CN114404447A - A method for treating ulcerative lesion with marine medicine - Google Patents
A method for treating ulcerative lesion with marine medicine Download PDFInfo
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- CN114404447A CN114404447A CN202210082186.4A CN202210082186A CN114404447A CN 114404447 A CN114404447 A CN 114404447A CN 202210082186 A CN202210082186 A CN 202210082186A CN 114404447 A CN114404447 A CN 114404447A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/614—Cnidaria, e.g. sea anemones, corals, coral animals or jellyfish
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to an application of a marine traditional Chinese medicine in preparing a medicine for treating diabetic skin ulcer, oral ulcer, chemotherapy drug extravasation, radioactive skin injury, skin ulceration caused by fungal infection and deep II-degree burn. The marine traditional Chinese medicine is a hydrogen molecule solid carrier, namely, the marine traditional Chinese medicine is prepared by solidifying hydrogen molecules on an edible solid carrier, and after the marine traditional Chinese medicine is taken into a human body, the marine traditional Chinese medicine releases the hydrogen molecules in the body when meeting water to diffuse to an ulcer or a damaged part, removes active oxygen free radicals and relieves oxidative damage, thereby achieving the purpose of curing skin ulcers such as diabetic skin ulcer, oral ulcer, chemotherapy drug extravasation, radioactive skin injury, skin ulceration caused by fungal infection, deep II-degree burn and the like. Compared with the existing medicines, the marine medicine disclosed by the invention is easier to permeate a cell membrane structure, and has better effects of astringing and resisting inflammation and clearing active oxygen free radicals to relieve oxidative damage.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to an application of a marine traditional Chinese medicine in preparing medicines for treating diabetic skin ulcer, oral ulcer, chemotherapy drug extravasation, radioactive skin injury, skin ulceration caused by fungal infection and II-degree burn.
Background
The diabetic skin ulcer is a common complication of diabetes, is frequently generated on feet of a patient, is also called as diabetic foot, and mainly refers to that the diabetic foot is infected by lower limbs and ulcerated to form deep tissue damage due to combined nerve and vascular diseases, and once the condition of the diabetic foot is serious, the diabetic foot directly influences the treatment effect of the diabetes of the patient, even causes amputation and death. At present, a plurality of medicines for treating the diabetic skin ulcer exist, but the treatment effect is not ideal.
Chemotherapy is one of the main means for treating malignant tumor, most chemotherapy is injected intravenously, and the extravasation of the needle medicine often causes local ulcer and is not cured for a long time. The occurrence of extravasated skin ulcers is the result of a combination of factors including local stimulation of the drug, slowed repair of epidermal cells by chemotherapeutic drugs, malnutrition, and the like. At present, drugs for extravasation type skin ulcer on the market are generally treated by hormone drugs, the drugs are difficult to fundamentally form the treatment effect, and the wound is easy to recur after healing.
Canker sores develop as a result of a combination of factors including topical trauma, stress, food, medication, malnutrition, altered hormone levels, and vitamin or trace element deficiencies. At present, medicines for treating oral ulcer on the market are generally treated by adopting hormone medicines or Chinese medicinal preparations such as buccal patches combined with heat-clearing and detoxifying medicines, the treatment method cannot fundamentally form the treatment effect, and the wound is easy to recur after healing.
Radioactive skin damage: chronic radiodermatitis and chronic radiation ulcer caused by long-term irradiation of small-dose rays belong to chronic radiation skin injuries; acute radiation dermatitis and radiation skin ulcer caused by external irradiation of a large dose of a local part of a body once or a plurality of times in a short time belong to acute radiation skin injuries. The medicines for treating radioactive skin injury on the market at present comprise antibiotic ointment or ointment prepared by cod liver oil and white wax, and the above treatment methods cannot be fundamentally treated.
Skin ulceration due to fungal infection: fungal infectious diseases are classified into 4 types according to the site of fungal invasion on the human body: superficial mycoses, dermatomycoses, subdermal tissue mycoses, and systemic mycoses; the former two are called superficial mycosis, the latter two are also called deep mycosis. At present, most of skin ulceration caused by fungal infection is treated by antibiotics, and antibiotic cream or oral antibiotics are coated on the skin ulceration, but the method cannot fundamentally form the treatment effect, and the sore healing is easy to relapse.
Deep II degree burns damage caused by flames, high temperature solids and intense radiant heat tissue damage caused by high temperature, chemicals or electricity. The treatment course of deep second degree burn is longer, infection easily occurs, and most wounds are coated with anti-inflammatory plaster or scald plaster, such as erythromycin ointment and moist burn ointment. However, this method cannot fundamentally produce a therapeutic effect.
In recent years, scientists are dedicated to developing new drugs and new products from the ocean and obtain good economic benefit and social benefit, and the ocean traditional Chinese medicine has rich resources and great development potential.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides application of a marine traditional Chinese medicine in preparing a medicine for treating diabetic skin ulcer, oral ulcer, chemotherapy drug extravasation, radioactive skin injury, skin ulceration caused by fungal infection and deep II-degree burn. After the marine traditional Chinese medicine is taken into a human body, hydrogen molecules are released in the human body when contacting water to diffuse at the targeted ulcer or damaged part, active oxygen free radicals are removed, and oxidative damage is relieved, so that the aims of curing diabetic skin ulcer, oral ulcer, chemotherapeutics extravasation and deep II-degree burn are fulfilled. Compared with the existing medicines, the marine medicine disclosed by the invention is easier to dry a microenvironment and permeate a cell membrane structure, and has better effects of astringing and resisting inflammation and clearing active oxygen free radicals to relieve oxidative damage.
The technical scheme adopted by the invention is as follows:
an application of marine Chinese medicine in preparing the medicines for treating diabetic skin ulcer, oral ulcer, the extravasation of chemotherapeutic medicine, radiation skin injury, skin ulcer caused by fungal infection, and deep II-degree burn is disclosed.
The marine traditional Chinese medicine is an external application medicine.
The marine traditional Chinese medicine is in the form of any one of capsules, powder, spray and patches.
The external application medicine is prepared after drying.
The marine traditional Chinese medicine is a hydrogen molecule solid carrier.
The hydrogen molecule solid carrier is prepared by solidifying hydrogen molecules on an edible solid carrier.
The hydrogen molecule solid carrier is absorbed into the body and can generate hydrogen.
The hydrogen molecule solid carrier is mainly carbonate of calcium and magnesium, and the carbonate of calcium and magnesium accounts for more than 50% of the content of solid substances.
The hydrogen molecule solid carrier is in any one of powder, granule and amorphous form.
The hydrogen molecule solid carrier includes but is not limited to calcium coral hydride.
The invention has the beneficial effects that:
the invention provides an application of a marine traditional Chinese medicine in preparing a medicine for treating diabetic skin ulcer, oral ulcer, chemotherapy drug extravasation, radioactive skin injury, skin ulceration caused by fungal infection and deep II degree burn, wherein the marine traditional Chinese medicine is a hydrogen molecule solid carrier, and is prepared by solidifying hydrogen molecules on an edible solid carrier, and after the marine traditional Chinese medicine is taken into a human body, the marine traditional Chinese medicine releases the hydrogen molecules in the body when meeting water to diffuse to the ulcer or damaged part, removes active oxygen free radicals, relieves oxidative damage, and further achieves the aim of curing the skin ulcer such as diabetic skin ulcer, oral ulcer, chemotherapy drug extravasation, deep II degree burn and the like. Compared with the existing medicines, the marine medicine disclosed by the invention is easier to dry a microenvironment and permeate a cell membrane structure, and has better effects of astringing and resisting inflammation and clearing active oxygen free radicals to relieve oxidative damage.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a graph showing the trend of changes in the ulcer surface of diabetic skin in a model group and an experimental group;
FIG. 2 is a photograph of the healing of diabetic skin ulcers on different days in a model group;
FIG. 3 is a photograph of the diabetic skin ulcer surface healed on different days in the experimental group;
FIG. 4 is a graph showing the trend of body weight changes in the model group and the experimental group in the diabetic skin ulcer healing effect evaluation experiment;
FIG. 5 is a graph showing the trend of blood glucose changes in the model group and the experimental group in the diabetic skin ulcer healing effect evaluation experiment;
FIG. 6 is a photograph of the healing of the oral ulcer surface of the experimental group on different days;
FIG. 7 is a photograph of the healing of the oral ulcer surface of the model group on different days;
FIG. 8 is a graph showing the trend of body weight changes in the blank group, model group and experimental group in the oral ulcer surface healing effect evaluation experiment;
FIG. 9 is a photograph of the healing of a model group of chemotherapy drugs on extravasation, burn ulcer surface for various days;
FIG. 10 is a photograph showing how the experimental group of chemotherapy drugs are applied to the affected area for healing after extravasation and burn for a different number of days.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Example 1
The embodiment provides application of a marine traditional Chinese medicine in treating diabetic skin ulcer. The marine traditional Chinese medicine is an external application medicine, and the marine traditional Chinese medicine is prepared by adding auxiliary materials which are conventionally used in the prior art into calcium hydride coral.
1. Experimental animals:
strain: SD rat, sex: female, body weight: 180 g.
2. Test grouping
Diabetes mellitus has a certain molding rate, and comprises a blank group (5), a model group (13) and an experimental group (10).
3. Test method
3.1 preparation of diabetic rat model
SD male rats with weight of 120 + -g are selected, and each rat has one cage per 5 cages. Feeding with high-fat and high-sugar feed (containing 10% of lard, 20% of sucrose, 3% of egg yolk and 67% of basal feed) at room temperature of 20-24 deg.C, and feeding for 30 days to increase body weight.
Fasted for 12 hours, rats were weighed and recorded. Adding 2.1g of citric acid into 100mL of double distilled water to prepare solution A, adding 2.94g of sodium citrate into 100mL of double distilled water to prepare solution B, mixing A, B solutions in a ratio of 1:1.32, measuring the pH value, and preparing a citric acid buffer solution with the pH value of 4.2-4.5. Urea zotocin (STZ) was dissolved in citric acid buffer at a concentration of 1% under ice bath conditions and injected into the left lower abdomen of rats with a dose of 40.0mg/kg on an empty stomach of rats. And continuously monitoring blood sugar after injection, wherein patients without obvious change in blood sugar value are subjected to supplementary injection once after being injected for 3 days for the first time, and patients with fasting blood sugar of more than 16.7mmol/L are selected to continue molding after being continuously injected for 5 days.
3.2 preparation of infected wound
A10% chloral hydrate solution is prepared, and the molded diabetic SD rat is anesthetized by intraperitoneal injection of 0.3ml/100g, and the rat is successfully anesthetized after about 5 minutes.
Removing hair around the right back and hip of a rat by using a manual razor, selecting the skin of the joint close to the limb of the right lower limb of the rat, cutting the whole skin layer of 0.5cm x 0.5cm by using a sterile surgical instrument to form a defective skin ulcer rat model, naturally exposing the model for one day after hemostasis, wherein the second day is the experiment starting day and is recorded as the first day of the experiment.
3.3 methods of administration
Model group: conventional irrigation (normal saline and alcohol), normal saline wet compress and anti-infective drug;
experimental groups: basic treatment and external application of marine traditional Chinese medicine.
4 index
4.1 blood glucose monitoring: every 3 days.
4.2 general observations: photographs were taken every other day and rat ulcer size, peripheral hyperemia recorded.
4.3 symptom Observation: rats were observed mainly for pain and the evaluation criteria are shown in table 1.
TABLE 1
4.4 sample Collection
Cutting ulcer specimen with length of 5mm, width of 3mm and depth reaching muscle layer, removing surface blood with sterile normal saline, placing in 10% formalin fixing solution, sealing the specimen bottles with adhesive tape, and storing in refrigerator at 4 deg.C.
4.5 pathological treatment
The specimen fixed by 10% formalin solution is dehydrated by alcohol gradient, transparent by xylene, soaked in wax, embedded by normal paraffin and cut into 5 μm sections by a slicer. Paraffin section xylene dewaxing, alcohol gradient downward water entering, tap water rinsing, hematoxylin staining for 5min, tap water rinsing, 1% dilute ammonia water bluing for 30 seconds, rinsing, eosin staining for 5min, rinsing, alcohol gradient dehydration, xylene transparency and neutral gum sealing. The digital scanner is digitized to observe histological changes.
5. Evaluation of Experimental results
5.1 evaluation of ulcer healing Effect
Fig. 1 is a graph showing the trend of the ulcer surface change of the model group and the experimental group, and fig. 2 and 3 are photographs of the healing condition of the ulcer surface of the model group and the experimental group respectively on different days. As can be seen from fig. 1-3, the ulcer surface wounds of the model group were large and healed slowly. The ulcer surface of the experimental group is obviously reduced, and the healing speed is high. Thus obtaining the marine traditional Chinese medicine which has a certain treatment effect on the diabetic skin ulcer.
5.2 weight Change assessment
As shown in fig. 4, the weight change trend graphs of the model group and the experimental group show that the weight of the experimental group increases faster than that of the model group. The marine traditional Chinese medicine has certain influence on the weight of a mouse.
5.3 blood glucose Change assessment
As shown in fig. 5, which is a blood glucose trend graph of the model group and the experimental group, it can be seen from the blood glucose trend graph that blood glucose of the model group is significantly higher than that of the other groups, and the drug intervention treatment has a certain inhibition effect on blood glucose of the mice.
5.4 Observation of symptoms
According to the regular observation of the symptom expression of the mice, the pain symptom of the model group is obviously higher than that of other groups, the experimental group recovers quickly, the symptom is obviously improved, and the mice are more active.
Example 2
The embodiment provides application of a marine traditional Chinese medicine in treating dental ulcer. The marine traditional Chinese medicine is an external application medicine, and the marine traditional Chinese medicine is prepared by adding auxiliary materials which are conventionally used in the prior art into calcium hydride coral.
1. Experimental animals:
strain: SD rat, sex: female, body weight: 180 g.
2. Test grouping
Blank group (3), model group (11), experimental group (10).
3. Test method
3.1 modeling:
SD rats of 7 weeks are selected, fed with standard diet, without water limitation, and the indoor temperature is kept at (22 +/-2) ° C. With an intermediate spacing 1 d. After the rats were anesthetized, a cotton ball containing 60% glacial acetic acid was placed flat on the upper and inner lower buccal lips at about 1mm of the left corner of the mouth of the rat, and the burning time was 60S, i.e., a white lesion with a diameter of about 3mm was observed. Dosing observations began the next day.
3.2 model evaluation
Ulcer healing is classified into 0, 1, 2 and 3 according to the degree of lesion from mild to severe.
Level 0: the disappearance of false membranes on the surface of the ulcer is observed by naked eyes, and the epithelium is complete; pathological observation shows that multiple layers of flat epithelial cells appear on the local part of the ulcer, the flat epithelial cells cover the whole ulcer surface, and inflammatory cells are not infiltrated in the deep part of the ulcer, and small blood vessels are not dilated and hyperemia are avoided, so that the ulcer is completely healed.
Level 1: a small amount of false membranes exist on the surface of the ulcer through visual observation, and the epithelium is nearly complete; pathological observation shows that local stratified squamous epithelial cells almost cover the ulcer surface, a small amount of inflammatory cell infiltration, and unobvious small blood vessel dilatation and congestion are seen in the deep ulcer part, and the healing is basically performed.
And 2, stage: large false membranes are observed on the surface of the ulcer by naked eyes, and the epithelium is incomplete; pathological observation shows that the surface of the ulcer is not covered by the stratified epithelial cells, the deep part of the ulcer is infiltrated by more inflammatory cells, and blood vessels are obviously dilated and congested, so that the ulcer is partially healed.
And 3, level: the whole ulcer surface is covered by the false membrane through visual observation, and the epithelium is damaged and falls off; in pathological observation, no stratified epithelial cells cover the part, a large amount of inflammatory cell infiltration can be seen in the deep part of the ulcer, and blood vessels are remarkably dilated and congested, so that the ulcer is completely unhealed.
3.3 intervention method:
and (3) taking 3 model groups after successful modeling, and observing the successful modeling condition by taking the HE and the IHC pathologically.
Local medication is applied on the next day after the molding is successful, and the model group is as follows: cleaning with clear water; experimental groups: the marine traditional Chinese medicine is applied to the oral cavity three times in the morning, at noon and at night.
4. Observation of indices
4.1 general observations: the rats were photographed daily and the size of the mucosal surface ulcer and the surrounding hyperemia were recorded.
4.2 symptom Observation: rats were observed mainly for pain and the evaluation criteria are shown in table 1 in example 1.
4.3 sample Collection
Cutting ulcer specimen with length of 5mm, width of 3mm and depth reaching submucosa, removing surface blood with sterile normal saline, placing in 10% formalin fixing solution, sealing the specimen bottles with adhesive tape, and storing in refrigerator at 4 deg.C.
4.4 pathological Observation
The specimen fixed by 10% formalin solution is dehydrated by alcohol gradient, transparent by xylene, soaked in wax, embedded by normal paraffin and cut into 5 μm sections by a slicer. Paraffin section xylene dewaxing, alcohol gradient downward water entering, tap water rinsing, hematoxylin staining for 5min, tap water rinsing, 1% dilute ammonia water bluing for 30 seconds, rinsing, eosin staining for 5min, rinsing, alcohol gradient dehydration, xylene transparency and neutral gum sealing. The digital scanner is digitized to observe histological changes.
5. Evaluation of Experimental results
5.1 evaluation of ulcer healing Effect
Fig. 6 and 7 are photographs of the healing of the oral ulcer surfaces of the experimental group and the model group on different days, respectively. As can be seen from FIGS. 6-7, the model group recovers slowly, and the experimental group is smeared with marine traditional Chinese medicines, so that the effect is obvious.
5.2 weight Change assessment
As shown in fig. 8, the weight change trend graphs of the blank group, the model group and the experimental group show that the blank group has no abnormality and the weight is continuously increased according to the weight change trend graphs. Due to the production of oral ulcers, other groups have a tendency of descending first and then rising continuously, and the effect of marine traditional Chinese medicine intervention cannot be seen on the whole.
5.3 Observation of symptoms
According to the regular observation of the symptom expression of the mice, the pain symptom of the model group is obviously higher than that of other groups, the experimental group recovers quickly, the symptom is obviously improved, and the mice are more active.
Example 3
The embodiment provides application of a marine traditional Chinese medicine in chemotherapy drug extravasation and deep II-degree burn. The marine traditional Chinese medicine is an external application medicine, and the marine traditional Chinese medicine is prepared by adding auxiliary materials which are conventionally used in the prior art into calcium hydride coral.
1. Experimental animals:
strain: c57 mice, sex: female, body weight: 20 g.
2. Test grouping
Model group (5), experimental group (6).
3. Test method
3.1 modeling:
a C57 mouse with 6 weeks is selected, the standard diet is adopted, water is not limited, and the indoor temperature is kept at (22 +/-2) DEG C. With an intermediate spacing 1 d. After anaesthesia, the mice had their backs depilated. 0.1ml of epirubicin at a concentration of 0.25mg/ml was injected subcutaneously in the upper dorsal half. In addition, a cotton swab is adopted, hot water with the temperature of 99 ℃ is soaked as a scald source, and the cotton swab is flatly paved on a simulated scald area of a mouse for 8s to prepare deep II-degree burn.
3.2 model evaluation
Ulcer healing is classified into 0, 1, 2 and 3 according to the degree of lesion from mild to severe.
0 grade, the false membrane on the surface of the ulcer disappears and the epithelium is complete through visual observation; pathological observation shows that multiple layers of flat epithelial cells appear on the local part of the ulcer, the flat epithelial cells cover the whole ulcer surface, and inflammatory cells are not infiltrated in the deep part of the ulcer, and small blood vessels are not dilated and hyperemia are avoided, so that the ulcer is completely healed.
Level 1: a small amount of false membranes exist on the surface of the ulcer through visual observation, and the epithelium is nearly complete; pathological observation shows that local stratified squamous epithelial cells almost cover the ulcer surface, a small amount of inflammatory cell infiltration, and unobvious small blood vessel dilatation and congestion are seen in the deep ulcer part, and the healing is basically performed.
And 2, stage: large false membranes are observed on the surface of the ulcer by naked eyes, and the epithelium is incomplete; pathological observation shows that the surface of the ulcer is not covered by the stratified epithelial cells, the deep part of the ulcer is infiltrated by more inflammatory cells, and blood vessels are obviously dilated and congested, so that the ulcer is partially healed.
And 3, level: the whole ulcer surface is covered by the false membrane through visual observation, and the epithelium is damaged and falls off; in pathological observation, no stratified epithelial cells cover the part, a large amount of inflammatory cell infiltration can be seen in the deep part of the ulcer, and blood vessels are remarkably dilated and congested, so that the ulcer is completely unhealed.
3.3 intervention method:
and (3) after the modeling is successful, taking 1 model group, and observing the successful modeling condition by taking the HE and the IHC pathologically.
Local medication is applied on the next day after the molding is successful, and the model group is as follows: conventional rinsing (with normal saline and alcohol); experimental groups: washing by a conventional method and smearing the marine traditional Chinese medicine for three times in the morning, noon and evening.
4. Observation of indices
4.1 general observations: the mice were photographed daily and the size of the mucosal surface ulcer and the surrounding hyperemia were recorded.
4.2 symptom Observation: the mice were observed mainly for pain and the evaluation criteria are given in table 1 of example 1.
4.3 sample Collection
Cutting a 5mm long, 3mm wide and full-thickness skin ulcer specimen, flushing blood on the surface with sterile normal saline, placing in 10% formalin fixing solution, sealing the specimen bottles with adhesive tapes, and storing in a refrigerator at 4 deg.C for later use.
4.4 pathological Observation
The specimen fixed by 10% formalin solution is dehydrated by alcohol gradient, transparent by xylene, soaked in wax, embedded by normal paraffin and cut into 5 μm sections by a slicer. Paraffin section xylene dewaxing, alcohol gradient downward water entering, tap water rinsing, hematoxylin staining for 5min, tap water rinsing, 1% dilute ammonia water bluing for 30 seconds, rinsing, eosin staining for 5min, rinsing, alcohol gradient dehydration, xylene transparency and neutral gum sealing. The digital scanner is digitized to observe histological changes.
5. Evaluation of Experimental results
5.1 evaluation of ulcer healing Effect
FIGS. 9 and 10 are photographs of the healing of the skin ulcer surface of the model group and the experimental group on different days, respectively. According to the record of the ulcer surface, the skin ulcer of the model group recovers slowly, and the recovery effect of the experimental group is faster by applying marine traditional Chinese medicines.
5.2 Observation of symptoms
According to the regular observation of the symptom expression of the mice, the pain symptom of the model group is obviously higher than that of the experimental group, the experimental group recovers quickly, the symptom is obviously improved, and the mice are active.
The present invention is not limited to the above-mentioned preferred embodiments, and any other products in various forms can be obtained by anyone in the light of the present invention, but any changes in the shape or structure thereof, which have the same or similar technical solutions as those of the present application, fall within the protection scope of the present invention.
Claims (10)
1. An application of marine Chinese medicinal composition in preparing medicine for treating diabetic skin ulcer, oral ulcer, chemotherapy drug extravasation, and deep II degree burn is provided.
2. The use of claim 1, wherein the marine herb is a topical agent.
3. The use of claim 1, wherein the marine traditional Chinese medicine is in the form of any one of capsule, powder, spray and patch.
4. The use of claim 2, wherein the topical medicament is prepared by drying.
5. The use of claim 1, wherein the marine herb is a solid carrier of hydrogen molecules.
6. Use according to claim 5, wherein the hydrogen molecule solid carrier is obtained by solidifying hydrogen molecules on an edible solid carrier.
7. Use according to claim 6, wherein the hydrogen molecule solid carrier is taken up in the body and is capable of generating hydrogen gas.
8. The use according to claim 6, wherein the hydrogen molecule solid carrier is mainly calcium carbonate and magnesium carbonate, and the calcium carbonate and the magnesium carbonate account for more than 50% of the solid substance content.
9. The use according to claim 6, wherein the hydrogen molecule solid carrier is in the form of any one of powder, granule, and amorphous.
10. The use of claim 6, wherein the hydrogen molecule solid carrier comprises but is not limited to calcium coral hydride.
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| CN106109489A (en) * | 2016-06-28 | 2016-11-16 | 西安交通大学 | The application in the medicine of the fat associated metabolic inflammation of preparation preventing and treating of the hydrogen molecule solid-state carrier |
| CN108042796A (en) * | 2018-01-04 | 2018-05-18 | 江西华文科创文化发展有限公司 | A kind of composition for removing free radical and preparation method and application |
| AU2020103238A4 (en) * | 2020-11-04 | 2021-01-14 | Dwivedi, Neeraj Umesh MR | A formulation for treatment of diabetic complications and method of preparation thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109489A (en) * | 2016-06-28 | 2016-11-16 | 西安交通大学 | The application in the medicine of the fat associated metabolic inflammation of preparation preventing and treating of the hydrogen molecule solid-state carrier |
| CN108042796A (en) * | 2018-01-04 | 2018-05-18 | 江西华文科创文化发展有限公司 | A kind of composition for removing free radical and preparation method and application |
| AU2020103238A4 (en) * | 2020-11-04 | 2021-01-14 | Dwivedi, Neeraj Umesh MR | A formulation for treatment of diabetic complications and method of preparation thereof |
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