CN114375308A - 针对tfpi的单克隆抗体 - Google Patents
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- CN114375308A CN114375308A CN202080061191.6A CN202080061191A CN114375308A CN 114375308 A CN114375308 A CN 114375308A CN 202080061191 A CN202080061191 A CN 202080061191A CN 114375308 A CN114375308 A CN 114375308A
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- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
本发明公开了一种针对组织因子途径抑制剂(TFPI)的单克隆抗体或其抗原结合片段，以及其医药用途。
Description
PCT国内申请，说明书已公开。
Claims (24)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910805428.6A CN112442127A (zh) | 2019-08-29 | 2019-08-29 | 针对tfpi的单克隆抗体 |
| CN2019108054286 | 2019-08-29 | ||
| PCT/CN2020/112057 WO2021037197A1 (zh) | 2019-08-29 | 2020-08-28 | 针对tfpi的单克隆抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114375308A true CN114375308A (zh) | 2022-04-19 |
| CN114375308B CN114375308B (zh) | 2023-12-12 |
Family
ID=74684615
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910805428.6A Pending CN112442127A (zh) | 2019-08-29 | 2019-08-29 | 针对tfpi的单克隆抗体 |
| CN202080061191.6A Active CN114375308B (zh) | 2019-08-29 | 2020-08-28 | 针对tfpi的单克隆抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910805428.6A Pending CN112442127A (zh) | 2019-08-29 | 2019-08-29 | 针对tfpi的单克隆抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220325000A1 (zh) |
| EP (1) | EP4023677A4 (zh) |
| JP (1) | JP2022545925A (zh) |
| KR (1) | KR20220061998A (zh) |
| CN (2) | CN112442127A (zh) |
| CA (1) | CA3152860A1 (zh) |
| WO (1) | WO2021037197A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117285632A (zh) * | 2022-06-17 | 2023-12-26 | 安源医药科技（上海）有限公司 | 针对tfpi的单克隆抗体及其用途 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140294832A1 (en) * | 2011-04-01 | 2014-10-02 | Bayer Healthcare Llc | Monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| CN105944100A (zh) * | 2008-08-04 | 2016-09-21 | 拜耳医药保健有限公司 | 针对组织因子途径抑制剂(tfpi)的单克隆抗体 |
| US20170073428A1 (en) * | 2015-08-19 | 2017-03-16 | Pfizer Inc. | Tissue factor pathway inhibitor antibodies and uses thereof |
| US20180030151A1 (en) * | 2015-02-25 | 2018-02-01 | Mogam Institute For Biomedical Research | Novel antibody binding to tfpi and composition comprising the same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102300876A (zh) * | 2008-12-22 | 2011-12-28 | 诺沃—诺迪斯克有限公司 | 针对组织因子途径抑制剂(tfpi)的抗体 |
| WO2010072691A1 (en) * | 2008-12-22 | 2010-07-01 | Novo Nordisk A/S | Antibodies against tissue factor pathway inhibitor |
| AU2010284329B2 (en) * | 2009-08-18 | 2015-04-16 | Takeda Pharmaceutical Company Limited | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
| BR112012022258A2 (pt) * | 2010-03-01 | 2016-10-25 | Bayer Healthcare Llc | anticorpos monoclonais otimizados contra inibidor de trajetória de fator de tecido ( tfpi) |
| JP2013533871A (ja) * | 2010-06-30 | 2013-08-29 | ノヴォ ノルディスク アー／エス | 組織因子経路インヒビターに特異的に結合することが可能な抗体 |
-
2019
- 2019-08-29 CN CN201910805428.6A patent/CN112442127A/zh active Pending
-
2020
- 2020-08-28 WO PCT/CN2020/112057 patent/WO2021037197A1/zh unknown
- 2020-08-28 US US17/639,139 patent/US20220325000A1/en active Pending
- 2020-08-28 EP EP20858624.8A patent/EP4023677A4/en active Pending
- 2020-08-28 CN CN202080061191.6A patent/CN114375308B/zh active Active
- 2020-08-28 KR KR1020227010177A patent/KR20220061998A/ko unknown
- 2020-08-28 CA CA3152860A patent/CA3152860A1/en active Pending
- 2020-08-28 JP JP2022513255A patent/JP2022545925A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105944100A (zh) * | 2008-08-04 | 2016-09-21 | 拜耳医药保健有限公司 | 针对组织因子途径抑制剂(tfpi)的单克隆抗体 |
| US20140294832A1 (en) * | 2011-04-01 | 2014-10-02 | Bayer Healthcare Llc | Monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| US20180030151A1 (en) * | 2015-02-25 | 2018-02-01 | Mogam Institute For Biomedical Research | Novel antibody binding to tfpi and composition comprising the same |
| US20170073428A1 (en) * | 2015-08-19 | 2017-03-16 | Pfizer Inc. | Tissue factor pathway inhibitor antibodies and uses thereof |
Non-Patent Citations (2)
| Title |
|---|
| IDA HILDEN等: "Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model", 《BLOOD》 * |
| 蔡旭等: "抗重组人组织因子途径抑制物1单抗抑制rhTFPI-1的抗凝作用", 《基础医学与临床》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3152860A1 (en) | 2021-03-04 |
| CN114375308B (zh) | 2023-12-12 |
| KR20220061998A (ko) | 2022-05-13 |
| EP4023677A4 (en) | 2023-10-18 |
| EP4023677A1 (en) | 2022-07-06 |
| JP2022545925A (ja) | 2022-11-01 |
| US20220325000A1 (en) | 2022-10-13 |
| WO2021037197A1 (zh) | 2021-03-04 |
| CN112442127A (zh) | 2021-03-05 |
| EP4023677A9 (en) | 2023-01-04 |
| WO2021037197A9 (zh) | 2022-03-24 |
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