CN114432359B

CN114432359B - Traditional Chinese medicine gargle, preparation method and application thereof in preparation of medicine for treating oral ulcer

Info

Publication number: CN114432359B
Application number: CN202210145346.5A
Authority: CN
Inventors: 徐丽萍; 戴巧定; 蔺娜
Original assignee: First Affiliated Hospital of ZCMU
Current assignee: First Affiliated Hospital of ZCMU
Priority date: 2022-02-17
Filing date: 2022-02-17
Publication date: 2023-02-28
Anticipated expiration: 2042-02-17
Also published as: CN114432359A

Abstract

The invention discloses a traditional Chinese medicine gargle which is prepared from the following raw materials in parts by mass: 10 to 20 portions of raw liquorice, 15 to 20 portions of mint, 15 to 20 portions of rabdosia rubescens, 15 to 20 portions of centella, 15 to 20 portions of angelica dahurica and 15 to 20 portions of eupatorium. The traditional Chinese medicine gargle provided by the invention can be applied to preparation of medicines for treating oral ulcer, has a very remarkable improvement effect on oral ulcer, and is favored by patients because the duration of single oral ulcer of the patients is shortened, the recurrence interval time is prolonged, the pain degree of ulcer is reduced, the quantity is reduced, and the ulcer range is also reduced after the gargle is used for treatment. The traditional Chinese medicine gargle disclosed by the invention is mild in prescription and wide in application range, can be adjusted according to specific diseases, and has wide application prospect.

Description

Traditional Chinese medicine gargle, preparation method and application thereof in preparation of medicine for treating oral ulcer

Technical Field

The invention relates to a traditional Chinese medicine gargle, a preparation method and application thereof in preparing a medicine for treating dental ulcer.

Background

Behcet's disease (Behcet's disease)

disease, BD), which is a disease mainly manifested by recurrent oral ulcer, genital ulcer, and ophthalmia, alsoThe systemic treatment medicine mainly comprises glucocorticoid (side effects are more, withdrawal is difficult), immunosuppressant (thalidomide has definite curative effect and wide application, but has serious teratogenesis and is forbidden by patients in the childbearing period with fertility requirements), and biological preparation (high price, super-adaptive use cannot be brought into the scope of medical insurance payment, opportunistic infection after long-term use and tumor occurrence risk increase).

Recurrent Oral Ulcer (ROU) is a common clinical oral mucosa disease with unknown etiology, has self-limiting, periodicity and recurrence, has pathogenesis related to immunologic dysfunction, is influenced by multiple factors such as heredity, diet, emotion, infection, endocrine and the like, cannot be radically cured at present, can improve symptoms to a certain extent by medicines, and lacks of ideal treatment means.

For oral mucosa symptoms, whether BD or ROU, modern clinical use chlorhexidine, povidone iodine and other anti-inflammatory preparations for gargling, and ulcer paste, iodine glycerol, lidocaine gel and other analgesic preparations for local external use for symptomatic treatment, but the effect is not good, severe patients need to use glucocorticoids and immunosuppressants systemically, have more adverse drug reactions, and are easy to relapse after stopping taking the medicine. The traditional Chinese medicine has the effects of treatment based on syndrome differentiation, oral administration of decoction or patent medicine, external application of tin powder, watermelon frost, external ulcer powder and the like, but because of the characteristics of disease symptoms, bitter and cold products such as heat clearing and detoxifying are added for prescription administration, a patient is difficult to persist for a long time, the patient is frequently used for a long time and enters the body through damaged mucous membranes to cause poisoning, the two medicines have the problem of relapse after stopping administration, and the disease is better than that of the patient in the middle and light years of 16-40 years old, so that the working pressure is high, the life rhythm is fast, and timely administration and re-diagnosis are difficult.

The gargle is taken as an oral mucosa administration treatment means, is convenient to administer, is beneficial to the absorption of the medicine through mucosa to avoid the first pass effect, avoids the degradation of gastrointestinal tracts, effectively improves the bioavailability, achieves local and systemic treatment, has received extensive clinical attention, is considered to be a promising treatment means, but is currently applied to clinical gargle preparations, such as chlorhexidine, cetylpyridinium chloride, povidone iodine and the like, mainly takes the anti-inflammatory and antibacterial effects, has no functions of promoting mucosa healing and reducing ulcer recurrence, has strong irritation, and is not suitable for patients with Behcet's disease with obvious local wound pain and recurrent oral ulcer. The traditional Chinese medicine gargle has the advantages of flexible adjustment of functional indications, proper taste, good freshness preservation degree and the like, and related researches prove that the curative effect of treating recurrent oral ulcer is higher than that of iodine-glycerol inunction, but the prescription medicines are all used in thousands of autumn.

Disclosure of Invention

The invention aims to provide the traditional Chinese medicine gargle for treating the Behcet disease dental ulcer and the recurrent dental ulcer, which has remarkable curative effect.

The technical scheme adopted by the invention is as follows:

a traditional Chinese medicine gargle is prepared from the following raw materials in parts by mass:

10 to 20 parts of raw liquorice, 15 to 20 parts of mint, 15 to 20 parts of rabdosia rubescens, 15 to 20 parts of centella, 15 to 20 parts of angelica dahurica and 15 to 20 parts of eupatorium.

Further, the traditional Chinese medicine gargle is preferably prepared from the following raw materials in parts by mass:

10 to 20 portions of raw liquorice, 15 to 20 portions of mint, 15 to 20 portions of rabdosia rubescens, 15 to 20 portions of centella, 15 to 20 portions of angelica dahurica and 15 to 20 portions of eupatorium.

More preferably, the traditional Chinese medicine gargle is prepared from the following raw materials in parts by mass:

10 parts of raw liquorice, 15 parts of mint, 15 parts of rabdosia rubescens, 15 parts of centella, 15 parts of angelica dahurica and 15 parts of eupatorium.

Further, the traditional Chinese medicine gargle can also contain other traditional Chinese medicine raw materials, and the raw materials of the traditional Chinese medicine gargle can also contain one or more of lotus plumule, radix zanthoxyli, radix rehmanniae, gentiana scabra bunge, achyranthes bidentata, fritillaria thunbergii, fructus forsythiae, rhizoma corydalis, borneol and rhizoma smilacis glabrae.

Further, the traditional Chinese medicine gargle can be prepared from the following raw materials:

the formula (I): 10 to 15 parts of raw liquorice, 15 to 20 parts of mint, 15 to 20 parts of rabdosia rubescens, 15 to 20 parts of centella, 15 to 20 parts of angelica dahurica, 15 to 20 parts of eupatorium and 3 to 5 parts of lotus plumule;

the formula (II): 10 to 15 parts of raw liquorice, 15 to 20 parts of mint, 15 to 20 parts of rabdosia rubescens, 15 to 20 parts of centella, 15 to 20 parts of angelica dahurica, 15 to 20 parts of eupatorium, 6 to 8 parts of radix zanthoxyli and 12 to 15 parts of radix rehmanniae;

the formula (III): 10 to 15 parts of raw liquorice, 15 to 20 parts of mint, 15 to 20 parts of rabdosia rubescens, 15 to 20 parts of centella, 15 to 20 parts of angelica dahurica, 15 to 20 parts of eupatorium and 6 to 8 parts of gentian;

the formula (IV): 20 parts of raw liquorice, 15-20 parts of mint, 15-20 parts of rabdosia rubescens, 15-20 parts of centella, 15-20 parts of angelica dahurica, 15-20 parts of eupatorium, 10-15 parts of achyranthes, 12-15 parts of thunberg fritillary bulb and 10-15 parts of fructus forsythiae;

the formula (V): 10 to 15 parts of raw liquorice, 15 to 20 parts of mint, 15 to 20 parts of rabdosia rubescens, 15 to 20 parts of centella, 15 to 20 parts of angelica dahurica, 15 to 20 parts of eupatorium, 15 to 20 parts of rhizoma corydalis and 1 to 2 parts of borneol;

the formula (VI): 10 to 15 portions of raw liquorice, 15 to 20 portions of mint, 15 to 20 portions of rabdosia rubescens, 15 to 20 portions of centella, 15 to 20 portions of angelica dahurica, 15 to 20 portions of eupatorium and 30 to 35 portions of rhizoma smilacis glabrae.

The parts in the formula are parts by mass.

Furthermore, the traditional Chinese medicine gargle is preferably prepared from the following raw materials according to one formula:

the formula (I): 10 parts of raw liquorice, 15 parts of mint, 15 parts of rabdosia rubescens, 15 parts of centella, 15 parts of angelica dahurica, 15 parts of eupatorium and 3 parts of lotus plumule;

the formula (II): 10 parts of raw liquorice, 15 parts of mint, 15 parts of rabdosia rubescens, 15 parts of centella, 15 parts of angelica dahurica, 15 parts of eupatorium, 6 parts of radix zanthoxyli and 12 parts of radix rehmanniae;

the formula (III): 10 parts of raw liquorice, 15 parts of mint, 15 parts of rabdosia rubescens, 15 parts of centella, 15 parts of angelica dahurica, 15 parts of eupatorium and 6 parts of gentian;

the formula (IV): 20 parts of raw liquorice, 15 parts of mint, 15 parts of rabdosia rubescens, 15 parts of centella, 15 parts of angelica dahurica, 15 parts of eupatorium, 10 parts of achyranthes bidentata, 12 parts of thunberg fritillary bulb and 10 parts of fructus forsythiae;

the formula (V): 10 parts of raw liquorice, 15 parts of mint, 15 parts of rabdosia rubescens, 15 parts of centella, 15 parts of angelica dahurica, 15 parts of eupatorium, 15 parts of rhizoma corydalis and 1 part of borneol;

the formula (VI): 10 parts of raw liquorice, 15 parts of mint, 15 parts of rabdosia rubescens, 15 parts of centella, 15 parts of angelica dahurica, 15 parts of eupatorium and 30 parts of rhizoma smilacis glabrae.

The invention also provides a preparation method of the traditional Chinese medicine gargle, which comprises the steps of taking the raw materials of each component according to a formula, adding water for soaking, heating and decocting twice, and finally concentrating the liquid medicine, wherein the volume of the liquid medicine is 2-4 times of the mass of the medicine.

The invention also provides application of the traditional Chinese medicine gargle in preparing a medicine for treating oral ulcer, wherein the oral ulcer comprises simple oral ulcer, recurrent oral ulcer or Behcet disease oral ulcer.

Further, the formula (I) can be used for preparing a medicament for treating oral ulcer mainly comprising tongue tip and/or tongue frenulum.

The formula (II) can be used for preparing a medicament for treating oral ulcer mainly comprising gum.

The formula (III) can be used for preparing the medicine for treating the oral ulcer mainly on the tongue edge and/or two sides of the oral mucosa.

The formula (IV) can be used for preparing a medicament for treating oral ulcer mainly comprising tongue root and/or throat.

The formula (V) can be used for preparing the medicine for treating the oral ulcer with obvious pain.

The formula (VI) can be used for preparing the medicine for treating the oral ulcer with much secretion on the ulcer surface.

The use method of the traditional Chinese medicine gargle comprises the following steps: gargling in oral cavity for 6 times/d, 50 mL/time, 1-5 min/time, and 1 week.

The traditional Chinese medicine gargle is prepared by carefully selecting 6 kinds of herbs which are suitable in compatibility, efficacy, modern pharmacology and taste according to four-qi and five-taste, and decocting the herbs based on the theory that 'aphthous stomatitis' is caused by deficiency of both qi and yin and the theory that the interior of damp toxin is marked as pathogenesis of traditional Chinese medicine, looking up book and literature. Wherein Glycyrrhrizae radix has effects of purging pathogenic fire, regulating stomach and flavoring; the mint has the functions of resuscitation inducing, bacteriostasis and pain relieving; herba Eupatorii aromatic has effects in activating spleen and eliminating turbid pathogen; herba Centellae has effects of clearing heat, promoting diuresis, removing toxic substance, inhibiting bacteria, and promoting repair; the angelica dahurica has the functions of detumescence, pus discharge, bacteriostasis, inflammation diminishing and pain relieving; rabdosia rubescens has effects of clearing heat and detoxicating, promoting blood circulation and relieving pain.

The traditional Chinese medicine gargle is already used for a plurality of BD and ROU patients in hospitalization and outpatient service, the improvement effect is very obvious, after the gargle is used for treatment, the duration of single oral ulcer of the patients is shortened, the recurrence interval time is prolonged, the pain degree of the ulcer is relieved, the quantity is reduced, the ulcer range is also reduced, and the gargle is favored by the patients. The traditional Chinese medicine gargle disclosed by the invention is mild in prescription and wide in application range, can be adjusted according to specific diseases, and has wide application prospect.

Drawings

FIG. 1 photograph of tongue ulcer before treatment of BD patient in example 1.

Figure 2 photo of the tongue of BD patient in example 1 after 2 weeks of gargle use.

FIG. 3 comparative graph of improvement in clinical symptoms before and after use of the gargle in patients with BD and ROU in example 2.

Detailed Description

The technical solution of the present invention is further described below with specific examples, but the scope of the present invention is not limited thereto.

Example 1

Preparing the oral ulcer gargle:

prescription: 10g of raw liquorice, 15g of mint, 15g of rabdosia rubescens, 15g of centella, 15g of angelica dahurica and 15g of eupatorium

The use method comprises the following steps: decocting 2 juices 150ml each for 300ml in 1 day

The gargle is applied to 1 patient with severe BD of pulmonary artery, lower limb deep vein thrombosis and digestive tract ulcer, and is continuously used for 2 weeks, the tongue ulcer before and after treatment is as shown in figures 1 and 2, and the oral cavity and tongue ulcer/mucosa exfoliation before treatment is frequently generated, and the oral mucosa and tongue body are intact after treatment.

Example 2

The gargle is used for a plurality of BD oral ulcer patients and patients with simple recurrent oral ulcer, and is suitable for the screening of the patients:

inclusion criteria were: (1) BD patients with oral ulcers: the rating is more than or equal to 4 points (2 points of eye damage, 2 points of genital ulcer, 2 points of oral ulcer, 1 point of skin damage, 1 point of nervous system damage, 1 point of vascular lesion, 1 point of positive acupuncture test and 10 points of total acupuncture test) according to 2013 international BD rating diagnosis standard; (2) patients with simple recurrent oral ulceration: meets the relevant diagnosis standard in oral mucosa pathology (the onset time is less than 10 days, single or a plurality of ulcers with different shapes appear on the oral mucosa and the keratosis combining part, and the disease repeatedly attacks more than 3 times). (3) With unlimited sex, the age > 18 years, agrees to participate and signs the "informed consent".

Exclusion criteria: (1) those with severe mental disorder cannot be matched.

The specific using method comprises the following steps: gargling in oral cavity for 6 times/day, 50 mL/time, 1-5 min/time, with a period of 1 week

After one week of treatment, the duration of single oral ulcer of the patients is shortened, the recurrence interval is prolonged, the pain degree of the ulcer is relieved, the number is reduced, the range is also reduced, and the clinical symptom improvement conditions of the BD and ROU patients before and after using the gargle are contrasted with a chart shown in figure 3. Wherein 14 BD patients and 19 ROU patients have more severe ulcer pain degree, duration, ulcer range, ulcer quantity, recurrence frequency and the like than ROU patients, but the improvement rates of the gargle for oral ulcer of the BD patients and the ROU patients are similar and have no obvious difference with each other. The improvement rate can reach more than 45 percent, and the effect is very obvious.

The gargle has mild prescription, good feedback, proper taste, minimal irritation and no adverse reaction when being used by patients in hospitalization, outpatient service and BD and ROU.

Of the 33 patients, 21 patients used the gargle of example 1, the six traditional Chinese medicines being the basic formulation. The prescription of other patients is adjusted on the basis of the basic prescription according to specific diseases.

Several typical cases are listed below:

case 1, sex: female, age: after the gargle of example 1 is used for 7 days, the ulcer healing time is shortened to 7 days, part of the ulcer is healed within 3-5 days, and the ulcer pain condition is obviously relieved in the process.

Case 2, sex: female, age: after the patients are aged 36 years old, BD is diagnosed, the patients repeatedly suffer from oral and vulvar ulcers for more than half a year, the living work and rest, the law of dietary deficiency and the induction factors of medicines and the like are denied, the ulcers mainly take the tongue tips, the pain is severe, the duration exceeds 1 week, one part is not healed, the other part is newly developed, the peripheral red halo is obvious, the people are complicated with vexation and irritability, 3g of lotus plumule is added into the basic formula of the gargle of the embodiment 1 to serve as the formula (I), the decoction and the use method are the same as the embodiment 1, 7 days after the gargle formula (I) is used, the new hairs are not developed after the ulcer of the tongue tips is healed, and the pain sense is obviously reduced in the process.

Case 3, sex: male, age: the preparation method is the same as that of the embodiment 1, after the basic formula of the gargle of the embodiment 1 is used, 6g of radix zanthoxyli and 12g of radix rehmanniae are added as the formula (II), the decoction and the use method are the same as the embodiment 1, after the formula (II) is used, the ulcer and the red swelling of the gum are relieved, the ulcer duration is shortened to 5 days, and the interval is prolonged to 1 month till the next ulcer.

Case 4, sex: male, age: 29 years old, ROU is diagnosed, oral ulcer is repeatedly treated for 3 years, the ulcer mainly takes the tongue edge and two sides of oral mucosa, the emotion is testy, the ulcer is attacked or aggravated when the pressure of work and life is high, a plurality of hospitals are rolled, the control is still available during medication, the medicine is released when the medicine is stopped, drug-induced liver damage occurs for a plurality of times, the oral medication is not very willing to be tried, 6g of gentian is added into the basic formula of the gargle in the embodiment 1 to serve as the formula (III), the decocting and using methods are the same as those in the embodiment 1, and after the formula (III) of the gargle is used for 7 days, the ulcer pain is relieved, the healing time is shortened, the emotion is improved, and the ulcer is not released after 2 months continuously.

Case 5, sex: male, age: age 56, diagnosis: BD, repeated oral ulcer lasts for more than 10 years, ulcer is mainly of tongue root and/or throat, multiple ulcer is generated in esophagus and stomach and intestine when the ulcer is serious, digestive tract ulcer is relieved after glucocorticoid, thalidomide and immunosuppression treatment, ulcer at the root of tongue is still recurrent, raw licorice is increased to 20g in the basic formula of the gargle of example 1, 10g of achyranthes root, 12g of thunberg fritillary bulb and 10g of weeping forsythia are added as formula (IV), the decoction and the use method are the same as example 1, and after 7 days of the gargle formula (IV), the number of ulcer is reduced, the area of single ulcer is reduced, the local pain degree is reduced, and the recurrence frequency of ulcer is also reduced.

Case 6, sex: female, age: age 46, diagnosis: ROU, repeated oral ulcer for 8 months, severe pain, no food intake and water intake, low fever in severe cases, bright red ulcer periphery, 1 time per month attack and 7-10 days of duration, rhizoma corydalis 15g and borneol 1g are added into the basic formula of the gargle of example 1 as a formula (V), the decoction and the use method are the same as example 1, and after 7 days of using the formula (V) of the gargle, the pain of the ulcer is obviously relieved, and the healing time is also shortened.

Case 7, sex: male, age: age 39, diagnosis: BD, repeated oral and perianal ulcers for 2 years, the ulcers healed during thalidomide treatment, and relapsed after withdrawal of the drug, the drug could not be used continuously (with fetal malformation risk) due to the requirement of birth of a fetus, the ulcers were painful, the range was wide, the onset of the ulcers did not have obvious intermission period, the secretion on the surface of the ulcers was large, 30g of glabrous greenbrier rhizome was added into the basic formula of the gargle of example 1 as the formula (VI), the decoction and the use method were the same as the example 1, and 7 days after the formula (VI) of the gargle was used, the distribution range of the ulcers was reduced, the secretion on the surface was reduced, and the surface of the single ulcer was reduced.

Example 3

The gargle formula is obtained by long-term clinical practice of the inventor through long-time grope tests, and the six traditional Chinese medicines of raw liquorice, mint, rabdosia rubescens, centella, angelica dahurica and eupatorium are taken as the basis, so that the curative effect is reduced due to the lack of any one of the traditional Chinese medicines, and specific cases are given below.

Case 8, sex: male, age: 22 years old, the patient is diagnosed in 7 months in 2019, ROU is diagnosed, repeated oral ulcer is half a year, a certain relation is formed between the repeated oral ulcer and frequent staying up and irregular work and rest, 15g of mint, 15g of rabdosia rubescens, 15g of centella asiatica, 15g of angelica dahurica and 15g of fortune eupatorium herb are prescribed, the gargle is prepared for use, the gargle is continuously used for 14 days, part of ulcer is healed within 6 days, the ulcer is basically and completely healed within 8 days, and the ulcer recurs after the gargle is stopped for 10 days.

Case 9, sex: female, age: the gargle is prepared for use, wherein the gargle is prepared from 10g of liquorice, 15g of mint, 15g of rabdosia rubescens, 15g of centella asiatica and 15g of radix angelicae, and the gargle is prepared for use, after 7 days of use, part of ulcer heals but still ulcer exists, and the purulent secretion of the ulcer surface is not obviously improved.

Case 10, sex: male, age: the gargle is prepared for use by 49 years old, the doctor visits the mouth 12 months in 2019, the BD is diagnosed, the mouth ulcer is repeatedly cured for 4 years, the reddish halo around the ulcer is obvious and accompanied with pain, 10g of liquorice, 15g of mint, 15g of rabdosia rubescens, 15g of angelica dahurica and 15g of eupatorium are prescribed, the gargle is prepared for use, the gargle is continuously used for 14 days, part of the ulcer is healed for 7 days, and the ulcer is basically healed completely after about 9 days.

Case 11, sex: male, age: age 30, visit at 5 months in 2020, diagnose ROU, typical symptoms: the repeated oral ulcer is more than half a year, the pain is obvious, 1 time per month, 10-15 days are kept, the pain is obvious and wide in range, 10g of liquorice, 15g of mint, 15g of rabdosia rubescens, 15g of centella asiatica and 15g of eupatorium fortunei are prescribed, the gargle is prepared for use, after 7 days of use, part of ulcer is healed, but new ulcer exists, and the number of ulcer is not changed.

Case 12, sex: female, age: the gargle is prepared by using 10g of raw liquorice, 15g of mint, 15g of centella asiatica, 15g of angelica dahurica and 15g of eupatorium, and is prepared into the gargle for use, wherein after the gargle is used for 7 days, part of ulcer is healed, after the gargle is used for 7 days, the ulcer is healed, and after the gargle is stopped, the gargle is easy to relapse.

Claims

1. The traditional Chinese medicine gargle for treating dental ulcer is characterized by being prepared from the following raw materials in parts by mass:

10 to 20 parts of raw liquorice, 15 to 20 parts of mint, 15 to 20 parts of rabdosia rubescens, 15 to 20 parts of asiatic pennywort herb, 15 to 20 parts of angelica dahurica and 15 to 20 parts of eupatorium.

2. The traditional Chinese medicine gargle for treating dental ulcer as claimed in claim 1, which is characterized in that the traditional Chinese medicine gargle is prepared from the following raw materials in parts by mass:

10 to 20 parts of raw licorice, 15 to 20 parts of mint, 15 to 20 parts of rabdosia rubescens, 15 to 20 parts of asiatic pennywort herb, 15 to 20 parts of angelica dahurica and 15 to 20 parts of eupatorium.

3. The traditional Chinese medicine gargle for treating dental ulcer as claimed in claim 2, which is characterized in that the traditional Chinese medicine gargle is prepared from the following raw materials in parts by mass: 10 parts of raw liquorice, 15 parts of mint, 15 parts of rabdosia rubescens, 15 parts of centella, 15 parts of angelica dahurica and 15 parts of eupatorium.

4. The preparation method of the traditional Chinese medicine gargle as defined in one of claims 1 to 3, which is characterized in that the method comprises the following steps: taking the raw materials of each component according to the formula, adding water for soaking, heating and decocting twice, and finally concentrating to obtain a liquid medicine with the volume 2 to 4 times of the mass of the medicine.

5. Use of the traditional Chinese medicine gargle according to any one of claims 1 to 3 in preparation of a medicine for treating oral ulcer.