CN114437911B - Gene sequencing device - Google Patents
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- CN114437911B CN114437911B CN202210035377.5A CN202210035377A CN114437911B CN 114437911 B CN114437911 B CN 114437911B CN 202210035377 A CN202210035377 A CN 202210035377A CN 114437911 B CN114437911 B CN 114437911B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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Abstract
The invention discloses a gene sequencing device, which comprises: the shell comprises two opposite side plate assemblies which are arranged at intervals, each side plate assembly is provided with a first guide groove, each first guide groove comprises a first transverse guide groove and a first vertical guide groove, and the upper end of each first vertical guide groove is communicated with the rear end of each first transverse guide groove; the chip mounting mechanism is arranged between the two side plate assemblies, first pin shafts are arranged on two sides of the chip mounting mechanism, and the first pin shafts on two sides of the chip mounting mechanism are respectively penetrated into the first guide grooves of the two side plate assemblies; the socket is arranged below the chip mounting mechanism; and the compressing mechanism comprises a driving source and a transmission assembly in driving connection with the driving source, the transmission assembly is in transmission fit with the chip mounting mechanism, and the driving source can drive the transmission assembly to drive the chip mounting mechanism to move along the first vertical guide groove so that the chip mounting mechanism is close to or far away from the socket.
Description
Technical Field
The invention relates to the technical field of gene sequencing, in particular to a gene sequencing device.
Background
The gene sequencing technology is also called DNA sequencing technology, namely the technology for obtaining the base arrangement sequence of the target DNA fragment, and the sequence of the target DNA fragment is obtained as the basis for further molecular biological research and genetic modification.
Since 2006, gene sequencing has rapidly entered the clinical field on a large scale, providing rich bioinformatic interpretation data while helping medical testing to achieve a spanned progression. During this period, the mainstream gene sequencing technique completed four iterations.
The traditional gene sequencing device is large in size, low in intelligent degree and complex in structure, and more driving sources are involved in the installation process of the microfluidic chip.
Disclosure of Invention
The present invention aims to solve at least one of the technical problems existing in the prior art. Therefore, the invention provides a gene sequencing device with a simple structure.
A gene sequencing device according to some embodiments of the present invention, the gene sequencing device comprising: the machine shell comprises two side plate assemblies which are opposite and are arranged at intervals, each side plate assembly is provided with a first guide groove, each first guide groove comprises a first transverse guide groove and a first vertical guide groove, and the upper end of each first vertical guide groove is communicated with the rear end of each first transverse guide groove; the chip mounting mechanism is arranged between the two side plate assemblies, first pin shafts are arranged on two sides of the chip mounting mechanism, and the first pin shafts on two sides of the chip mounting mechanism are respectively arranged in the first guide grooves of the two side plate assemblies in a penetrating manner; the socket is arranged below the chip mounting mechanism; and the compressing mechanism comprises a driving source and a transmission assembly in driving connection with the driving source, the transmission assembly is in transmission fit with the chip mounting mechanism, and the driving source can drive the transmission assembly to drive the chip mounting mechanism to move along the first vertical guide groove so that the chip mounting mechanism is close to or far away from the socket.
The gene sequencing device provided by the embodiment of the invention has at least the following technical effects:
when the gene sequencing device is in use, when the chip mounting mechanism is at the initial position, the microfluidic chip can be inserted into the chip mounting mechanism from the front to the back, the chip mounting mechanism can receive a thrust force in the process of inserting the microfluidic chip and moves backwards along the first transverse guide groove of the first guide groove, when the chip mounting mechanism moves backwards until the first pin shaft abuts against the side wall of the first vertical guide groove, the driving source is started, and the driving assembly is driven to act, so that the driving assembly drives the chip mounting mechanism to move downwards along the first vertical guide groove and gradually approach the socket until the microfluidic chip is tightly attached to the socket and connected with the socket. Therefore, in the process of carrying out gene sequencing by utilizing the gene sequencing device, the step of connecting the microfluidic chip with the socket is simple, and the installation of the microfluidic chip can be realized by only a single driving source, so that the structure is simple.
According to some embodiments of the invention, the transmission assembly comprises two transmission members and a connecting member for connecting the two transmission members, the two transmission members are respectively and movably arranged on the two side plate assemblies, and the two transmission members are respectively in transmission fit with two sides of the chip mounting mechanism.
According to some embodiments of the invention, both the driving members are cams, and the driving source is configured to drive both the driving members to rotate simultaneously.
According to some embodiments of the invention, each of the driving members is provided with a guiding groove, and the first pins on two sides of the chip mounting mechanism are respectively inserted into the guiding grooves of the two cams.
According to some embodiments of the invention, each of the guide slots includes a transverse segment and an arcuate segment in communication with the transverse segment.
According to some embodiments of the invention, the chip mounting mechanism is provided with a chip slot into which a microfluidic chip can be inserted in a front-to-back direction.
According to some embodiments of the invention, the chip mounting mechanism includes a first mounting member provided with the chip slot, and a second mounting member provided on the first mounting member;
the gene sequencing device further comprises a valve control assembly arranged on the second mounting piece, and the valve control assembly is used for controlling the opening and closing of a valve on a microfluidic chip inserted into the chip slot.
According to some embodiments of the invention, the second mounting member is provided with a plurality of through holes, the valve control assembly comprises a plurality of valve control members, each valve control member comprises a lifting driving member and a pressing block in driving connection with the lifting driving member, and the pressing blocks of the valve control members are correspondingly penetrated in the through holes one by one.
According to some embodiments of the invention, the first pin is provided on both sides of the second mounting member;
the two sides of the first installation piece are respectively provided with a second pin shaft, the two side plate assemblies are respectively provided with a second guide groove, each second guide groove comprises a second transverse guide groove and a second vertical guide groove, the upper ends of the second vertical guide grooves are communicated with the rear ends of the second transverse guide grooves, and the second pin shafts on the two sides of the first installation piece are respectively penetrated in the second guide grooves of the two side plate assemblies.
According to some embodiments of the invention, the second mounting piece is disposed above the first mounting piece, and an elastic piece is disposed between the second mounting piece and the first mounting piece, the length of the first vertical guide groove is greater than that of the second vertical guide groove, and the second mounting piece is controlled to be capable of moving towards or away from the first mounting piece.
Drawings
The foregoing and/or additional aspects and advantages of the invention will become apparent and may be better understood from the following description of embodiments taken in conjunction with the accompanying drawings in which:
FIG. 1 is a schematic diagram showing the internal structure of a genetic sequencing apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic diagram showing the internal structure of a genetic sequencing apparatus according to an embodiment of the present invention;
FIG. 3 is a schematic diagram showing a partial structure of a genetic sequencing apparatus according to an embodiment of the present invention;
FIG. 4 is a schematic diagram showing a partial structure of a genetic sequencing apparatus according to an embodiment of the present invention;
FIG. 5 is a schematic view of a partial enlarged structure at A of the graph shown in FIG. 4;
FIG. 6 is a schematic diagram of a chip mounting mechanism according to an embodiment of the invention;
fig. 7 is a schematic structural diagram of a microfluidic chip according to an embodiment of the present invention.
Reference numerals:
10. a microfluidic chip; 11. a valve;
100. a housing; 110. a side panel assembly; 111. a first guide groove; 112. a second guide groove;
200. a chip mounting mechanism; 210. a first mounting member; 210a, chip slot; 211. a second pin; 220. a second mounting member; 221. a first pin; 222. a through hole; 230. an elastic member; 240. an induction piece; 250. a contact pin;
300. a socket;
400. a compressing mechanism; 420. a transmission assembly; 421. a transmission member; 4211. a guide groove; 4211a, transverse segment; 4211b, an arcuate segment; 422. a connecting piece;
500. a valve control assembly; 510. a valve control; 511. a lifting driving member; 5111. a motor; 5112. a screw rod;
600. a position sensor.
Detailed Description
Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the invention.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and to simplify the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present invention. Furthermore, features defining "first", "second" may include one or more such features, either explicitly or implicitly. In the description of the present invention, unless otherwise indicated, the meaning of "a plurality" is two or more.
In the description of the present invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
As shown in fig. 1 and 2, one embodiment of a gene sequencing device includes a housing 100, a chip mounting mechanism 200, a socket 300, and a pressing mechanism 400.
Referring to fig. 4 and 5, the casing 100 includes two opposite side plate assemblies 110 disposed at intervals, and each side plate assembly 110 is provided with a first guide groove 111.
Specifically, the two side plate assemblies 110 are respectively located at the left and right sides, and the first guide grooves 111 on the two side plate assemblies 110 are disposed opposite to each other.
Further, each of the first guide grooves 111 includes a first lateral guide groove and a first vertical guide groove communicating with the first lateral guide groove, an upper end of the first vertical guide groove communicates with a rear end of the first lateral guide groove, and a lower end of the first vertical guide groove is located below the first lateral guide groove.
Referring to fig. 1 and 5, the chip mounting mechanism 200 is disposed between the two side plate assemblies 110, and two sides of the chip mounting mechanism 200 are respectively in guiding fit with the first guiding grooves 111 of the two side plate assemblies 110, and the first guiding grooves 111 of the two side plate assemblies 110 can play a guiding role on the chip mounting mechanism 200.
As shown in fig. 2 to 5, specifically, the first pins 221 are disposed on both sides of the chip mounting mechanism 200, and the first pins 221 on both sides of the chip mounting mechanism 200 are respectively disposed in the first guide grooves 111 of the two side plate assemblies 110.
When the first pin shaft 221 is penetrating through the first transverse guide groove, the chip mounting mechanism 200 can move along the first transverse guide groove along the transverse direction, and the chip mounting mechanism 200 can also realize limiting in the up-down direction under the action of the first transverse guide groove; when the first pin shaft 221 penetrates through the first vertical guide groove, the chip mounting mechanism 200 can vertically move along the first vertical guide groove, and the chip mounting mechanism 200 can also realize limiting in the front-rear direction under the action of the first vertical guide groove.
As shown in fig. 2, the socket 300 is disposed below the chip mounting mechanism 200, and referring to fig. 2 and 7, the chip mounting mechanism 200 is used for mounting the microfluidic chip 10, and the chip mounting mechanism 200 can be controlled to move toward or away from the socket 300, wherein the movement of the chip mounting mechanism 200 toward the socket 300 can enable the microfluidic chip 10 to be closely attached to and connected with the socket 300.
As shown in fig. 1, the pressing mechanism 400 includes a driving source (not shown) and a transmission assembly 420 drivingly connected to the driving source, the transmission assembly 420 being in driving engagement with the chip mounting mechanism 200. Referring to fig. 1 and fig. 5, the driving source can drive the driving assembly 420 to drive the chip mounting mechanism 200 to move along the first vertical guide slot, so that the chip mounting mechanism 200 is close to or far from the socket 300.
As shown in fig. 1 to 5, when the above-mentioned gene sequencing device is in use, when the chip mounting mechanism 200 is at the initial position, the microfluidic chip 10 may be inserted into the chip mounting mechanism 200 in a front-to-back direction, during the process of inserting the microfluidic chip 10, the chip mounting mechanism 200 will receive a pushing force and move backward along the first transverse guide groove of the first guide groove 111, when the chip mounting mechanism 200 moves backward until the first pin shaft 221 abuts against the side wall of the first vertical guide groove, the driving source is started, and the driving assembly 420 is driven to act, so that the driving assembly 420 drives the chip mounting mechanism 200 to move downward along the first vertical guide groove and gradually approach the socket 300 until the microfluidic chip 10 is tightly attached to and connected with the socket 300. In this way, in the process of performing gene sequencing by using the above-mentioned gene sequencing device, the step of connecting the microfluidic chip 10 with the socket 300 is simple, and the installation of the microfluidic chip 10 can be realized only by a single driving source, so that the structure is simple.
It should be noted that, when the chip mounting mechanism 200 is in the initial position, the first pins 221 on both sides of the chip mounting mechanism 200 are respectively inserted into the front ends of the first transverse guide grooves of the two side plate assemblies 110.
As shown in fig. 1, further, a position sensor 600 is disposed in the casing 100, the position sensor 600 is electrically connected to an input end of a controller, the driving source is electrically connected to an output end of the controller, and when the chip mounting mechanism 200 moves backward to make the first pin 221 abut against a side wall of the first vertical guide slot, the chip mounting mechanism 200 triggers the position sensor 600 at this time, and the position sensor 600 transmits a signal to the controller so that the controller controls the driving source to start or stop.
Specifically, the position sensor 600 is disposed at the rear of the chip mounting mechanism 200, the rear end of the chip mounting mechanism 200 is provided with the sensing piece 240, and when the chip mounting mechanism 200 moves backward to make the first pin 221 abut against the side wall of the first vertical guide slot, the position sensor 600 senses the sensing piece 240 and transmits a signal to the controller.
As shown in fig. 1 and 2, in one embodiment, the transmission assembly 420 includes two transmission members 421 and a connecting member 422 for connecting the two transmission members 421, where the two transmission members 421 are movably disposed on the two side plate assemblies 110, and the two transmission members 421 are respectively in transmission fit with two sides of the chip mounting mechanism 200.
The driving source is used for directly driving one driving member 421 to act, so that the connecting member 422 drives the other driving member 421 to act, and the two driving members 421 respectively drive the two sides of the chip mounting mechanism 200 to move when acting, so that the stability of the chip mounting mechanism 200 during moving can be ensured.
As shown in fig. 3 and 4, specifically, the two transmission members 421 are cams, and the driving source is used to drive the two transmission members 421 to rotate simultaneously. In this way, when the first pins 221 on both sides of the chip mounting mechanism 200 are respectively inserted into the first vertical guide grooves of the two side plate assemblies 110, the driving source drives the two cams to rotate and can drive the chip mounting mechanism 200 to move along the first vertical guide grooves.
More specifically, the driving source is a motor.
Further, each transmission member 421 is provided with a guiding groove 4211, and the first pins 221 on two sides of the chip mounting mechanism 200 are respectively inserted into the guiding grooves 4211 of the two transmission members 421. As such, when the driving source drives the two driving members 421 to rotate in the first direction, the driving members 421 may press down the chip mounting mechanism 200 through the first pin 221 so that the chip mounting mechanism 200 moves downward, and when the driving source drives the two driving members 421 to rotate in the second direction opposite to the first direction, the driving members 421 may lift up the chip mounting mechanism 200 through the first pin 221 so that the chip mounting mechanism 200 moves upward.
Wherein the chip mounting mechanism 200 gradually approaches the socket 300 when moving downward, so that the microfluidic chip 10 mounted on the chip mounting mechanism 200 can be connected with the socket 300; the chip mounting mechanism 200 gradually moves away from the socket 300 when moving upward, so that the microfluidic chip 10 mounted on the chip mounting mechanism 200 can be separated from the socket 300, thereby facilitating the removal of the microfluidic chip 10.
Further, with reference to fig. 3 and 4, each guide groove 4211 includes a lateral segment 4211a and an arcuate segment 4211b in communication with the lateral segment 4211 a. When the chip mounting mechanism 200 is at the initial position, the transverse section 4211a is parallel to the first transverse guide groove, at this time, during the process of inserting the microfluidic chip 10 into the chip mounting mechanism 200, the first pin 221 moves backward along the transverse section 4211a and the first transverse guide groove, and when the first pin 221 abuts against the side wall of the first vertical guide groove, after the driving source drives, the driving source drives the two driving members 421 to rotate, so that the first pin 221 moves downward along the first vertical guide groove while moving from the transverse section 4211a to the arc-shaped section 4211b.
Specifically, the axis of the arc-shaped segment 4211b is spaced from the rotation center line of the transmission member 421, so that the first pin 221 can be moved upward or downward along the first vertical guide groove when the driving source drives the transmission member 421 to rotate.
As shown in fig. 2, in one embodiment, the chip mounting mechanism 200 is provided with a chip slot 210a, and the microfluidic chip 10 can be inserted into the chip slot 210a from front to back, and the chip slot 210a is used for limiting the microfluidic chip 10.
Referring to fig. 2 and 6, further, the chip mounting mechanism 200 includes a first mounting member 210 having a chip slot 210a, and a second mounting member 220 disposed on the first mounting member 210. The gene sequencing device further comprises a valve control assembly 500 disposed on the second mounting member 220, wherein the valve control assembly 500 is used for controlling the opening and closing of the valve on the microfluidic chip 10 inserted into the chip slot 210 a.
Referring to fig. 2, 6 and 7, in particular, the first mount 210 is used to mount the microfluidic chip 10, and the second mount 220 is used to mount the valve control assembly 500. The microfluidic chip 10 is provided with a plurality of valves 11, and when the microfluidic chip 10 is inserted into the chip slot 210a, the valve control assembly 500 can control the opening and closing of each valve 11.
More specifically, the second mounting member 220 is provided with a plurality of through holes 222, the valve control assembly 500 includes a plurality of valve control members 510, each valve control member 510 includes a lifting driving member 511 and a pressing block in driving connection with the lifting driving member 511, the pressing blocks of the plurality of valve control members 510 penetrate through the plurality of through holes 222 in a one-to-one correspondence manner, and when the microfluidic chip 10 is inserted into the chip slot 210a, the pressing blocks of the plurality of valve control members 510 are oppositely arranged in a one-to-one correspondence manner with the plurality of valves 11 on the microfluidic chip 10.
Specifically, the valve 11 on the microfluidic chip 10 is a rubber valve, when the pressing block presses the valve 11, the valve 11 seals the flow channel on the microfluidic chip, and when the pressing block does not press the valve, the valve resets, and the flow channel on the microfluidic chip 10 is conducted.
As shown in fig. 2 and 3, in one embodiment, the first pins 221 are disposed on two sides of the second mounting member 220, the second pins 211 are disposed on two sides of the first mounting member 210, and in combination with fig. 5, the two side plate assemblies 110 are further provided with second guide grooves 112, each second guide groove 112 includes a second transverse guide groove and a second vertical guide groove, the upper ends of the second vertical guide grooves are communicated with the rear ends of the second transverse guide grooves, and the second pins 211 on two sides of the first mounting member 210 are respectively disposed in the second guide grooves 112 of the two side plate assemblies 110 in a penetrating manner. In this way, the stability of the entire chip mounting mechanism 200 during the movement can be ensured by the co-engagement of the first pin 221 with the first guide groove 111 and the co-engagement of the second pin 211 with the second guide groove 112.
Further, the second mounting piece 220 is disposed above the first mounting piece 210, and an elastic piece 230 is disposed between the second mounting piece 220 and the first mounting piece 210, the length of the first vertical guide slot is greater than that of the second vertical guide slot, and the second mounting piece 220 is controlled to be able to move towards or away from the first mounting piece 210.
Alternatively, the elastic member 230 is a spring.
Thus, in the process of installing the microfluidic chip 10, when the second pin shaft 211 abuts against the bottom of the second vertical chute, under the action of the driving source, the driving member 421 can further drive the second mounting member 220 to move towards the first mounting member 210, so that the distance between the second mounting member 220 and the first mounting member 210 is close, and the pressing block on the valve control member 510 is closer to the valve 11 on the microfluidic chip 10, so that the lifting driving member 511 only needs to control the pressing block to lift in a smaller range to control the opening and closing of the valve.
Specifically, the elevation driving member 511 includes a motor 5111 and a screw 5112 connected to the motor 5111, and the pressing block is fixed to a nut of the screw 5112.
Further, the second mounting member 220 is provided with a pin 250, and the pin 250 extends from the upper and lower sides penetrating the second mounting member 220 and from the lower side of the second mounting member 220, so that the pin 250 can be inserted into the liquid port of the microfluidic chip 10 by moving the second mounting member 220 downward.
Specifically, the pins 250 include a liquid inlet pin for being inserted into the liquid inlet 12 of the microfluidic chip 10 and a liquid outlet pin for being inserted into the liquid outlet 13 of the microfluidic chip 10.
In the description of the present specification, reference to the terms "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: many changes, modifications, substitutions and variations may be made to the embodiments without departing from the spirit and principles of the invention, the scope of which is defined by the claims and their equivalents.
Claims (9)
1. A genetic sequencing device, comprising:
the machine shell comprises two side plate assemblies which are opposite and are arranged at intervals, each side plate assembly is provided with a first guide groove, each first guide groove comprises a first transverse guide groove and a first vertical guide groove, and the upper end of each first vertical guide groove is communicated with the rear end of each first transverse guide groove;
the chip mounting mechanism is arranged between the two side plate assemblies, first pin shafts are arranged on two sides of the chip mounting mechanism, and the first pin shafts on two sides of the chip mounting mechanism are respectively arranged in the first guide grooves of the two side plate assemblies in a penetrating manner;
the socket is arranged below the chip mounting mechanism; and
the pressing mechanism comprises a driving source and a transmission assembly in driving connection with the driving source, the transmission assembly is in transmission fit with the chip mounting mechanism, and the driving source can drive the transmission assembly to drive the chip mounting mechanism to move along the first vertical guide groove so as to enable the chip mounting mechanism to be close to or far away from the socket;
the chip mounting mechanism is provided with a chip slot, and the microfluidic chip can be inserted into the chip slot from front to back.
2. The genetic sequencing apparatus of claim 1, wherein the transmission assembly comprises two transmission members and a connecting member for connecting the two transmission members, the two transmission members are respectively movably arranged on the two side plate assemblies, and the two transmission members are respectively in transmission fit with two sides of the chip mounting mechanism.
3. The genetic sequencing apparatus of claim 2, wherein both of the driving members are cams, and the driving source is configured to drive both of the driving members to rotate simultaneously.
4. The gene sequencing device according to claim 3, wherein each of the driving members is provided with a guide groove, and the first pins on both sides of the chip mounting mechanism are respectively inserted into the guide grooves of the two cams.
5. The genetic sequencing apparatus of claim 4, wherein each of the guide slots comprises a transverse segment and an arcuate segment in communication with the transverse segment.
6. The genetic sequencing apparatus of claim 1, wherein the chip mounting mechanism comprises a first mount provided with the chip slot, and a second mount provided on the first mount;
the gene sequencing device further comprises a valve control assembly arranged on the second mounting piece, and the valve control assembly is used for controlling the opening and closing of a valve on a microfluidic chip inserted into the chip slot.
7. The genetic sequencing apparatus of claim 6, wherein the second mounting member has a plurality of through holes, the valve control assembly comprises a plurality of valve control members, each of the valve control members comprises a lifting driving member and a pressing block in driving connection with the lifting driving member, and the pressing blocks of the plurality of valve control members are correspondingly arranged in the plurality of through holes in a penetrating manner.
8. The genetic sequencing apparatus of claim 6, wherein the first pin is provided on both sides of the second mount;
the two sides of the first installation piece are respectively provided with a second pin shaft, the two side plate assemblies are respectively provided with a second guide groove, each second guide groove comprises a second transverse guide groove and a second vertical guide groove, the upper ends of the second vertical guide grooves are communicated with the rear ends of the second transverse guide grooves, and the second pin shafts on the two sides of the first installation piece are respectively penetrated in the second guide grooves of the two side plate assemblies.
9. The genetic sequencing apparatus of claim 8, wherein the second mount is disposed above the first mount with an elastic member disposed between the second mount and the first mount, wherein the length of the first vertical channel is greater than the length of the second vertical channel, and wherein the second mount is controlled to be movable toward or away from the first mount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210035377.5A CN114437911B (en) | 2022-01-13 | 2022-01-13 | Gene sequencing device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210035377.5A CN114437911B (en) | 2022-01-13 | 2022-01-13 | Gene sequencing device |
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| CN114437911A CN114437911A (en) | 2022-05-06 |
| CN114437911B true CN114437911B (en) | 2023-08-01 |
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