CN114437911A - Gene sequencing device - Google Patents
Gene sequencing device Download PDFInfo
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- CN114437911A CN114437911A CN202210035377.5A CN202210035377A CN114437911A CN 114437911 A CN114437911 A CN 114437911A CN 202210035377 A CN202210035377 A CN 202210035377A CN 114437911 A CN114437911 A CN 114437911A
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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Abstract
The invention discloses a gene sequencing device, which comprises: the shell comprises two side plate assemblies which are opposite and arranged at intervals, a first guide groove is formed in each side plate assembly, each first guide groove comprises a first transverse guide groove and a first vertical guide groove, and the upper end of each first vertical guide groove is communicated with the rear end of the corresponding first transverse guide groove; the chip mounting mechanism is arranged between the two side plate components, first pin shafts are arranged on two sides of the chip mounting mechanism, and the first pin shafts on the two sides of the chip mounting mechanism are respectively arranged in the first guide grooves of the two side plate components in a penetrating manner; the socket is arranged below the chip mounting mechanism; and the pressing mechanism comprises a driving source and a transmission assembly in driving connection with the driving source, the transmission assembly is in transmission fit with the chip mounting mechanism, and the driving source can drive the transmission assembly to drive the chip mounting mechanism to move along the first vertical guide groove so as to enable the chip mounting mechanism to be close to or far away from the socket.
Description
Technical Field
The invention relates to the technical field of gene sequencing, in particular to a gene sequencing device.
Background
The gene sequencing technology is also called DNA sequencing technology, namely the technology for obtaining the base sequence of the target DNA fragment, and the obtaining of the sequence of the target DNA fragment is the basis for further molecular biological research and gene modification.
Since 2006, gene sequencing rapidly entered the clinical field on a large scale, provided abundant bioinformatics interpretation data, and helped medical testing to achieve striding-type progress. Meanwhile, four iterations of mainstream gene sequencing technology were completed.
The traditional gene sequencing device is generally large in size and low in intelligent degree, and the installation process of the microfluidic chip involves more driving source actions and is complex in structure.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the invention provides a gene sequencing device with a simple structure.
A gene sequencing apparatus according to some embodiments of the present invention, the gene sequencing apparatus comprising: the shell comprises two side plate assemblies which are opposite and arranged at intervals, each side plate assembly is provided with a first guide groove, each first guide groove comprises a first transverse guide groove and a first vertical guide groove, and the upper end of each first vertical guide groove is communicated with the rear end of the corresponding first transverse guide groove; the chip mounting mechanism is arranged between the two side plate assemblies, first pin shafts are arranged on two sides of the chip mounting mechanism, and the first pin shafts on two sides of the chip mounting mechanism are respectively arranged in the first guide grooves of the two side plate assemblies in a penetrating manner; the socket is arranged below the chip mounting mechanism; and the pressing mechanism comprises a driving source and a transmission assembly in driving connection with the driving source, the transmission assembly is in transmission fit with the chip mounting mechanism, and the driving source can drive the transmission assembly to drive the chip mounting mechanism to move along the first vertical guide groove so as to enable the chip mounting mechanism to be close to or far away from the socket.
The gene sequencing device provided by the embodiment of the invention has at least the following technical effects:
when the gene sequencing device is used, when the chip mounting mechanism is at an initial position, the micro-fluidic chip can be inserted into the chip mounting mechanism from the front to the back, in the process of inserting the micro-fluidic chip, the chip mounting mechanism can be pushed by a pushing force and can move backwards along the first transverse guide groove of the first guide groove, when the chip mounting mechanism moves backwards until the first pin shaft is abutted against the side wall of the first vertical guide groove, the driving source is started and drives the transmission assembly to act, so that the transmission assembly drives the chip mounting mechanism to move downwards along the first vertical guide groove to gradually approach the socket until the micro-fluidic chip is tightly attached to the socket and connected together. Therefore, in the process of performing gene sequencing by using the gene sequencing device, the step of connecting the microfluidic chip with the socket is simple, the microfluidic chip can be installed by only a single driving source, and the structure is simple.
According to some embodiments of the present invention, the driving assembly includes two driving members and a connecting member for connecting the two driving members, the two driving members are respectively movably disposed on the two side plate assemblies, and the two driving members are respectively in driving fit with two sides of the chip mounting mechanism.
According to some embodiments of the invention, the drive source is configured to drive the two transmission members to rotate simultaneously.
According to some embodiments of the present invention, each of the driving members is provided with a guiding groove, and the first pin shafts on two sides of the chip mounting mechanism are further respectively inserted into the guiding grooves of the two cams.
According to some embodiments of the invention, each of the guide slots comprises a transverse segment and an arcuate segment communicating with the transverse segment.
According to some embodiments of the invention, the chip mounting mechanism is provided with a chip slot into which the microfluidic chip can be inserted from front to back.
According to some embodiments of the invention, the chip mounting mechanism includes a first mounting part provided with the chip socket, and a second mounting part provided on the first mounting part;
the gene sequencing device further comprises a valve control assembly arranged on the second mounting piece, and the valve control assembly is used for controlling opening and closing of a valve on the microfluidic chip inserted in the chip slot.
According to some embodiments of the present invention, a plurality of through holes are formed in the second mounting member, the valve control assembly includes a plurality of valve control members, each of the valve control members includes a lifting driving member and a pressing block in driving connection with the lifting driving member, and the pressing blocks of the plurality of valve control members are correspondingly inserted into the plurality of through holes.
According to some embodiments of the invention, the first pin is disposed on both sides of the second mounting member;
the both sides of first installed part all are provided with second round pin axle, two still all be equipped with the second guide way on the curb plate subassembly, every the second guide way all includes horizontal guide slot of second and the vertical guide slot of second, the upper end of the vertical guide slot of second with the rear end intercommunication of the horizontal guide slot of second, the both sides of first installed part the second round pin axle is worn to locate two respectively in the second guide slot of curb plate subassembly.
According to some embodiments of the invention, the second mounting member is arranged above the first mounting member, and an elastic member is arranged between the second mounting member and the first mounting member, the length of the first vertical guide groove is greater than that of the second vertical guide groove, and the second mounting member is controlled to be movable towards or away from the first mounting member.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
FIG. 1 is a first schematic diagram of the internal structure of a gene sequencing apparatus according to an embodiment of the present invention;
FIG. 2 is a second schematic diagram of the internal structure of the gene sequencing apparatus according to the first embodiment of the present invention;
FIG. 3 is a schematic diagram showing a partial structure of a gene sequencing apparatus according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of a second partial structure of the gene sequencing apparatus according to the first embodiment of the present invention;
FIG. 5 is a schematic view of a portion of the enlarged structure at A of the graph shown in FIG. 4;
FIG. 6 is a schematic structural view of a chip mounting mechanism according to an embodiment of the present invention;
fig. 7 is a schematic structural diagram of a microfluidic chip according to an embodiment of the present invention.
Reference numerals:
10. a microfluidic chip; 11. a valve;
100. a housing; 110. a side plate assembly; 111. a first guide groove; 112. a second guide groove;
200. a chip mounting mechanism; 210. a first mounting member; 210a, a chip slot; 211. a second pin shaft; 220. a second mount; 221. a first pin shaft; 222. a through hole; 230. an elastic member; 240. an induction sheet; 250. inserting a pin;
300. a socket;
400. a hold-down mechanism; 420. a transmission assembly; 421. a transmission member; 4211. a guide groove; 4211a, a transverse segment; 4211b, arc segment; 422. a connecting member;
500. a valve control assembly; 510. a valve control member; 511. a lifting drive member; 5111. a motor; 5112. a lead screw;
600. a position sensor.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential", and the like, indicate orientations and positional relationships based on the orientations and positional relationships shown in the drawings, and are used merely for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention. Furthermore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
As shown in fig. 1 and fig. 2, a gene sequencing apparatus according to an embodiment includes a housing 100, a chip mounting mechanism 200, a socket 300, and a pressing mechanism 400.
Referring to fig. 4 and 5, the casing 100 includes two side plate assemblies 110 disposed opposite to each other at an interval, and each of the side plate assemblies 110 is provided with a first guide groove 111.
Specifically, the two side plate assemblies 110 are respectively located at the left and right sides, and the first guide grooves 111 on the two side plate assemblies 110 are oppositely arranged.
Further, each first guide groove 111 includes a first transverse guide groove and a first vertical guide groove communicated with the first transverse guide groove, an upper end of the first vertical guide groove is communicated with a rear end of the first transverse guide groove, and a lower end of the first vertical guide groove is located below the first transverse guide groove.
Referring to fig. 1 and 5, the chip mounting mechanism 200 is disposed between the two side plate assemblies 110, and two sides of the chip mounting mechanism 200 are respectively in guiding fit with the first guide grooves 111 of the two side plate assemblies 110, and the first guide grooves 111 of the two side plate assemblies 110 can guide the chip mounting mechanism 200.
As shown in fig. 2 to fig. 5, in particular, the first pin shafts 221 are disposed on both sides of the chip mounting mechanism 200, and the first pin shafts 221 on both sides of the chip mounting mechanism 200 are respectively inserted into the first guide grooves 111 of the two side plate assemblies 110.
When the first pin shaft 221 penetrates through the first transverse guide groove, the chip mounting mechanism 200 can move transversely along the first transverse guide groove, and the chip mounting mechanism 200 can also realize up-down limiting under the action of the first transverse guide groove; when the first pin shaft 221 penetrates through the first vertical guide groove, the chip mounting mechanism 200 can vertically move along the first vertical guide groove, and the chip mounting mechanism 200 can also realize the front-back direction limitation under the effect of the first vertical guide groove.
As shown in fig. 2, the socket 300 is disposed below the chip mounting mechanism 200, and in conjunction with fig. 2 and fig. 7, the chip mounting mechanism 200 is used for mounting the microfluidic chip 10, and the chip mounting mechanism 200 can be controlled to move toward or away from the socket 300, wherein the movement of the chip mounting mechanism 200 toward the socket 300 can make the microfluidic chip 10 and the socket 300 tightly contact and connect together.
As shown in fig. 1, the pressing mechanism 400 includes a driving source (not shown) and a driving assembly 420 in driving connection with the driving source, wherein the driving assembly 420 is in driving fit with the chip mounting mechanism 200. Referring to fig. 1 and 5, the driving source can drive the transmission assembly 420 to drive the chip mounting mechanism 200 to move along the first vertical guide slot, so that the chip mounting mechanism 200 is close to or far away from the socket 300.
As shown in fig. 1 to 5, when the gene sequencing apparatus is used, when the chip mounting mechanism 200 is at the initial position, the microfluidic chip 10 may be inserted onto the chip mounting mechanism 200 from the front to the back direction, during the process of inserting the microfluidic chip 10, the chip mounting mechanism 200 may receive a pushing force and move backward along the first transverse guide groove of the first guide groove 111, when the chip mounting mechanism 200 moves backward until the first pin 221 abuts against the side wall of the first vertical guide groove, the driving source is started and drives the transmission component 420 to move, so that the transmission component 420 drives the chip mounting mechanism 200 to move downward along the first vertical guide groove and gradually approach the socket 300 until the microfluidic chip 10 and the socket 300 are tightly attached and connected together. Therefore, in the process of performing gene sequencing by using the gene sequencing device, the step of connecting the microfluidic chip 10 with the socket 300 is simple, the microfluidic chip 10 can be installed only by a single driving source, and the structure is simple.
It should be noted that the initial position of the chip mounting mechanism 200 means that the first pin shafts 221 on both sides of the chip mounting mechanism 200 are respectively inserted into the front ends of the first transverse guide grooves of the two side plate assemblies 110.
As shown in fig. 1, further, a position sensor 600 is disposed in the casing 100, the position sensor 600 is electrically connected to an input terminal of a controller, the driving source is electrically connected to an output terminal of the controller, when the chip mounting mechanism 200 moves backward to make the first pin 221 abut against the side wall of the first vertical guide slot, the chip mounting mechanism 200 triggers the position sensor 600, and the position sensor 600 transmits a signal to the controller, so that the controller controls the start and stop of the driving source.
Specifically, the position sensor 600 is disposed behind the chip mounting mechanism 200, the sensing piece 240 is disposed at the rear end of the chip mounting mechanism 200, and when the chip mounting mechanism 200 moves backward to make the first pin shaft 221 abut against the side wall of the first vertical guide groove, the position sensor 600 senses the sensing piece 240 and transmits a signal to the controller.
As shown in fig. 1 and fig. 2, in one embodiment, the transmission assembly 420 includes two transmission members 421 and a connecting member 422 for connecting the two transmission members 421, the two transmission members 421 are respectively movably disposed on the two side plate assemblies 110, and the two transmission members 421 are respectively in transmission fit with two sides of the chip mounting mechanism 200.
The driving source is used for directly driving one transmission member 421 to move, so as to drive the other transmission member 421 to move through the connecting member 422, and the two transmission members 421 respectively drive the two sides of the chip mounting mechanism 200 to move when moving, thereby ensuring the stability of the chip mounting mechanism 200 when moving.
As shown in fig. 3 and 4, specifically, both the transmission members 421 are cams, and the driving source is used for driving the two transmission members 421 to rotate simultaneously. Thus, when the first pin shafts 221 on the two sides of the chip mounting mechanism 200 respectively penetrate the first vertical guide grooves of the two side plate assemblies 110, the driving source drives the two cams to rotate, so as to drive the chip mounting mechanism 200 to move along the first vertical guide grooves.
More specifically, the drive source is a motor.
Further, each transmission member 421 is provided with a guide groove 4211, and the first pins 221 on two sides of the chip mounting mechanism 200 are respectively inserted into the guide grooves 4211 of the two transmission members 421. In this way, when the driving source drives the two transmission members 421 to rotate along the first direction, the transmission members 421 can press down the chip mounting mechanism 200 through the first pin 221, so that the chip mounting mechanism 200 moves downward, and when the driving source drives the two transmission members 421 to rotate along the second direction opposite to the first direction, the transmission members 421 can lift up the chip mounting mechanism 200 through the first pin 221, so that the chip mounting mechanism 200 moves upward.
Wherein the chip mounting mechanism 200 gradually approaches the socket 300 while moving downward, so that the microfluidic chip 10 mounted on the chip mounting mechanism 200 can be connected to the socket 300; the chip mounting mechanism 200 is gradually moved away from the socket 300 when moving upward, so that the microfluidic chip 10 mounted on the chip mounting mechanism 200 can be separated from the socket 300, thereby facilitating the removal of the microfluidic chip 10.
With reference to fig. 3 and 4, further, each guide groove 4211 includes a transverse segment 4211a and an arc-shaped segment 4211b communicating with the transverse segment 4211 a. When the chip mounting mechanism 200 is located at the initial position, the transverse section 4211a is parallel to the first transverse guiding groove, and at this time, in the process of inserting the microfluidic chip 10 into the chip mounting mechanism 200, the first pin 221 moves backward along the transverse section 4211a and the first transverse guiding groove, and when the first pin 221 abuts against the side wall of the first vertical guiding groove, the driving source drives the two transmission members 421 to rotate, so that the first pin 221 moves downward along the first vertical guiding groove while moving from the transverse section 4211a to the arc-shaped section 4211 b.
Specifically, the axis of the arc segment 4211b is spaced from the rotation center line of the transmission member 421, so that when the driving source drives the transmission member 421 to rotate, the first pin shaft 221 can move upwards or downwards along the first vertical guide groove.
As shown in fig. 2, in one embodiment, the chip mounting mechanism 200 is provided with a chip slot 210a, the microfluidic chip 10 can be inserted into the chip slot 210a from front to back, and the chip slot 210a is used for limiting the position of the microfluidic chip 10.
With reference to fig. 2 and fig. 6, further, the chip mounting mechanism 200 includes a first mounting member 210 provided with a chip slot 210a, and a second mounting member 220 provided on the first mounting member 210. The gene sequencing device further comprises a valve control assembly 500 disposed on the second mounting member 220, wherein the valve control assembly 500 is used for controlling the opening and closing of a valve on the microfluidic chip 10 inserted into the chip slot 210 a.
Referring to fig. 2, 6 and 7, in particular, the first mounting member 210 is used for mounting the microfluidic chip 10, and the second mounting member 220 is used for mounting the valve control assembly 500. The microfluidic chip 10 is provided with a plurality of valves 11, and after the microfluidic chip 10 is inserted into the chip slot 210a, the valve control assembly 500 can control the opening and closing of each valve 11.
More specifically, the second mounting member 220 is provided with a plurality of through holes 222, the valve control assembly 500 includes a plurality of valve control members 510, each valve control member 510 includes a lifting driving member 511 and a pressing block in driving connection with the lifting driving member 511, the pressing blocks of the plurality of valve control members 510 are correspondingly inserted into the plurality of through holes 222, and when the microfluidic chip 10 is inserted into the chip slot 210a, the pressing blocks of the plurality of valve control members 510 are correspondingly arranged with respect to the plurality of valves 11 on the microfluidic chip 10.
Specifically, the valve 11 on the microfluidic chip 10 is a rubber valve, when the pressing block presses the valve 11, the valve 11 plugs the flow channel on the microfluidic chip, and when the pressing block does not press the valve, the valve resets, and the flow channel on the microfluidic chip 10 is conducted.
As shown in fig. 2 and 3, in one embodiment, first pin shafts 221 are disposed on both sides of the second mounting member 220, second pin shafts 211 are disposed on both sides of the first mounting member 210, referring to fig. 5, second guide grooves 112 are further disposed on both the two side plate assemblies 110, each second guide groove 112 includes a second transverse guide groove and a second vertical guide groove, an upper end of the second vertical guide groove is communicated with a rear end of the second transverse guide groove, and the second pin shafts 211 on both sides of the first mounting member 210 are respectively inserted into the second guide grooves 112 of the two side plate assemblies 110. In this way, the first pin shaft 221 and the first guide groove 111 cooperate with each other, and the second pin shaft 211 and the second guide groove 112 cooperate with each other, so that the stability of the entire chip mounting mechanism 200 during the movement process can be ensured.
Further, the second mounting part 220 is disposed above the first mounting part 210, and an elastic member 230 is disposed between the second mounting part 220 and the first mounting part 210, the length of the first vertical guide groove is greater than that of the second vertical guide groove, and the second mounting part 220 is controlled to be able to move toward or away from the first mounting part 210.
Optionally, the elastic member 230 is a spring.
So, at the in-process of installation micro-fluidic chip 10, when the bottom of second round pin axle 211 and the vertical spout of second offsets, under the effect of driving source, driving medium 421 can also continue to drive second installed part 220 and move towards first installed part 210, thereby make second installed part 220 and first installed part 210's distance be close, thereby make the briquetting on the valve control piece 510 be close to the valve 11 on the micro-fluidic chip 10 more, so, lift driving piece 511 only needs the control briquetting to go up and down at less within range can control opening and close of valve.
Specifically, the lifting driving member 511 includes a motor 5111 and a screw 5112 connected to the motor 5111, and the pressing block is fixed on a nut of the screw 5112.
Further, the second mounting member 220 is provided with pins 250, the pins 250 extend from the upper and lower sides penetrating the second mounting member 220 and from the lower side of the second mounting member 220, and the pins 250 can be inserted into the liquid ports of the microfluidic chip 10 by moving the second mounting member 220 downward.
Specifically, the pins 250 include a liquid inlet pin for inserting into the liquid inlet 12 of the microfluidic chip 10 and a liquid outlet pin for inserting into the liquid outlet 13 of the microfluidic chip 10.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples" or the like mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims (10)
1. A gene sequencing apparatus, comprising:
the motor comprises a shell, a first guide groove and a second guide groove, wherein the shell comprises two side plate assemblies which are opposite and arranged at intervals, each side plate assembly is provided with the first guide groove, each first guide groove comprises a first transverse guide groove and a first vertical guide groove, and the upper end of the first vertical guide groove is communicated with the rear end of the first transverse guide groove;
the chip mounting mechanism is arranged between the two side plate assemblies, first pin shafts are arranged on two sides of the chip mounting mechanism, and the first pin shafts on two sides of the chip mounting mechanism are respectively arranged in the first guide grooves of the two side plate assemblies in a penetrating manner;
the socket is arranged below the chip mounting mechanism; and
the pressing mechanism comprises a driving source and a transmission assembly in driving connection with the driving source, the transmission assembly is in transmission fit with the chip mounting mechanism, and the driving source can drive the transmission assembly to drive the chip mounting mechanism to move along the first vertical guide groove so as to enable the chip mounting mechanism to be close to or far away from the socket.
2. The gene sequencing apparatus of claim 1, wherein the transmission assembly comprises two transmission members and a connecting member for connecting the two transmission members, the two transmission members are movably disposed on the two side plate assemblies respectively, and the two transmission members are in transmission engagement with two sides of the chip mounting mechanism respectively.
3. The gene sequencing apparatus of claim 2, wherein both of the transmission members are cams, and the driving source is configured to drive the two transmission members to rotate simultaneously.
4. The gene sequencing device of claim 3, wherein each of the transmission members is provided with a guide groove, and the first pins on both sides of the chip mounting mechanism are respectively inserted into the guide grooves of the two cams.
5. The gene sequencing apparatus of claim 4, wherein each of the guide slots comprises a transverse segment and an arcuate segment in communication with the transverse segment.
6. The gene sequencing apparatus of claim 1, wherein the chip mounting mechanism is provided with a chip slot into which the microfluidic chip can be inserted in a front-to-back direction.
7. The gene sequencing apparatus of claim 6, wherein the chip mounting mechanism comprises a first mounting member provided with the chip slot, and a second mounting member provided on the first mounting member;
the gene sequencing device further comprises a valve control assembly arranged on the second mounting piece, and the valve control assembly is used for controlling opening and closing of a valve on the micro-fluidic chip inserted into the chip slot.
8. The gene sequencing device of claim 7, wherein a plurality of through holes are formed in the second mounting member, the valve control assembly comprises a plurality of valve control members, each valve control member comprises a lifting driving member and a pressing block in driving connection with the lifting driving member, and the pressing blocks of the plurality of valve control members are correspondingly arranged through the plurality of through holes.
9. The gene sequencing apparatus of claim 7, wherein the first pin is disposed on both sides of the second mounting member;
the both sides of first installed part all are provided with second round pin axle, two still all be equipped with the second guide way on the curb plate subassembly, every the second guide way all includes horizontal guide slot of second and the vertical guide slot of second, the upper end of the vertical guide slot of second with the rear end intercommunication of the horizontal guide slot of second, the both sides of first installed part the second round pin axle is worn to locate two respectively in the second guide slot of curb plate subassembly.
10. A gene sequencing apparatus according to claim 9, wherein the second mounting member is arranged above the first mounting member with a resilient member arranged between the second mounting member and the first mounting member, the first vertical guide slot having a greater length than the second vertical guide slot, the second mounting member being controllable to move towards or away from the first mounting member.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210035377.5A CN114437911B (en) | 2022-01-13 | 2022-01-13 | Gene sequencing device |
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|---|---|---|---|
| CN202210035377.5A CN114437911B (en) | 2022-01-13 | 2022-01-13 | Gene sequencing device |
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| CN114437911A true CN114437911A (en) | 2022-05-06 |
| CN114437911B CN114437911B (en) | 2023-08-01 |
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