CN114213693A - Antibacterial and antifouling medical breathing tool and preparation method thereof - Google Patents
Antibacterial and antifouling medical breathing tool and preparation method thereof Download PDFInfo
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- CN114213693A CN114213693A CN202111662942.2A CN202111662942A CN114213693A CN 114213693 A CN114213693 A CN 114213693A CN 202111662942 A CN202111662942 A CN 202111662942A CN 114213693 A CN114213693 A CN 114213693A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/04—Coating
- C08J7/0427—Coating with only one layer of a composition containing a polymer binder
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
- C08J7/16—Chemical modification with polymerisable compounds
- C08J7/18—Chemical modification with polymerisable compounds using wave energy or particle radiation
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2327/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Derivatives of such polymers
- C08J2327/02—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Derivatives of such polymers not modified by chemical after-treatment
- C08J2327/04—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
- C08J2327/06—Homopolymers or copolymers of vinyl chloride
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- Chemical Kinetics & Catalysis (AREA)
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Abstract
The invention discloses a preparation method of an antibacterial and antifouling medical breathing apparatus, which comprises the following steps: step S1, immersing the respiration appliance body into a hydrophobic photoinitiator solution to form a hydrophobic layer on the surface of the respiration appliance body; and step S2, coating the functional pre-polymerized coating on the surface of the hydrophobic layer to form a functional layer. The functional pre-polymerized coating comprises: hydrophilic monomer, hydrophilic photoinitiator, antibacterial agent and water. And step S3, placing the functional layer under ultraviolet light for irradiation, and grafting and polymerizing the functional pre-polymerization coating on the surface of the breathing appliance body to obtain the antibacterial and antifouling medical breathing appliance. The antibacterial and antifouling coating on the surface of the antibacterial and antifouling medical breathing appliance is combined with the breathing appliance body by a chemical grafting method, so that the coating is not easy to fall off, the stability is stronger, and the service life is longer. In addition, the coating also contains an antibacterial agent, so that a bacterial biofilm is difficult to form on the surface of the tool, and the antibacterial effect is strong.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to an antibacterial and antifouling medical breathing apparatus and a preparation method thereof.
Background
Prolonged mechanical ventilation in the clinic is likely to cause nosocomial infections, namely Ventilator-associated Pneumonia (VAP), which has become the first leading killer of the ICU as the highest incidence and mortality complication.
Relevant researches show that serious multiple drug-resistant bacteria infection exists in hospital with infection parts below respiratory tracts, upper respiratory tracts and surgical incisions, and the ICU infection rate is different from 10 to 50 percent. The main cause of nosocomial infection is bacterial colonization caused by long-term retention of tracheal catheters, tracheostomy tubes, respirator masks and the like.
At present, medical breathing appliances (such as endotracheal tubes, tracheostomy tubes, breathing machine masks, laryngeal masks, breathing circuit threaded tubes and the like) are mainly used for resisting bacteria by introducing an antibacterial coating on the surface of a material, but the existing coating is usually modified by a physical adsorption method, and the coating is easily swelled or shrunk under the influence of environmental humidity, generates deformation and internal stress and causes the coating to fall off.
Disclosure of Invention
The invention aims to provide an antibacterial antifouling medical breathing tool with a surface coating which is not easy to fall off and a preparation method thereof.
In order to achieve the aim, the invention provides a preparation method of an antibacterial and antifouling medical breathing apparatus, which comprises the following steps:
step S1, immersing the respiration appliance body into a hydrophobic photoinitiator solution to form a hydrophobic layer on the surface of the respiration appliance body; the solvent of the hydrophobic photoinitiator solution is an organic solvent, and the concentration of the hydrophobic photoinitiator in the organic solvent is 1-20 wt.%;
step S2, coating a functional pre-polymerized coating on the surface of the hydrophobic layer to form a functional layer; the functional pre-polymerization coating comprises: hydrophilic monomer, hydrophilic photoinitiator, antibacterial agent and water, wherein the concentration of the hydrophilic monomer is 0.1-50 wt.%, the concentration of the hydrophilic photoinitiator is 0.1-10 wt.%, and the concentration of the antibacterial agent is 0.1-10 wt.%;
and step S3, placing the functional layer under ultraviolet light for irradiation, and grafting and polymerizing the functional pre-polymerization coating on the surface of the breathing appliance body to obtain the antibacterial and antifouling medical breathing appliance.
Optionally, the hydrophobic photoinitiator comprises: one or more of benzophenone, 4-methoxybenzophenone and 1-hydroxycyclohexyl phenyl ketone.
Optionally, the organic solvent comprises: acetone and ethanol, wherein the mass ratio of the acetone to the ethanol is 1:0.25-1: 4.
Optionally, the antibacterial agent is a silver-chitosan nanocomposite.
Optionally, the hydrophilic monomer comprises: one or more of acrylic acid, acrylamide, N-dimethylacrylamide, N-vinyl pyrrolidone, hydroxyethyl methacrylate, polyethylene glycol methacrylate, methoxy polyethylene glycol acrylate and N-isopropyl acrylamide.
Optionally, the hydrophilic photoinitiator comprises: 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone, 2-hydroxy-2-methyl-1-phenyl-1-propanone, alpha-ketoglutaric acid, aqueous thioxanthone, aqueous benzimide and one or more acyl phosphates.
Optionally, in step S1, the respiration appliance body is immersed in the hydrophobic photoinitiator solution for 30S-30 min.
Optionally, in step S3, the irradiation time of the ultraviolet light is 30S-60 min.
Optionally, the breathing apparatus comprises: at least one of a tracheal tube, a tracheostomy tube, a respirator mask, a laryngeal mask, and a breathing circuit threaded tube.
The invention also provides the antibacterial antifouling medical breathing appliance prepared by the preparation method.
Compared with the prior art, the invention has the beneficial effects that:
(1) the invention adopts a chemical grafting method to combine the antibacterial antifouling coating on the surface of the material, and the antibacterial antifouling coating is not easy to fall off, has strong stability and long service life.
(2) The antibacterial antifouling coating contains an antibacterial agent silver-chitosan nano composite material, and due to the addition of the antibacterial agent, a bacterial biofilm is difficult to form on the surface of the tool, and the antibacterial effect is strong.
(3) The raw materials used in the invention have low price, the operation is simple and efficient, and the method is beneficial to large-scale preparation.
(4) Compared with the common commercially available medical breathing apparatus, the medical breathing apparatus prepared by the invention can effectively reduce the adhesion of cells and proteins by over 80 percent, and the killing rate of adhered bacteria is more than 99 percent.
Drawings
FIG. 1 is an image of adhered cells on the inner wall of a conventional commercial endotracheal tube and the endotracheal tube prepared in example 1 after they were infiltrated in a cell culture solution for 24 hours. FIG. 1 (a) is a diagram showing adhesion cells on the inner wall of a conventional commercial catheter, and FIG. 1 (b) is a diagram showing adhesion cells on the inner wall of a tracheal catheter prepared in example 1.
FIG. 2 is an image of fluorescent-labeled protein adhered to the inner wall of a conventional commercial endotracheal tube and the endotracheal tube prepared in example 1 after they were infiltrated in a protein culture solution for 24 hours. FIG. 2 (a) is a photograph showing the inner wall adhesion fluorescent-labeled protein of a conventional commercial catheter, and FIG. 2 (b) is a photograph showing the inner wall adhesion fluorescent-labeled protein of an endotracheal tube prepared by the procedure of example 1.
FIG. 3 shows the absorbance of 488nm wavelength light by fluorescence labeled protein adhered to the inner wall of a common commercial tracheal catheter and the tracheal catheter prepared in example 1 after soaking in protein culture solution for 24 hours, wherein PVC is the common commercial tracheal catheter, and PVC-PAAm is the tracheal catheter prepared according to the procedure in example 1.
FIG. 4 is a diagram showing the state of sputum plugs formed at the front, middle and rear ends of a common commercial endotracheal tube, example 1 and example 2 after repeatedly washing the inner wall for 24 hours by a sputum simulant. Fig. 4 (a) is a cross-sectional view of the front, middle and end portions of the catheter after the endotracheal tube of general commercial use, example 1 and example 2 was repeatedly washed for 24 hours by the sputum simulant, and fig. 4 (b) is a weight statistical view of the front, middle and end portions of the catheter after the endotracheal tube of general commercial use, example 1 was repeatedly washed for 24 hours by the sputum simulant, wherein PVC-ETT is the endotracheal tube of general commercial use, and PVC/PAAm-ETT is the endotracheal tube prepared according to the procedure of example 1.
Detailed Description
The technical solution of the present invention is further described below with reference to the accompanying drawings and examples.
The invention provides a preparation method of an antibacterial and antifouling medical breathing apparatus, which comprises the following steps:
step S1, immersing the respiration appliance body into a hydrophobic photoinitiator solution to form a hydrophobic layer on the surface of the respiration appliance body; the solvent of the hydrophobic photoinitiator solution is an organic solvent, and the concentration of the hydrophobic photoinitiator in the organic solvent is 1-20 wt.%;
step S2, coating a functional pre-polymerized coating on the surface of the hydrophobic layer to form a functional layer; the functional pre-polymerization coating comprises: hydrophilic monomer, hydrophilic photoinitiator and water, wherein the concentration of the hydrophilic monomer is 0.1-50 wt.%, and the concentration of the hydrophilic photoinitiator is 0.1-10 wt.%;
and step S3, placing the functional layer under ultraviolet light for irradiation, and grafting and polymerizing the functional pre-polymerization coating on the surface of the breathing appliance body to obtain the antibacterial and antifouling medical breathing appliance.
The preparation principle of the invention is as follows: medical breathing appliances (such as endotracheal tubes, tracheostomy tubes, breathing machine masks, laryngeal masks, breathing circuit threaded tubes and the like) are generally made of polymer PVC, hydrophobic photoinitiators enable the surface of the polymer to generate a graftable active site under the irradiation of ultraviolet light, hydrophilic monomers are grafted on the active site, and meanwhile hydrophilic photoinitiators enable the hydrophilic monomers to polymerize into macromolecular chains to form a continuous antibacterial antifouling coating on the surface of the polymer.
The antibacterial and antifouling coating on the surface of the antibacterial and antifouling medical breathing appliance is combined with the breathing appliance body by a chemical grafting method, so that the coating is not easy to fall off, the stability is stronger, and the service life is longer. In addition, the coating also contains an antibacterial agent, so that a bacterial biofilm is difficult to form on the surface of the tool, and the antibacterial effect is strong.
In some embodiments, the hydrophobic photoinitiator comprises: one or more of Benzophenone (BP), 4-methoxybenzophenone (Methyl-BP) and 1-hydroxycyclohexyl phenyl ketone (HCPK). The hydrophobic photoinitiator has extremely low corrosivity, does not damage the breathing appliance body material basically, can produce active sites on the surface of the material under the irradiation of ultraviolet light, enables the antibacterial antifouling coating to be covalently grafted on the surface of the breathing appliance body, and has strong binding force and difficult shedding of the coating.
In some embodiments, the organic solvent is a mixture of acetone and ethanol, and the mass ratio of acetone to ethanol is 1:0.25-1: 4.
In some embodiments, the hydrophilic monomer comprises: one or more of Acrylic Acid (AA), acrylamide (AAm), N-Dimethylacrylamide (DMAA), N-Vinylpyrrolidone (VP), hydroxyethyl methacrylate (HEMA), polyethylene glycol methacrylate (mPEG-MAA), methoxypolyethylene glycol acrylate (mPEG-DA) and N-isopropylacrylamide (NIPAM).
In some embodiments, the hydrophilic photoinitiator comprises: 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone (I2959), 2-hydroxy-2-methyl-1-phenyl-1-propanone (HMPP), alpha-ketoglutaric acid (alpha-KGA), aqueous Thioxanthone (TX), aqueous Benzimide (BZ) and Acyl Phosphate (APO).
In some embodiments, the antimicrobial agent is a silver-chitosan nanocomposite. The silver-chitosan nano composite material has a strong bactericidal effect, so that a bacterial biofilm is difficult to form on the surface of the tool, and the silver can be slowly released by the modification of the chitosan, so that the antibacterial effect is more durable.
In some embodiments, in step S1, the respiration appliance body is immersed in the hydrophobic photoinitiator solution for a period of time ranging from 30S to 30 min.
In some embodiments, in step S3, the ultraviolet light is irradiated for 30S-60 min.
Example 1
The embodiment provides a preparation method of an antibacterial and antifouling medical tracheal catheter, which specifically comprises the following steps:
(1) sequentially adding the AAm, the I2959 and the silver-chitosan nano composite antibacterial agent into 15ml of deionized water according to the mass fraction of 20%, 1% and 3%, and stirring until the materials are completely dissolved to form a functional pre-polymerization coating;
(2) immersing the inner wall of the medical tracheal catheter into BP solution with the mass fraction of 10%, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 1: 4), taking out after 10min, and drying by nitrogen;
(3) and (3) coating the functional pre-polymerization coating in the step (1) on the inner wall of the catheter treated in the step (2), and uniformly irradiating for 45min by using a 365nm ultraviolet light source.
(4) And (4) washing the inner wall of the tracheal catheter treated in the step (3) with deionized water for 5 times, removing the unconnected coating material, and drying with nitrogen to obtain the tracheal catheter with the antibacterial and antifouling functions.
As shown in FIG. 1, a common commercial endotracheal tube and the endotracheal tube prepared in this example were immersed in a cell culture solution for 24 hours, and cell images of the adhesion of the inner walls of both endotracheal tubes were observed under a microscope. The results show that the tracheal tube of the present embodiment can effectively reduce cell adhesion by more than 80%.
As shown in fig. 2 and 3, the common commercial endotracheal tube and the endotracheal tube of this example were immersed in a protein culture solution for 24 hours, and protein images of the adhesion of the inner walls of the two endotracheal tubes were observed under a microscope. The results show that the tracheal tube of the present example can effectively reduce protein adhesion by more than 80%.
Example 2
The embodiment provides a preparation method of an antibacterial and antifouling medical tracheostomy tube, which specifically comprises the following steps:
(1) sequentially adding 40%, 5% and 6% of HEMA, HMPP and silver-chitosan nano composite antibacterial agent by mass into 15ml of deionized water, and stirring until the antibacterial agent is completely dissolved to form a functional pre-polymerization coating;
(2) immersing the inner wall of the medical tracheostomy tube into a solution with 5% Methyl-BP by mass fraction, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 2: 3), taking out after 8min, and drying by nitrogen;
(3) and (3) uniformly coating the functional pre-polymerization coating in the step (1) on the inner wall of the tracheostomy tube treated in the step (2), and uniformly irradiating for 5min by using a 365nm ultraviolet light source.
(4) And (4) washing the inner wall of the tracheostomy tube treated in the step (3) by using deionized water for 5 times, removing the unconnected coating material, and drying by using nitrogen to obtain the tracheostomy tube with the antibacterial and antifouling functions.
As shown in fig. 4, the state diagram of the front, middle and end sputum plugs of the common commercial endotracheal tube, the endotracheal tube prepared in example 1 and example 2, after repeatedly washing the inner wall for 24 hours by the sputum simulant. The results show that the endotracheal tubes of example 1 and example 2 can significantly reduce the formation of sputum plugs.
Example 3
The embodiment provides a preparation method of an antibacterial and antifouling respirator mask, which specifically comprises the following steps:
(1) sequentially adding DMAA, alpha-KGA and silver-chitosan nano composite antibacterial agent into 15ml of deionized water according to the mass fractions of 25%, 1% and 3%, and stirring until the DMAA, the alpha-KGA and the silver-chitosan nano composite antibacterial agent are completely dissolved to form a functional pre-polymerization coating;
(2) soaking the inner surface of the respirator mask in BP solution with mass fraction of 8%, wherein the solvent is mixture of acetone and ethanol (acetone: ethanol is 1: 4), taking out after 12min, and drying with nitrogen;
(3) and (3) uniformly coating the functional pre-polymerization coating in the step (1) on the inner surface of the respirator mask treated in the step (2), and uniformly irradiating for 18min by using a 365nm ultraviolet light source.
(4) And (4) washing the inner surface of the respirator mask treated in the step (3) with deionized water for 5 times, removing the unconnected coating material, and drying with nitrogen to obtain the respirator mask with the antibacterial and antifouling functions.
Example 4
The embodiment provides a preparation method of an antibacterial and antifouling laryngeal mask, which specifically comprises the following steps:
(1) sequentially adding 12 percent, 6 percent and 3 percent of mPEG-DA, TX and silver-chitosan nano composite antibacterial agent into 15ml of deionized water according to the mass fraction, and stirring until the mPEG-DA, TX and silver-chitosan nano composite antibacterial agent are completely dissolved to form a functional pre-polymerization coating;
(2) immersing the inner wall of the laryngeal mask into a 15% HCPK solution by mass fraction, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 1: 4), taking out after 5min, and drying by nitrogen;
(3) and (3) uniformly coating the functional pre-polymerization coating in the step (1) on the inner wall of the laryngeal mask treated in the step (3), and uniformly irradiating for 25min by using a 365nm ultraviolet light source.
(4) And (4) washing the inner wall of the laryngeal mask treated in the step (3) with deionized water for 5 times, removing the unconnected coating material, and drying with nitrogen to obtain the tracheal catheter with the antibacterial and antifouling functions.
Example 5
The embodiment provides a preparation method of an antibacterial and antifouling medical breathing loop threaded pipe, which specifically comprises the following steps:
(1) sequentially adding 50 percent, 10 percent and 7 percent of mPEG-MAA, BZ and silver-chitosan nano composite antibacterial agent into 15ml of deionized water according to mass fraction, and stirring until the materials are completely dissolved to form a functional prepolymerization coating;
(2) immersing the inner wall of a threaded pipe of the medical breathing loop into a BP solution with the mass fraction of 10%, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 1: 4), taking out after 5min, and drying by nitrogen;
(3) and (3) uniformly coating the functional pre-polymerization coating in the step (1) on the inner wall of the breathing loop threaded pipe treated in the step (2), and uniformly irradiating for 50min by using a 365nm ultraviolet light source.
(4) And (4) washing the inner wall of the tracheal catheter treated in the step (3) with deionized water for 5 times, removing the unconnected coating material, and drying with nitrogen to obtain the breathing loop threaded pipe with the antibacterial and antifouling functions.
Example 6
The embodiment provides a preparation method of an antibacterial and antifouling medical tracheal catheter, which specifically comprises the following steps:
(1) sequentially adding 30 percent, 1.2 percent and 33 percent of mPEG-MAA, BZ and silver-chitosan nano composite antibacterial agent by mass into 15ml of deionized water, and stirring until the materials are completely dissolved to form a functional pre-polymerization coating;
(2) immersing the inner wall of the medical tracheal catheter into BP solution with the mass fraction of 10%, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 1.5: 3.5), taking out after 5min, and drying by nitrogen;
(3) and (3) uniformly coating the functional pre-polymerization coating in the step (1) on the inner wall of the catheter treated in the step (2), and uniformly irradiating for 40min by using a 365nm ultraviolet light source.
(4) And (4) washing the inner wall of the tracheal catheter treated in the step (3) with deionized water for 5 times, removing the unconnected coating material, and drying with nitrogen to obtain the tracheal catheter with the antibacterial and antifouling functions.
Example 7
The embodiment provides a preparation method of an antibacterial and antifouling medical tracheostomy tube, which specifically comprises the following steps:
(1) sequentially adding 2%, 1% and 2% of NIPAM, APO and silver-chitosan nano composite antibacterial agent by mass percent into 15ml of deionized water, and stirring until the materials are completely dissolved to form a functional pre-polymerization coating;
(2) immersing the inner wall of the medical tracheostomy tube into a BP solution with the mass fraction of 8%, wherein the solvent is a mixture of acetone and ethanol (acetone: ethanol is 1: 1), taking out the tracheostomy tube after 40 seconds, and drying the tracheostomy tube by nitrogen;
(3) and (3) uniformly coating the functional pre-polymerization coating in the step (1) on the inner wall of the tracheostomy tube treated in the step (2), and uniformly irradiating for 40s by using a 365nm ultraviolet light source.
(4) And (4) washing the inner wall of the tracheal catheter treated in the step (3) with deionized water for 5 times, removing the unconnected coating material, and drying with nitrogen to obtain the tracheostomy tube with the antibacterial and antifouling functions.
Example 8
The embodiment provides a preparation method of an antibacterial and antifouling respirator mask, which specifically comprises the following steps:
(1) sequentially adding 30 percent, 1.5 percent and 3 percent of AAm, HMPP and silver-chitosan nano composite antibacterial agent by mass percent into 15ml of deionized water, and stirring until the AAm, the HMPP and the silver-chitosan nano composite antibacterial agent are completely dissolved to form a functional pre-polymerization coating;
(2) soaking the inner surface of the respirator in BP solution with mass fraction of 10%, wherein the solvent is mixture of acetone and ethanol (acetone: ethanol is 1: 4), taking out after 10min, and drying with nitrogen;
(3) and (3) uniformly coating the functional pre-polymerization coating in the step (1) on the inner surface of the respirator mask treated in the step (2), and uniformly irradiating for 35min by using a 365nm ultraviolet light source.
(4) And (4) washing the inner surface of the respirator mask treated in the step (3) with deionized water for 5 times, removing the unconnected coating material, and drying with nitrogen to obtain the respirator mask with the antibacterial and antifouling functions.
In conclusion, the antibacterial and antifouling coating on the surface of the antibacterial and antifouling medical breathing apparatus is combined with the breathing apparatus body by a chemical grafting method, so that the coating is not easy to fall off, the stability is higher, and the service life is longer. In addition, the coating also contains an antibacterial agent, so that a bacterial biofilm is difficult to form on the surface of the tool, and the antibacterial effect is strong.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.
Claims (10)
1. A preparation method of an antibacterial and antifouling medical breathing apparatus is characterized by comprising the following steps:
step S1, immersing the respiration appliance body into a hydrophobic photoinitiator solution to form a hydrophobic layer on the surface of the respiration appliance body; the solvent of the hydrophobic photoinitiator solution is an organic solvent, and the concentration of the hydrophobic photoinitiator in the organic solvent is 1-20 wt.%;
step S2, coating a functional pre-polymerized coating on the surface of the hydrophobic layer to form a functional layer; the functional pre-polymerization coating comprises: hydrophilic monomer, hydrophilic photoinitiator, antibacterial agent and water, wherein the concentration of the hydrophilic monomer is 0.1-50 wt.%, the concentration of the hydrophilic photoinitiator is 0.1-10 wt.%, and the concentration of the antibacterial agent is 0.1-10 wt.%;
and step S3, placing the functional layer under ultraviolet light for irradiation, and grafting and polymerizing the functional pre-polymerization coating on the surface of the breathing appliance body to obtain the antibacterial and antifouling medical breathing appliance.
2. The method of claim 1, wherein the hydrophobic photoinitiator comprises: one or more of benzophenone, 4-methoxybenzophenone and 1-hydroxycyclohexyl phenyl ketone.
3. The method of claim 1, wherein the organic solvent comprises: acetone and ethanol, wherein the mass ratio of the acetone to the ethanol is 1:0.25-1: 4.
4. The method of claim 1, wherein the antibacterial agent is a silver-chitosan nanocomposite.
5. The method of claim 1, wherein the hydrophilic monomer comprises: one or more of acrylic acid, acrylamide, N-dimethylacrylamide, N-vinyl pyrrolidone, hydroxyethyl methacrylate, polyethylene glycol methacrylate, methoxy polyethylene glycol acrylate and N-isopropyl acrylamide.
6. The method of claim 1, wherein the hydrophilic photoinitiator comprises: 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone, 2-hydroxy-2-methyl-1-phenyl-1-propanone, alpha-ketoglutaric acid, aqueous thioxanthone, aqueous benzimide and one or more acyl phosphates.
7. The method of claim 1, wherein the body of the respirator is immersed in the hydrophobic photoinitiator solution for a period of time of 30S to 30min in step S1.
8. The method of claim 1, wherein in step S3, the uv light is irradiated for 30S-60 min.
9. The method of manufacturing of claim 1, wherein the respiratory appliance comprises: at least one of a tracheal tube, a tracheostomy tube, a respirator mask, a laryngeal mask, and a breathing circuit threaded tube.
10. An antibacterial and antifouling medical breathing device prepared by the preparation method according to any one of claims 1 to 9, comprising: the breathing appliance comprises a breathing appliance body and an antibacterial and antifouling coating grafted on the surface of the breathing appliance body.
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| CN102382332A (en) * | 2009-08-11 | 2012-03-21 | 聊城大学 | Method for liquid-phase synthesis of nano complex of silver, chitosan and/or chitosan derivatives |
| CN102921049A (en) * | 2012-09-28 | 2013-02-13 | 深圳清华大学研究院 | Antibacterial medical catheter and preparation method thereof |
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