CN114380700A - 用于靶向化疗的非铂基抗癌化合物 - Google Patents
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- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| RS62639B1 (sr) | 2015-07-06 | 2021-12-31 | Alkermes Inc | Hetero-halo inhibitori histonskih deacetilaza |
| HUE057838T2 (hu) | 2016-06-07 | 2022-06-28 | Jacobio Pharmaceuticals Co Ltd | SHP2 inhibitorokként hasznos új heterociklusos származékok |
| EP3484528B1 (en) | 2016-07-18 | 2020-11-25 | Janssen Pharmaceutica NV | Tau pet imaging ligands |
| MD3570834T2 (ro) | 2017-01-11 | 2022-04-30 | Alkermes Inc | Inhibitori biciclici ai histon deacetilazei |
| TWI664175B (zh) | 2017-03-23 | 2019-07-01 | 大陸商北京加科思新藥研發有限公司 | 用於作為shp2抑制劑之新穎雜環衍生物 |
| JP7152471B2 (ja) | 2017-08-07 | 2022-10-12 | ロダン・セラピューティクス，インコーポレーテッド | ヒストン脱アセチル化酵素の二環阻害剤 |
| CN112839935A (zh) | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
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|---|---|---|---|---|
| US20030219440A1 (en) * | 2002-04-17 | 2003-11-27 | Annette Tobia | 3-deoxyglucosone and skin |
| US20060089316A1 (en) * | 2004-10-25 | 2006-04-27 | Brown Truman R | Method for reducing a susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof |
| CN101203509A (zh) * | 2005-02-16 | 2008-06-18 | 先灵公司 | 具有cxcr3拮抗剂活性的胺-连接的吡啶基和苯基取代的哌嗪-哌啶 |
| DK200801600A (en) * | 2008-11-17 | 2010-05-18 | Engkilde Kaare | Method for treatment of inflammatory diseases |
| WO2014094178A1 (en) * | 2012-12-20 | 2014-06-26 | Lu qing-bin | Radiosensitizer compounds for use in combination with radiation |
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|---|---|---|---|---|
| US3822261A (en) * | 1972-10-30 | 1974-07-02 | Dow Chemical Co | 5,6-dihalo-2-fluoroalkyl-1h-imidazo(4,5-b)pyrazines |
| EP0743855A1 (en) * | 1994-01-03 | 1996-11-27 | Acea Pharmaceuticals, Inc. | 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/nmda receptor |
| DE102004054545A1 (de) * | 2004-09-16 | 2006-04-06 | Max-Delbrück-Centrum für Molekulare Medizin | Änderung des Beladungszustandes von MHC-Molekülen |
| GB0428082D0 (en) * | 2004-12-22 | 2005-01-26 | Welcome Trust The Ltd | Therapeutic compounds |
| JP5178738B2 (ja) * | 2006-12-20 | 2013-04-10 | メルク・シャープ・アンド・ドーム・コーポレーション | 新規なｊｎｋ阻害剤 |
| EP3150589A1 (en) * | 2007-06-08 | 2017-04-05 | MannKind Corporation | Ire-1a inhibitors |
| ATE551336T1 (de) * | 2007-08-16 | 2012-04-15 | Hoffmann La Roche | Substituierte hydantoine |
| US8722720B2 (en) * | 2009-10-28 | 2014-05-13 | Newlink Genetics Corporation | Imidazole derivatives as IDO inhibitors |
| WO2012096813A1 (en) * | 2011-01-11 | 2012-07-19 | Merck Sharp & Dohme Corp. | Imidazole derivatives |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030219440A1 (en) * | 2002-04-17 | 2003-11-27 | Annette Tobia | 3-deoxyglucosone and skin |
| US20060089316A1 (en) * | 2004-10-25 | 2006-04-27 | Brown Truman R | Method for reducing a susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof |
| CN101203509A (zh) * | 2005-02-16 | 2008-06-18 | 先灵公司 | 具有cxcr3拮抗剂活性的胺-连接的吡啶基和苯基取代的哌嗪-哌啶 |
| DK200801600A (en) * | 2008-11-17 | 2010-05-18 | Engkilde Kaare | Method for treatment of inflammatory diseases |
| WO2014094178A1 (en) * | 2012-12-20 | 2014-06-26 | Lu qing-bin | Radiosensitizer compounds for use in combination with radiation |
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| CN106232581A (zh) | 2016-12-14 |
| KR20160070784A (ko) | 2016-06-20 |
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