CN114401991A - 用于调节髓系细胞炎性表型的抗siglec-9组合物和方法及其用途 - Google Patents

用于调节髓系细胞炎性表型的抗siglec-9组合物和方法及其用途 Download PDF

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CN114401991A
CN114401991A CN202080056075.5A CN202080056075A CN114401991A CN 114401991 A CN114401991 A CN 114401991A CN 202080056075 A CN202080056075 A CN 202080056075A CN 114401991 A CN114401991 A CN 114401991A
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cells
myeloid
macrophages
cell
agent
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T·I·诺沃布兰塞瓦
I·费尔德曼
S·L·萨金斯基
J·A·瓦勒
R·芬尼西
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Viseo Pharmaceutical Co
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Viseo Pharmaceutical Co
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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CN202080056075.5A 2019-06-04 2020-06-02 用于调节髓系细胞炎性表型的抗siglec-9组合物和方法及其用途 Pending CN114401991A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962857194P 2019-06-04 2019-06-04
US62/857194 2019-06-04
US201962867577P 2019-06-27 2019-06-27
US62/867577 2019-06-27
US202063032292P 2020-05-29 2020-05-29
US63/032292 2020-05-29
PCT/US2020/035703 WO2020247372A1 (en) 2019-06-04 2020-06-02 Anti-siglec-9 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof

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CN114401991A true CN114401991A (zh) 2022-04-26

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US (1) US20220396627A1 (https=)
EP (1) EP3980462A4 (https=)
JP (1) JP2022535417A (https=)
KR (1) KR20220042056A (https=)
CN (1) CN114401991A (https=)
AU (1) AU2020288824A1 (https=)
BR (1) BR112021024314A2 (https=)
CA (1) CA3142433A1 (https=)
IL (1) IL288511A (https=)
TW (1) TW202110890A (https=)
WO (1) WO2020247372A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121281695A (zh) * 2025-12-11 2026-01-06 山东师范大学 用于药物发现的分子生成方法、系统、介质及设备

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11987612B2 (en) 2019-11-04 2024-05-21 Alector Llc Siglec-9 ECD fusion molecules
AU2021329884A1 (en) * 2020-08-17 2023-02-16 SURGE Therapeutics, Inc. Immune modulation of myeloid derived suppressive cell function for cancer treatment
WO2023192993A2 (en) * 2022-03-31 2023-10-05 The Wistar Institute Of Anatomy And Biology Antibodies against human siglec-7 and use thereof for immunotherapy
US20250215078A1 (en) * 2022-03-31 2025-07-03 The Wistar Institute Of Anatomy And Biology Antibodies Against Human Siglec-9 and Use Thereof for Immunotherapy
WO2024054527A1 (en) * 2022-09-06 2024-03-14 The Research Institute At Nationwide Children's Hospital Genetically engineered bone marrow derived myeloid cells for treatment of central nervous system tumors
AU2023411024A1 (en) * 2022-12-23 2025-08-07 The Wistar Institute Of Anatomy And Biology Siglec 9 inhibitors and methods of use thereof for enhancing immunotherapy efficacy
CN116380755B (zh) * 2023-03-20 2023-11-21 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） CD127+PMN-MDSCs在诊断支气管肺发育不良中的应用及诊断试剂盒
CN117741143B (zh) * 2024-02-20 2024-05-07 首都医科大学附属北京地坛医院 Siglec-9蛋白及其特异性抗体在制备神经梅毒或神经损伤诊断产品中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101035807A (zh) * 2004-06-09 2007-09-12 泰勒公司 Siglec－6相关疾病的诊断和治疗
CN108431041A (zh) * 2015-10-29 2018-08-21 艾利妥 抗siglec-9抗体及其使用方法
WO2019011855A1 (en) * 2017-07-10 2019-01-17 Innate Pharma ANTIBODIES NEUTRALIZING SIGLEC-9

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001352977A (ja) * 2000-06-12 2001-12-25 Kirin Brewery Co Ltd 樹状細胞（ＤＣ）膜分子Ｓｉｇｌｅｃ−９に対する抗体、並びにそれを用いたＤＣ検出法及びＤＣ分離法
GB0521991D0 (en) * 2005-10-28 2005-12-07 Univ Dundee Siglec-9 binding agents
WO2017123745A1 (en) * 2016-01-12 2017-07-20 Palleon Pharma Inc. Use of siglec-7 or siglec-9 antibodies for the treatment of cancer
GB201611535D0 (en) * 2016-07-01 2016-08-17 King S College London Methods and compositions for treating cancer with siglec-9 activity modulators

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101035807A (zh) * 2004-06-09 2007-09-12 泰勒公司 Siglec－6相关疾病的诊断和治疗
CN108431041A (zh) * 2015-10-29 2018-08-21 艾利妥 抗siglec-9抗体及其使用方法
WO2019011855A1 (en) * 2017-07-10 2019-01-17 Innate Pharma ANTIBODIES NEUTRALIZING SIGLEC-9

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
褚萨萨;尤娜;张馨;杨志国;朱进;汪茂荣;: "人源化抗Siglec-9抗体Fab片段的制备及鉴定", 中国免疫学杂志, no. 06, 20 June 2018 (2018-06-20), pages 83 - 87 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121281695A (zh) * 2025-12-11 2026-01-06 山东师范大学 用于药物发现的分子生成方法、系统、介质及设备
CN121281695B (zh) * 2025-12-11 2026-03-31 山东师范大学 用于药物发现的分子生成方法、系统、介质及设备

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EP3980462A4 (en) 2023-09-20
JP2022535417A (ja) 2022-08-08
KR20220042056A (ko) 2022-04-04
BR112021024314A2 (pt) 2022-02-15
EP3980462A1 (en) 2022-04-13
WO2020247372A1 (en) 2020-12-10
IL288511A (en) 2022-01-01
TW202110890A (zh) 2021-03-16
US20220396627A1 (en) 2022-12-15
CA3142433A1 (en) 2020-12-10

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