CN114467987A - Antimicrobial agent for anaerobic microorganisms and preparation method thereof - Google Patents
Antimicrobial agent for anaerobic microorganisms and preparation method thereof Download PDFInfo
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- 244000005700 microbiome Species 0.000 title claims abstract description 46
- 239000004599 antimicrobial Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title abstract description 4
- 239000000654 additive Substances 0.000 claims abstract description 53
- 230000000996 additive effect Effects 0.000 claims abstract description 50
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- 241000234282 Allium Species 0.000 claims abstract description 26
- 235000002732 Allium cepa var. cepa Nutrition 0.000 claims abstract description 26
- 240000002234 Allium sativum Species 0.000 claims abstract description 26
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims abstract description 26
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims abstract description 26
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims abstract description 26
- 235000004611 garlic Nutrition 0.000 claims abstract description 26
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims abstract description 24
- SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229960004995 magnesium peroxide Drugs 0.000 claims abstract description 22
- 239000004343 Calcium peroxide Substances 0.000 claims abstract description 20
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000019402 calcium peroxide Nutrition 0.000 claims abstract description 20
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 16
- 229960001631 carbomer Drugs 0.000 claims abstract description 16
- 239000011347 resin Substances 0.000 claims abstract description 16
- 229920005989 resin Polymers 0.000 claims abstract description 16
- HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960000282 metronidazole Drugs 0.000 claims abstract description 15
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960005053 tinidazole Drugs 0.000 claims abstract description 15
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940120146 EDTMP Drugs 0.000 claims abstract description 12
- YDONNITUKPKTIG-UHFFFAOYSA-N [Nitrilotris(methylene)]trisphosphonic acid Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CP(O)(O)=O YDONNITUKPKTIG-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960001484 edetic acid Drugs 0.000 claims abstract description 12
- NFDRPXJGHKJRLJ-UHFFFAOYSA-N edtmp Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CCN(CP(O)(O)=O)CP(O)(O)=O NFDRPXJGHKJRLJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 239000007787 solid Substances 0.000 claims abstract description 11
- BAERPNBPLZWCES-UHFFFAOYSA-N (2-hydroxy-1-phosphonoethyl)phosphonic acid Chemical compound OCC(P(O)(O)=O)P(O)(O)=O BAERPNBPLZWCES-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 7
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims abstract description 6
- 229940045872 sodium percarbonate Drugs 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 36
- 238000006243 chemical reaction Methods 0.000 claims description 25
- 239000000843 powder Substances 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 17
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 9
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 9
- 239000012535 impurity Substances 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000013618 particulate matter Substances 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 238000004506 ultrasonic cleaning Methods 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- -1 Ether Sulfone Chemical class 0.000 claims description 3
- DDAQLPYLBPPPRV-UHFFFAOYSA-N [4-(hydroxymethyl)-2-oxo-1,3,2lambda5-dioxaphosphetan-2-yl] dihydrogen phosphate Chemical compound OCC1OP(=O)(OP(O)(O)=O)O1 DDAQLPYLBPPPRV-UHFFFAOYSA-N 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 239000012257 stirred material Substances 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 230000004060 metabolic process Effects 0.000 abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 14
- 229910052760 oxygen Inorganic materials 0.000 description 13
- 239000001301 oxygen Substances 0.000 description 13
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- 230000000845 anti-microbial effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 150000002898 organic sulfur compounds Chemical class 0.000 description 3
- 239000010865 sewage Substances 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000222336 Ganoderma Species 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 240000000599 Lentinula edodes Species 0.000 description 1
- 235000001715 Lentinula edodes Nutrition 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 241000606701 Rickettsia Species 0.000 description 1
- 241000589970 Spirochaetales Species 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000000370 acceptor Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960004275 glycolic acid Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- MSLRPWGRFCKNIZ-UHFFFAOYSA-J tetrasodium;hydrogen peroxide;dicarbonate Chemical compound [Na+].[Na+].[Na+].[Na+].OO.OO.OO.[O-]C([O-])=O.[O-]C([O-])=O MSLRPWGRFCKNIZ-UHFFFAOYSA-J 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/06—Aluminium; Calcium; Magnesium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/42—Aloeaceae [Aloe family] or Liliaceae [Lily family], e.g. aloe, veratrum, onion, garlic or chives
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
Abstract
The invention provides an antimicrobial agent for anaerobic microorganisms and a preparation method thereof, and relates to the technical field of antimicrobial agents. An antimicrobial agent for anaerobic microorganisms comprises the following raw materials in parts by weight: 55-60 parts of carbomer resin, 8-10 parts of calcium peroxide, 8-10 parts of magnesium peroxide, 8-10 parts of sodium percarbonate, 6-8 parts of glycolic acid, 6-8 parts of citric acid, 2-3 parts of ethylene diamine tetraacetic acid, 2-3 parts of hydroxyethylidene diphosphonic acid, 2-3 parts of aminotrimethylene phosphonic acid, 2-3 parts of ethylene diamine tetramethylene phosphonic acid, 14-16 parts of garlic, 12-14 parts of onion, 8-10 parts of broccoli, 7-9 parts of metronidazole and 12-14 parts of tinidazole. Through the combined use of the additive A, the additive B, the solid additive and the liquid additive, the normal metabolism of microorganisms is inhibited, the production cost is effectively controlled, and the secondary pollution to the surrounding environment is avoided.
Description
Technical Field
The invention relates to the technical field of antimicrobial agents, in particular to an antimicrobial agent for anaerobic microorganisms and a preparation method thereof.
Background
The microorganisms include: the microorganism group is small in individual, closely related to human beings, covers various beneficial and harmful types, widely relates to various fields such as food, medicine, industry and agriculture, environmental protection, sports and the like, and is divided into the following 8 types in textbooks of China: bacteria, viruses, fungi, actinomycetes, rickettsia, mycoplasma, chlamydia and spirochete, some microorganisms can be seen by naked eyes, such as mushrooms, lucid ganoderma, lentinus edodes and the like belonging to fungi, the microorganisms are non-cell organisms consisting of a few components such as nucleic acid, protein and the like, and the microorganisms can be further divided into three types, namely aerobic microorganisms, facultative anaerobic microorganisms and anaerobic microorganisms.
Since the concern on environment and health is increasing in recent years, the antimicrobial and the safety and environmental protection are becoming problems to be solved at present, and the antimicrobial agents existing on the market at present basically cause certain harm to the environment or health, secondly, most antimicrobial agents only aim at aerobic microorganisms, and in the aspect of sewage treatment, a large amount of carbon dioxide, ammonia gas and the like are generated due to normal metabolism of anaerobic microorganisms, so that the odor of sewage is easy to smell, therefore, the problem of solving the antimicrobial agent for the anaerobic microorganisms is a necessary development problem in the future, and meanwhile, some antimicrobial agents have the problem of easy secondary pollution to the surrounding environment in the using process.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides an antimicrobial agent for anaerobic microorganisms, which solves the problems that the antimicrobial agent is not environment-friendly and toxic, has poor effect on the anaerobic microorganisms and is easy to cause secondary pollution.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: an antimicrobial agent for anaerobic microorganisms, comprising the following raw materials in parts by weight: 55-60 parts of carbomer resin, 8-10 parts of calcium peroxide, 8-10 parts of magnesium peroxide, 8-10 parts of sodium peroxycarbonate, 6-8 parts of glycolic acid, 6-8 parts of citric acid, 2-3 parts of ethylene diamine tetraacetic acid, 2-3 parts of hydroxyethylidene diphosphate, 2-3 parts of aminotrimethylene phosphonic acid, 2-3 parts of ethylene diamine tetramethylene phosphonic acid, 14-16 parts of garlic, 12-14 parts of onion, 8-10 parts of broccoli, 7-9 parts of metronidazole and 12-14 parts of tinidazole.
Preferably, a method for preparing an antimicrobial agent for anaerobic microorganisms, comprising the steps of:
s1, preparing an additive A
Sequentially putting the same weight parts of calcium peroxide, magnesium peroxide and sodium peroxycarbonate into a grinding machine, treating for 15-18 min at a speed of 280-320 r/min, then sieving the calcium peroxide, the magnesium peroxide and the sodium peroxycarbonate in a powder state to remove internal particulate matter impurities, then simultaneously adding the calcium peroxide, the magnesium peroxide and the sodium peroxycarbonate in the powder state into a powder mixer, and treating for 30-35 min at a speed of 150-180 r/min to obtain an additive A;
s2, preparing an additive B
Sequentially adding half of carbomer resin, glycolic acid, citric acid, ethylene diamine tetraacetic acid, hydroxyethylidene diphosphonic acid, aminotrimethylene phosphonic acid and ethylene diamine tetramethylene phosphonic acid into a reaction kettle, stirring for 15-20 min at the rotating speed of 330-350 r/min under the environment that the temperature is set to be 30-35 ℃, stopping stirring, raising the temperature to 40-45 ℃, standing for 50-55 min, adding the remaining half of carbomer resin into the reaction kettle, adjusting the temperature to be 30-35 ℃ again, and stirring at the rotating speed of 260-280 r/min;
taking out the fully stirred materials, putting the materials into a sealed container, storing the materials in an environment with the temperature set to be 20-25 ℃, taking out part of samples from the sealed container, detecting the pH value of the samples, and obtaining an additive B after the detection is qualified;
s3, preparing a liquid additive and a solid additive
Firstly, cleaning garlic, onion and broccoli in an ultrasonic cleaning machine, then drying the cleaned garlic, onion and broccoli in a drying box at the temperature of 30-35 ℃, then treating the garlic, onion and broccoli in a juice squeezing machine, collecting squeezed juice, and carrying out decoloring and filtering treatment to obtain a liquid additive;
putting the extruded residues into a drying box, drying at the temperature of 40-45 ℃, putting the dried residues into a high-speed pulverizer after drying, and pulverizing at the rotating speed of 650-700 r/min for 30-35 min to obtain a solid additive;
s4, preparing the auxiliary additive of the medicine
Sequentially putting metronidazole and tinidazole into a superfine grinding machine, treating for 8-10 min at a rotating speed of 500-550 r/min, then sieving the metronidazole and tinidazole in a powder state, removing internal particulate matter impurities, then simultaneously adding the metronidazole and tinidazole in the powder state into a powder mixer, and treating for 5-8 min at a rotating speed of 100-120 r/min to obtain a medicine auxiliary additive;
s5, mixing
Firstly, putting half of the additive B into a reaction kettle, then adding a solid additive into the reaction kettle, stirring and treating at a rotating speed of 330-350 r/min for 15-20 min in an environment with a temperature set to be 30-35 ℃, after stirring and treating, raising the temperature in the stirring kettle to 35-40 ℃, standing for 1.0-1.1 h, after standing, slowly adding the liquid additive into the reaction kettle, adding the remaining half of the additive B into the reaction kettle, stirring and treating at a rotating speed of 380-400 r/min for 20-25 min, after stirring and treating, adding the auxiliary drug additive into the reaction kettle, adjusting the temperature to be 30-35 ℃, stirring and treating at a rotating speed of 330-350 r/min for 15-20 min, after stirring and treating, slowly adding the additive A into the reaction kettle, stirring and treating at a rotating speed of 220-240 r/min for 40-45 min in an environment with a temperature set to be 10-15 ℃, the antimicrobial agent is obtained.
Preferably, the ratio of the calcium peroxide to the magnesium peroxide to the sodium percarbonate is 1: 1: 1, the ratio of the glycolic acid to the citric acid to the ethylenediamine tetraacetic acid to the hydroxyethylidene diphosphonic acid to the aminotrimethylene phosphonic acid to the ethylenediamine tetramethylene phosphonic acid by weight is 2: 2: 1: 1: 1: 1.
preferably, the stirring time after the remaining half of the carbomer resin is added in the step S2 is 25-30 min, and the qualified range of the pH value detection of the mixture in the sealed container in the step S2 is that the pH value is less than or equal to 3.0.
Preferably, the cleaning time of the garlic, the onion and the broccoli in the ultrasonic cleaning machine in the step S3 is 20-25 min, the drying treatment time of the garlic, the onion and the broccoli in the step S3 is 30-35 min, and the collected juice in the step S3 is decolorized by adopting a Polyester Ether Sulfone (PES)/polyvinyl pyrrolidone (PVP) composite membrane ultrafiltration technology.
(III) advantageous effects
The present invention provides an antimicrobial agent for anaerobic microorganisms. The method has the following beneficial effects:
1. according to the invention, calcium peroxide, magnesium peroxide and sodium percarbonate are treated and then added as an additive A, when the calcium peroxide, the magnesium peroxide and the sodium percarbonate contact with water, oxygen is slowly and continuously released, so that the oxygen content of a water body is effectively increased, and the purpose of inhibiting the normal metabolism of anaerobic microorganisms is achieved.
2. The antimicrobial agent contains a certain amount of organic sulfur compounds which have the function of sterilization by adding the treated garlic, onion and broccoli as liquid additives and solid additives, so that the normal metabolism of microorganisms is effectively inhibited, the production cost is effectively controlled by adding the garlic, onion and broccoli, the performance of the antimicrobial agent is effectively enhanced by adding the treated metronidazole and tinidazole as auxiliary additives of medicaments, and the inhibition effect on the normal metabolism of microorganisms is enhanced.
3. The antimicrobial agent is prepared from carbomer resin, calcium peroxide, magnesium peroxide, sodium percarbonate, glycolic acid, citric acid, ethylene diamine tetraacetic acid, hydroxyethylidene diphosphonic acid, aminotrimethylene phosphonic acid, ethylene diamine tetramethylene phosphonic acid, garlic, onion and broccoli, wherein the raw materials are nontoxic and harmless, so that the inhibition capability of aerobic microorganisms and facultative anaerobic microorganisms is effectively improved while the normal metabolism of the aerobic microorganisms and the facultative anaerobic microorganisms is inhibited, and the raw materials are adopted to accord with the modern environmental protection concept, so that the secondary pollution to the surrounding environment is avoided while the normal metabolism of the microorganisms is inhibited.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example (b):
the embodiment of the invention provides an antimicrobial agent for anaerobic microorganisms, which comprises the following raw materials in parts by weight: 55-60 parts of carbomer resin, 8-10 parts of calcium peroxide, 8-10 parts of magnesium peroxide, 8-10 parts of sodium peroxycarbonate, 6-8 parts of glycolic acid, 6-8 parts of citric acid, 2-3 parts of ethylene diamine tetraacetic acid, 2-3 parts of hydroxyethylidene diphosphate, 2-3 parts of aminotrimethylene phosphonic acid, 2-3 parts of ethylene diamine tetramethylene phosphonic acid, 14-16 parts of garlic, 12-14 parts of onion, 8-10 parts of broccoli, 7-9 parts of metronidazole and 12-14 parts of tinidazole.
A method for preparing an antimicrobial agent for anaerobic microorganisms, comprising the steps of:
s1, preparing an additive A
Sequentially putting the same weight parts of calcium peroxide, magnesium peroxide and sodium peroxycarbonate into a grinding machine, treating for 15-18 min at 280-320 r/min, then sieving the calcium peroxide, magnesium peroxide and sodium peroxycarbonate in powder state to remove internal particulate matter impurities, then simultaneously adding the calcium peroxide, magnesium peroxide and sodium peroxycarbonate in powder state into a powder mixer, treating for 30-35 min at 150-180 r/min to obtain an additive A, wherein the calcium oxide has the oxygen release characteristic when meeting water, is non-toxic and does not pollute the environment, is a widely used excellent oxygen supply agent, the magnesium peroxide releases oxygen when meeting water, adsorbs impurities in water, the sodium peroxycarbonate also generates oxygen when meeting water, and the calcium peroxide, magnesium peroxide and sodium peroxycarbonate are matched for use to generate certain oxygen in a water body, thereby enriching the oxygen content of the water body, for anaerobic microorganisms, the anaerobic microorganisms lack a perfect respiring enzyme system, and other substances except oxygen are used as acceptors, and can only ferment in a low oxygen partial pressure or anaerobic environment, and free oxygen exists, so that molecular oxygen can not be utilized, and will be poisoned by it and even die because it undergoes metabolism in an aerobic environment, often producing superoxide anion and hydrogen peroxide, both of which have strong killing effect, anaerobic microorganisms lack catalase, peroxidase, superoxide dismutase or respiratory enzymes with high redox potential, are affected by toxic oxygen groups in the presence of oxygen, and cannot grow and reproduce, thereby realizing the inhibition effect on anaerobic microorganisms, and the released substances after the reaction do not cause secondary damage to the surrounding environment, wherein, the magnesium peroxide can not only generate oxygen but also adsorb impurities after reacting with water;
s2, preparing an additive B
Sequentially adding half of carbomer resin, glycolic acid, citric acid, ethylene diamine tetraacetic acid, hydroxyethylidene diphosphonic acid, aminotrimethylene phosphonic acid and ethylene diamine tetramethylene phosphonic acid into a reaction kettle, stirring for 15-20 min at the rotating speed of 330-350 r/min under the environment that the temperature is set to be 30-35 ℃, stopping stirring, raising the temperature to 40-45 ℃, standing for 50-55 min, adding the remaining half of carbomer resin into the reaction kettle, adjusting the temperature to be 30-35 ℃ again, and stirring at the rotating speed of 260-280 r/min;
secondly, taking out the fully stirred materials, putting the materials into a sealed container, storing the materials in an environment with the temperature set to be 20-25 ℃, taking out part of samples from the sealed container to carry out PH value detection, and after the detection is qualified, the additive B can be obtained, the carbomer resin is hydrophilic in the acidic form and has weak acidity, the carbomer resin is used as the base material of the antimicrobial agent, the stability of the antimicrobial agent is effectively improved, and simultaneously, the viscosity is favorable for the mutual connection of the raw materials, glycolic acid, citric acid, ethylene diamine tetraacetic acid, hydroxyethylidene diphosphonic acid, aminotrimethylene phosphonic acid and ethylene diamine tetramethylene phosphonic acid can be dissolved in water, the purpose of changing the PH value of the water is realized by the matching use of the materials, for anaerobic microorganisms, the growth of all anaerobic microorganisms can be basically inhibited when the pH value in the environment is less than or equal to 3;
s3, preparing a liquid additive and a solid additive
Firstly, putting garlic, onions and broccoli into an ultrasonic cleaning machine for cleaning, then putting the cleaned garlic, onions and broccoli into a drying box, drying in an environment with the temperature set to be 30-35 ℃, then putting the garlic, the onions and the broccoli into a juice squeezing machine for processing, collecting squeezed juice, and performing decolorization and filtration treatment to obtain a liquid additive;
putting the extruded residues into a drying box, drying the residues in an environment with the temperature set to be 40-45 ℃, putting the dried residues into a high-speed pulverizer after drying, pulverizing the dried residues for 30-35 min at the rotating speed of 650-700 r/min to obtain a solid additive, wherein garlic, onion and broccoli all have organic sulfur compounds which have the functions of bacteriostasis and sterilization, so that the growth and the propagation of microorganisms are effectively suppressed, and only part of the organic sulfur compounds can be extracted by extruding the garlic, the onion and the broccoli, so that the residual waste residues are crushed and mixed with other solid materials, the utilization of the garlic, the onion and the broccoli is effectively guaranteed, and the environmental protection and the safety of the microbial agent are improved by adding plants;
s4, preparing the auxiliary additive of the medicine
Sequentially putting metronidazole and tinidazole into a superfine grinding machine, treating for 8-10 min at the rotating speed of 500-550 r/min, screening the metronidazole and tinidazole in powder state, removing internal particulate matter impurities, simultaneously adding the metronidazole and tinidazole in powder state into a powder mixing machine, and treating for 5-8 min at the rotating speed of 100-120 r/min to obtain a medicine auxiliary additive, wherein both the metronidazole and the tinidazole have an antimicrobial effect, and the antimicrobial effect can be effectively improved by properly adding medicines;
s5, mixing
Firstly, putting half of the additive B into a reaction kettle, then adding a solid additive into the reaction kettle, stirring and treating at a rotating speed of 330-350 r/min for 15-20 min in an environment with a temperature set to be 30-35 ℃, after stirring and treating, raising the temperature in the stirring kettle to 35-40 ℃, standing for 1.0-1.1 h, after standing, slowly adding the liquid additive into the reaction kettle, adding the remaining half of the additive B into the reaction kettle, stirring and treating at a rotating speed of 380-400 r/min for 20-25 min, after stirring and treating, adding the auxiliary drug additive into the reaction kettle, adjusting the temperature to be 30-35 ℃, stirring and treating at a rotating speed of 330-350 r/min for 15-20 min, after stirring and treating, slowly adding the additive A into the reaction kettle, stirring and treating at a rotating speed of 220-240 r/min for 40-45 min in an environment with a temperature set to be 10-15 ℃, the antimicrobial agent can be obtained, the sewage in the same area is divided into three equal parts and is respectively placed into a culture dish, then the three equal parts of materials are respectively marked as water A, water B and water C, the water A is not treated under the state of normal temperature and pressure, a proper amount of the existing antimicrobial agent on the market is added into the water B, the prepared antimicrobial agent is added into the water C, and the contents of the microorganisms in the water A, the water B and the water C are counted and recorded by a microscope every 12 hours, so that the following table is obtained:
| 1h | 12h | 24h | 36h | 48h | 60h | |
| a water | 254 | 268 | 289 | 305 | 334 | 379 |
| B water | 258 | 244 | 223 | 215 | 201 | 185 |
| C water | 267 | 236 | 221 | 208 | 185 | 142 |
It is understood that the microbial agent prepared as described above can effectively inhibit the metabolism of microorganisms.
The weight ratio of the calcium peroxide to the magnesium peroxide to the sodium carbonate peroxide is 1: 1: 1, the weight ratio of glycolic acid to citric acid to ethylenediamine tetraacetic acid to hydroxyethylidene diphosphonic acid to aminotrimethylene phosphonic acid to ethylenediamine tetramethylene phosphonic acid is 2: 2: 1: 1: 1: 1.
and (3) after the remaining half of the carbomer resin is added into the S2, stirring for 25-30 min, wherein the qualified range of the pH value detection of the mixture in the sealed container by the S2 is that the pH value is less than or equal to 3.0.
The garlic, the onion and the broccoli are cleaned in an ultrasonic cleaning machine for 20-25 min in S3, the garlic, the onion and the broccoli are dried for 30-35 min in S3, collected juice is decolorized in S3 by adopting a Polyester Ether Sulfone (PES)/polyvinylpyrrolidone (PVP) composite membrane ultrafiltration technology, and the garlic, the onion and the broccoli are decolorized so as to avoid pollution of internal pigments to a water body.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. An antimicrobial agent for anaerobic microorganisms, characterized in that: the material comprises the following raw materials in parts by weight: 55-60 parts of carbomer resin, 8-10 parts of calcium peroxide, 8-10 parts of magnesium peroxide, 8-10 parts of sodium peroxycarbonate, 6-8 parts of glycolic acid, 6-8 parts of citric acid, 2-3 parts of ethylene diamine tetraacetic acid, 2-3 parts of hydroxyethylidene diphosphate, 2-3 parts of aminotrimethylene phosphonic acid, 2-3 parts of ethylene diamine tetramethylene phosphonic acid, 14-16 parts of garlic, 12-14 parts of onion, 8-10 parts of broccoli, 7-9 parts of metronidazole and 12-14 parts of tinidazole.
2. The method for preparing an antimicrobial agent for anaerobic microorganisms according to claim 1, characterized in that: the method comprises the following steps:
s1, preparing an additive A
Sequentially putting the same weight parts of calcium peroxide, magnesium peroxide and sodium peroxycarbonate into a grinding machine, treating for 15-18 min at a speed of 280-320 r/min, then sieving the calcium peroxide, the magnesium peroxide and the sodium peroxycarbonate in a powder state to remove internal particulate matter impurities, then simultaneously adding the calcium peroxide, the magnesium peroxide and the sodium peroxycarbonate in the powder state into a powder mixer, and treating for 30-35 min at a speed of 150-180 r/min to obtain an additive A;
s2, preparing an additive B
Sequentially adding half of carbomer resin, glycolic acid, citric acid, ethylene diamine tetraacetic acid, hydroxyethylidene diphosphonic acid, aminotrimethylene phosphonic acid and ethylene diamine tetramethylene phosphonic acid into a reaction kettle, stirring for 15-20 min at the rotating speed of 330-350 r/min under the environment that the temperature is set to be 30-35 ℃, stopping stirring, raising the temperature to 40-45 ℃, standing for 50-55 min, adding the remaining half of carbomer resin into the reaction kettle, adjusting the temperature to be 30-35 ℃ again, and stirring at the rotating speed of 260-280 r/min;
taking out the fully stirred materials, putting the materials into a sealed container, storing the materials in an environment with the temperature set to be 20-25 ℃, taking out part of samples from the sealed container, detecting the pH value of the samples, and obtaining an additive B after the detection is qualified;
s3, preparing a liquid additive and a solid additive
Firstly, cleaning garlic, onion and broccoli in an ultrasonic cleaning machine, then drying the cleaned garlic, onion and broccoli in a drying box at the temperature of 30-35 ℃, then treating the garlic, onion and broccoli in a juice squeezing machine, collecting squeezed juice, and carrying out decoloring and filtering treatment to obtain a liquid additive;
putting the extruded residues into a drying box, drying at the temperature of 40-45 ℃, putting the dried residues into a high-speed pulverizer after drying, and pulverizing at the rotating speed of 650-700 r/min for 30-35 min to obtain a solid additive;
s4, preparing the auxiliary additive of the medicine
Sequentially putting metronidazole and tinidazole into a superfine grinding machine, treating for 8-10 min at a rotating speed of 500-550 r/min, then sieving the metronidazole and tinidazole in a powder state, removing internal particulate matter impurities, then simultaneously adding the metronidazole and tinidazole in the powder state into a powder mixer, and treating for 5-8 min at a rotating speed of 100-120 r/min to obtain a medicine auxiliary additive;
s5, mixing
Firstly, putting half of the additive B into a reaction kettle, then adding a solid additive into the reaction kettle, stirring and treating at a rotating speed of 330-350 r/min for 15-20 min in an environment with a temperature set to be 30-35 ℃, after stirring and treating, raising the temperature in the stirring kettle to 35-40 ℃, standing for 1.0-1.1 h, after standing, slowly adding the liquid additive into the reaction kettle, adding the remaining half of the additive B into the reaction kettle, stirring and treating at a rotating speed of 380-400 r/min for 20-25 min, after stirring and treating, adding the auxiliary drug additive into the reaction kettle, adjusting the temperature to be 30-35 ℃, stirring and treating at a rotating speed of 330-350 r/min for 15-20 min, after stirring and treating, slowly adding the additive A into the reaction kettle, stirring and treating at a rotating speed of 220-240 r/min for 40-45 min in an environment with a temperature set to be 10-15 ℃, the antimicrobial agent is obtained.
3. An antimicrobial agent for anaerobic microorganisms according to claim 1, characterized in that: the weight ratio of the calcium peroxide to the magnesium peroxide to the sodium percarbonate is 1: 1: 1, the ratio of the glycolic acid to the citric acid to the ethylenediamine tetraacetic acid to the hydroxyethylidene diphosphonic acid to the aminotrimethylene phosphonic acid to the ethylenediamine tetramethylene phosphonic acid by weight is 2: 2: 1: 1: 1: 1.
4. the method for producing an antimicrobial agent for anaerobic microorganisms according to claim 2, characterized in that: and the stirring time after the remaining half of the carbomer resin is added into the S2 is 25-30 min, and the qualified range of the pH value detection of the mixture in the sealed container in the S2 is that the pH value is less than or equal to 3.0.
5. The method for producing an antimicrobial agent for anaerobic microorganisms according to claim 2, characterized in that: the cleaning time of the garlic, the onion and the broccoli in the ultrasonic cleaning machine in the S3 is 20-25 min, the drying treatment time of the garlic, the onion and the broccoli in the S3 is 30-35 min, and the collected juice in the S3 is decolorized by adopting a Polyester Ether Sulfone (PES)/polyvinylpyrrolidone (PVP) composite membrane ultrafiltration technology.
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