CN112915181A - Qi-tonifying and vitality-restoring ointment formula and application thereof - Google Patents
Qi-tonifying and vitality-restoring ointment formula and application thereof Download PDFInfo
- Publication number
- CN112915181A CN112915181A CN202110200945.8A CN202110200945A CN112915181A CN 112915181 A CN112915181 A CN 112915181A CN 202110200945 A CN202110200945 A CN 202110200945A CN 112915181 A CN112915181 A CN 112915181A
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- parts
- tonifying
- raw
- radix
- vitality
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Abstract
The invention relates to a qi-tonifying and vitality-restoring ointment formula and application thereof, wherein the qi-tonifying and vitality-restoring ointment formula is prepared from the following raw material medicines in parts by weight: 80-120 parts of sun-dried ginseng, 180 parts of radix astragali preparata, 180 parts of raw radix astragali, 180 parts of radix pseudostellariae, 180 parts of radix codonopsis pilosulae, 180 parts of rhizoma dioscoreae, 180 parts of raw semen coicis, 180 parts of cooked semen coicis, 180 parts of polyporus umbellatus, 180 parts of poria cocos, 80-100 parts of pericarpium citri reticulatae, 80-100 parts of radix curcumae, 80-100 parts of fructus lycii, 80-100 parts of mulberry, 180 parts of loranthus parasiticus, 80-100 parts of cortex eucommiae, 80-120 parts of achyranthes bidentata, 80-100 parts of raw liquorice, 200 parts of donkey-hide gelatin, 300 parts of maltose, 200 parts of honey and 300 parts of yellow wine. The qi-tonifying and vitality-restoring ointment can obviously improve the overall functions of people with qi deficiency and has obvious fatigue relieving effect.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a qi-tonifying and vitality-restoring ointment formula and application thereof.
Background
The traditional Chinese medicine health-preserving paste formula is a semi-fluid preparation prepared by repeatedly decocting traditional Chinese medicine decoction pieces according to the principle of traditional Chinese medicine, removing residues, taking juice, evaporating and concentrating, and adding sugar, honey or donkey-hide gelatin and the like, has good effects on weak and susceptible people, sub-health states, chronic diseases, special crowds such as children, women, old people and the like, and is increasingly widely applied in modern clinic.
In long-term clinical practice, the applicant uses a self-prepared qi-tonifying and vitality-restoring ointment formula to perform intervention treatment on people with qi-deficiency constitution in winter seasons, and can remarkably improve the symptoms of qi deficiency of people with qi-deficiency constitution, so that the people with qi-deficiency constitution tend to be mild in quality. The basic formula of the qi-tonifying and vitality-restoring ointment comprises the following components: 150 g of white ginseng (decocted separately), 150 g of honey-fried astragalus root, 150 g of raw astragalus root, 150 g of codonopsis pilosula, 150 g of fried bighead atractylodes rhizome, 90 g of pericarpium citri reticulatae, 200 g of raw coix seed, 200 g of cooked coix seed, 150 g of whole angelica, 150 g of common yam rhizome, 200 g of white poria, 100 g of lotus seed pulp, 90 g of wide curcuma aromatica, 90 g of medlar, 90 g of vinegar radix bupleuri, 150 g of loranthus parasiticus, 90 g of raw liquorice, 100 g of longan pulp, 100 g of black sesame, 100 g of walnut pulp, 100 g of red date and fine materials: 300 g of donkey-hide gelatin, 100 g of antler gelatin, 500 g of white honey and 500 g of yellow wine. The preparation method comprises the following steps: preparing 999 Chinese medicinal granules, fine materials, and adjuvants (yellow wine, Mel, etc.) with corresponding variety and dosage according to above prescription, mixing all Chinese medicinal granules in a pot, adding water, dissolving, heating, and stirring. The traditional Chinese medicine formula particles are melted completely and stirred uninterruptedly until the medicine is concentrated to obtain the ointment.
In the later practical process, the applicant adjusts the medicine to obtain another prescription on the basis of earlier work, and animal experiments prove that the effect is more obvious.
Disclosure of Invention
The invention aims to provide a qi-tonifying and vitality-restoring ointment formula aiming at the defects in the prior art.
The invention further aims to provide a preparation method of the qi-tonifying and vitality-restoring cream.
The invention also aims to provide application of the qi-tonifying and vitality-restoring cream.
In order to achieve the first purpose, the invention adopts the technical scheme that:
the qi-tonifying and vitality-restoring ointment formula is prepared from the following raw material medicines in parts by weight: 80-120 parts of sun-dried ginseng, 180 parts of radix astragali preparata, 180 parts of raw radix astragali, 180 parts of radix pseudostellariae, 180 parts of radix codonopsis pilosulae, 180 parts of rhizoma dioscoreae, 180 parts of raw semen coicis, 180 parts of cooked semen coicis, 180 parts of polyporus umbellatus, 180 parts of poria cocos, 80-100 parts of pericarpium citri reticulatae, 80-100 parts of radix curcumae, 80-100 parts of fructus lycii, 80-100 parts of mulberry, 180 parts of loranthus parasiticus, 80-100 parts of cortex eucommiae, 80-120 parts of achyranthes bidentata, 80-100 parts of raw liquorice, 200 parts of donkey-hide gelatin, 300 parts of maltose, 200 parts of honey and 300 parts of yellow wine.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 90-110 parts of sun-dried ginseng, 160 parts of radix astragali preparata 140-.
More preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 100 parts of sun-dried ginseng, 150 parts of roasted astragalus, 150 parts of raw astragalus, 150 parts of radix pseudostellariae, 150 parts of radix codonopsis pilosulae, 150 parts of Chinese yam, 150 parts of raw coix seed, 150 parts of cooked coix seed, 150 parts of polyporus umbellatus, 150 parts of poria cocos, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 90 parts of mulberry fruit, 150 parts of parasitic loranthus, 90 parts of salted eucommia bark, 100 parts of radix achyranthis bidentatae, 90 parts of raw licorice, 250 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine.
Preferably, the preparation method is as follows: decocting raw materials except colla Corii Asini, maltose, Mel and yellow wine, removing residue, adding concentrated juice into colla Corii Asini, maltose, Mel and yellow wine, melting, and collecting paste.
Preferably, it further comprises a pharmaceutically acceptable carrier.
In order to achieve the second object, the invention adopts the technical scheme that:
the preparation method of the qi-tonifying and vitality-restoring paste formula comprises the steps of taking raw materials except the donkey-hide gelatin, the maltose, the white honey and the yellow wine, carrying out thick decoction, removing residues, taking thick juice, adding the donkey-hide gelatin, the maltose, the white honey and the yellow wine, melting and collecting paste.
In order to achieve the third object, the invention adopts the technical scheme that:
the application of the qi-tonifying and vitality-restoring ointment formula in preparing food, health-care products or medicines for improving qi deficiency symptoms of qi-deficiency individuals.
The application of the qi-tonifying and vitality-restoring ointment formula in preparing foods, health-care products or medicines for improving chronic fatigue syndrome.
Herein, the sun-dried ginseng, i.e., ginseng dried by a drying apparatus after being washed clean. The radix astragali Preparata refers to parched radix astragali. Slicing radix astragali, i.e. radix astragali after sun drying. Radix Pseudostellariae is dry root tuber of Pseudostellaria heterophylla of Caryophyllaceae. Radix Codonopsis is radix Codonopsis produced in Shanxi province, smooth county. The dioscorea opposita is a medicinal dioscorea opposita produced in the south of Henan. The raw Coicis semen is dried mature seed of Gramineae plant Coicis semen, sun-dried in autumn when fruit is mature, and directly used after removing shell, tawny seed coat and impurities. The cooked Coicis semen is obtained by parching Coicis semen with wheat bran until its surface turns yellowish. Polyporus umbellatus is sclerotium of Polyporus umbellatus of Polyporaceae. Poria refers to Poria cocos (Schw.) wolf produced in Yunnan province. Guang Chen Pi is a special product in Xinhui province of Jiangmen city, Guangdong province. Guang Yu jin is the special product of Guangdong province. Fructus Lycii is mature fruit of Lycium barbarum L of Solanaceae. The Mori fructus is fruit cluster of mulberry of Moraceae arbor. Herba Taxilli is dry stem and branch with leaves of herba Taxilli of Taxilliaceae. Salted eucommia bark is prepared by parching cortex Eucommiae with saline water. Achyranthes bidentata is a special achyranthes bidentata produced in Jiaozuo city in Henan province. Raw licorice refers to the dry root and rhizome of the medicinal plant licorice. The Dong E jiao is a glue block prepared by removing hair from donkey skin of Equidae donkey and decocting.
The invention has the advantages that:
1. the qi-tonifying and primordial qi-restoring cream formula disclosed by the invention has the advantages that sun-dried ginseng can greatly tonify primordial qi, spleen and lung are benefited, raw roasted astragalus root can tonify qi, strengthen superficial resistance and warm middle-jiao, radix pseudostellariae can invigorate spleen and enrich blood, body fluid is generated and thirst is resolved, codonopsis pilosula emphasizes on strengthening spleen and tonifying lung, and qi and blood are invigorated, all the medicines are combined, qi and blood are tonified, yin and yang are applied simultaneously, and the medicine is combined by taking. Rhizoma dioscoreae has the effects of tonifying spleen and qi, and strengthening body resistance to consolidate the constitution; the coix seed is matched with fried coix seed, so that the spleen is strengthened, the body resistance is strengthened, the dampness is promoted and the evil is eliminated, the umbellate pore fungus and the poria cocos are used together, the spleen strengthening effect is achieved, the damp turbidity of the lung and the spleen is infiltrated downwards, and the reinforcing and reducing effects of the six-ingredient rehmannia pill are achieved; the composition is used as a ministerial drug. Radix Curcumae has effects in promoting blood circulation, cooling blood, clearing away heart-fire, and relieving depression; the pericarpium citri reticulatae has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm, and tonifying the medicines without stagnation; the medlar is used for improving eyesight, the loranthus parasiticus is used for strengthening tendons and bones, the mulberry is used for nourishing liver and kidney, the eucommia ulmoides and the achyranthes bidentata are used for nourishing liver and kidney, and strengthening tendons and bones, and the medicines are used for tonifying liver and kidney and are used as adjuvant medicines. The liquorice invigorates the spleen and regulates the middle warmer, the maltose tonifies the middle warmer and qi, strengthens the spleen and stomach, the donkey-hide gelatin nourishes the blood and nourishes yin, the white honey tonifies the middle warmer and moistens dryness, the yellow wine invigorates the blood circulation and removes obstruction in channels, the medicine is guided to the channels, the taste is modified, and the taste is improved, so that the medicine is delicious and is harmonized. The whole formula takes spleen and stomach as the basis, has the functions of tonifying liver and kidney, regulating qi and blood, warming and nourishing middle jiao, and treating accompanying symptoms so as to strengthen spleen and tonify qi, reinforce vitality and fix the instruction, and has the effect of regulating yin and yang.
2. Animal experiments show that the qi-tonifying and vitality-restoring ointment formula has obvious fatigue relieving effect on mice with chronic fatigue syndrome and obvious effect.
Detailed Description
The following provides a detailed description of specific embodiments of the present invention.
Example 1 preparation of a Qi-invigorating and recovery-restoring cream formulation of the present invention
100 parts of sun-dried ginseng, 150 parts of roasted astragalus root, 150 parts of raw astragalus root, 150 parts of radix pseudostellariae, 150 parts of radix codonopsis pilosulae, 150 parts of Chinese yam, 150 parts of raw coix seed, 150 parts of cooked coix seed, 150 parts of polyporus umbellatus, 150 parts of poria cocos, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 90 parts of mulberry fruit, 150 parts of loranthus parasiticus, 90 parts of salted eucommia bark, 100 parts of radix achyranthis bidentatae and 90 parts of raw liquorice. The medicines are decocted in a thick mode, dregs are removed, 250g of donkey-hide gelatin, 250g of maltose, 250g of white honey and 250g of yellow wine are added into thick juice, and melting is carried out to obtain paste.
EXAMPLE 2 preparation of the Qi benefiting and vitality restoring cream formulation of the present invention (II)
80 parts of sun-dried ginseng, 180 parts of roasted astragalus, 120 parts of raw astragalus, 180 parts of radix pseudostellariae, 120 parts of radix codonopsis, 180 parts of Chinese yam, 120 parts of raw coix seed, 180 parts of cooked coix seed, 120 parts of polyporus umbellatus, 180 parts of poria cocos, 80 parts of pericarpium citri reticulatae, 100 parts of radix curcumae, 80 parts of wolfberry fruit, 100 parts of mulberry fruit, 120 parts of loranthus parasiticus, 100 parts of salted eucommia bark, 80 parts of radix achyranthis bidentatae and 100 parts of raw liquorice. The above medicines are decocted in a thick mode, dregs are removed, 200 parts of donkey-hide gelatin, 300 parts of maltose, 200 parts of white honey and 300 parts of yellow wine are added into thick juice, and melting and paste collection are carried out.
EXAMPLE 3 preparation of the Qi benefiting and vitality restoring cream formulation of the present invention (III)
80 parts of sun-dried ginseng, 120 parts of roasted astragalus, 180 parts of raw astragalus, 180 parts of radix pseudostellariae, 120 parts of radix codonopsis pilosulae, 120 parts of Chinese yam, 180 parts of raw coix seed, 180 parts of cooked coix seed, 120 parts of polyporus umbellatus, 120 parts of poria cocos, 100 parts of pericarpium citri reticulatae, 100 parts of radix curcumae, 80 parts of wolfberry fruit, 80 parts of mulberry fruit, 180 parts of loranthus parasiticus, 100 parts of salted eucommia ulmoides, 80 parts of radix achyranthis bidentatae and 80 parts of raw liquorice. The above medicines are decocted in a thick mode, dregs are removed, 300 parts of donkey-hide gelatin, 300 parts of maltose, 200 parts of white honey and 200 parts of yellow wine are added into thick juice, and melting and paste collection are carried out.
EXAMPLE 4 preparation of the Qi benefiting and vitality restoring cream formulation of the present Invention (IV)
120 parts of sun-dried ginseng, 180 parts of roasted astragalus, 120 parts of raw astragalus, 120 parts of radix pseudostellariae, 180 parts of radix codonopsis pilosulae, 180 parts of Chinese yam, 120 parts of raw coix seed, 120 parts of cooked coix seed, 180 parts of polyporus umbellatus, 180 parts of poria cocos, 80 parts of pericarpium citri reticulatae, 80 parts of radix curcumae, 100 parts of wolfberry fruit, 100 parts of mulberry fruit, 120 parts of loranthus parasiticus, 80 parts of salted eucommia bark, 120 parts of radix achyranthis bidentatae and 100 parts of raw liquorice. The above medicines are decocted in a thick mode, dregs are removed, 200 parts of donkey-hide gelatin, 200 parts of maltose, 300 parts of white honey and 300 parts of yellow wine are added into thick juice, and melting and paste collection are carried out.
Example 5 preparation of a Qi-invigorating and recovery-restoring cream formulation of the present invention (V)
120 parts of sun-dried ginseng, 120 parts of roasted astragalus, 180 parts of raw astragalus, 120 parts of radix pseudostellariae, 180 parts of radix codonopsis pilosulae, 120 parts of Chinese yam, 180 parts of raw coix seed, 120 parts of cooked coix seed, 180 parts of polyporus umbellatus, 120 parts of poria cocos, 100 parts of pericarpium citri reticulatae, 80 parts of radix curcumae, 100 parts of wolfberry fruit, 80 parts of mulberry fruit, 180 parts of loranthus parasiticus, 100 parts of salted eucommia bark, 80 parts of radix achyranthis bidentatae and 100 parts of raw liquorice. The above medicines are decocted in a thick mode, dregs are removed, 300 parts of donkey-hide gelatin, 200 parts of maltose, 300 parts of white honey and 200 parts of yellow wine are added into thick juice, and melting and paste collection are carried out.
EXAMPLE 6 preparation of the Qi benefiting and vitality restoring cream formulation of the present invention (VI)
80 parts of sun-dried ginseng, 120 parts of roasted astragalus root, 120 parts of raw astragalus root, 180 parts of radix pseudostellariae, 180 parts of radix codonopsis pilosulae, 180 parts of Chinese yam, 120 parts of raw coix seed, 120 parts of cooked coix seed, 120 parts of polyporus umbellatus, 180 parts of poria cocos, 100 parts of pericarpium citri reticulatae, 100 parts of radix curcumae, 80 parts of wolfberry fruit, 80 parts of mulberry fruit, 120 parts of loranthus parasiticus, 100 parts of salted eucommia bark, 120 parts of radix achyranthis bidentatae and 100 parts of raw liquorice. The above medicines are decocted for concentration and dregs are removed, 200 parts of donkey-hide gelatin, 200 parts of maltose, 200 parts of white honey and 300 parts of yellow wine are added into the concentrated juice, and the mixture is melted and taken out.
EXAMPLE 7 preparation of the Qi benefiting and vitality restoring cream formulation of the present invention (Qi)
120 parts of sun-dried ginseng, 180 parts of roasted astragalus, 180 parts of raw astragalus, 120 parts of radix pseudostellariae, 120 parts of radix codonopsis pilosulae, 120 parts of Chinese yam, 180 parts of raw coix seed, 180 parts of cooked coix seed, 180 parts of polyporus umbellatus, 120 parts of poria cocos, 80 parts of pericarpium citri reticulatae, 80 parts of radix curcumae, 100 parts of wolfberry fruit, 100 parts of mulberry fruit, 180 parts of loranthus parasiticus, 80 parts of salted eucommia bark, 80 parts of radix achyranthis bidentatae and 80 parts of raw liquorice. The above medicines are decocted in a thick mode, dregs are removed, 300 parts of donkey-hide gelatin, 300 parts of maltose, 300 parts of white honey and 200 parts of yellow wine are added into thick juice, and melting and paste collection are carried out.
EXAMPLE 8 preparation of the Qi benefiting and vitality restoring cream formulation of the present invention (eight)
80 parts of sun-dried ginseng, 120 parts of roasted astragalus root, 120 parts of raw astragalus root, 180 parts of radix pseudostellariae, 180 parts of radix codonopsis pilosulae, 180 parts of Chinese yam, 120 parts of raw coix seed, 120 parts of cooked coix seed, 120 parts of polyporus umbellatus, 180 parts of poria cocos, 100 parts of pericarpium citri reticulatae, 100 parts of radix curcumae, 100 parts of wolfberry fruit, 100 parts of mulberry fruit, 180 parts of loranthus parasiticus, 80 parts of salted eucommia bark, 80 parts of radix achyranthis bidentatae and 80 parts of raw liquorice. The above medicines are decocted in a thick mode, dregs are removed, 300 parts of donkey-hide gelatin, 300 parts of maltose, 300 parts of white honey and 200 parts of yellow wine are added into thick juice, and melting and paste collection are carried out.
EXAMPLE 9 preparation of the Qi benefiting and vitality restoring cream formulation of the present invention (nine)
90 parts of sun-dried ginseng, 160 parts of roasted astragalus, 140 parts of raw astragalus, 160 parts of radix pseudostellariae, 140 parts of radix codonopsis pilosulae, 160 parts of Chinese yam, 140 parts of raw coix seed, 160 parts of cooked coix seed, 140 parts of polyporus umbellatus, 160 parts of poria cocos, 80 parts of pericarpium citri reticulatae, 100 parts of radix curcumae, 80 parts of wolfberry fruit, 100 parts of mulberry fruit, 140 parts of loranthus parasiticus, 100 parts of salted eucommia bark, 90 parts of radix achyranthis bidentatae and 100 parts of raw liquorice. Decocting the above medicines in a thick mode, removing residues, adding 240 parts of donkey-hide gelatin, 260 parts of maltose, 240 parts of white honey and 260 parts of yellow wine into thick juice, melting and collecting paste.
Example 10 preparation of a Qi-invigorating and recovery cream formulation of the invention (ten)
110 parts of sun-dried ginseng, 160 parts of roasted astragalus, 140 parts of raw astragalus, 140 parts of radix pseudostellariae, 160 parts of radix codonopsis, 160 parts of Chinese yam, 140 parts of raw coix seed, 140 parts of cooked coix seed, 160 parts of polyporus umbellatus, 160 parts of poria cocos, 80 parts of pericarpium citri reticulatae, 80 parts of radix curcumae, 100 parts of wolfberry fruit, 100 parts of mulberry fruit, 140 parts of loranthus parasiticus, 80 parts of salted eucommia bark, 110 parts of radix achyranthis bidentatae and 100 parts of raw liquorice. Decocting the above medicines in a thick mode, removing residues, adding 240 parts of donkey-hide gelatin, 240 parts of maltose, 260 parts of white honey and 260 parts of yellow wine into thick juice, melting and collecting paste.
EXAMPLE 11 preparation of a Qi benefiting and vitality restoring cream formulation of the present invention (eleven)
90 parts of sun-dried ginseng, 140 parts of roasted astragalus, 160 parts of raw astragalus, 160 parts of radix pseudostellariae, 140 parts of radix codonopsis pilosulae, 140 parts of Chinese yam, 160 parts of raw coix seed, 160 parts of cooked coix seed, 140 parts of polyporus umbellatus, 140 parts of poria cocos, 100 parts of pericarpium citri reticulatae, 100 parts of radix curcumae, 80 parts of wolfberry fruit, 80 parts of mulberry fruit, 160 parts of loranthus parasiticus, 100 parts of salted eucommia ulmoides, 90 parts of radix achyranthis bidentatae and 80 parts of raw liquorice. The medicines are decocted for thick time and dregs are removed, thick juice is taken to be added with 260 parts of donkey-hide gelatin, 260 parts of maltose, 240 parts of white honey and 240 parts of yellow wine, and the mixture is melted and collected into paste.
EXAMPLE 12 preparation of the Qi benefiting and vitality restoring cream formulation of the present invention (twelve)
110 parts of sun-dried ginseng, 140 parts of roasted astragalus, 160 parts of raw astragalus, 140 parts of radix pseudostellariae, 160 parts of radix codonopsis, 140 parts of Chinese yam, 160 parts of raw coix seed, 140 parts of cooked coix seed, 160 parts of polyporus umbellatus, 140 parts of poria cocos, 100 parts of pericarpium citri reticulatae, 80 parts of radix curcumae, 100 parts of wolfberry fruit, 80 parts of mulberry fruit, 160 parts of loranthus parasiticus, 80 parts of salted eucommia bark, 110 parts of radix achyranthis bidentatae and 80 parts of raw liquorice. The medicines are decocted for thick time and dregs are removed, thick juice is taken to be added with 260 parts of donkey-hide gelatin, 240 parts of maltose, 260 parts of white honey and 240 parts of yellow wine, and the mixture is melted and collected into paste.
Example 13 intervention of the Qi-invigorating recovery paste formulation of the invention on the behavioural sciences of rats with chronic fatigue syndrome
1 materials and methods
1.1 animals
The SPF grade SD healthy rats are male, 50 in total, have the body mass of 180-220 g, and are provided by the animal experiment center of Shanghai medical university. Adaptive feeding for 1 week at room temperature of about 23 deg.C and relative humidity of 40-70%.
1.2 test drugs
The invention relates to a qi-tonifying and vitality-restoring ointment formula which comprises the following components in parts by weight: prepared as described in example 1. The preparation is administered by mixing with purified water.
The original qi-tonifying and vitality-restoring ointment formula comprises the following components: 150 g of white ginseng (decocted separately), 150 g of honey-fried astragalus root, 150 g of raw astragalus root, 150 g of codonopsis pilosula, 150 g of fried bighead atractylodes rhizome, 90 g of pericarpium citri reticulatae, 200 g of raw coix seed, 200 g of cooked coix seed, 150 g of whole angelica, 150 g of common yam rhizome, 200 g of white poria, 100 g of lotus seed pulp, 90 g of wide curcuma aromatica, 90 g of medlar, 90 g of vinegar-processed bupleurum, 150 g of Chinese taxillus twig, 90 g of raw liquorice, 100 g of longan pulp, 100 g of black sesame, 100 g of walnut pulp and 100 g of red date. The above medicines are decocted for concentration and dregs are removed, and the concentrated juice is added with 300 g of donkey-hide gelatin, 100 g of antler gelatin, 350 g of white honey and 350 g of yellow wine to be melted and collected into paste. The preparation is administered by mixing with purified water.
Ginsenoside tablets: purchased from yawei pharmaceutical limited, joint venture, china medicine, and the quasi-character: 03032019. the preparation method comprises grinding ginsenoside tablet, mixing with purified water, and making into solution.
1.3 grouping and Molding
The 50 SD rats are randomly divided into 5 groups, including a normal group, a model group, a qi-tonifying and recovery paste formula group, an original qi-tonifying and recovery paste formula group and a ginsenoside group, wherein each group comprises 10 rats. The other 4 groups except the normal control group were molded by the complex stimulation method.
Specifically, a chronic binding method, a cold water swimming method and a random day and night inversion method are adopted for compound stimulation molding. Single day chronic restraint method: the restraint cylinder is manufactured by self, the size of the restraint cylinder is suitable for being filled into a rat but the head of the rat cannot rotate freely, the head of the rat is drilled into the restraint cylinder towards the ventilation opening, the rat does not have strong resistance, and the rat is then erected on a wood board and is restrained for 30min each time. A double-day cold water swimming method: a swimming pool with size of 200cm × 80cm × 80cm is prepared, water depth is set to 50cm, water temperature is 10 + -1 deg.C, and rats are placed into swimming for 8min every time, and the swimming pool is carried out every other day. Random day and night inversion method: the continuous fluorescent lamp irradiation is given at 18:00 nights to 6:00 next morning, and the sun is placed in a dark closed environment for 3 times. The mold was made for 2 weeks. All rats were free to eat basal diet and distilled water during molding. The model rats have the typical characteristics of chronic fatigue, such as obviously reduced body mass, food intake and activity capacity, sensitivity to external stimulation and the like, which indicates that the modeling is successful.
1.4 modes of administration
The corresponding liquid medicine is given to each group 1min before the start of each molding for intragastric administration. The invention relates to a qi-tonifying and recovery paste formula set and an original qi-tonifying and recovery paste formula set, which are prepared from 10g of crude drugs/(kg. d)-1The dosage of (1) is administered to corresponding liquid medicine for intragastric administration, wherein the crude drug is raw materials except sugar and yellow wine. Ginsenoside group 70 mg/(kg. d)-1The ginsenoside solution is administered by intragastric administration. The administration volume was 5 ml. The normal group and the model group were given an equal volume of physiological saline. For 2 consecutive weeks.
1.5 behavioral index Studies
1.5.1 open field experiments
SD rats are placed in a box (80cm multiplied by 40cm) with 25 squares with the same area on the bottom surface and black-coated inner walls, the number of the squares which the rats pass through (taking four claws all enter the same square) within 3min is measured and is counted as the horizontal movement frequency, and the number of the vertical hind limbs (the front claws are emptied or climb the box wall) is counted as the vertical frequency.
1.5.2 rat tail suspension experiment
A1 cm portion of the tail end of the SD rat was fixed to a stainless steel plate to make the rat in an inverted state, and the struggle frequency (the total number of times the rat turned upside down from the inverted state) and the immobility time (the total time the rat was in a state of standing still) were observed within 5 min.
1.5.3 exhaustive swimming test
The SD rat is placed in a swimming pool with the water depth of 50cm and the temperature of 28 ℃ for swimming, and the swimming time is exhausted by taking the fact that the rat can not float out of the water surface when entering the water until the head part of the rat can not float out of the water surface for 10 s.
1.6 statistical methods
Data processing is carried out by using SPSS 23.0 statistical software
Data between groups are shown to be compared using one-way anova. P<A difference of 0.05 is statistically significant.
2 results
2.1 open field test results
The results (table 1) show that the number of crossing and the number of erections of the model group rats are significantly reduced compared with the normal control group, and the difference is statistically significant (P < 0.05). The number of the crossing and the erecting times of the rats in each administration group are obviously increased compared with those of the rats in the model group, and the difference has statistical significance (P < 0.05). The rats in the qi-tonifying and recovery paste formula group have the most penetration times and the most erection times, and compared with the original qi-tonifying and recovery paste formula group and the ginsenoside group, the differences have statistical significance (P is less than 0.05).
TABLE 1 number of crossing of rats andnumber of times of erection
Note: compared with the control group, the compound of the formula,*P<0.05; in comparison with the set of models,#P<0.05; compared with the qi-tonifying and vitality-restoring ointment formula group of the invention,△P<0.05。
2.2 rat tail suspension test results
The results (table 2) show that the number of struggling times of the model group rats is obviously reduced compared with the control group, the immobility time is obviously prolonged, and the difference has statistical significance (P < 0.05). Compared with the model group, the struggling times of rats in each administration group are increased, the immobility time is prolonged, and the differences of the rats in the original qi-tonifying and recovery cream formula group compared with the model group have statistical significance except that the differences of the suspension immobility time of the rats in the original qi-tonifying and recovery cream formula group compared with the model group have no statistical significance (P < 0.05). Compared with the qi-tonifying and recovery paste formula group, the struggle times of rats in the original qi-tonifying and recovery paste formula group and the ginsenoside group are obviously less than that in the qi-tonifying and recovery paste formula group (P <0.05), and the immobility time is obviously longer than that in the qi-tonifying and recovery paste formula group (P < 0.05).
TABLE 2 struggle times and immobility time for each group of rats
Note: compared with the control group, the compound of the formula,*P<0.05; in comparison with the set of models,#P<0.05; compared with the qi-tonifying and vitality-restoring ointment formula group of the invention,△P<0.05。
2.3 exhaustive swimming test results
The results (table 3) show that the model group depleted swimming time was significantly shortened compared to the control group, with the difference being statistically significant (P < 0.05). Compared with the model group, the exhaustive swimming time of the rats in each administration group is remarkably prolonged, and the difference has statistical significance (P < 0.05). The exhaustion swimming time of the rats in the qi-tonifying and recovery paste formula group is obviously longer than that of the rats in the original qi-tonifying and recovery paste formula group and ginsenoside group, and the differences have statistical significance (P < 0.05).
TABLE 3 exhaustive swimming time for each group of rats
Note: compared with the control group, the compound of the formula,*P<0.05; in comparison with the set of models,#P<0.05; compared with the qi-tonifying and vitality-restoring ointment formula group of the invention,△P<0.05。
the above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.
Claims (8)
1. The qi-tonifying and vitality-restoring ointment formula is characterized by being prepared from the following raw material medicines in parts by weight: 80-120 parts of sun-dried ginseng, 180 parts of radix astragali preparata, 180 parts of raw radix astragali, 180 parts of radix pseudostellariae, 180 parts of radix codonopsis pilosulae, 180 parts of rhizoma dioscoreae, 180 parts of raw semen coicis, 180 parts of cooked semen coicis, 180 parts of polyporus umbellatus, 180 parts of poria cocos, 80-100 parts of pericarpium citri reticulatae, 80-100 parts of radix curcumae, 80-100 parts of fructus lycii, 80-100 parts of mulberry, 180 parts of loranthus parasiticus, 80-100 parts of cortex eucommiae, 80-120 parts of achyranthes bidentata, 80-100 parts of raw liquorice, 200 parts of donkey-hide gelatin, 300 parts of maltose, 200 parts of honey and 300 parts of yellow wine.
2. The qi-tonifying and vitality-restoring cream formula according to claim 1 is characterized by being prepared from the following raw material medicines in parts by weight: 90-110 parts of sun-dried ginseng, 160 parts of radix astragali preparata 140-.
3. The traditional Chinese medicine composition according to claim 2, which is prepared from the following raw materials in parts by weight: 100 parts of sun-dried ginseng, 150 parts of roasted astragalus, 150 parts of raw astragalus, 150 parts of radix pseudostellariae, 150 parts of radix codonopsis pilosulae, 150 parts of Chinese yam, 150 parts of raw coix seed, 150 parts of cooked coix seed, 150 parts of polyporus umbellatus, 150 parts of poria cocos, 90 parts of pericarpium citri reticulatae, 90 parts of radix curcumae, 90 parts of wolfberry fruit, 90 parts of mulberry fruit, 150 parts of parasitic loranthus, 90 parts of salted eucommia bark, 100 parts of radix achyranthis bidentatae, 90 parts of raw licorice, 250 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow wine.
4. The qi-tonifying and recovery cream formulation according to any one of claims 1 to 3, characterized by being prepared by the following method: decocting raw materials except colla Corii Asini, maltose, Mel and yellow wine, removing residue, adding concentrated juice into colla Corii Asini, maltose, Mel and yellow wine, melting, and collecting paste.
5. The qi benefiting restoration cream formulation according to any one of claims 1-4, further comprising a pharmaceutically acceptable carrier.
6. The preparation method of the qi-tonifying and vitality-restoring paste prescription according to any one of claims 1 to 3, which is characterized in that the raw materials except the dong donkey-hide gelatin, the maltose, the white honey and the yellow wine are taken, the thick juice is taken, the dong donkey-hide gelatin, the maltose, the white honey and the yellow wine are added, and the paste is obtained after melting.
7. Use of the qi-tonifying recovery cream formulation of any one of claims 1 to 3 in the preparation of a food, health product or medicament for improving the symptoms of qi deficiency in a subject with qi deficiency.
8. Use of the qi-tonifying recovery cream formulation of any one of claims 1 to 3 in the preparation of a food, health product or medicament for ameliorating chronic fatigue syndrome.
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| CN114432410A (en) * | 2021-12-28 | 2022-05-06 | 上海中医药大学附属曙光医院 | Blood-activating and stasis-removing ointment formula and application thereof |
| CN114451551A (en) * | 2022-02-17 | 2022-05-10 | 上海中医药大学附属曙光医院 | Yang-warming and qi-tonifying paste formula and application thereof |
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| CN112717068A (en) * | 2021-02-08 | 2021-04-30 | 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) | Traditional Chinese medicine composition for treating chronic fatigue syndrome and application thereof |
-
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| CN112717068A (en) * | 2021-02-08 | 2021-04-30 | 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) | Traditional Chinese medicine composition for treating chronic fatigue syndrome and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 张晓天等: "中药膏方对体质的改善研究", 《首届中日传统医药与亚健康学术论坛》 * |
| 张晓天等: "益气复元膏方对气虚质人群的临床干预研究", 《河南中医》 * |
| 郭丽雯等: "益气复元膏方改善气虚质病人整体机能的疗效观察", 《安徽医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114432410A (en) * | 2021-12-28 | 2022-05-06 | 上海中医药大学附属曙光医院 | Blood-activating and stasis-removing ointment formula and application thereof |
| CN114451551A (en) * | 2022-02-17 | 2022-05-10 | 上海中医药大学附属曙光医院 | Yang-warming and qi-tonifying paste formula and application thereof |
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