CN114432204B - Repairing cream with skin inflammation relieving and repairing effects - Google Patents
Repairing cream with skin inflammation relieving and repairing effects Download PDFInfo
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- CN114432204B CN114432204B CN202210193852.1A CN202210193852A CN114432204B CN 114432204 B CN114432204 B CN 114432204B CN 202210193852 A CN202210193852 A CN 202210193852A CN 114432204 B CN114432204 B CN 114432204B
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- chitosan
- solution
- polyphenol
- repairing
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Landscapes
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Abstract
The invention discloses a repair cream with the effects of relieving skin inflammation and repairing, which comprises the following components in parts by weight: 61-75 parts of water, 12-18 parts of emollient, 3-5 parts of emulsifier, 10-15 parts of humectant, 0.1-0.3 part of thickener, 0.2-0.5 part of antioxidant, 0.1-0.2 part of astringent, 0.025-1 part of ceramide, 0.00375-0.5 part of ergothioneine, 0.44-1 part of kava root extract, 0.088-0.2 part of lactuca sativa polyphenol/carboxymethyl chitosan microsphere, 0.02-0.05 part of essence and 0.08-0.1 part of preservative. The invention takes the lactuca sativa polyphenol/chitosan microsphere, kava root extract, ergothioneine and ceramide as active ingredients for repairing and relieving skin inflammation, and a repairing cream product with good repairing effect and long protection time is obtained.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a repair cream with the effects of relieving skin inflammation and repairing.
Background
Along with the continuous improvement of life quality, the demands of people on daily cosmetics are continuously increased, and besides the demands of cosmetics on functionality, health is also more emphasized, so that natural plant component materials become important sources.
However, many people are sensitive skin, and even the components extracted from natural plants are sometimes more irritating, so that the skin is not suitable for sensitive skin. Sensitive skin is a special state of skin, and is fragile and weak in resistance, and symptoms such as red blood streak, edema and telangiectasis are easy to appear after external stimulus, so that the requirements on cosmetics are high, and mild and non-irritating cosmetic components are suitable to use. In addition, sensitive skin has a thinner epidermis layer, poor defenses, and is prone to inflammation or sunburn. Therefore, how to find a safe and effective method for improving the condition of sensitive skin is the most focused topic at present.
Disclosure of Invention
Aiming at the problem that the existing cosmetics have strong irritation to sensitive skin in the prior art, the invention aims to provide the repair cream with the effects of relieving skin inflammation and repairing.
The aim of the invention is realized by adopting the following technical scheme:
a repairing cream with the effects of relieving skin inflammation and repairing comprises the following components in parts by weight:
61-75 parts of water, 12-18 parts of emollient, 3-5 parts of emulsifier, 10-15 parts of humectant, 0.1-0.3 part of thickener, 0.2-0.5 part of antioxidant, 0.1-0.2 part of astringent, 0.025-1 part of ceramide, 0.00375-0.5 part of ergothioneine, 0.44-1 part of kava root extract, 0.088-0.2 part of lactuca sativa polyphenol/carboxymethyl chitosan microsphere, 0.02-0.05 part of essence and 0.08-0.1 part of preservative.
Preferably, the emollient is at least one of caprylic triglyceride, capric triglyceride, hydrogenated polyisobutene, isononyl isononanoate isopropyl myristate, polydimethylsiloxane, ethylhexyl palmitate, ethylhexyl stearate.
Preferably, the emulsifier is at least one of cetostearyl alcohol, sorbitan olive oleate, cetostearyl glucoside, glycerol stearate, PEG-100 stearate.
Preferably, the humectant is at least one of glycerin, propylene glycol, butylene glycol, betaine, and sodium hyaluronate.
Preferably, the thickener is one of acrylic acid/C10-30 alkanol acrylate cross-linked polymer and acrylic acid ester/C10-30 alkanol acrylate cross-linked polymer.
Preferably, the antioxidant is a tocopheryl diacid ester.
Preferably, the astringent is allantoin.
Preferably, the extraction method of the lactuca sativa polyphenol comprises the following steps:
step 1, picking fresh lettuce leaves, removing root parts of the fresh lettuce leaves, cleaning the surfaces of the root parts, draining, and cutting into blocks to obtain the lettuce blocks, and carrying out fresh-keeping treatment for later use;
step 2, placing the dried lettuce blocks in a vacuum drying oven, and drying and dewatering to obtain dried lettuce;
step 3, crushing dried lettuce into powder, and then placing the powder in an ultrafine pulverizer for treatment to obtain the dried lettuce powder;
step 4, placing the lactuca sativa powder into an ethanol solution for extraction treatment to obtain a first extract and first filter residues;
step 5, the first filter residue is firstly placed in alkali liquor for treatment, then acid liquor is dripped to adjust the pH value to be less than 2, and then supernatant fluid is collected through centrifugation, and after extraction and redissolution, a second extract is obtained;
and step 6, combining the first extracting solution and the second extracting solution, and evaporating under reduced pressure until the first extracting solution and the second extracting solution are completely dried to obtain the lactuca sativa polyphenol.
Preferably, the dicing in the step 1 is cutting into pieces with the volume size of 8-12 mm 3 。
Preferably, in the step 1, the temperature of the fresh-keeping treatment is 0-4 ℃, and the fresh-keeping treatment is wrapped by a fresh-keeping film.
Preferably, in the step 2, in the process of drying and dewatering, the vacuum degree is set to be-0.08 to-0.1 MPa, the temperature is set to be 65-85 ℃, and the drying and dewatering time is 3-5 h.
Preferably, in the step 3, the particle size of the lactuca sativa powder is 1-5 μm.
Preferably, in the step 4, the mass fraction of the ethanol solution is 60% -80%; the mass ratio of the lactuca sativa powder to the ethanol solution is 1:20-50.
Preferably, in the step 4, after the mountain lettuce powder is mixed with the ethanol solution, stirring is performed for 0.5 to 1 hour at a speed of 200 to 400rpm at room temperature, centrifugal separation is performed, and after the obtained filter residues are repeatedly extracted for three times, supernatant and precipitate are respectively collected to obtain a first extract and a first filter residue.
Preferably, in the step 5, the alkali solution is a sodium hydroxide solution or a potassium hydroxide solution with the concentration of 1-3 mol/L, and the acid solution is a hydrochloric acid solution with the concentration of 1-3 mol/L; the mass ratio of the first filter residue to the alkali liquor is 1:30-50.
Preferably, in the step 5, after the first filter residue is mixed with the alkali liquor, the temperature is raised to 35-50 ℃ under the protection of inert gas, the heat preservation treatment is carried out for 3-6 hours, and then the acid liquor is added dropwise to adjust the pH to be less than 2.
Preferably, in the step 5, ethyl acetate is used as an extractant for extraction, and ethanol is used as a solvent for re-dissolution; the mass of the ethanol solvent added by re-dissolution is 10-20 times of that of the first filter residue.
Preferably, in the step 6, the temperature of the reduced pressure evaporation is set to 55 to 65 ℃.
Preferably, the preparation method of the lactuca sativa polyphenol/chitosan microsphere comprises the following steps:
s1, weighing chitosan, mixing the chitosan into an acetic acid solution, and stirring and mixing until the chitosan is completely dissolved to obtain a chitosan solution;
s2, mixing the medical paraffin oil with span 80, and uniformly stirring and dispersing to obtain a medical paraffin oil mixed solution;
s3, dropwise adding the chitosan solution into the continuously stirred medical paraffin oil mixed solution, continuously stirring for 0.5-1 h after the dropwise adding is finished, and then dropwise adding alkali liquor until the pH value of the system is 8.5-9.5 to obtain a mixed reaction solution;
s4, dropwise adding glycolaldehyde solution into the mixed reaction solution, uniformly mixing, standing at room temperature for 8-12 h, collecting solid particles, and drying to obtain chitosan porous microspheres;
s5, mixing the lactuca sativa polyphenol into an ethanol solution, stirring until the lactuca sativa polyphenol is completely dissolved, adding chitosan porous microspheres, uniformly mixing by ultrasound, stirring at room temperature for 6-8 h, standing for 1-2 h, and drying under reduced pressure to obtain the lactuca sativa polyphenol/chitosan microspheres.
Preferably, in the step S1, the acetic acid solution is obtained by mixing acetic acid and water according to a mass ratio of 1:20-100; the mass ratio of chitosan to acetic acid solution is 3-5:100.
Preferably, in the step S2, the mass ratio of the medical paraffin oil to span 80 is 1:0.02-0.05.
Preferably, in the step S3, the mass ratio of the chitosan solution to the medical paraffin oil mixed solution is 1:5-10.
Preferably, in the step S4, the glycolaldehyde solution is obtained by mixing glycolaldehyde and water according to a mass ratio of 1:15-20, and the mass ratio of the mixed reaction solution to the glycolaldehyde solution is 1:0.1-0.3.
Preferably, in the step S5, the ethanol solution is obtained by mixing ethanol and water according to a mass ratio of 1:2-4; the mass ratio of the lactuca sativa polyphenol to the chitosan porous microsphere to the ethanol solution is 1:2.2-4.6:10-15.
Preferably, the preparation method of the repair cream with the effects of relieving skin inflammation and repairing comprises the following steps:
step P1, weighing water, an emollient, an emulsifier, a humectant and a thickener according to the amount, mixing into a first container, heating to 70-80 ℃, and uniformly mixing and dispersing to obtain a first mixed dispersion liquid;
step P2, weighing antioxidant, astringent, essence and preservative according to parts by weight, mixing into a second container, heating to 70-80 ℃, and uniformly mixing and dispersing to obtain a second mixed dispersion liquid;
step P3, mixing the first mixed dispersion liquid and the second mixed dispersion liquid into an emulsifying device, heating to 70-80 ℃, and uniformly mixing and dispersing to obtain a third mixed dispersion liquid;
and step P4, after the third mixed dispersion liquid is cooled to 45-50 ℃, adding the mountain lettuce polyphenol/chitosan microsphere, the kava root extract, the ergothioneine and the ceramide which are weighed according to parts by weight, uniformly mixing and dispersing, and cooling to room temperature to obtain the repairing cream with the effects of relieving skin inflammation and repairing.
The beneficial effects of the invention are as follows:
1. according to the invention, the lactuca sativa polyphenol/chitosan microsphere, the ceramide, the ergothioneine and the kava pepper are used as active ingredients for repairing and relieving skin inflammation, wherein the ceramide, the ergothioneine and the kava pepper can rapidly play a role in relieving the inflammation, and the lactuca sativa polyphenol/chitosan microsphere can continuously dissolve out effective substances so as to play a role in long-time repairing, and the moisturizing agent, the emollient, the emulsifier, the thickening agent, the antioxidant and the astringent are used as auxiliary materials, so that a repairing cream product with good repairing effect and long protection time is obtained.
2. The Ceramide (Ceramide) is a type of phospholipid taking the Ceramide as a framework, and mainly comprises Ceramide phosphorylcholine and Ceramide phosphorylethanolamine, wherein the phospholipid is a main component of a cell membrane, 40% -50% of sebum in a stratum corneum is composed of the Ceramide, and ergothioneine has a cell protecting effect and an anti-inflammatory effect; the main medicinal components of Kavalactones (Kavalactones), kavain, kawain (Kawain) and the like can bidirectionally regulate neurotransmitters, have various effects of resisting anxiety and depression, sedating and hypnotizing, local anesthesia, anticonvulsant and the like, have no drug dependence, have the effects of inhibiting bacteria, diminishing inflammation, relieving pain and itching and the like, effectively reduce inflammatory reaction and accelerate healing, so as to play a role in relieving and repairing.
3. The invention extracts the rhizomes of the plant lactuca sativa to obtain the lactuca sativa polyphenol finally. The extraction process of the mountain lettuce polyphenol is different from the conventional plant extraction, and the invention firstly cuts root parts of the mountain lettuce into pieces, dries and grinds the root parts of the mountain lettuce, and then carries out alcohol extraction, so that mountain lettuce cells after vacuum drying and grinding are more damaged, and the release of phenols in the mountain lettuce is promoted to a certain extent by cell rupture, so that the subsequent extraction process can become more efficient; and then, carrying out a two-way extraction method of alcohol extraction and alkali extraction, wherein the alcohol extraction is used for dissolving out free phenols and flavonoid products, the alkali extraction is used for dissolving out combined phenols, and the reasonable utilization of the two-way extraction method can further promote the dissolution and extraction of most phenols in the lactuca sativa, so that more extracts are obtained.
4. In the field of medicine, chitosan is a common medical substance, and has the effects of promoting wound healing, stopping bleeding, inhibiting scar, easing pain and inhibiting bacteria; the addition of the lactuca sativa polyphenol improves the repairability of the chitosan. The invention combines the extracted lactuca sativa polyphenol and chitosan to form the microsphere material with the chitosan as the shell and the lactuca sativa polyphenol as the inner core. Compared with the chitosan alone, the microsphere material has better repairing effect, the unique porous microsphere structure also has better slow release performance, can continuously secrete the lactuca sativa polyphenol in one day of coating the repairing cream, has good protecting and repairing effects on sunburn and skin inflammation of the skin, reduces the irritation of the skin care product to the skin, and enhances the resistance of the skin to the outside.
Drawings
The invention will be further described with reference to the accompanying drawings, in which embodiments do not constitute any limitation of the invention, and other drawings can be obtained by one of ordinary skill in the art without inventive effort from the following drawings.
FIG. 1 is a comparison of H & E staining after the end of dosing of the different models.
Detailed Description
The technical features, objects and advantages of the present invention will be more clearly understood from the following detailed description of the technical aspects of the present invention, but should not be construed as limiting the scope of the invention.
The kava root extract referred to in the present invention is purchased from zhejiang huitong pharmaceutical limited.
The invention is further described with reference to the following examples.
Example 1
A repairing cream with the effects of relieving skin inflammation and repairing comprises the following components in parts by weight:
68 parts of water, 15 parts of an emollient, 4 parts of an emulsifier, 12 parts of a humectant, 0.2 part of a thickener, 0.3 part of an antioxidant, 0.1 part of an astringent, 0.16 part of ceramide, 0.084 part of ergothioneine, 0.57 part of kava root extract, 0.16 part of lactuca sativa polyphenol/carboxymethyl chitosan microsphere, 0.03 part of essence and 0.09 part of a preservative.
The emollient is caprylic triglyceride. The emulsifier is cetostearyl alcohol. The humectant is glycerin. The thickener is acrylic acid/C10-30 alkanol acrylate cross-linked polymer. The antioxidant is tocopheryl diacid ester. The astringent is allantoin.
The Lactuca sativa polyphenol is extracted from rhizomes of Lactuca sativa.
The extraction method of the lactuca sativa polyphenol comprises the following steps:
step 1, picking fresh mountain lettuce, removing leaves to obtain root parts, cleaning the surfaces of the root parts, draining, and cutting into 10mm volume 3 Obtaining a mountain lettuce block, and wrapping the mountain lettuce block with a preservative film at the temperature of 0-4 ℃ for standby;
step 2, placing the dried lettuce blocks in a vacuum drying oven, setting the vacuum degree to be-0.1 MPa, setting the temperature to be 75 ℃, and drying and dewatering for 4 hours to obtain dried lettuce;
step 3, crushing the dried lettuce into powder, and then placing the powder in an ultrafine pulverizer to treat the powder to obtain the lettuce powder with the particle size of 1-5 mu m;
step 4, placing the mountain lettuce powder into an ethanol solution with the mass fraction of 70% for extraction treatment, wherein the mass ratio of the mountain lettuce powder to the ethanol solution is 1:35, stirring at the speed of 300rpm for 0.5h at room temperature, performing centrifugal separation, repeatedly extracting the obtained filter residues for three times, and respectively collecting supernatant and precipitate to obtain a first extract and a first filter residue;
step 5, the first filter residue is firstly placed in a sodium hydroxide solution or a potassium hydroxide solution with the concentration of 2mol/L for treatment, the mass ratio of the first filter residue to the alkali liquor is 1:40, the temperature is raised to 45 ℃ under the protection of inert gas, the temperature is kept for 5 hours, then hydrochloric acid solution with the concentration of 2mol/L is added dropwise to adjust the pH to be less than 2, the supernatant is collected after centrifugation, and after ethyl acetate extraction treatment, ethanol with the mass of 15 times of the mass of the first filter residue is added for redissolution, so that a second extract is obtained;
and step 6, combining the first extracting solution and the second extracting solution, and evaporating under reduced pressure at 60 ℃ until the first extracting solution and the second extracting solution are completely dried to obtain the lactuca sativa polyphenol.
The preparation method of the lactuca sativa polyphenol/chitosan microsphere comprises the following steps:
s1, weighing chitosan, mixing the chitosan into an acetic acid solution, wherein the acetic acid solution is obtained by mixing acetic acid and water according to a mass ratio of 1:80, and stirring and mixing until the chitosan and the acetic acid solution are completely dissolved to obtain a chitosan solution, wherein the mass ratio of the chitosan to the acetic acid solution is 4:100;
s2, mixing the medical paraffin oil with span 80, wherein the mass ratio of the medical paraffin oil to the span 80 is 1:0.03, and stirring and dispersing uniformly to obtain a medical paraffin oil mixed solution;
s3, dropwise adding the chitosan solution into the continuously stirred medical paraffin oil mixed solution, wherein the mass ratio of the chitosan solution to the medical paraffin oil mixed solution is 1:8, continuously stirring for 0.8h after the dropwise adding is finished, and then dropwise adding alkali liquor until the pH value of the system is 8.5-9.5, so as to obtain a mixed reaction solution;
s4, dropwise adding an glycolaldehyde solution into the mixed reaction solution, wherein the glycolaldehyde solution is obtained by mixing glycolaldehyde and water according to a mass ratio of 1:18, the mass ratio of the mixed reaction solution to the glycolaldehyde solution is 1:0.2, after the dropwise adding is finished, uniformly mixing, standing for 10 hours at room temperature, collecting solid particles, and drying to obtain the chitosan porous microspheres;
s5, mixing the lactuca sativa polyphenol into an ethanol solution, stirring until the lactuca sativa polyphenol is completely dissolved, adding chitosan porous microspheres, mixing ethanol and water according to a mass ratio of 1:3 to obtain the ethanol solution, uniformly mixing the lactuca sativa polyphenol, the chitosan porous microspheres and the ethanol solution by ultrasound according to a mass ratio of 1:3.8:12, stirring for 7 hours at room temperature, standing for 1.5 hours, and drying under reduced pressure to obtain the lactuca sativa polyphenol/chitosan microspheres.
The preparation method of the repair cream with the effects of relieving skin inflammation and repairing comprises the following steps:
step P1, weighing water, an emollient, an emulsifier, a humectant and a thickener according to the amount, mixing into a first container, heating to 75 ℃, and uniformly mixing and dispersing to obtain a first mixed dispersion liquid;
step P2, weighing antioxidant, astringent, essence and preservative according to parts by weight, mixing into a second container, heating to 75 ℃, and uniformly mixing and dispersing to obtain a second mixed dispersion liquid;
step P3, mixing the first mixed dispersion liquid and the second mixed dispersion liquid into an emulsifying device, heating to 75 ℃, and uniformly mixing and dispersing to obtain a third mixed dispersion liquid;
and step P4, after the third mixed dispersion liquid is cooled to 45 ℃, adding the mountain lettuce polyphenol/chitosan microsphere, the kava root extract, the ergothioneine and the ceramide which are weighed according to parts by weight, uniformly mixing and dispersing, and cooling to room temperature to obtain the repairing cream with the effects of relieving skin inflammation and repairing.
Example 2
A repairing cream with the effects of relieving skin inflammation and repairing comprises the following components in parts by weight:
61 parts of water, 12 parts of an emollient, 3 parts of an emulsifier, 10 parts of a humectant, 0.1 part of a thickener, 0.2 part of an antioxidant, 0.1 part of an astringent, 0.025 part of ceramide, 0.00375 parts of ergothioneine, 0.44 part of kava root extract, 0.088 part of a mountain lettuce polyphenol/carboxymethyl chitosan microsphere, 0.02 part of essence and 0.08 part of a preservative.
The emollient is a triglyceride of capric acid. The emulsifier is sorbitan olive oleate. The humectant is propylene glycol. The thickening agent is acrylic ester/C10-30 alkanol acrylic ester cross-linked polymer. The antioxidant is tocopheryl diacid ester. The astringent is allantoin.
The Lactuca sativa polyphenol is extracted from rhizomes of Lactuca sativa.
The extraction method of the lactuca sativa polyphenol comprises the following steps:
step 1, picking fresh mountain lettuce, removing leaves to obtain root parts, cleaning the surfaces of the root parts, draining, and cutting into 8mm volume 3 Obtaining a mountain lettuce block, and wrapping the mountain lettuce block with a preservative film at the temperature of 0-4 ℃ for standby;
step 2, placing the dried lettuce blocks in a vacuum drying oven, setting the vacuum degree to be-0.08 MPa, setting the temperature to be 65 ℃, and drying and dewatering for 3 hours to obtain dried lettuce;
step 3, crushing the dried lettuce into powder, and then placing the powder in an ultrafine pulverizer to treat the powder to obtain the lettuce powder with the particle size of 1-5 mu m;
step 4, placing the mountain lettuce powder into an ethanol solution with the mass fraction of 60% for extraction treatment, wherein the mass ratio of the mountain lettuce powder to the ethanol solution is 1:20, stirring at the speed of 200rpm for 0.5h at room temperature, performing centrifugal separation, repeatedly extracting the obtained filter residues for three times, and respectively collecting supernatant and precipitate to obtain a first extract and a first filter residue;
step 5, the first filter residue is firstly placed in a 1mol/L sodium hydroxide solution or a potassium hydroxide solution for treatment, the mass ratio of the first filter residue to alkali liquor is 1:30, the temperature is raised to 35 ℃ under the protection of inert gas, the temperature is kept for 3 hours, then a hydrochloric acid solution with the concentration of 1mol/L is added dropwise to adjust the pH value to be less than 2, the supernatant is collected after centrifugation, and after the extraction treatment of ethyl acetate, ethanol with the mass of 10 times of the mass of the first filter residue is added for redissolution, so that a second extract is obtained;
and step 6, combining the first extracting solution and the second extracting solution, and evaporating under reduced pressure at 55 ℃ until the first extracting solution and the second extracting solution are completely dried to obtain the lactuca sativa polyphenol.
The preparation method of the lactuca sativa polyphenol/chitosan microsphere comprises the following steps:
s1, weighing chitosan, mixing the chitosan into an acetic acid solution, wherein the acetic acid solution is obtained by mixing acetic acid and water according to a mass ratio of 1:20, and stirring and mixing until the chitosan and the acetic acid solution are completely dissolved to obtain a chitosan solution, wherein the mass ratio of the chitosan to the acetic acid solution is 3:100;
s2, mixing the medical paraffin oil with span 80, wherein the mass ratio of the medical paraffin oil to the span 80 is 1:0.02, and stirring and dispersing uniformly to obtain a medical paraffin oil mixed solution;
s3, dropwise adding the chitosan solution into the continuously stirred medical paraffin oil mixed solution, wherein the mass ratio of the chitosan solution to the medical paraffin oil mixed solution is 1:5, continuously stirring for 0.5h after the dropwise adding is finished, and then dropwise adding alkali liquor until the pH value of the system is 8.5-9.5, so as to obtain a mixed reaction solution;
s4, dropwise adding an glycolaldehyde solution into the mixed reaction solution, wherein the glycolaldehyde solution is obtained by mixing glycolaldehyde and water according to a mass ratio of 1:15, the mass ratio of the mixed reaction solution to the glycolaldehyde solution is 1:0.1, after the dropwise adding is finished, uniformly mixing, standing for 8 hours at room temperature, collecting solid particles, and drying to obtain the chitosan porous microspheres;
s5, mixing the lactuca sativa polyphenol into an ethanol solution, stirring until the lactuca sativa polyphenol is completely dissolved, adding chitosan porous microspheres, mixing ethanol and water according to a mass ratio of 1:2 to obtain the ethanol solution, uniformly mixing the lactuca sativa polyphenol, the chitosan porous microspheres and the ethanol solution by ultrasound according to a mass ratio of 1:2.2:10, stirring for 6 hours at room temperature, standing for 1 hour, and drying under reduced pressure to obtain the lactuca sativa polyphenol/chitosan microspheres.
The preparation method of the repair cream with the effects of relieving skin inflammation and repairing comprises the following steps:
step P1, weighing water, an emollient, an emulsifier, a humectant and a thickener according to the amount, mixing into a first container, heating to 70 ℃, and uniformly mixing and dispersing to obtain a first mixed dispersion liquid;
step P2, weighing antioxidant, astringent, essence and preservative according to parts by weight, mixing into a second container, heating to 70 ℃, and uniformly mixing and dispersing to obtain a second mixed dispersion liquid;
step P3, mixing the first mixed dispersion liquid and the second mixed dispersion liquid into an emulsifying device, heating to 70 ℃, and uniformly mixing and dispersing to obtain a third mixed dispersion liquid;
and step P4, after the third mixed dispersion liquid is cooled to 45 ℃, adding the mountain lettuce polyphenol/chitosan microsphere, the kava root extract, the ergothioneine and the ceramide which are weighed according to parts by weight, uniformly mixing and dispersing, and cooling to room temperature to obtain the repairing cream with the effects of relieving skin inflammation and repairing.
Example 3
A repairing cream with the effects of relieving skin inflammation and repairing comprises the following components in parts by weight:
75 parts of water, 18 parts of an emollient, 5 parts of an emulsifier, 15 parts of a humectant, 0.3 part of a thickener, 0.5 part of an antioxidant, 0.2 part of an astringent, 1 part of ceramide, 0.5 part of ergothioneine, 1 part of kava root extract, 0.2 part of mountain lettuce polyphenol/carboxymethyl chitosan microsphere, 0.05 part of essence and 0.1 part of a preservative.
The emollient is hydrogenated polyisobutene. The emulsifier is cetylstearyl glucoside. The humectant is butanediol. The thickener is acrylic acid/C10-30 alkanol acrylate cross-linked polymer. The antioxidant is tocopheryl diacid ester. The astringent is allantoin.
The Lactuca sativa polyphenol is extracted from rhizomes of Lactuca sativa.
The extraction method of the lactuca sativa polyphenol comprises the following steps:
step 1, picking fresh mountain lettuce, removing leaves to obtain root parts, cleaning the surfaces of the root parts, draining, and cutting into the volume of 12mm 3 Obtaining a mountain lettuce block, and wrapping the mountain lettuce block with a preservative film at the temperature of 0-4 ℃ for standby;
step 2, placing the dried lettuce blocks in a vacuum drying oven, setting the vacuum degree to be-0.1 MPa, setting the temperature to be 85 ℃, and drying and dewatering for 5 hours to obtain dried lettuce;
step 3, crushing the dried lettuce into powder, and then placing the powder in an ultrafine pulverizer to treat the powder to obtain the lettuce powder with the particle size of 1-5 mu m;
step 4, placing the mountain lettuce powder into an ethanol solution with the mass fraction of 80% for extraction treatment, wherein the mass ratio of the mountain lettuce powder to the ethanol solution is 1:50, stirring at the speed of 400rpm for 1h at room temperature, performing centrifugal separation, repeatedly extracting the obtained filter residues for three times, and respectively collecting supernatant and precipitate to obtain a first extract and a first filter residue;
step 5, the first filter residue is firstly placed in a sodium hydroxide solution or a potassium hydroxide solution with the concentration of 3mol/L for treatment, the mass ratio of the first filter residue to the alkali liquor is 1:50, the temperature is raised to 50 ℃ under the protection of inert gas, the temperature is kept for 6 hours, then hydrochloric acid solution with the concentration of 3mol/L is added dropwise to adjust the pH to be less than 2, the supernatant is collected after centrifugation, and after ethyl acetate extraction treatment, ethanol with the mass of 20 times of the mass of the first filter residue is added for redissolution, so that a second extract is obtained;
and step 6, combining the first extracting solution and the second extracting solution, and evaporating under reduced pressure at 65 ℃ until the first extracting solution and the second extracting solution are completely dried to obtain the lactuca sativa polyphenol.
The preparation method of the lactuca sativa polyphenol/chitosan microsphere comprises the following steps:
s1, weighing chitosan, mixing the chitosan into an acetic acid solution, wherein the acetic acid solution is obtained by mixing acetic acid and water according to a mass ratio of 1:100, and stirring and mixing until the chitosan and the acetic acid solution are completely dissolved to obtain a chitosan solution;
s2, mixing the medical paraffin oil with span 80, wherein the mass ratio of the medical paraffin oil to the span 80 is 1:0.05, and stirring and dispersing uniformly to obtain a medical paraffin oil mixed solution;
s3, dropwise adding the chitosan solution into the continuously stirred medical paraffin oil mixed solution, wherein the mass ratio of the chitosan solution to the medical paraffin oil mixed solution is 1:10, continuously stirring for 1h after the dropwise adding is finished, and then dropwise adding alkali liquor until the pH value of the system is 8.5-9.5, so as to obtain a mixed reaction solution;
s4, dropwise adding an glycolaldehyde solution into the mixed reaction solution, wherein the glycolaldehyde solution is obtained by mixing glycolaldehyde and water according to a mass ratio of 1:20, the mass ratio of the mixed reaction solution to the glycolaldehyde solution is 1:0.3, after the dropwise adding is finished, uniformly mixing, standing for 12 hours at room temperature, collecting solid particles, and drying to obtain the chitosan porous microspheres;
s5, mixing the lactuca sativa polyphenol into an ethanol solution, stirring until the lactuca sativa polyphenol is completely dissolved, adding chitosan porous microspheres, mixing ethanol and water according to a mass ratio of 1:4 to obtain the ethanol solution, uniformly mixing the lactuca sativa polyphenol, the chitosan porous microspheres and the ethanol solution by ultrasound according to a mass ratio of 1:4.6:15, stirring for 8 hours at room temperature, standing for 2 hours, and drying under reduced pressure to obtain the lactuca sativa polyphenol/chitosan microspheres.
The preparation method of the repair cream with the effects of relieving skin inflammation and repairing comprises the following steps:
step P1, weighing water, an emollient, an emulsifier, a humectant and a thickener according to the amount, mixing into a first container, heating to 80 ℃, and uniformly mixing and dispersing to obtain a first mixed dispersion liquid;
step P2, weighing antioxidant, astringent, essence and preservative according to parts by weight, mixing into a second container, heating to 80 ℃, and uniformly mixing and dispersing to obtain a second mixed dispersion liquid;
step P3, mixing the first mixed dispersion liquid and the second mixed dispersion liquid into an emulsifying device, heating to 80 ℃, and uniformly mixing and dispersing to obtain a third mixed dispersion liquid;
and step P4, after the third mixed dispersion liquid is cooled to 50 ℃, adding the mountain lettuce polyphenol/chitosan microsphere, the kava root extract, the ergothioneine and the ceramide which are weighed according to parts by weight, uniformly mixing and dispersing, and cooling to room temperature to obtain the repairing cream with the effects of relieving skin inflammation and repairing.
Example 4
A repair cream with skin inflammation relieving and repair effects, which is different from example 1 in that:
the emollient is isononyl isononanoate isopropyl myristate. The emulsifier is glycerol stearate. The humectant is betaine.
Example 5
A repair cream with skin inflammation relieving and repair effects, which is different from example 1 in that:
the emollient is polydimethylsiloxane. The emulsifier is PEG-100 stearate. The humectant is sodium hyaluronate.
Example 6
A repair cream with skin inflammation relieving and repair effects, which is different from example 1 in that:
the emollient is ethylhexyl palmitate.
Example 7
A repair cream with skin inflammation relieving and repair effects, which is different from example 1 in that:
the emollient is ethylhexyl stearate.
Example 8
A repair cream with skin inflammation relieving and repair effects, which is different from example 1 in that:
the emollient is any two or more of caprylic triglyceride, capric triglyceride, hydrogenated polyisobutene, isononyl isononanoate isopropyl myristate, polydimethylsiloxane, ethylhexyl palmitate and ethylhexyl stearate. The emulsifier is any two or more of cetostearyl alcohol, sorbitan olive oleate, cetostearyl glucoside, glycerol stearate and PEG-100 stearate. The humectant is any two or more of glycerol, propylene glycol, butanediol, betaine and sodium hyaluronate. The thickening agent is one of acrylic acid/C10-30 alkanol acrylate cross-linked polymer and acrylic acid ester/C10-30 alkanol acrylate cross-linked polymer. The antioxidant is tocopheryl diacid ester. The astringent is allantoin.
In order to more clearly illustrate the present invention, the present invention also makes the following detection experiments for the repair cream of example 1:
1. purpose of testing
In a 3D skin modelAnd (3) applying the sample to be tested to the 3D skin model in a surface drug administration mode for testing the tool, and evaluating the repairing efficacy of the sample to be tested through the change of the model tissue morphology after drug administration.
2. Test materials
2.1 test System
The skin model used in this test is a 3D skin model
2.2 major reagents
KC2500, MTT, epiGrowth culture, DMSO, 4% paraformaldehyde, xylene, hematoxylin, eosin, hydrochloric acid, absolute ethanol, diethyl ether.
2.3 Main device
CO2 incubator (Thermo, 150I), ultra clean bench (Sujingtai, SW-CJ-1F), inverted microscope (Olympus, CKX 41), microplate reader (BioTek, epoch)
3. Test method
3.1 test protocol
The protocol arrangement is shown in table 1 below:
table 1 sample repair efficacy evaluation protocol
3.2 model reception
According to the maintenance efficacy evaluation protocol of table 1, 6 well plates were prepared, 3.7ml of growth broth was added to each well, and the model on Day3 (TA 3) of gas-liquid interface culture, i.e., the model on Day of reception (Day 0), was transferred to the labeled 6 well plates; each test group required 3 models, all 6-well plates with models were transferred to CO 2 Culturing in incubator (37 ℃ C., 5% CO) 2 )。
3.3 administration and histamine stimulation
From the Day of model reception (Day 0), the positive control and example 1 sample group were subjected to histamine treatment daily (50 mJ/cm) 2 ) The blank group was not histamine-treated and only the culture medium was changed every day. The positive control group (KA, 500. Mu.g/mL) and the sample group were administered twice at Day3 and Day5, respectively, by surface administration and a volume of 10. Mu.L. After the model is continuously cultured for 7 days (Day 7), samples are collected and tested.
4. Statistical analysis of results
GraphPad Prism was used to map and the results were expressed as mean±sd. Comparisons between groups were performed using t-test statistical analysis. All statistical analyses were double tailed. p <0.05 was considered to have significant differences and p <0.01 was considered to have very significant differences.
5. Test results
5.1H & E staining
H & E staining was performed after model dosing was completed as shown in figure 1. The results of the tissue morphology test show that compared with the BC group, the stratum corneum of the sample repair cream administration model of the example 1 is obviously thickened, the boundaries of four layers of structures are clear, and the basal layer cells are compactly arranged. Compared with the PC group, the sample repairing cream of the embodiment 1 has certain barrier improvement effect on the 3D skin model.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made to the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention.
Claims (8)
1. The repairing cream with the effects of relieving skin inflammation and repairing is characterized by comprising the following components in parts by weight:
61-75 parts of water, 12-18 parts of an emollient, 3-5 parts of an emulsifier, 10-15 parts of a humectant, 0.1-0.3 part of a thickener, 0.2-0.5 part of an antioxidant, 0.1-0.2 part of an astringent, 0.025-1 part of ceramide, 0.00375-0.5 part of ergothioneine, 0.44-1 part of kava root extract, 0.088-0.2 part of lactuca sativa polyphenol/carboxymethyl chitosan microsphere, 0.02-0.05 part of essence and 0.08-0.1 part of a preservative;
the preparation method of the lactuca sativa polyphenol/chitosan microsphere comprises the following steps:
s1, weighing chitosan, mixing the chitosan into an acetic acid solution, and stirring and mixing until the chitosan is completely dissolved to obtain a chitosan solution;
s2, mixing the medical paraffin oil with span 80, and uniformly stirring and dispersing to obtain a medical paraffin oil mixed solution;
s3, dropwise adding the chitosan solution into the continuously stirred medical paraffin oil mixed solution, continuously stirring for 0.5-1 h after the dropwise adding is finished, and then dropwise adding alkali liquor until the pH value of the system is 8.5-9.5 to obtain a mixed reaction solution;
s4, dropwise adding glycolaldehyde solution into the mixed reaction solution, uniformly mixing, standing at room temperature for 8-12 h, collecting solid particles, and drying to obtain chitosan porous microspheres;
s5, mixing the lactuca sativa polyphenol into an ethanol solution, stirring until the lactuca sativa polyphenol is completely dissolved, adding chitosan porous microspheres, stirring at room temperature for 6-8 hours after ultrasonic mixing is uniform, standing for 1-2 hours, and drying under reduced pressure to obtain the lactuca sativa polyphenol/chitosan microspheres.
2. A repair cream with skin inflammation relief and repair effect according to claim 1, wherein the emollient is at least one of caprylic triglyceride, capric triglyceride, hydrogenated polyisobutene, isononyl isononanoate isopropyl myristate, polydimethylsiloxane, ethylhexyl palmitate, ethylhexyl stearate.
3. A repair cream with skin inflammation relieving and repair effects according to claim 1, wherein the emulsifier is at least one of cetostearyl alcohol, sorbitan olive oleate, cetostearyl glucoside, glyceryl stearate, PEG-100 stearate.
4. The repair cream with skin inflammation relieving and repairing effects according to claim 1, wherein the humectant is at least one of glycerin, propylene glycol, butylene glycol, betaine and sodium hyaluronate.
5. The cream of claim 1, wherein the thickener is one of acrylic/C10-30 alkanol acrylate cross-linked polymer and acrylic/C10-30 alkanol acrylate cross-linked polymer.
6. A repair cream with skin inflammation relief and repair effects according to claim 1, wherein the antioxidant is tocopheryl diacid ester.
7. A repair cream with skin inflammation relieving and repair effects according to claim 1, wherein the astringent is allantoin.
8. The repair cream with skin inflammation relieving and repairing effects according to claim 1, wherein the extraction method of the lactuca sativa polyphenol is as follows:
step 1, picking fresh lettuce leaves, removing root parts of the fresh lettuce leaves, cleaning the surfaces of the root parts, draining, and cutting into blocks to obtain the lettuce blocks, and carrying out fresh-keeping treatment for later use;
step 2, placing the dried lettuce blocks in a vacuum drying oven, and drying and dewatering to obtain dried lettuce;
step 3, crushing dried lettuce into powder, and then placing the powder in an ultrafine pulverizer for treatment to obtain the dried lettuce powder;
step 4, placing the lactuca sativa powder into an ethanol solution for extraction treatment to obtain a first extract and first filter residues;
and 5, firstly, placing the first filter residue in alkali liquor for treatment, then, dropwise adding acid liquor to adjust the pH value to be less than 2, and then, centrifugally collecting supernatant, and obtaining a second extract after extraction and redissolution.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2924334A1 (en) * | 2007-11-30 | 2009-06-05 | Lvmh Rech | COSMETIC COMPOSITION COMPRISING ASCORBIC 2-GLUCOSIDE ACID AND ERGOTHIONEIN |
| CN105963197A (en) * | 2016-06-18 | 2016-09-28 | 广州丹奇日用化工厂有限公司 | Oil control and whelk removal cream containing cichoric acid and preparation method of oil control and whelk removal cream |
| CN113332168A (en) * | 2021-06-02 | 2021-09-03 | 林琚 | Polypeptide and ceramide compounded anti-aging repair cream and preparation method thereof |
| CN113827531A (en) * | 2021-10-21 | 2021-12-24 | 杭州原极品牌管理有限公司 | Semitransparent gel-like essence and preparation method thereof |
-
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- 2022-03-01 CN CN202210193852.1A patent/CN114432204B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2924334A1 (en) * | 2007-11-30 | 2009-06-05 | Lvmh Rech | COSMETIC COMPOSITION COMPRISING ASCORBIC 2-GLUCOSIDE ACID AND ERGOTHIONEIN |
| CN105963197A (en) * | 2016-06-18 | 2016-09-28 | 广州丹奇日用化工厂有限公司 | Oil control and whelk removal cream containing cichoric acid and preparation method of oil control and whelk removal cream |
| CN113332168A (en) * | 2021-06-02 | 2021-09-03 | 林琚 | Polypeptide and ceramide compounded anti-aging repair cream and preparation method thereof |
| CN113827531A (en) * | 2021-10-21 | 2021-12-24 | 杭州原极品牌管理有限公司 | Semitransparent gel-like essence and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 卡瓦胡椒的医药用途;李继珩;医药导报(05);283-384 * |
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