BR112021024314A2 - Composições e métodos anti-siglec-9 para modular fenótipos inflamatórios de células mieloides e usos dos mesmos - Google Patents

Composições e métodos anti-siglec-9 para modular fenótipos inflamatórios de células mieloides e usos dos mesmos

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Publication number
BR112021024314A2
BR112021024314A2 BR112021024314A BR112021024314A BR112021024314A2 BR 112021024314 A2 BR112021024314 A2 BR 112021024314A2 BR 112021024314 A BR112021024314 A BR 112021024314A BR 112021024314 A BR112021024314 A BR 112021024314A BR 112021024314 A2 BR112021024314 A2 BR 112021024314A2
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Brazil
Prior art keywords
siglec
compositions
methods
myeloid cell
cell phenotypes
Prior art date
Application number
BR112021024314A
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English (en)
Inventor
Igor Feldman
A Wahle Joseph
Ryan Phennicie
L Sazinsky Stephen
I Novobrantseva Tatiana
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Verseau Therapeutics Inc
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Publication date
Application filed by Verseau Therapeutics Inc filed Critical Verseau Therapeutics Inc
Publication of BR112021024314A2 publication Critical patent/BR112021024314A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
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    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4614—Monocytes; Macrophages
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    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

composições e métodos anti-siglec-9 para modular fenótipos inflamatórios de células mieloides e usos dos mesmos. a presente invenção é baseada, em parte, na descoberta de composição anti-siglec-9 (por exemplo, anticorpos monoclonais e fragmentos de ligação ao antígeno dos mesmos), que regula fenótipos inflamatórios de células mieloides, tais como células mieloides supressoras, monócitos, macrófagos, neutrófilos e/ou células dendríticas, incluindo polarização, ativação e/ou função e métodos de usar essas composições anti-siglec-9 para propósitos terapêuticos, diagnósticos, prognósticos e de triagem.
BR112021024314A 2019-06-04 2020-06-02 Composições e métodos anti-siglec-9 para modular fenótipos inflamatórios de células mieloides e usos dos mesmos BR112021024314A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962857194P 2019-06-04 2019-06-04
US201962867577P 2019-06-27 2019-06-27
US202063032292P 2020-05-29 2020-05-29
PCT/US2020/035703 WO2020247372A1 (en) 2019-06-04 2020-06-02 Anti-siglec-9 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof

Publications (1)

Publication Number Publication Date
BR112021024314A2 true BR112021024314A2 (pt) 2022-02-15

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BR112021024314A BR112021024314A2 (pt) 2019-06-04 2020-06-02 Composições e métodos anti-siglec-9 para modular fenótipos inflamatórios de células mieloides e usos dos mesmos

Country Status (11)

Country Link
US (1) US20220396627A1 (pt)
EP (1) EP3980462A4 (pt)
JP (1) JP2022535417A (pt)
KR (1) KR20220042056A (pt)
CN (1) CN114401991A (pt)
AU (1) AU2020288824A1 (pt)
BR (1) BR112021024314A2 (pt)
CA (1) CA3142433A1 (pt)
IL (1) IL288511A (pt)
TW (1) TW202110890A (pt)
WO (1) WO2020247372A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202132329A (zh) 2019-11-04 2021-09-01 美商阿列克特有限責任公司 Ｓｉｇｌｅｃ－９ ｅｃｄ融合分子及其使用方法
AU2021329884A1 (en) * 2020-08-17 2023-02-16 SURGE Therapeutics, Inc. Immune modulation of myeloid derived suppressive cell function for cancer treatment
WO2023192993A2 (en) * 2022-03-31 2023-10-05 The Wistar Institute Of Anatomy And Biology Antibodies against human siglec-7 and use thereof for immunotherapy
WO2023192990A2 (en) * 2022-03-31 2023-10-05 The Wistar Institute Of Anatomy And Biology Antibodies against human siglec-9 and use thereof for immunotherapy
WO2024054527A1 (en) * 2022-09-06 2024-03-14 The Research Institute At Nationwide Children's Hospital Genetically engineered bone marrow derived myeloid cells for treatment of central nervous system tumors
CN116380755B (zh) * 2023-03-20 2023-11-21 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） CD127+PMN-MDSCs在诊断支气管肺发育不良中的应用及诊断试剂盒
CN117741143B (zh) * 2024-02-20 2024-05-07 首都医科大学附属北京地坛医院 Siglec-9蛋白及其特异性抗体在制备神经梅毒或神经损伤诊断产品中的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0521991D0 (en) * 2005-10-28 2005-12-07 Univ Dundee Siglec-9 binding agents
SG11201803567XA (en) * 2015-10-29 2018-05-30 Alector Llc Anti-siglec-9 antibodies and methods of use thereof
EP3402516A4 (en) * 2016-01-12 2020-01-08 Palleon Pharmaceuticals Inc. USE OF ANTIBODIES DIRECTED AGAINST SIGLEC-7 OR SIGLEC-9 IN THE TREATMENT OF CANCER
GB201611535D0 (en) * 2016-07-01 2016-08-17 King's College London Methods and compositions for treating cancer with siglec-9 activity modulators
CN111263769B (zh) * 2017-07-10 2024-01-02 先天制药公司 Siglec-9中和性抗体

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EP3980462A4 (en) 2023-09-20
CA3142433A1 (en) 2020-12-10
JP2022535417A (ja) 2022-08-08
WO2020247372A1 (en) 2020-12-10
IL288511A (en) 2022-01-01
TW202110890A (zh) 2021-03-16
EP3980462A1 (en) 2022-04-13
CN114401991A (zh) 2022-04-26
US20220396627A1 (en) 2022-12-15
KR20220042056A (ko) 2022-04-04
AU2020288824A1 (en) 2022-02-03

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