CN117752755A - Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating pharyngitis and a preparation method thereof, wherein the traditional Chinese medicine composition comprises, by mass, 5-15 parts of periostracum cicadae, 15-25 parts of orange peel, 5-15 parts of burdock, 2-7 parts of blackberry lily, 5-12 parts of nutgrass galingale rhizome, 2-7 parts of radix curcumae, 10-20 parts of concha arcae, 5-15 parts of rhizoma pinellinae praeparata, 10-20 parts of dark plum, 5-15 parts of liquorice, 5-15 parts of dwarf lilyturf tuber, 2-7 parts of schisandra chinensis, 45-55 parts of medicated leaven and 15-25 parts of red knotweed flower. The pharmaceutical composition is composed of traditional Chinese medicines, improves the safety of the medicines, increases the application range and the population, and clinical test results show that the pharmaceutical composition can effectively treat chronic pharyngitis, and has obvious elimination or alleviation effects on symptoms such as pharyngeal discomfort, foreign body sensation, itching sensation, burning sensation, dryness sensation and/or irritation sensation, pharyngeal pain, pharyngeal cough, nausea sensation and pharyngeal mucosa thickening, sticky or thick secretion and the like caused by the chronic pharyngitis. The medicine composition has precise and appropriate medicine taste and is inexhaustible, and the treatment effect can be influenced by changing the medicine proportion.

Description

Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof

Technical Field

The invention relates to the technical field of medicaments for treating pharyngitis, in particular to a traditional Chinese medicine composition for treating pharyngitis and a preparation method thereof.

Background

Pharyngitis is a collective name of pharyngeal mucosa, submucosa and lymphoid tissue inflammation caused by bacterial infection, virus infection, environment and other factors, is nonspecific inflammation of human pharynx, can occur independently, and can also be combined with other upper respiratory tract inflammation. The clinical manifestations of pharyngitis are pain, discomfort, burning, dryness and foreign body sensation in the pharynx, the patient usually "shoots out" to clear the sore throat, easy nausea, phlegm in the pharynx, and irritating cough caused by itching of the pharynx. In modern society, the occurrence of chronic pharyngitis is obviously increased, specific statistical data are not reported, but in clinic, the ten people nine-pharynx is more said, and the incidence rate of the disease is higher. Pharyngitis is one of common and frequently-occurring diseases in clinic, and is inflammation of pharyngeal mucosa, mucosal tissue and lymphoid tissue, and can be divided into acute pharyngitis and chronic pharyngitis.

Besides dysphagia, dyspnea can affect sound production, dysphagia due to pharyngeal purulent sputum, and dysphagia due to speech pronunciation and mouth and tongue confusion. Western medicine considers that the main causes of pharyngitis are viral and bacterial infection, which are mostly infected by spray or direct contact, and in addition, the general resistance is weakened, such as fatigue, catching cold, excessive smoking and drinking, etc., which are often the causes of the disease; the traditional Chinese medicine considers that the throat is the part of the channels such as the heart of the hand and the shaoyin, the liver of the foot and the shaoyin, the spleen of the foot and the shaoyin, the stomach of the foot and the sun of the hand and the small intestine, so the pathological changes of the throat are mostly related to the qi disorder and dysfunction of the channels such as heart, lung, liver, kidney, spleen and stomach, small intestine, and the like, and the pharyngitis is a common disease name of the traditional Chinese medicine department, and is first seen in the internal channel. The throat obstruction syndrome called by Nei Jing is a general term for various diseases, including throat obstruction, throat wind, tonsillitis, aphonia, diphtheria and partial oral cavity diseases, is a generalized throat obstruction, is considered to be the cause of the disease, is considered to be complicated by Western doctors, is mostly related to factors such as spicy diet, smoking and drinking, emotional depression, air pollution and the like, and is mostly responsible for factors such as pathogenic toxin feeling, five-emotion overdue, congenital endowment deficiency and the like in traditional Chinese medicine. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is quite troublesome in treating Western medicine, or relieves symptoms by means of watermelon frost throat-moistening tablets and throat-clearing dropping pills, the pharyngitis is difficult to heal by using a Western medicine method, repeated attacks are easy, the symptoms are light in time, the disease which can be healed originally in early stage is long-term and is not easy to rest, and long-term pain is brought to patients.

Disclosure of Invention

Aiming at the problems of the background technology, the invention aims to provide a traditional Chinese medicine composition for treating pharyngitis and a preparation method thereof, which have the effects of clearing heat, resolving phlegm, relieving sore throat and relieving pain, have obvious clinical effects on treating pharyngitis, have high cure rate and are not easy to relapse after healing.

The invention provides a traditional Chinese medicine composition for treating pharyngitis, which comprises the following traditional Chinese medicine raw materials in parts by mass: 5-15 parts of periostracum cicadae, 15-25 parts of orange peel, 5-15 parts of burdock, 2-7 parts of blackberry lily, 5-12 parts of nutgrass galingale rhizome, 2-7 parts of turmeric root-tuber, 10-20 parts of concha arcae, 5-15 parts of rhizoma pinellinae praeparata, 10-20 parts of dark plum fruit, 5-15 parts of liquorice, 5-15 parts of dwarf lilyturf tuber, 2-7 parts of shizandra berry, 45-55 parts of medicated leaven and 15-25 parts of red knotweed flower.

Further, the traditional Chinese medicine comprises the following traditional Chinese medicine raw materials in parts by weight: 10g of cicada slough, 20g of orange peel, 10g of burdock, 5g of blackberry lily, 8 g of nutgrass galingale rhizome, 5g of turmeric root-tuber, 15g of concha arcae, 10g of rhizoma pinellinae praeparata, 15g of dark plum fruit, 10g of liquorice, 10g of dwarf lilyturf tuber, 5g of Chinese magnoliavine fruit, 50 g of medicated leaven and 20g of red knotweed flower.

The invention also provides a preparation method of the traditional Chinese medicine composition for treating pharyngitis, which comprises the following steps:

(1) Weighing the raw materials in weight ratio;

(2) Drying the raw materials at 60-100deg.C, grinding into fine powder, and fermenting in sealed container at 30-37deg.C for 25-35 days to obtain product for treating pharyngitis.

The cicada slough Gan Hanqing is hot, light in weight and floating upwards, is longer than the cicada slough for dispelling wind-heat in lung meridian to disperse lung qi, relieve sore throat, and open voice to treat dumb, can be used for wind-heat type common cold, and has better compatibility with burdock fruit, and symptoms of hoarseness or sore throat at the beginning of warm diseases.

Orange peel, pericarpium Citri Tangerinae, having effects of regulating qi-flowing, invigorating spleen, regulating middle warmer, eliminating dampness, and eliminating phlegm.

Burdock, fructus Arctii, which is pungent, bitter and bitter in flavor and has the effects of clearing heat and cold energy, dispelling wind-heat in ascending and dispersing, dispersing lung qi and eliminating phlegm, and clearing and relieving throat, can be used for treating wind-heat type common cold with symptoms of throat swelling and pain, or cough with excessive phlegm, has remarkable antibacterial effect on pneumococcus, and the water-soaking agent has different degrees of inhibition effects on various pathogenic dermatophytes, and can be used for treating wind-heat type common cold, or symptoms of initial warm disease, fever, sore throat and the like.

Blackberry lily, bitter and cold. Enter lung meridian. Clear away heat and toxic materials, remove phlegm, and relieve sore throat.

Rhizoma Cyperi, has effects of nourishing liver, spleen, and triple energizer meridian, dispersing stagnated liver qi, regulating menstruation, relieving pain, and can be used for treating diseases caused by liver depression and qi stagnation.

Yu jin is pungent and bitter in flavor and cold in nature; return to heart, liver and lung meridians; has effects of promoting qi circulation, promoting blood circulation, relieving pain, clearing away heart-fire, resolving stagnation, cooling blood, stopping bleeding, and eliminating jaundice of liver and gallbladder.

The concha arcae has the effects of resolving phlegm and removing blood stasis, is commonly used for treating persistent phlegm cementation and sticky difficult fluke, and has very obvious curative effect.

Ban Xia is pungent and warm in nature and toxic in nature, and enters spleen and stomach and lung simultaneously, and can move water dampness, descend adverse qi and dispel damp phlegm in spleen and stomach. Spleen strengthening and phlegm and saliva self-eliminating due to water dampness, stomach harmonizing due to qi descending and distention and fullness and vomiting self-stopping, so it is a good herb for drying dampness and phlegm, checking adverse qi, relieving vomiting, and resolving masses.

Dark plum fruit, fructus mume, astringing to promote the production of body fluid, and relieving ascarid to expel parasites. For chronic cough, dysphoria with smothery sensation, chronic malaria, chronic diarrhea, dysentery, hematochezia, hematuria, metrorrhagia, ascariasis, abdominal pain, emesis, ancylostomiasis, psoriasis, and pterygium.

Licorice root, radix Glycyrrhizae Praeparata, has the effect of clearing away heat and toxic materials. For pain and stranguria in penis. (1) Medical Start Source (S): it is good at relieving pain in stems. "(2) [ medical entrance ]: raw use, purging stomach fire, relieving fever and removing heat accumulation in chest.

Radix Ophiopogonis has effects of nourishing yin, promoting salivation, moistening lung, and clearing heart fire. Can be used for treating dry cough due to lung dryness. Cough due to deficiency of both the body fluid, thirst, vexation, insomnia, internal heat, thirst, constipation due to intestinal dryness, and diphtheria. It can be used for treating cough due to lung dryness, hematemesis, hemoptysis, consumptive lung disease, pulmonary abscess, dysphoria with smothery sensation, diabetes, heat disease, fluid consumption, dry throat and mouth, and constipation.

Fructus Schisandrae chinensis, sour and sweet in taste, has effect of promoting fluid production, and can be used for treating body fluid consumption thirst, internal heat diabetes, etc. Fructus Schisandrae chinensis also has astringent and astringent effects, and can be used for relieving chronic diarrhea, spontaneous perspiration and night sweat.

The medicated leaven has the effects of strengthening spleen and stomach, promoting digestion and regulating middle warmer, is mainly used for treating spleen and stomach weakness, food stagnation, chest stuffiness and abdominal distention, infantile dyspepsia, various food stagnation, dyspepsia, short breath and debilitation and other spleen and stomach weakness symptoms.

The red knotweed flower has the effects of promoting blood circulation to remove food retention, strengthening spleen to remove dampness, clearing heat and detoxicating, and the like, has salty taste, can cool and return to liver and kidney meridians, can play a role in promoting blood circulation to remove food retention, and has good effect of improving lump and swelling caused by blood stasis and food retention. Has effects of invigorating spleen and promoting diuresis, and can be used for treating diseases such as gastritis and gastric ulcer caused by spleen and stomach weakness and spleen and stomach damp-heat; the cool can play a role in clearing away heat and toxic materials, has good effects on aphtha and gum swelling and pain caused by heat toxin suction accumulation, and can also be used for treating diseases such as eye sores, red swelling, conjunctivitis and the like caused by fire heat attack.

Compared with the prior art, the invention has the beneficial effects that: the pharmaceutical composition is composed of traditional Chinese medicines, improves the safety of the medicines, increases the application range and the population, and clinical test results show that the pharmaceutical composition can effectively treat chronic pharyngitis, and has obvious elimination or alleviation effects on symptoms such as pharyngeal discomfort, foreign body sensation, itching sensation, burning sensation, dryness sensation and/or irritation sensation, pharyngeal pain, pharyngeal cough, nausea sensation and pharyngeal mucosa thickening, sticky or thick secretion and the like caused by the chronic pharyngitis. Meanwhile, the medicine composition has precise and appropriate medicine taste compatibility, and the treatment effect can be influenced by changing the medicine proportion.

Detailed Description

The invention is further described in connection with the following detailed description, in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the invention easy to understand.

Example 1

A traditional Chinese medicine composition for treating pharyngitis consists of the following traditional Chinese medicine raw materials in parts by mass: 10g of cicada slough, 20g of orange peel, 10g of burdock, 5g of blackberry lily, 8 g of nutgrass galingale rhizome, 5g of turmeric root-tuber, 15g of concha arcae, 10g of rhizoma pinellinae praeparata, 15g of dark plum fruit, 10g of liquorice, 10g of dwarf lilyturf tuber, 5g of Chinese magnoliavine fruit, 50 g of medicated leaven and 20g of red knotweed flower.

A preparation method of a traditional Chinese medicine composition for treating pharyngitis comprises the following steps:

(1) Weighing the raw materials in weight ratio;

(2) Drying the raw materials at 60-100deg.C, grinding into fine powder, and fermenting in sealed container at 30-37deg.C for 30 days to obtain product for treating pharyngitis.

Example 2

A traditional Chinese medicine composition for treating pharyngitis consists of the following traditional Chinese medicine raw materials in parts by mass: cicada slough 5g, orange peel 15g, burdock 5g, blackberry lily 7 g, nutgrass galingale rhizome 5g, turmeric 7 g, concha arcae 10g, rhizoma pinellinae praeparata 5g, dark plum 10g, licorice 5g, dwarf lilyturf tuber 15g, schisandra fruit 7 g, medicated leaven 55 g and red knotweed flower 25 g.

A preparation method of a traditional Chinese medicine composition for treating pharyngitis comprises the following steps:

(1) Weighing the raw materials in weight ratio;

(2) Drying the raw materials at 60-100deg.C, grinding into fine powder, and fermenting in sealed container at 30-37deg.C for 25 days to obtain product for treating pharyngitis.

Example 3

A traditional Chinese medicine composition for treating pharyngitis consists of the following traditional Chinese medicine raw materials in parts by mass: 15 parts of cicada slough, 25 parts of orange peel, 15 parts of burdock, 2 parts of blackberry lily, 5 parts of nutgrass galingale rhizome, 7 parts of turmeric root-tuber, 20 parts of concha arcae, 15 parts of prepared pinellia tuber, 20 parts of dark plum, 15 parts of liquorice, 15 parts of dwarf lilyturf tuber, 7 parts of shizandra berry, 55 parts of medicated leaven and 25 parts of red knotweed flower.

A preparation method of a traditional Chinese medicine composition for treating pharyngitis comprises the following steps:

(1) Weighing the raw materials in weight ratio;

(2) Drying the raw materials at 60-100deg.C, grinding into fine powder, and fermenting in sealed container at 30-37deg.C for 35 days to obtain product for treating pharyngitis.

Diagnostic criteria: referring to the traditional Chinese medicine industry standard of the people's republic of China, namely the traditional Chinese medicine disease diagnosis curative effect standard-otorhinolaryngology disease diagnosis curative effect standard, the main symptoms are dry throat, itching throat, burning, slight pain and throat foreign body sensation; the main physical sign is chronic congestion of pharyngeal mucosa, or atrophy, hypertrophic pharyngeal lateral cable, hyperplasia of lymphatic follicular hyperplasia of pharyngeal rear wall; the course of the disease: for more than 2 months; medical history: can have repeated attack history of acute pharyngitis, smoking and drinking, spicy food history, or long-term smoke and harmful gas irritation history. And combining with the differentiation of symptoms in traditional Chinese medicine: often dry throat, but without desire to drink, cough, easy expectoration, aversion to cold, excessive sweating, easy cold, tiredness, debilitation, low voice, loose stool, light pharyngeal congestion, longer course of disease and acute attack. The throat is slightly dry, slightly itching and slightly painful, has foreign body obstruction feeling or phlegm adhesion feeling, is easy to feel sweats, is tired and debilitated, and sometimes has the effects of soreness and weakness of waist and knees, clear urine and long, and lassitude and cold limbs. The Chinese medicinal composition has the symptoms, and can be used for diagnosing lung-spleen qi deficiency type chronic pharyngitis and kidney-yang deficiency type chronic pharyngitis by combining with local physical signs.

The beneficial effects of the invention are demonstrated by specific clinical trials below.

Test example 1

1. Clinical effects of the Chinese medicinal composition of the invention

1. Clinical data

300 cases of chronic pharyngitis patients are aged 25-55 years.

1.1 inclusion criteria

(1) Diagnosing the patient with chronic simple pharyngitis or chronic hypertrophic pharyngitis. Symptoms are discomfort of the pharynx (foreign body sensation, itching sensation, burning sensation, dryness sensation and/or irritation sensation), and symptoms such as slight pain of the pharynx, cough of the pharynx, nausea sensation, thickening of the mucosa of the pharynx, sticky or purulent secretion and the like of part of patients.

(2) The age is between 25 and 55 years.

1.2 exclusion criteria

(1) Those who do not meet inclusion criteria;

(2) patients and family members refused to cooperate with the therapist;

(3) allergic constitution, or those known to be allergic to the present medicinal component;

(4) patients who are taking part in clinical trials of other medications.

2. Therapeutic method

Test group: the pharyngitis powder prepared in example 1, example 2 and example 3 of the present invention was administered to a patient. The administration method comprises the following steps: 1g of the medicine is contained on the Jiquan acupoint of the tongue each time, the tongue is used for pushing the upper forehead, the mouth is closed without speaking, the Jiquan acupoint can continuously promote the production of body fluid, and the medicine is melted by body fluid and swallowed to the lower throat part. It is administered for 10-15 min each time and 5-8 times each day.

Control group: 300 patients are divided into three groups of a control group 1, a control group 2 and a control group 3, 50 patients in each group are respectively taken with three conventional medicines for treating pharyngitis, namely lily fixed gold particles, watermelon frost lozenge and sarcandra glabra lozenge, in the three groups of the control group 1, the control group 2 and the control group 3, and the taking method is as follows: the same administration method as in the example group was used.

3. Standard of efficacy

And (3) curing: symptoms such as dysphagia, cough, pharyngalgia and the like are eliminated by congestion and swelling of the mucous membrane of the pharynx;

the effect is shown: the clinical symptoms and the pharyngeal mucosa congestion and swelling are improved;

the method is effective: clinical symptoms and pharyngeal mucosa congestion and swelling are relieved;

invalidation: clinical symptoms and pharyngeal mucosa congestion and swelling are unchanged and even the illness is aggravated;

total effective rate= (effective rate + cure rate)/total number of people x 100%.

4. Curative effect judging and clinical observation data

Specifically, the treatment effect of the patients in the observation group and the control group is as follows,

specifically, the clinical data show that the total effective rate of the traditional Chinese medicine composition prepared by the traditional Chinese medicine composition in the technical scheme on pharyngitis reaches 96%, and the curative effect is obviously higher than that of the traditional Chinese medicine composition for treating pharyngitis. Although the prescription drugs of example 2 and example 3 are the same as those of example 1, the treatment effect of the pharyngitis powder prepared in example 1 on chronic pharyngitis symptoms is obviously better than that of example 2 and example 3 under different drug ratios.

In conclusion, the pharmaceutical composition disclosed by the invention is composed of traditional Chinese medicines, so that the safety of the medicine is improved, the application range and the population are increased, and clinical test results show that the pharmaceutical composition disclosed by the invention can be used for effectively treating chronic pharyngitis, and has obvious effects of eliminating or relieving symptoms such as pharyngeal discomfort, foreign body sensation, itching sensation, burning sensation, dryness sensation and/or irritation sensation, pharyngeal pain, pharyngeal cough, nausea sensation accompanied by thickening pharyngeal mucosa, sticky or thick secretion and the like caused by the chronic pharyngitis. Meanwhile, the medicine composition has precise and appropriate medicine taste compatibility, and the treatment effect can be influenced by changing the medicine proportion.

The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.

Claims (3)

1. The traditional Chinese medicine composition for treating pharyngitis is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 5-15 parts of periostracum cicadae, 15-25 parts of orange peel, 5-15 parts of burdock, 2-7 parts of blackberry lily, 5-12 parts of nutgrass galingale rhizome, 2-7 parts of turmeric root-tuber, 10-20 parts of concha arcae, 5-15 parts of rhizoma pinellinae praeparata, 10-20 parts of dark plum fruit, 5-15 parts of liquorice, 5-15 parts of dwarf lilyturf tuber, 2-7 parts of shizandra berry, 45-55 parts of medicated leaven and 15-25 parts of red knotweed flower.

2. The traditional Chinese medicine composition for treating pharyngitis according to claim 1, which is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 10g of cicada slough, 20g of orange peel, 10g of burdock, 5g of blackberry lily, 8 g of nutgrass galingale rhizome, 5g of turmeric root-tuber, 15g of concha arcae, 10g of rhizoma pinellinae praeparata, 15g of dark plum fruit, 10g of liquorice, 10g of dwarf lilyturf tuber, 5g of Chinese magnoliavine fruit, 50 g of medicated leaven and 20g of red knotweed flower.

3. The preparation method of the traditional Chinese medicine composition for treating pharyngitis is characterized by comprising the following steps:

(1) Weighing the raw materials in weight ratio;

(2) Drying the raw materials at 60-100deg.C, grinding into fine powder, and fermenting in sealed container at 30-37deg.C for 25-35 days to obtain product for treating pharyngitis.