar industry Co., Ltd.) into the rose pulp, stirring with an electric stirrer, introducing into a fermentation tank, and sterilizing the liquid in the fermentation tank with an ultrasonic food sterilizer under the working conditions of 30KHz frequency and 10 minutes time. After sterilization, 0.22 g of lactic acid and 0.22 g of bifidobacterium were added for fermentation for 16 hours. And filtering the fermented solution after fermentation by using a microporous filter membrane, and adding the obtained filtrate into a production type micro-jet high-pressure homogenizer for homogenization to obtain the rose probiotic solution. And (3) after the rose probiotic solution is placed and cooled to room temperature, carrying out low-temperature freeze spray drying by using a freeze spray dryer, and finally obtaining 90g of rose probiotic freeze-dried powder.
S3QQ sugar product preparation: 170 g of the short peptide donkey-hide gelatin freeze-dried powder obtained in the step S1, 90g of the rose probiotic freeze-dried powder obtained in the step S2, 240g of food-grade compound amino acid (produced by Wakka Japonica biotechnology Co., Ltd., Zhuhai), 40g of sodium alginate, 30g of chitosan oligosaccharide, 500g of gelatin and 100g of pectin are added into a small QQ sugar machine for experiments, and 1170 g of QQ soft sweets are finally obtained. Each sugar weighed 6 grams, totaling 195.
Volunteer B had adenomyosis, taken 3 times daily, and was pseudoscopically on day 8 with 75% less sensation of pain. The administration was continued and the pain was felt to disappear completely by supposition on day 38.
Wherein, the equipment used in the preparation process is as follows:
water-cooling medicinal material breaker: model LFJ-18B, manufactured by Xiangming mechanical Equipment, Inc. of Guangzhou city;
the universal crusher for medicinal materials: type 20B, available from Emano;
fluidized bed jet mill: model ZRF-118, available from the company Emano;
traditional Chinese medicine ultrasonic extractor: BILON-CT5 model, manufactured by Shanghai Bilang instruments;
production type micro-jet high-pressure homogenizer: model will20-600, manufactured by Suzhou microflow nanotechnology, Inc.;
freezing and spraying a dryer: GS-P1000, manufactured by Shanghai Guxin Biotechnology, Inc.;
pump type liquid crusher: WDJ-150A, manufactured by Zhejiang Fengli crushing equipment Limited;
fermentation tank: shanghai Baoxing biological equipment engineering Co., Ltd;
ultrasonic food sterilization machine: hangzhou Jiazhen ultrasonic science and technology limited;
microporous filter membrane: MBR-microporous membrane, environment-friendly technology of Shandong Haolin Limited.
Example 2:
a composition for treating dysmenorrhea comprises the following raw materials in parts by weight: 240g of donkey-hide gelatin, 90g of double-petal red rose, 260g of food-grade compound amino acid, 30g of sodium alginate, 25g of chitosan oligosaccharide and auxiliary materials: 500g of gelatin and 100g of pectin, wherein the donkey-hide gelatin is raw-grade donkey-hide gelatin produced by Dong-E donkey-hide gelatin company; the rose is red rose with multiple petals and flat yin in Shandong, the water content is less than or equal to 12.0 wt%, and the total ash content is less than or equal to 7.0 wt%.
A method of making a QQ saccharide from a composition as described above, comprising the steps of:
s1 preparation of short peptide donkey-hide gelatin freeze-dried powder: the donkey-hide gelatin blocks enter a water-cooling medicinal material crusher to be crushed into small particles with the diameter of below 6 mm, then enter a medicinal material universal crusher to crush the particles into 60 meshes, and finally enter a fluidized bed jet mill meeting the GMP-268 requirement to obtain 236 g of donkey-hide gelatin powder with the particle size of about 500 meshes. Adding colla Corii Asini powder and 236 ml of 1% sodium bicarbonate solution into a traditional Chinese medicine ultrasonic extractor, and processing for 30 min; filtering the obtained solution with microporous membrane to obtain continuous filtrate; adding 24 ml of trypsin solution with the concentration of 1mg/1ml into the subsequent filtrate, adding the solution into a production type micro-jet high-pressure homogenizer for homogenization, and simultaneously carrying out enzymolysis for 2.5 hours to finally obtain the short peptide donkey-hide gelatin solution. After the short-peptide donkey-hide gelatin solution is cooled to room temperature, low-temperature freeze spray drying is carried out through a freeze spray dryer, and finally 234 g of short-peptide donkey-hide gelatin freeze-dried powder is obtained.
S2 preparation of rose probiotic freeze-dried powder: removing impurities and bad flowers from 90g of fresh Shandong Pingyin double-petal red rose petals to obtain 86 g of usable petals, washing with sterile water for 2 times, adding 774 g of distilled water, and injecting into a pump type liquid pulverizer together to pulverize to obtain rose slurry; 78 g of brown sugar (produced by Nanjing Ganyuan sugar industry Co., Ltd.) was added to the rose syrup, the mixture was stirred sufficiently with an electric stirrer, and introduced into a fermentation tank, and the liquid in the fermentation tank was sterilized with an ultrasonic food sterilizer under the operating conditions of 30KHz frequency and 10 minutes duration. After sterilization, 0.19 g of lactic acid and 0.19 g of bifidobacterium were added for fermentation for 16 hours. And filtering the fermented solution after fermentation by using a microporous filter membrane, and adding the obtained filtrate into a production type micro-jet high-pressure homogenizer for homogenization to obtain the rose probiotic solution. And (3) after the rose probiotic solution is placed and cooled to room temperature, carrying out low-temperature freeze spray drying by using a freeze spray dryer, and finally obtaining 81 g of rose probiotic freeze-dried powder.
S3QQ sugar product preparation: 234 g of short-peptide donkey-hide gelatin freeze-dried powder obtained in S1, 81 g of rose probiotic freeze-dried powder obtained in S2, 260g of food-grade compound amino acid (produced by Wakka biological technology Co., Ltd., Zhuhai), 30g of sodium alginate, 25g of chitosan oligosaccharide, 600 g of gelatin and 50g of pectin are added into a small QQ sugar machine for experiments, and 1280 g of QQ soft sweets are finally obtained. Each sugar weighed 6 grams, totaling 213.
Volunteer F had adenomyosis, taken 3 times daily, and was pseudoscopically on day 4 with 50% less sensation of pain. The patients continue to take the medicine, feel that the pain disappears 75% after taking the medicine for example again on day 32, and feel that the pain does not feel any pain at all after taking the medicine for example again on day 60.
Example 3:
a composition for treating dysmenorrhea comprises the following raw materials in parts by weight: 160g of donkey-hide gelatin, 120g of double-petal red rose, 190g of food-grade compound amino acid, 45g of sodium alginate, 35g of chitosan oligosaccharide and auxiliary materials: 500g of gelatin and 100g of pectin, wherein the donkey-hide gelatin is raw-grade donkey-hide gelatin produced by Dong-E donkey-hide gelatin company; the rose is red rose with multiple petals and flat yin in Shandong, the water content is less than or equal to 12.0 wt%, and the total ash content is less than or equal to 7.0 wt%.
A method of making a QQ saccharide from a composition as described above comprising the steps of:
s1 preparation of short peptide donkey-hide gelatin freeze-dried powder: the donkey-hide gelatin blocks enter a water-cooling medicinal material crusher to be crushed into small particles with the diameter of below 6 mm, then enter a medicinal material universal crusher to crush the particles into 60 meshes, and finally enter a fluidized bed jet mill meeting the GMP-268 requirement to obtain about 500 meshes of donkey-hide gelatin powder 158 g. Adding colla Corii Asini powder and 158 ml of 1% sodium bicarbonate solution into a traditional Chinese medicine ultrasonic extractor, and processing for 30 min; filtering the obtained solution with microporous membrane to obtain continuous filtrate; adding 24 ml of trypsin solution with the concentration of 1mg/1ml into the subsequent filtrate, adding the solution into a production type micro-jet high-pressure homogenizer for homogenization and enzymolysis at the same time, and finally obtaining the short peptide donkey-hide gelatin solution after 2.5 hours. After the short-peptide donkey-hide gelatin solution is cooled to room temperature, low-temperature freeze spray drying is carried out through a freeze spray dryer, and 150 g of short-peptide donkey-hide gelatin freeze-dried powder is finally obtained.
S2 preparation of rose probiotic freeze-dried powder: removing impurities and bad flowers from fresh Shandong Pingyin double-petal red rose petals to obtain 115 g of usable petals, washing with sterile water for 2 times, adding 990 g of distilled water, and injecting into a pump type liquid pulverizer together to pulverize to obtain rose slurry; adding 99 g of brown sugar (produced by Nanjing Ganyuan sugar industry Co., Ltd.) into the rose pulp, stirring with an electric stirrer, introducing into a fermentation tank, and sterilizing the liquid in the fermentation tank with an ultrasonic food sterilizer under the working conditions of 30KHz frequency and 10 minutes time. After sterilization, 0.26 g of lactic acid and 0.26 g of bifidobacterium were added for fermentation for 16 hours. And filtering the fermented solution after fermentation by using a microporous filter membrane, and adding the obtained filtrate into a production type micro-jet high-pressure homogenizer for homogenization to obtain the rose probiotic solution. And (3) after the rose probiotic solution is placed and cooled to room temperature, carrying out low-temperature freeze spray drying by using a freeze spray dryer to finally obtain 114 g of rose probiotic freeze-dried powder.
S3QQ sugar product preparation: 150 g of the short peptide donkey-hide gelatin freeze-dried powder obtained in the step S1, 114 g of the rose probiotic freeze-dried powder obtained in the step S2, 190g of food-grade compound amino acid (produced by Wakka Japonica Biotech Co., Ltd., Zhuhai), 45g of sodium alginate, 35g of chitosan oligosaccharide, 450 g of gelatin and 90g of pectin are added into a small QQ sugar machine for experiments, and 1070 g of QQ soft sweets are finally obtained. Each sugar weighed 6 grams, totaling 179.
Volunteers H with dysmenorrhea took 3 tablets per day, assumed at day 16, and originally took 2 tablets of ibuprofen each time, only 1 tablet this time. Pain is felt to be much less. The administration was continued, and on day 44, the patient was assumed again, and pain was completely relieved.
Example 4:
a full-automatic production line of 300 type jelly sweets produced by Shanghai Quizhong food machinery factory is adopted, a batch of bulk QQ candies are fully automatically produced by adopting the raw materials and the proportion of the raw materials of the implementation 1 to 3, and the QQ candies of which each package is 6 g are obtained by a FWM-800 full-automatic packaging machine produced by Zhejiang Haizian packaging equipment Limited. The candies are automatically boxed by a QCZ-120 horizontal type automatic box packing machine of Shanghai Quanchi mechanical company Limited and then packed by a full-automatic packing machine produced by Strobique.
After trial of 120 volunteers, 40 volunteers of the QQ candy products prepared in the formulas of the examples 1 to 3 are tried, and after the QQ candy is taken for one month, the pain is obviously relieved no matter whether primary pain or secondary pain exists, and disappears by 50%; after 3 months of administration, the pain completely disappeared.
Therefore, the composition for treating dysmenorrhea takes inner membrane shedding as a treatment target, the composition for treating dysmenorrhea is provided, and the short peptide donkey-hide gelatin freeze-dried powder, the rose probiotic freeze-dried powder and the food-grade compound amino acid are used for helping the inner membrane shedding; the anticoagulant function of the sodium alginate is utilized to help the menstrual blood to be discharged; the chitosan oligosaccharide is used for promoting the healing of endometrial wounds, has remarkable effect and no toxic or side effect, has the advantages of simple and convenient preparation, convenient use, low cost, convenient production and wide application range, and has good application prospect.
It is to be understood that the present invention has been described with reference to certain embodiments, and that various changes in the features and embodiments, or equivalent substitutions may be made therein by those skilled in the art without departing from the spirit and scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.
Claims (10)
1. The composition for treating dysmenorrhea is characterized by comprising the following raw materials in parts by weight: 16-24 parts of donkey-hide gelatin, 9-12 parts of rose, 19-26 parts of food-grade compound amino acid, 3-5 parts of sodium alginate and 2-4 parts of chitosan oligosaccharide.
2. The composition for treating dysmenorrhea according to claim 1, comprising the following raw materials in parts by weight: 20 parts of donkey-hide gelatin, 10 parts of rose, 24 parts of food-grade compound amino acid, 4 parts of sodium alginate and 3 parts of chitosan oligosaccharide.
3. Composition for the treatment of dysmenorrhea according to claim 1 or 2, wherein said rose is rose of pernya.
4. The composition for treating dysmenorrhea according to claim 3, further comprising conventional adjuvants for preparing medicines, health products or foods.
5. A process for the preparation of a composition for the treatment of dysmenorrhea according to any one of claims 1 to 4, comprising the steps of:
s1 preparation of short peptide donkey-hide gelatin freeze-dried powder: grinding and crushing donkey-hide gelatin to obtain donkey-hide gelatin powder, adding the donkey-hide gelatin powder and a solution with an equal proportion (1ml/mg) into an ultrasonic extractor for processing for 30 minutes to obtain an extracted solution, filtering the extracted solution by using a microporous membrane to obtain a subsequent filtrate, adding a trypsin solution into the subsequent filtrate for mixing and homogenizing, performing enzymolysis to obtain a short-peptide donkey-hide gelatin solution, cooling the short-peptide donkey-hide gelatin solution to room temperature, and performing low-temperature freezing spray drying to obtain a short-peptide donkey-hide gelatin freeze-dried powder;
s2 preparation of rose probiotic freeze-dried powder: adding 9 times of distilled water by mass into sterile water-washed rose, crushing to obtain rose pulp, adding 10 wt% of sugar into the rose pulp for sterilization, adding lactic acid and bifidobacterium, fermenting for 16 hours to obtain a fermentation solution, filtering the fermentation solution with a microporous filter membrane, homogenizing the obtained filtrate to obtain a rose probiotic solution, cooling the rose probiotic solution to room temperature, and performing low-temperature freeze spray drying to obtain rose probiotic freeze-dried powder;
preparation of S3 product: and (3) preparing the oligopeptide donkey-hide gelatin freeze-dried powder obtained in the step (S1), the rose probiotic freeze-dried powder obtained in the step (S2) and other raw materials into tablets, granules, capsules, mixtures or QQ candies.
6. The composition for treating dysmenorrhea according to claim 5, wherein said E-jiao powder in S1 is 500 mesh.
7. The composition for treating dysmenorrhea according to claim 5, wherein said solution in S1 is sodium bicarbonate or ammonium bicarbonate solution, and said sugar in S2 is white sugar, brown sugar or black sugar.
8. The composition for treating dysmenorrhea according to claim 5, wherein the concentration of said trypsin solution in S1 is 1mg/1ml, and the mass of trypsin in said trypsin solution is one ten thousandth of the mass of colla Corii Asini.
9. The composition for treating dysmenorrhea according to claim 8, wherein the amount of lactic acid added in S2 is 0.015-0.03 wt% of the amount of fermented liquid, and the amount of Bifidobacterium added is 0.015-0.03 wt% of the amount of fermented liquid.
10. Use of a composition according to any one of claims 1 to 4 for the preparation of a medicament or food product for the treatment of dysmenorrhea.
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