CN114366858A - Tracheal catheter with antibacterial and anti-phlegm-thrombus functions and preparation method thereof - Google Patents
Tracheal catheter with antibacterial and anti-phlegm-thrombus functions and preparation method thereof Download PDFInfo
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- CN114366858A CN114366858A CN202111662908.5A CN202111662908A CN114366858A CN 114366858 A CN114366858 A CN 114366858A CN 202111662908 A CN202111662908 A CN 202111662908A CN 114366858 A CN114366858 A CN 114366858A
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Abstract
The invention discloses a tracheal catheter with antibacterial and anti-phlegm-thrombus functions and a preparation method thereof, wherein the tracheal catheter comprises the following steps: s1, pretreating the inner wall of the commercial tracheal catheter by using a hydrophobic initiator solution; s2, preparing a functional pre-polymerization coating, and stirring and dissolving the components to obtain the functional pre-polymerization coating; the functional pre-polymerization coating comprises a hydrophilic monomer, a water-based initiator, a polyphenol cross-linking agent, a hydrophilic colloid, an antibacterial agent and deionized water; s3, applying the functional pre-polymerization coating on the inner wall of the commercial tracheal catheter, and bonding and connecting the functional pre-polymerization coating and the inner wall of the commercial tracheal catheter under the irradiation of an ultraviolet light source; s4, washing away the unconnected paint to obtain the tracheal catheter with the functions of antibiosis and sputum prevention. According to the tracheal catheter provided by the invention, the inner wall of the commercial tracheal catheter is bonded with the functional pre-polymerization coating, so that the binding force is stronger, and the tracheal catheter has an obvious antibacterial and anti-sputum-plug function.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a tracheal catheter with antibacterial and phlegm-thrombus preventing functions and a preparation method thereof.
Background
The trachea intubation is a common clinical technique for rescuing patients with respiratory dysfunction, and a tracheal catheter is placed in the oral cavity or the nasal cavity through the glottis to provide the best condition for keeping the upper respiratory tract smooth, so that the patients are prevented from generating oxygen deficiency and carbon dioxide retention. However, the friction between the tube wall and the airway can stimulate the respiratory mucosa due to the breakage of the normal respiratory tract structure of the tracheal cannula, so that the capability of clearing the secretion is reduced; simultaneously, the cough and swallowing reflex of the patient are weakened, pathogens at the oropharynx permeate into the lower respiratory tract along with secretion, and bacterial biofilms can be formed on the tube wall. With the widespread use of Mechanical Ventilation (MV), respiratory failure caused by many critical diseases and trauma is effectively treated and improved. The associated risks include Ventilator-associated Pneumonia (VAP), pulmonary barotrauma due to special instrumentation, blockage of the tracheal intubation line, or blockage of the airway due to sputum scab formation. Among them, ventilator-associated pneumonia is the highest complication in morbidity and mortality.
Clinically, endocrine accumulates in the lumen of the tracheal catheter after several hours of intubation, and sputum embolus (or sputum scab) is easy to form in 24 hours. The complete or incomplete blockage of the tracheal tube due to the accumulation of secretions is beneficial to the colonization of bacteria and the formation of a biofilm, and provides conditions for ventilator-associated pneumonia. Ventilator-associated pneumonia has a high incidence and mortality in intensive care units, and incomplete blockages can eventually progress to complete blockages, and can even lead to dyspnea and asphyxia death. The clinical common counter measures include regular oral cavity cleaning, ward environment management, subglottal secretion drainage, artificial airway humidification, application of new biological materials and antibiotics and the like, and the measures not only increase the labor load of nursing personnel and improve the economic cost, but also cannot fundamentally solve the problem that the tracheal catheter is easy to block.
The tracheal catheter modified by silver-plated gas or curcumin can effectively reduce the formation of a biological membrane in 5-10 days of mechanical ventilation, but cannot reduce secretion aggregation and sputum thrombus formation. The Sharklet TM-micropattered ETT is characterized in that rhombic micro-patterns with the width of 2mm and different lengths similar to sharkskin textures are etched on the inner wall of the tracheal catheter to increase the surface energy of the inner wall of the catheter and improve the hydrophilicity, so that the accumulation of biological substances on the inner wall is reduced.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides an antibacterial phlegm-embolism prevention tracheal catheter which can effectively play a role in resisting bacteria and phlegm embolism.
In order to achieve the aim, the invention provides a preparation method of a tracheal catheter with antibacterial and anti-phlegm-thrombus functions, which comprises the following steps:
s1, pretreating the inner wall of the commercial tracheal catheter by using a hydrophobic initiator solution; the hydrophobic initiator in the hydrophobic initiator solution is selected from any one or a combination of a plurality of benzophenone, 4-methoxybenzophenone, bis (4- (dimethylamino) phenyl) ketone and 1-hydroxycyclohexyl phenyl ketone;
s2, preparing a functional pre-polymerization coating, and stirring and dissolving the components to obtain the functional pre-polymerization coating; the functional pre-polymerized coating comprises a hydrophilic monomer, a water-based initiator, a polyphenol cross-linking agent, a hydrophilic colloid, an antibacterial agent and deionized water, wherein the hydrophilic monomer: aqueous initiator: a polyphenol crosslinking agent: hydrophilic colloid: antibacterial agents: deionized water (0.1% -50%): (0.1% -10%): (0.1% -10%): (1% -20%): (0.1% -10%): the balance is calculated by mass ratio;
s3, applying the functional pre-polymerization coating on the inner wall of the commercial tracheal catheter, and bonding and connecting the functional pre-polymerization coating and the inner wall of the commercial tracheal catheter under the irradiation of an ultraviolet light source;
s4, washing away the unconnected paint to obtain the tracheal catheter with the functions of antibiosis and sputum prevention.
Preferably, the polyphenol cross-linking agent is selected from one or a combination of more than two of procyanidine, tea polyphenol and tannic acid.
Preferably, in step S2, the dissolving process further includes a standing process, the standing temperature is 0 to 15 ℃, and the standing time is 10 to 50 min.
Preferably, in the hydrophobic initiator, the ratio of 1-hydroxycyclohexyl phenyl ketone: benzophenone: 4-methoxybenzophenone: (benzophenone + bis (4- (dimethylamino) phenyl) methanone) ═ 1-20%: (1-20%): (1-20%): (1-20%), wherein benzophenone: bis (4- (dimethylamino) phenyl) methanone, 1:5-5:1, in mass ratio.
Preferably, the hydrophilic monomer is selected from any one or a combination of any two or more of acrylic acid, acrylamide, N-dimethylacrylamide, N-vinylpyrrolidone, hydroxyethyl methacrylate, polyethylene glycol methacrylate, methoxypolyethylene glycol acrylate and N-isopropylacrylamide.
Preferably, the aqueous initiator is selected from any one or a combination of more than two of 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl phenylpropanone, 2-hydroxy-2-methyl-1-phenyl-1-acetone, alpha-ketoglutaric acid, aqueous thioxanthone, aqueous benzimide and acyl phosphate.
Preferably, in step S1, the pre-treatment time for the commercial endotracheal tube is 30S to 30 min.
Preferably, in step S3, the time for the ultraviolet light source to irradiate the commercial endotracheal tube is 30S to 60 min.
Preferably, in step S1, the solvent in the hydrophobic initiator solution comprises a mixture of acetone and ethanol, wherein the ratio of acetone: the ethanol accounts for 1: 4-4: 1 in volume ratio.
The invention also provides the tracheal catheter with the functions of antibiosis and phlegm prevention, which is prepared by the method and comprises the commercial tracheal catheter and a coating, wherein the coating is formed by bonding and connecting the functional pre-polymerization coating and the inner wall of the commercial tracheal catheter.
The invention has the beneficial effects that:
(1) according to the invention, the hydrophobic initiator solution has extremely low corrosivity on the tracheal catheter, the tracheal catheter body can not be damaged basically, the connection mode of the functional pre-polymerization coating and the inner wall of the commercial tracheal catheter under the irradiation of ultraviolet light is covalent anchoring grafting, the binding force is strong, and the coating is not easy to fall off;
(2) compared with the common commercial tracheal catheter, the tracheal catheter prepared by the preparation method can effectively reduce more than 80% of mucus adhesion and more than 80% of bacteria adhesion, and the killing rate of the adhered bacteria is more than 99%.
Drawings
FIG. 1 is an image of adhered cells on the inner wall of a conventional commercial endotracheal tube and an endotracheal tube prepared according to the procedure in example 1 of the present invention after they were infiltrated in a cell culture solution for 24 hours;
wherein (a) is a map of the adhesion cells on the inner wall of a common commercial catheter, (b) is a map of the adhesion cells on the inner wall of a tracheal catheter prepared by the method in example 1 of the present invention, and (c) is a statistical map obtained by counting the adhesion cells in (a) and (b).
FIG. 2 is a graph showing the real-time adsorption amount of proteins in a flowing protein solution of a film-shaped raw material for a general commercial endotracheal tube and a film-shaped raw material for an endotracheal tube prepared according to the procedure in example 1, in which PVC is a film-shaped raw material for a general commercial endotracheal tube, and PVC-PAAm is a film-shaped raw material for an endotracheal tube prepared according to the procedure in example 1, measured by a quartz crystal microbalance.
Fig. 3 (a) is a cross-sectional view of the front, middle and end portions of the catheter after the conventional commercial endotracheal tube and the endotracheal tube prepared according to the steps of example 1 and example 2 have repeatedly washed the inner wall for 24 hours by the sputum simulant, and (b) is a weight statistical view of the front, middle and end portions of the catheter after the conventional commercial endotracheal tube and the endotracheal tube prepared according to the step of example 1 have repeatedly washed the inner wall for 24 hours by the sputum simulant, wherein PVC-ETT is the conventional commercial endotracheal tube, and PVC/PAAm-ETT is the endotracheal tube prepared according to the step of example 1.
Detailed Description
The technical solution of the present invention is further described below with reference to the accompanying drawings and examples.
Example 1
A preparation method of a tracheal catheter with antibacterial and anti-phlegm-thrombus functions specifically comprises the following steps:
(1) sequentially adding acrylamide (AAm), 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone (I2959), Procyanidine (PC) and gelatin into 15ml of deionized water according to the mass fractions of 20%, 1% and 5%, and stirring at 80 ℃ until the materials are completely dissolved;
(2) adding the silver-chitosan nano composite antibacterial agent into the solution in which the components in the step (1) are completely dissolved according to the mass fraction of 3%, and stirring while cooling at room temperature until the antibacterial agent is uniformly dispersed;
(3) placing the solution in which the silver-chitosan nano composite antibacterial agent is uniformly dispersed in the step (2) in an environment at 4 ℃ for 40min to obtain a functional pre-polymerization coating;
(4) immersing the inner wall of a commercial tracheal catheter into a Benzophenone (BP) solution with the mass fraction of 10% for 10min, taking out, and drying by nitrogen to finish pretreatment; wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol ═ 1: 4);
(5) uniformly coating the functional pre-polymerization coating in the step (3) on the inner wall of the commercial tracheal catheter pretreated in the step (4), and uniformly irradiating for 45min by using a 365nm ultraviolet light source; the functional pre-polymerization coating is subjected to bonding reaction with the inner wall of the commercial tracheal catheter under the action of ultraviolet light, a hydrophobic initiator and a water-based initiator to realize bonding connection. The bonding reaction mechanism is as follows:
the formula (a) is that a hydrophobic initiator captures hydrogen atoms on methylene on a PVC molecular chain in a commercial tracheal catheter under the action of ultraviolet irradiation to generate free radicals, the formula (b) is that a water-based initiator captures hydrogen atoms on methylene in a hydrophilic monomer (acrylamide in the formula) under the action of ultraviolet irradiation to generate free radicals, and the formula (c) is that double bonds in the hydrophilic monomer containing the free radicals are connected with the free radicals on the PVC containing the free radicals to form covalent bonds to complete grafting, and meanwhile, the free radicals on the hydrophilic monomer in the formula (b) are connected with other hydrophilic monomers to form hydrophilic molecular chains through polymerization.
When the range is expanded to the whole coating function pre-polymerization coating, namely, the hydrophilic monomer is polymerized into a hydrophilic molecular chain in a gel network (formed by mixing and stirring a polyphenol cross-linking agent and hydrophilic colloid) to form a molecular chain-gel network interpenetrating structure to connect the hydrophilic colloid and graft the hydrophilic colloid on a PVC substrate, the connection mode of the whole coating and the substrate is the bonding connection described herein.
(6) And (4) washing the inner wall of the tracheal catheter treated in the step (5) with deionized water for 5 times, removing the unconnected paint, and drying with nitrogen to obtain the tracheal catheter with the functions of resisting bacteria and preventing phlegm embolism.
The cell adhesion experiment is respectively carried out on a common commercial tracheal catheter and the tracheal catheter with the antibacterial and anti-thrombus functions prepared by the invention, as shown in (a) in figure 1, under the observation of an electron microscope, after the inner wall of the common commercial tracheal catheter is subjected to the cell adhesion experiment, a large number of cells are adhered to the inner wall, as shown in (b) in figure 1, under the observation of the electron microscope, after the cell adhesion experiment is carried out on the inner wall of the tracheal catheter with the antibacterial and anti-thrombus functions prepared by the invention, the inner wall is almost free from cell adhesion, and after cell counting, as shown in (c) in figure 1, the number of adhered cells of the tracheal catheter with the antibacterial and anti-thrombus functions prepared by the invention is reduced by 85% compared with that of the common tracheal catheter, and the tracheal catheter prepared by the invention is proved to have the obvious antibacterial and anti-thrombus functions.
Respectively carrying out protein adsorption experiments on a film raw material of a common commercial tracheal catheter and a film raw material of the tracheal catheter with the antibacterial and anti-phlegm-thrombus functions, which is prepared by the method disclosed by the invention, as shown in figure 2, after the film raw material of the common commercial tracheal catheter adsorbs protein in a flowing protein solution, a quartz crystal microbalance is used for detecting, the protein adsorption amount is found to be large, and when the adsorption amount is the highest, the adsorption amount reaches 300ng/cm-2After the tracheal catheter film-shaped raw material with the functions of resisting bacteria and preventing phlegm thrombus is used for adsorbing protein in a flowing protein solution, a quartz crystal microbalance is used for detecting, the protein adsorption amount is less, and only 70ng/cm is needed when the adsorption amount is the highest-2Proved by the invention, the prepared tracheal catheter has obvious functions of antibiosis and sputum prevention.
Example 2
A preparation method of a tracheal catheter with antibacterial and anti-phlegm-thrombus functions specifically comprises the following steps:
(1) sequentially adding hydroxyethyl methacrylate (HEMA), 2-hydroxy-2-methyl-1-phenyl-1-acetone (HMPP), tea polyphenol (GTP) and gelatin into 15ml of deionized water according to the mass fraction of 40%, 5%, 2% and 5%, and stirring at 80 ℃ until the materials are completely dissolved;
(2) adding the silver-chitosan nano composite antibacterial agent into the solution in which the components in the step (1) are completely dissolved according to the mass fraction of 6%, and stirring while cooling at room temperature until the antibacterial agent is uniformly dispersed;
(3) placing the solution in which the silver-chitosan nano composite antibacterial agent is uniformly dispersed in the step (2) in an environment with the temperature of 8 ℃ for 40min to obtain a functional pre-polymerization coating;
(4) immersing the inner wall of a commercial tracheal catheter in a 5% 4-methoxybenzophenone (Methyl-BP) solution for 8min, taking out, and drying with nitrogen to finish pretreatment; wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol ═ 2: 3);
(5) uniformly coating the functional pre-polymerization coating in the step (3) on the inner wall of the commercial tracheal catheter treated in the step (4), and uniformly irradiating for 5min by using a 365nm ultraviolet light source; the functional pre-polymerization coating is subjected to bonding reaction with the inner wall of a commercial tracheal catheter under the action of ultraviolet light, a hydrophobic initiator and a water-based initiator to realize bonding connection;
(6) and (4) washing the inner wall of the tracheal catheter treated in the step (5) with deionized water for 5 times, removing the unconnected paint, and drying with nitrogen to obtain the tracheal catheter with the functions of resisting bacteria and preventing phlegm embolism.
Taking a common commercial tracheal catheter and a tracheal catheter with the antibacterial and anti-thrombus functions prepared according to the embodiments 1 and 2 of the invention, repeatedly washing the inner wall of the tracheal catheter for 24 hours by a sputum simulant, and observing the front end, the middle section and the tail end of the tracheal catheter, wherein the section view of the tracheal catheter shown in fig. 3 (a) shows that the inner wall of the common commercial tracheal catheter is adhered with a relatively obvious sputum simulant after the common commercial tracheal catheter is repeatedly washed for 24 hours by the sputum simulant, and the inner walls of the tracheal catheters with the antibacterial and anti-thrombus functions prepared according to the embodiments 1 and 2 of the invention are both adhered with less sputum simulant after the tracheal catheter is repeatedly washed for 24 hours by the sputum simulant; the weights of the sputum simulants adhered to the front end, the middle section and the tail end of the catheter are counted, and as shown in (b) in fig. 3, compared with the common commercial tracheal catheter, the weights of the sputum simulants adhered to the front end, the middle section and the tail end of the tracheal catheter with the antibacterial and sputum-plug-preventing functions, which is prepared by the invention, are obviously less, and the sputum adhesion of more than 80% can be effectively reduced. The tracheal catheter prepared by the method has obvious antibacterial and anti-sputum-thrombus functions.
Example 3
A preparation method of a tracheal catheter with antibacterial and anti-phlegm-thrombus functions specifically comprises the following steps:
(1) adding N, N-Dimethylacrylamide (DMAA), alpha-ketoglutaric acid (alpha-KGA), Tannic Acid (TA) and agar into 15ml of deionized water according to mass fractions of 25%, 1%, 1.5% and 6%, and stirring at 80 ℃ until the materials are completely dissolved;
(2) adding the silver-chitosan nano composite antibacterial agent into the solution in which the components in the step (1) are completely dissolved according to the mass fraction of 3%, and stirring while cooling at room temperature until the antibacterial agent is uniformly dispersed;
(3) placing the solution in which the silver-chitosan nano composite antibacterial agent is uniformly dispersed in the step (2) in an environment at 4 ℃ for 30min to obtain a functional pre-polymerization coating;
(4) immersing the inner wall of a commercial tracheal catheter into a solution of (benzophenone (BP) + bis (4- (dimethylamino) phenyl) ketone (MK)) (wherein BP: MK is 3:2) with the mass fraction of 8% for 12min, taking out, and drying by nitrogen, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 1: 4);
(5) uniformly coating the functional pre-polymerization coating in the step (3) on the inner wall of the commercial tracheal catheter treated in the step (4), and uniformly irradiating for 18min by using a 365nm ultraviolet light source; the functional pre-polymerization coating is subjected to bonding reaction with the inner wall of a commercial tracheal catheter under the action of ultraviolet light, a hydrophobic initiator and a water-based initiator to realize bonding connection;
(6) and (4) washing the inner wall of the tracheal catheter treated in the step (5) with deionized water for 5 times, removing the unconnected paint, and drying with nitrogen to obtain the tracheal catheter with the functions of resisting bacteria and preventing phlegm embolism.
Example 4
A preparation method of a tracheal catheter with antibacterial and anti-phlegm-thrombus functions specifically comprises the following steps:
(1) sequentially adding 12% by mass, 6% by mass, 0.25% by mass and 1% by mass of methoxy polyethylene glycol acrylate (mPEG-DA), aqueous Thioxanthone (TX), Procyanidine (PC) and agar into 15ml of deionized water, and stirring at 80 ℃ until the materials are completely dissolved;
(2) adding the silver-chitosan nano composite antibacterial agent into the solution in which the components in the step (1) are completely dissolved according to the mass fraction of 3%, and stirring while cooling at room temperature until the antibacterial agent is uniformly dispersed;
(3) placing the solution in which the silver-chitosan nano composite antibacterial agent is uniformly dispersed in the step (2) in an environment with the temperature of 8 ℃ for 50min to obtain a functional pre-polymerization coating;
(4) immersing the inner wall of a commercial tracheal catheter in a 15% by mass 1-hydroxycyclohexyl phenyl ketone (HCPK) solution for 5min, taking out, and drying with nitrogen, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 1: 4);
(5) uniformly coating the functional pre-polymerization coating in the step (3) on the inner wall of the commercial tracheal catheter treated in the step (4), and uniformly irradiating for 25min by using a 365nm ultraviolet light source; the functional pre-polymerization coating is subjected to bonding reaction with the inner wall of a commercial tracheal catheter under the action of ultraviolet light, a hydrophobic initiator and a water-based initiator to realize bonding connection;
(6) and (4) washing the inner wall of the tracheal catheter treated in the step (5) with deionized water for 5 times, removing the unconnected paint, and drying with nitrogen to obtain the tracheal catheter with the functions of resisting bacteria and preventing phlegm embolism.
Example 5
A preparation method of a tracheal catheter with antibacterial and anti-phlegm-thrombus functions specifically comprises the following steps:
(1) sequentially adding 50 percent, 10 percent, 1.2 percent and 5 percent of polyethylene glycol methacrylate (mPEG-MAA), aqueous Benzimide (BZ), tea polyphenol (GTP) and gelatin into 15ml of deionized water according to mass fraction, and stirring at 80 ℃ until the materials are completely dissolved;
(2) adding 7% of silver-chitosan nano composite antibacterial agent by mass into the solution in which the components in the step (1) are completely dissolved, and stirring while cooling at room temperature until the antibacterial agent is uniformly dispersed;
(3) placing the solution in which the silver-chitosan nano composite antibacterial agent is uniformly dispersed in the step (2) in an environment at the temperature of 2 ℃ for 50min to obtain a functional pre-polymerization coating;
(4) immersing the inner wall of a commercial tracheal catheter in a Benzophenone (BP) solution with the mass fraction of 10% for 5min, taking out, and drying by nitrogen, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 1: 4);
(5) uniformly coating the functional pre-polymerization coating in the step (3) on the inner wall of the commercial tracheal catheter treated in the step (4), and uniformly irradiating for 50min by using a 365nm ultraviolet light source; the functional pre-polymerization coating is subjected to bonding reaction with the inner wall of a commercial tracheal catheter under the action of ultraviolet light, a hydrophobic initiator and a water-based initiator to realize bonding connection;
(6) and (4) washing the inner wall of the tracheal catheter treated in the step (5) with deionized water for 5 times, removing the unconnected paint, and drying with nitrogen to obtain the tracheal catheter with the functions of resisting bacteria and preventing phlegm embolism.
Example 6
A preparation method of a tracheal catheter with antibacterial and anti-phlegm-thrombus functions specifically comprises the following steps:
(1) sequentially adding 30 percent, 1.2 percent, 3 percent and 5 percent of polyethylene glycol methacrylate (mPEG-MAA), aqueous Benzimide (BZ), Tannic Acid (TA) and gelatin into 15ml of deionized water according to mass fraction, and stirring at 80 ℃ until the materials are completely dissolved;
(2) adding the silver-chitosan nano composite antibacterial agent into the solution in which the components in the step (1) are completely dissolved according to the mass fraction of 3%, and stirring while cooling at room temperature until the antibacterial agent is uniformly dispersed;
(3) placing the solution in which the silver-chitosan nano composite antibacterial agent is uniformly dispersed in the step (2) in an environment at 4 ℃ for 50min to obtain a functional pre-polymerization coating;
(4) immersing the inner wall of a commercial tracheal catheter in a Benzophenone (BP) solution with the mass fraction of 10% for 5min, taking out, and drying by nitrogen, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol: 1.5: 3.5);
(5) uniformly coating the functional pre-polymerization coating in the step (3) on the inner wall of the commercial tracheal catheter treated in the step (4), and uniformly irradiating for 40min by using a 365nm ultraviolet light source; the functional pre-polymerization coating is subjected to bonding reaction with the inner wall of a commercial tracheal catheter under the action of ultraviolet light, a hydrophobic initiator and a water-based initiator to realize bonding connection;
(6) and (4) washing the inner wall of the tracheal catheter treated in the step (5) with deionized water for 5 times, removing the unconnected paint, and drying with nitrogen to obtain the tracheal catheter with the functions of resisting bacteria and preventing phlegm embolism.
Example 7
A preparation method of a tracheal catheter with antibacterial and anti-phlegm-thrombus functions specifically comprises the following steps:
(1) sequentially adding 2%, 1%, 6% and 20% of N-isopropylacrylamide (NIPAM), Acyl Phosphate (APO), Procyanidine (PC) and agar into 15ml of deionized water according to mass fraction, and stirring at 80 ℃ until the materials are completely dissolved;
(2) adding the silver-chitosan nano composite antibacterial agent into the solution in which the components in the step (1) are completely dissolved according to the mass fraction of 2%, and stirring while cooling at room temperature until the antibacterial agent is uniformly dispersed;
(3) placing the solution in which the silver-chitosan nano composite antibacterial agent is uniformly dispersed in the step (2) in an environment at 4 ℃ for 30min to obtain a functional pre-polymerization coating;
(4) immersing the inner wall of a commercial tracheal catheter into a solution of (benzophenone (BP) + bis (4- (dimethylamino) phenyl) ketone (MK)) (wherein BP: MK is 4:1) with the mass fraction of 8% for 40s, taking out the solution, and drying the solution by nitrogen, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 1: 1);
(5) uniformly coating the functional pre-polymerization coating in the step (3) on the inner wall of the commercial tracheal catheter treated in the step (4), and uniformly irradiating for 40s by using a 365nm ultraviolet light source; the functional pre-polymerization coating is subjected to bonding reaction with the inner wall of a commercial tracheal catheter under the action of ultraviolet light, a hydrophobic initiator and a water-based initiator to realize bonding connection;
(6) and (4) washing the inner wall of the tracheal catheter treated in the step (5) with deionized water for 5 times, removing the unconnected paint, and drying with nitrogen to obtain the tracheal catheter with the functions of resisting bacteria and preventing phlegm embolism.
Example 8
A preparation method of a tracheal catheter with antibacterial and anti-phlegm-thrombus functions specifically comprises the following steps:
(1) sequentially adding acrylamide (AAm), 2-hydroxy-2-methyl-1-phenyl-1-acetone (HMPP), tea polyphenol (GTP) and agar into 15ml of deionized water according to the mass fraction of 30%, 1.5%, 0.36% and 3%, and stirring at 80 ℃ until the materials are completely dissolved;
(2) adding the silver-chitosan nano composite antibacterial agent into the solution in which the components in the step (1) are completely dissolved according to the mass fraction of 3%, and stirring while cooling at room temperature until the antibacterial agent is uniformly dispersed;
(3) placing the solution in which the silver-chitosan nano composite antibacterial agent is uniformly dispersed in the step (2) in an environment at 4 ℃ for 30min to obtain a functional pre-polymerization coating;
(4) immersing the inner wall of a commercial tracheal catheter in a Benzophenone (BP) solution with the mass fraction of 10% for 10min, taking out, and drying by nitrogen, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 1: 4);
(5) uniformly coating the functional pre-polymerization coating in the step (3) on the inner wall of the commercial tracheal catheter treated in the step (4), and uniformly irradiating for 35min by using a 365nm ultraviolet light source; the functional pre-polymerization coating is subjected to bonding reaction with the inner wall of a commercial tracheal catheter under the action of ultraviolet light, a hydrophobic initiator and a water-based initiator to realize bonding connection;
(6) and (4) washing the inner wall of the tracheal catheter treated in the step (5) with deionized water for 5 times, removing the unconnected paint, and drying with nitrogen to obtain the tracheal catheter with the functions of resisting bacteria and preventing phlegm embolism.
In conclusion, the inner wall of the commercial tracheal catheter is bonded and connected with the functional pre-polymerization coating, so that the tracheal catheter with the antibacterial and anti-phlegm-embolism functions has stronger bonding force, low operation difficulty and low cost, and has obvious antibacterial and anti-phlegm-embolism functions.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.
Claims (10)
1. A preparation method of a tracheal catheter with antibacterial and anti-phlegm-thrombus functions is characterized by comprising the following steps:
s1, pretreating the inner wall of the commercial tracheal catheter by using a hydrophobic initiator solution; the hydrophobic initiator in the hydrophobic initiator solution is selected from any one or a combination of a plurality of benzophenone, 4-methoxybenzophenone, bis (4- (dimethylamino) phenyl) ketone and 1-hydroxycyclohexyl phenyl ketone;
s2, preparing a functional pre-polymerization coating, and stirring and dissolving the components to obtain the functional pre-polymerization coating; the functional pre-polymerized coating comprises a hydrophilic monomer, a water-based initiator, a polyphenol cross-linking agent, a hydrophilic colloid, an antibacterial agent and deionized water, wherein the hydrophilic monomer: aqueous initiator: a polyphenol crosslinking agent: hydrophilic colloid: antibacterial agents: deionized water (0.1% -50%): (0.1% -10%): (0.1% -10%): (1% -20%): (0.1% -10%): the balance is calculated by mass ratio;
s3, applying the functional pre-polymerization coating on the inner wall of the commercial tracheal catheter, and bonding and connecting the functional pre-polymerization coating and the inner wall of the commercial tracheal catheter under the irradiation of an ultraviolet light source;
s4, washing away the unconnected paint to obtain the tracheal catheter with the functions of antibiosis and sputum prevention.
2. The method for preparing an endotracheal tube having antibacterial and anti-phlegm-thrombus effects as claimed in claim 1, wherein the polyphenol based cross-linking agent is one or a combination of two or more of procyanidins, tea polyphenols and tannic acid.
3. The method for preparing an endotracheal tube having antibacterial and anti-thrombolysis functions as claimed in claim 1, wherein in step S2, the dissolving step further comprises a standing treatment, the standing temperature is 0 to 15 ℃, and the standing time is 10 to 50 min.
4. The method for preparing an endotracheal tube having antibacterial and anti-thrombus functions as claimed in claim 1, wherein, in the hydrophobic initiator, 1-hydroxycyclohexyl phenyl ketone: benzophenone: 4-methoxybenzophenone: (benzophenone + bis (4- (dimethylamino) phenyl) methanone) ═ 1-20%: (1-20%): (1-20%): (1-20%), wherein benzophenone: bis (4- (dimethylamino) phenyl) methanone, 1:5-5:1, in mass ratio.
5. The method for preparing an antibacterial anti-sputum-plug endotracheal tube according to claim 1, characterized in that the hydrophilic monomer is any one or a combination of any two or more of acrylic acid, acrylamide, N-dimethylacrylamide, N-vinylpyrrolidone, hydroxyethyl methacrylate, polyethylene glycol methacrylate, methoxypolyethylene glycol acrylate and N-isopropylacrylamide.
6. The method of claim 1, wherein the aqueous initiator is selected from the group consisting of 2-hydroxy-4- (2-hydroxyethoxy) -2-methylpropiophenone, 2-hydroxy-2-methyl-1-phenyl-1-propanone, α -ketoglutarate, aqueous thioxanthone, aqueous benzimide, and acyl phosphate.
7. The method for preparing an endotracheal tube having antibacterial and anti-thrombolysis functions as claimed in claim 1, wherein the time for pretreating a commercial endotracheal tube in the step S1 is 30S to 30 min.
8. The method for preparing an endotracheal tube having antibacterial and anti-thrombolysis functions as claimed in claim 1, wherein in step S3, the time for irradiating the commercial endotracheal tube with the ultraviolet light source is 30S to 60 min.
9. The method for preparing an endotracheal tube having antibacterial and anti-sputum-plug functions as claimed in claim 1, wherein, in step S1, the solvent in the hydrophobic initiator solution comprises a mixture of acetone and ethanol, and the ratio of acetone: the ethanol accounts for 1: 4-4: 1 in volume ratio.
10. An endotracheal tube having antibacterial and anti-thrombogenic functions, prepared according to any one of claims 1 to 9, characterized in that said endotracheal tube comprises said commercial endotracheal tube and a coating layer formed by bonding and connecting said functional pre-polymeric coating to the inner wall of said commercial endotracheal tube.
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| CN115737937A (en) * | 2022-12-12 | 2023-03-07 | 广东省人民医院 | Fluorescent hydrogel lubrication catheter and preparation method thereof |
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