CN114451551A

CN114451551A - Yang-warming and qi-tonifying paste formula and application thereof

Info

Publication number: CN114451551A
Application number: CN202210147960.5A
Authority: CN
Inventors: 张晓天; 韦硕硕; 钱呈秋; 余佩思; 唐嘉仪; 余承鸿; 朱蕴华; 王莹
Original assignee: Shuguang Hospital Affiliated to Shanghai University of TCM
Current assignee: Shuguang Hospital Affiliated to Shanghai University of TCM
Priority date: 2022-02-17
Filing date: 2022-02-17
Publication date: 2022-05-10
Anticipated expiration: 2042-02-17
Also published as: CN114451551B

Abstract

The invention relates to a yang-warming and qi-tonifying paste formula which is prepared from the following raw material medicines in parts by weight: 80-100 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 90-110 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 160 parts of radix codonopsis pilosulae 140, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of medlar, 160 parts of loranthus parasiticus 140-. The invention also provides application of the yang-warming and qi-tonifying paste formula. The invention warms and tonifies kidney yang, strengthens spleen and benefits qi, and benefits essence and fills marrow. The invention improves or treats yang deficiency constitution syndrome.

Description

Yang-warming and qi-tonifying paste formula and application thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, and in particular relates to a yang-warming and qi-tonifying paste formula and application thereof.

Background

In 1994, WHO defined the word "reproductive health", social development directly affected the level of cognition and the importance of medical health in individuals, and indirectly affected the reproductive health of women.

At present, the total birth rate of defective fetuses in China is as high as 5.6%, the abundance or insufficiency of the essence of the genitals of parents and the constitutional features determine the thickness and weakness of the innate endowments of the offspring and the robustness of the fetuses, and the innate endowments of the couples in the pre-pregnant reproductive age are the best in the mild constitutional state to breed the children, so that the growth and development of the offspring and the enhancement of the disease resistance are facilitated. It has been shown that the pregnancy rate of the fetus in both couples is as high as 2/3 due to the physical condition of the female. It is seen that the constitution of the mother has a profound effect on the health of the fetus and the conception. The prenatal health examination of the pregnant woman for later use before childbirth can effectively reduce the birth defects of the newborn. At present, in a plurality of areas of China, great attention is paid to physical conditioning and periodic examination of pregnant women, and the physical conditioning and periodic examination of the pregnant women are managed to reduce the physical defect of the baby girls.

At present, a new generation of women support half day of a workplace, the working pressure is gradually heavy, the daily work and rest are irregular, the dietary structure is unbalanced, the objective living environment has various factors such as industrialized air pollution, noise pollution, light pollution and the like, the innate endowment is insufficient, and the physical conditions of the women in the period of childbearing age are not optimistic. In most areas, the importance degree of health management of the female in the early pregnancy is low, and the popularization and the standardization are lacked. The traditional Chinese medicine conditioning can comprehensively aim at the health condition of the pregnant women in the childbearing age, carry out physical survey and adjustment of the unbalanced physical constitution of the pregnant women in the childbearing age, and fill the blank of health management of the women in the childbearing age in a special period.

The method can correct and regulate the unbalanced constitution, and if the group in the child bearing age does the method, the overall constitution condition of the offspring can be improved by regulating the constitution state of parents, namely, the method starts from regulating the constitution of the group in the child bearing age to realize the goal of 'good birth and good care'. Especially after the national second birth policy is opened, based on the factors, the conditioning of the biased constitution of women in the child bearing age (including the old lying-in women) in China is very slow. Although constitutions have a certain stability, constitutions can be adjusted if the acquired conditioning method is appropriate. The traditional Chinese medicine improves the physique through syndrome differentiation treatment of the unbalanced physique and personalized conditioning of the traditional Chinese medicine, and can improve the unbalanced physique condition of women in the childbearing age.

The ointment formula has mild physique conditioning effect, can effectively improve the partial physique state after being taken for a long time, has obvious curative effect on conditioning the patients with the yang deficiency physique by the winter-made ointment formula, can effectively improve the symptoms of the yang deficiency physique and reduce the judgment score of the yang deficiency physique compared with other conditioning methods.

Chinese patent document CN106581426A discloses a medicinal liquor for improving qi deficiency constitution type to reach mild constitution type and a formula thereof, wherein the medicinal liquor comprises pure grain liquor and medicinal materials; the medicinal materials comprise cornu Cervi Pantotrichum, Korean Ginseng, radix astragali, radix Codonopsis, radix Panacis Quinquefolii, radix Rhodiolae, Ganoderma, radix Pseudostellariae, Glycyrrhrizae radix, fructus Schisandrae chinensis, Achyranthis radix, Poria, Corni fructus, rhizoma Polygonati Odorati, fructus Lycii, herba Cynomorii, Eucommiae cortex, and radix Angelicae sinensis; the invention has the beneficial effects that: people with qi deficiency constitution often drink the medicinal liquor, and the medicinal liquor can achieve the purpose of gradually improving qi deficiency constitution to achieve the purpose of moderating constitution.

However, the existing paste formula for warming yang and tonifying qi, which has obvious curative effect and small side effect, is not reported.

Disclosure of Invention

The invention aims to provide a paste formula for warming yang and tonifying qi aiming at the defects in the prior art.

Still another purpose of the invention is to provide application of the yang-warming and qi-tonifying paste formula.

In order to achieve the first purpose, the invention adopts the technical scheme that: the paste prescription for warming yang and tonifying qi is prepared from the following raw material medicines in parts by weight: 80-100 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 90-110 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 160 parts of radix codonopsis pilosulae 140, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of medlar, 160 parts of loranthus parasiticus 140-.

Preferably, the yang-warming and qi-tonifying paste formula is prepared from the following raw material medicines in parts by weight: 85-95 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 95-105 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 145-part of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of medlar, 145-part of taxillus chinensis, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice root, 90 parts of red date, 100 parts of black sesame seed, 200 parts of donkey-hide gelatin, 100 parts of deerhorn glue, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine

More preferably, the yang-warming and qi-tonifying paste formula comprises 90 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 100 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 150 parts of codonopsis pilosula, 150 parts of raw astragalus membranaceus, 150 parts of roasted astragalus membranaceus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 150 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice root, 90 parts of red date, 100 parts of black sesame, 200 parts of donkey-hide gelatin, 100 parts of antler gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine.

In order to achieve the second object, the invention adopts the technical scheme that:

the application of the paste formula for warming yang and tonifying qi in preparation of foods, health-care products or medicines for improving or treating yang deficiency constitutional syndromes.

Preferably, the syndrome of yang deficiency refers to aversion to cold, cold limbs, resistance to summer and winter, preference for hot drinks, and clear and long urine.

The invention has the advantages that:

1. the treatment principle of the invention is as follows: to warm and tonify kidney yang, strengthen spleen and replenish qi, replenish essence and replenish marrow.

Compatibility of medicines: the yang-warming and qi-tonifying prescription is prepared by adding and reducing degerming materials into middle-jiao soup, middle-jiao-tonifying and qi-tonifying soup, Guilu Erjiao Wan and Shenling Baizhu powder, is prepared by decocting cornu cervi degelatinatum and colla cornus cervi, has warm nature, is good at warming and nourishing governor vessels, warming kidney and tonifying yang, replenishing vital essence and nourishing blood, tender rhizoma curculiginis, herba epimedii, warming kidney and tonifying yang, dispelling cold dampness, radix morindae officinalis, tonifying kidney yang, strengthening bones and muscles and eliminating rheumatism, and also has the effect of strengthening liver and kidney by using loranthus parasiticus. Korean red ginseng has the characteristics of large fire and sufficient energy, is a first choice nourishing medicinal material for people with excessive yin and yang deficiency, is good in tonifying qi and fire, restoring pulse and tonifying spleen, is emphasized by radix codonopsis pilosulae and white ginseng to tonify spleen and lung, tonify qi and nourish blood, and is also emphasized by Chinese yam to tonify spleen and qi, and strengthen body resistance and consolidate constitution. The medicines are combined together to supplement qi, strengthen yang and tonify spleen and kidney, and are combined as monarch medicines.

Raw roasted astragalus root, radix astragali, rhizoma atractylodis macrocephalae, semen coicis, rhizoma polygonati, rhizoma atractylodis macrocephalae, rhizoma atractylodis macrocephalae, rhizoma atractylodis, and rhizoma atractylodis, which are used as ministeris, which are used for strengthening, and rhizoma atractylodis, and stomach strengthening, and rhizoma polygonati, and rhizoma atractylodis, and is used as ministeris, and is used for strengthening, and is also used as ministeris, and also used as ministeries, and has the functions of nourishing yin, and tonifying spleen and nourishing, and tonifying the functions of nourishing yin, and tonifying the functions of the lung, and tonifying the functions of nourishing, and tonifying qi, tonifying the spleen and nourishing, and tonifying the spleen. Taking ginseng, poria cocos and bighead atractylodes rhizome as bulk drugs, strengthening the spleen and excreting dampness, supplementing the heart and spleen with arillus longan, nourishing the blood and soothing the nerves, nourishing the heart and soothing the nerves, tonifying the spleen and tonifying the kidney with lotus seed pulp, nourishing yin and improving eyesight with medlar, tonifying the kidney with walnut meat and controlling nocturnal emission; radix Curcumae has effects in promoting blood circulation, cooling blood, clearing away heart-fire, and relieving depression; guang Chen Pi regulates qi to invigorate spleen, eliminates dampness to resolve phlegm, and tonifies all the herbs without stagnation. The prepared licorice root strengthens the spleen and regulates the middle warmer, the black sesame tonifies the liver and the kidney, the essence and the blood are benefited, the red jujube strengthens the spleen, nourishes the blood and calms the nerves, the maltose is blended with the white honey to blend the taste, and the yellow wine introduces the medicines to the channels to blend the medicines together. The whole formula takes spleen and kidney as the basis, warms yang and transforms qi, and also nourishes yin and spirit, and treats accompanying symptoms to achieve the effects of warming and invigorating kidney yang, strengthening spleen and replenishing qi, and replenishing vital essence and marrow.

The main diseases to be treated by the invention are: people with yang deficiency such as aversion to cold, cold limbs, resistance to summer and winter, preference for hot drinks, clear and long urine, etc.

The using method comprises the following steps: the dosage of the ointment is determined according to the disease condition or the physical condition of the patient and the nature of the medicine, and is closely related to the digestive function of the patient. Generally, the dosage should be gradually increased from small dosage, such as taking one spoon of 10-15 g for adult every day, and if digestion function is normal, taking twice after 1 week for 1 day, i.e. 1 time each with empty stomach after getting up in the morning and 1 hour before sleeping in the evening.

2. Animal experiments show that the paste formula for warming yang and tonifying qi has an obvious effect on the HPA axis of a rat with kidney-yang deficiency and an obvious effect.

Detailed Description

The following provides a detailed description of specific embodiments of the present invention.

Example 1 preparation of a formula of a paste for warming yang and invigorating qi (I)

90 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 100 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 150 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry, 150 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler glue, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

EXAMPLE 2 preparation of a formula of a paste for warming yang and invigorating qi in accordance with the present invention

90 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 90 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 160 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 155 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler glue, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

Example 3 preparation of a formula of a paste for warming yang and invigorating qi in accordance with the present invention

80 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 110 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 145 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 150 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler glue, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

Example 4 preparation of a formula of a paste for warming yang and invigorating qi (IV)

100 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 95 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 155 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 140 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler gelatin, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

Example 5 preparation of a formula of a paste for warming yang and invigorating qi (V) of the present invention

85 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 105 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 150 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 160 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler glue, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

Example 6 preparation of a formula of a paste for warming yang and invigorating qi (VI) according to the invention

95 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 100 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 140 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry, 145 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler glue, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

Example 7 preparation of a formula of a paste for warming yang and invigorating qi (seven)

90 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 110 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 155 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 150 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler glue, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

EXAMPLE 8 preparation of a formula of a paste for warming yang and invigorating qi (VIII)

80 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 95 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 150 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 140 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler glue, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

Example 9 preparation of a formula of a paste for warming yang and invigorating qi in accordance with the present invention (nine)

100 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 105 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 140 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 160 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler gelatin, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

Example 10 preparation of a formula of a paste for warming yang and invigorating qi (ten)

85 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 100 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 160 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry, 145 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler glue, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

Example 11 preparation of a formula of a paste for warming yang and invigorating qi in accordance with the present invention (eleven)

95 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 90 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 145 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 155 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler gelatin, decocting the medicines for removing residues, adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice, melting and collecting paste.

Example 12

1.1 animals

50 female rats with SPF grade, 3 months old and about 180-. And (3) changing padding and water in the cage every day to keep dry and clean, and controlling the feeding temperature to be 19-21 ℃ and the humidity to be 75-82%.

1.2 test drugs

Traditional Chinese medicine control group: the traditional Chinese medicine comprises the following components: 90 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 100 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 150 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of cynomorium songaricum, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of cinnamon, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of monkshood, 150 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame and 100 parts of antler glue, decocting the medicines for removing residues, and adding 200 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine into thick juice. The preparation is administered by mixing with purified water.

The invention relates to a formula II of yang-warming qi-tonifying paste: prepared as described in example 2. The preparation is administered by mixing with purified water.

The yang-warming and qi-tonifying paste disclosed by the invention is prepared from the following components in percentage by weight: prepared as described in example 1. The preparation is administered by mixing with purified water.

Hydrocortisone injection (2mL:10 mg/injection, Shanghai modern Hussen pharmaceutical industry, national drug Standard: H41021930).

1.3 grouping and Molding

According to the random number table method, 10 rats were selected from 50 rats as a normal control group, the remaining 40 rats were subjected to kidney-yang deficiency molding, and hydrocortisone was injected into the molded rats at a dose of 25mg/kg at the abundant muscle of the hind limb for 12 consecutive days. Based on the diagnosis standard of kidney yang deficiency in Chinese diagnostics, after the modeling treatment, the rats have reduced food intake and water intake, reduced activity, slow response, reduced body temperature, cold contraction of limbs, reduced physical quality, and rare hair loss, etc., which prompts the success of modeling, and the rats are divided into four groups according to a random digital table method after the success of modeling: a model group, a traditional Chinese medicine control group, a yang-warming and qi-tonifying paste formula group 2 and a yang-warming and qi-tonifying paste formula group 1.

1.4 modes of administration and observations and statistics

After successful modeling, rats in each group were weighed and different interventions were performed on each group starting on day 2.

The normal control group was perfused with 2mL of physiological saline daily for 28 consecutive days, anesthetized in the morning on day 29, weighed and sacrificed.

Model groups, 2mL of saline was gavaged daily for 28 consecutive days, rats were anesthetized in the morning on day 29 and weighed for sacrifice.

A traditional Chinese medicine control group, which is to administer corresponding liquid medicine for intragastric administration according to the dose of 10g crude drugs/(kg. d) -1, wherein the crude drugs are raw materials except sugar and yellow wine; the gavage was continued for 28 days, and the rats were anesthetized in the morning on day 29 and weighed and sacrificed.

The invention relates to a yang-warming and qi-tonifying paste formula 2, which is prepared by taking 10g of crude drugs/(kg.d) -1 according to the dose of (example 2) and then administering the corresponding liquid medicine for intragastric administration, wherein the crude drugs are raw materials except sugar and yellow wine; the gavage was continued for 28 days, and the rats were anesthetized in the morning on day 29 and weighed and sacrificed.

The invention relates to a yang-warming and qi-tonifying paste formula set 1, which is characterized in that 10g of crude drugs/(kg.d) -1 are given to corresponding liquid medicines according to the dose of (example 1) and the crude drugs are filled into stomach, wherein the crude drugs are raw materials except sugar and yellow wine; the gavage was continued for 28 days, and the rats were anesthetized in the morning on day 29 and weighed and sacrificed.

Observation indexes are as follows:

1, measuring the contents of T, ACTH and CORT in serum by an ELISA method, adopting a heart blood taking method, taking blood, placing in a centrifuge tube, controlling the temperature to be 4 ℃, standing for 2h, centrifuging for 10min (rotating speed is 3000r/min), separating serum, and placing in a refrigerator at-20 ℃ for detection. Serum T, ACTH, CORT levels were measured by enzyme-linked immunosorbent assay (ELISA) and performed exactly according to the procedures of the ELISA kit instructions.

2. And measuring the body mass of the rat and the weights of the hypothalamus, the pituitary and the adrenal gland, and recording the body mass when each group of rats successfully model and the body mass after the 29 th gastrodia elata is drunk. After sacrifice, the rats were dissected and the adrenal, pituitary, hypothalamic tissues were peeled off and weighed.

Statistical method

SPSS21.0 meter software is adopted to process data, and each group of statistical data is calculated according to

The inter-group comparison was performed using one-way analysis of variance (ANO-VA). P < 0.05 indicates that the difference is statistically significant.

1.5 results:

1. comparison of T, ACTH and CORT contents in serum of rats of each group

Compared with a normal control group, the contents of serum T, ACTH and CORT of the kidney-yang deficiency model rat after model building are obviously reduced (P is less than 0.05), and the success of model building is prompted. Compared with a model group, the traditional Chinese medicine control group, the yang-warming and qi-tonifying paste formula group 2 and the yang-warming and qi-tonifying paste formula group 1 have improved serum T content (P is less than 0.05), and the yang-warming and qi-tonifying paste formula group 1 has the best effect; compared with the model group, the traditional Chinese medicine control group has no obvious effect on improving the ACTH level, and the Yang warming and Qi benefiting paste formula group 2 and the Yang warming and Qi benefiting paste formula group 1 can obviously improve the ACTH level (P is less than 0.05); the yang-warming and qi-tonifying paste formula 1 can improve the CORT level (P is less than 0.05) to a certain extent. Compared with the normal control group, the differences of the serum T, ACTH and CORT in the yang-warming and qi-tonifying paste formula group 2 and the yang-warming and qi-tonifying paste formula group 1 have statistical significance (P is less than 0.05). The results are shown in Table 1.

TABLE 1 comparison of the serum T, ACTH, CORT content in rats of each group

Note: p < 0.05 compared to the normal control group; compared with the model group, # PP < 0.05; compared with the traditional Chinese medicine control group, the delta P is less than 0.05.

2. Compared with a normal control group, the weight increase of rats in the weight ratio of the body weight of rats to the weight of hypothalamus, pituitary gland and adrenal gland of each group is obviously slowed down; compared with the model group, the body mass changes of rats in the traditional Chinese medicine control group, the yang-warming and qi-tonifying paste formula group 2 and the yang-warming and qi-tonifying paste formula group 1 are increased to different degrees (P is less than 0.05), and the yang-warming and qi-tonifying paste formula group 1 is most obvious. Compared with a normal control group, the weight of the adrenal gland, the pituitary gland and the hypothalamus of the rat in the model group is obviously reduced (P is less than 0.05); compared with a model group, the medicine dry prognosis shows that the yang-warming and qi-tonifying paste formula group 1 shows obvious difference (P is less than 0.05). The results are shown in Table 2.

TABLE 2 comparison of rat body mass and hypothalamic, pituitary and adrenal gland weights for each group

The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.

Claims

1. The yang-warming and qi-tonifying paste formula is characterized by being prepared from the following raw material medicines in parts by weight: 80-100 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 90-110 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 160 parts of codonopsis pilosula 140, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of medlar, 160 parts of loranthus 140, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice root, 90 parts of red date, 100 parts of black sesame, 200 parts of donkey-hide gelatin, 100 parts of deerhorn glue, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine.

2. The yang-warming and qi-tonifying paste formula according to claim 1 is characterized by being prepared from the following raw material medicines in parts by weight: 85-95 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 95-105 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 155 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of medlar, 145 parts of taxillus chinensis, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice root, 90 parts of red date, 100 parts of black sesame seed, 200 parts of donkey-hide gelatin, 100 parts of deerhorn glue, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine.

3. The yang-warming and qi-tonifying paste formula according to claim 2 is characterized by being prepared from the following raw material medicines in parts by weight: 90 parts of red ginseng, 90 parts of white ginseng, 90 parts of cornu cervi degelatinatum, 100 parts of tender curculigo orchioides, 150 parts of epimedium herb, 90 parts of morinda officinalis, 150 parts of codonopsis pilosula, 150 parts of raw astragalus, 150 parts of roasted astragalus, 150 parts of fried bighead atractylodes rhizome, 200 parts of raw coix seed, 200 parts of cooked coix seed, 150 parts of white poria, 150 parts of common yam rhizome, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 150 parts of parasitic loranthus, 100 parts of walnut meat, 100 parts of lotus seed meat, 100 parts of longan pulp, 90 parts of honey-fried licorice, 90 parts of red date, 100 parts of black sesame, 200 parts of donkey-hide gelatin, 100 parts of antler gelatin, 250 parts of maltose, 250g parts of white honey and 250 parts of yellow wine.

4. Use of the paste formulation for warming yang and invigorating qi according to claims 1 to 3 for the preparation of food, health product or medicament for improving or treating yang deficiency constitutional syndrome.

5. The use of claim 4, wherein the syndrome of yang deficiency is aversion to cold, cold limbs, tolerance to summer but not winter, preference for hot drinks, and clear and profuse urine.