CA3142433A1 - Anti-siglec-9 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof - Google Patents

Anti-siglec-9 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof Download PDF

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Publication number
CA3142433A1
CA3142433A1 CA3142433A CA3142433A CA3142433A1 CA 3142433 A1 CA3142433 A1 CA 3142433A1 CA 3142433 A CA3142433 A CA 3142433A CA 3142433 A CA3142433 A CA 3142433A CA 3142433 A1 CA3142433 A1 CA 3142433A1
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Prior art keywords
cells
macrophages
agent
myeloid cells
antigen
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CA3142433A
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English (en)
French (fr)
Inventor
Tatiana I. NOVOBRANTSEVA
Igor Feldman
Stephen L. SAZINSKY
Joseph A. WAHLE
Ryan PHENNICIE
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Verseau Therapeutics Inc
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Verseau Therapeutics Inc
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Publication of CA3142433A1 publication Critical patent/CA3142433A1/en
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07—ORGANIC CHEMISTRY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/50—Cell markers; Cell surface determinants
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CA3142433A 2019-06-04 2020-06-02 Anti-siglec-9 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof Pending CA3142433A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962857194P 2019-06-04 2019-06-04
US62/857,194 2019-06-04
US201962867577P 2019-06-27 2019-06-27
US62/867,577 2019-06-27
US202063032292P 2020-05-29 2020-05-29
US63/032,292 2020-05-29
PCT/US2020/035703 WO2020247372A1 (en) 2019-06-04 2020-06-02 Anti-siglec-9 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof

Publications (1)

Publication Number Publication Date
CA3142433A1 true CA3142433A1 (en) 2020-12-10

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Application Number Title Priority Date Filing Date
CA3142433A Pending CA3142433A1 (en) 2019-06-04 2020-06-02 Anti-siglec-9 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof

Country Status (11)

Country Link
US (1) US20220396627A1 (https=)
EP (1) EP3980462A4 (https=)
JP (1) JP2022535417A (https=)
KR (1) KR20220042056A (https=)
CN (1) CN114401991A (https=)
AU (1) AU2020288824A1 (https=)
BR (1) BR112021024314A2 (https=)
CA (1) CA3142433A1 (https=)
IL (1) IL288511A (https=)
TW (1) TW202110890A (https=)
WO (1) WO2020247372A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11987612B2 (en) 2019-11-04 2024-05-21 Alector Llc Siglec-9 ECD fusion molecules
AU2021329884A1 (en) * 2020-08-17 2023-02-16 SURGE Therapeutics, Inc. Immune modulation of myeloid derived suppressive cell function for cancer treatment
WO2023192993A2 (en) * 2022-03-31 2023-10-05 The Wistar Institute Of Anatomy And Biology Antibodies against human siglec-7 and use thereof for immunotherapy
US20250215078A1 (en) * 2022-03-31 2025-07-03 The Wistar Institute Of Anatomy And Biology Antibodies Against Human Siglec-9 and Use Thereof for Immunotherapy
WO2024054527A1 (en) * 2022-09-06 2024-03-14 The Research Institute At Nationwide Children's Hospital Genetically engineered bone marrow derived myeloid cells for treatment of central nervous system tumors
AU2023411024A1 (en) * 2022-12-23 2025-08-07 The Wistar Institute Of Anatomy And Biology Siglec 9 inhibitors and methods of use thereof for enhancing immunotherapy efficacy
CN116380755B (zh) * 2023-03-20 2023-11-21 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） CD127+PMN-MDSCs在诊断支气管肺发育不良中的应用及诊断试剂盒
CN117741143B (zh) * 2024-02-20 2024-05-07 首都医科大学附属北京地坛医院 Siglec-9蛋白及其特异性抗体在制备神经梅毒或神经损伤诊断产品中的应用
CN121281695B (zh) * 2025-12-11 2026-03-31 山东师范大学 用于药物发现的分子生成方法、系统、介质及设备

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001352977A (ja) * 2000-06-12 2001-12-25 Kirin Brewery Co Ltd 樹状細胞（ＤＣ）膜分子Ｓｉｇｌｅｃ−９に対する抗体、並びにそれを用いたＤＣ検出法及びＤＣ分離法
CN101035807A (zh) * 2004-06-09 2007-09-12 泰勒公司 Siglec－6相关疾病的诊断和治疗
GB0521991D0 (en) * 2005-10-28 2005-12-07 Univ Dundee Siglec-9 binding agents
CA3003458A1 (en) * 2015-10-29 2017-05-04 Alector Llc Anti-siglec-9 antibodies and methods of use thereof
WO2017123745A1 (en) * 2016-01-12 2017-07-20 Palleon Pharma Inc. Use of siglec-7 or siglec-9 antibodies for the treatment of cancer
GB201611535D0 (en) * 2016-07-01 2016-08-17 King S College London Methods and compositions for treating cancer with siglec-9 activity modulators
AU2018298676A1 (en) * 2017-07-10 2019-12-19 Innate Pharma Siglec-9-neutralizing antibodies

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AU2020288824A1 (en) 2022-02-03
EP3980462A4 (en) 2023-09-20
JP2022535417A (ja) 2022-08-08
KR20220042056A (ko) 2022-04-04
BR112021024314A2 (pt) 2022-02-15
EP3980462A1 (en) 2022-04-13
WO2020247372A1 (en) 2020-12-10
IL288511A (en) 2022-01-01
TW202110890A (zh) 2021-03-16
US20220396627A1 (en) 2022-12-15
CN114401991A (zh) 2022-04-26

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