CN114375310A - 数个异二聚体及其数个使用方法 - Google Patents

数个异二聚体及其数个使用方法 Download PDF

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Publication number
CN114375310A
CN114375310A CN202080063464.0A CN202080063464A CN114375310A CN 114375310 A CN114375310 A CN 114375310A CN 202080063464 A CN202080063464 A CN 202080063464A CN 114375310 A CN114375310 A CN 114375310A
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amino acid
acid sequence
type
heterodimer
membrane protein
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马克·L·泰科辛斯基
阿米·塔米尔
埃德温·布雷默
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Kahr Medical Ltd
Thomas Jefferson University
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Kahr Medical Ltd
Thomas Jefferson University
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080063464.0A 2019-07-11 2020-07-08 数个异二聚体及其数个使用方法 Pending CN114375310A (zh)

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US201962872741P 2019-07-11 2019-07-11
US62/872,741 2019-07-11
PCT/IL2020/050762 WO2021005599A1 (en) 2019-07-11 2020-07-08 Heterodimers and methods of use thereof

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CN114375310A true CN114375310A (zh) 2022-04-19

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US (1) US20220267409A1 (enExample)
EP (1) EP3997114A1 (enExample)
JP (1) JP2022541742A (enExample)
KR (1) KR20220044284A (enExample)
CN (1) CN114375310A (enExample)
AU (1) AU2020311636A1 (enExample)
BR (1) BR112022000319A2 (enExample)
CA (1) CA3146248A1 (enExample)
IL (1) IL289748A (enExample)
MX (1) MX2022000367A (enExample)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111454369A (zh) * 2020-04-10 2020-07-28 润方(长春)生物科技有限公司 一种用于制备异二聚物蛋白质的方法
WO2024245380A1 (en) * 2023-05-31 2024-12-05 Fbd Biologics Limited Cd47/pd-l1-targeting protein complex and methods of use thereof
WO2024260419A1 (en) * 2023-06-22 2024-12-26 Fbd Biologics Limited Multi-targeting protein complex and methods of use thereof
US12583926B2 (en) 2023-05-31 2026-03-24 Fbd Biologics Limited CD47/pd-L1-targeting protein complex and methods of use thereof

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
CN110536693B (zh) 2017-01-05 2023-12-22 卡尔医学有限公司 Pd1-41bbl融合蛋白及使用其的方法
RU2769769C2 (ru) 2017-01-05 2022-04-05 Кахр Медикал Лтд. СЛИТЫЙ БЕЛОК SIRPα-4-1BBL И СПОСОБЫ ЕГО ПРИМЕНЕНИЯ
US11566060B2 (en) 2017-01-05 2023-01-31 Kahr Medical Ltd. PD1-CD70 fusion protein and methods of use thereof
US11299530B2 (en) 2017-01-05 2022-04-12 Kahr Medical Ltd. SIRP alpha-CD70 fusion protein and methods of use thereof
EP3820887A4 (en) 2018-07-11 2022-04-20 KAHR Medical Ltd. Pd1-4-1bbl variant fusion protein and methods of use thereof
KR102945860B1 (ko) 2018-07-11 2026-03-31 카 메디컬 리미티드 SIRPalpha-4-1BBL 변이체 융합 단백질 및 이의 사용 방법
US20240076346A1 (en) * 2021-01-13 2024-03-07 Kahr Medical Ltd. Type i membrane proteins heterodimers and methods of use thereof
CN118401564A (zh) * 2022-01-18 2024-07-26 Fbd生物制品有限公司 靶向cd47/pd-l1的蛋白质复合物和其使用方法
JPWO2024128081A1 (enExample) * 2022-12-16 2024-06-20

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US20150376260A1 (en) * 2013-01-01 2015-12-31 Kahr Medical Ltd. Stable Form Of Signal Converting Protein Fusion Proteins, And Methods Of Use And Preparation Thereof
US20170095531A1 (en) * 2015-10-01 2017-04-06 Heat Biologics, Inc. Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins
CN107001485A (zh) * 2014-11-24 2017-08-01 苏州丁孚靶点生物技术有限公司 蛋白质异二聚体及其用途
WO2018127919A1 (en) * 2017-01-05 2018-07-12 Kahr Medical Ltd. A SIRP1 alpha-41BBL FUSION PROTEIN AND METHODS OF USE THEREOF
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