CN115089769A - Hydrophilic coating special for polyurethane medical catheter and manufacturing method thereof - Google Patents
Hydrophilic coating special for polyurethane medical catheter and manufacturing method thereof Download PDFInfo
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- CN115089769A CN115089769A CN202210804699.1A CN202210804699A CN115089769A CN 115089769 A CN115089769 A CN 115089769A CN 202210804699 A CN202210804699 A CN 202210804699A CN 115089769 A CN115089769 A CN 115089769A
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- Prior art keywords
- hydrophilic coating
- catheter
- hydrophilic
- diluent
- polyurethane medical
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- Pending
Links
- 239000011248 coating agent Substances 0.000 title claims abstract description 27
- 238000000576 coating method Methods 0.000 title claims abstract description 27
- 229920002635 polyurethane Polymers 0.000 title claims abstract description 15
- 239000004814 polyurethane Substances 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 15
- 239000003085 diluting agent Substances 0.000 claims abstract description 14
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 11
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 11
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 10
- 239000000314 lubricant Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- 230000001050 lubricating effect Effects 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 2
- 239000012956 1-hydroxycyclohexylphenyl-ketone Substances 0.000 claims description 2
- GJKGAPPUXSSCFI-UHFFFAOYSA-N 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone Chemical compound CC(C)(O)C(=O)C1=CC=C(OCCO)C=C1 GJKGAPPUXSSCFI-UHFFFAOYSA-N 0.000 claims description 2
- GTELLNMUWNJXMQ-UHFFFAOYSA-N 2-ethyl-2-(hydroxymethyl)propane-1,3-diol;prop-2-enoic acid Chemical class OC(=O)C=C.OC(=O)C=C.OC(=O)C=C.CCC(CO)(CO)CO GTELLNMUWNJXMQ-UHFFFAOYSA-N 0.000 claims description 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 2
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 claims description 2
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 claims description 2
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims description 2
- NDWUBGAGUCISDV-UHFFFAOYSA-N 4-hydroxybutyl prop-2-enoate Chemical compound OCCCCOC(=O)C=C NDWUBGAGUCISDV-UHFFFAOYSA-N 0.000 claims description 2
- FIHBHSQYSYVZQE-UHFFFAOYSA-N 6-prop-2-enoyloxyhexyl prop-2-enoate Chemical compound C=CC(=O)OCCCCCCOC(=O)C=C FIHBHSQYSYVZQE-UHFFFAOYSA-N 0.000 claims description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 2
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims description 2
- 239000012965 benzophenone Substances 0.000 claims description 2
- MQDJYUACMFCOFT-UHFFFAOYSA-N bis[2-(1-hydroxycyclohexyl)phenyl]methanone Chemical compound C=1C=CC=C(C(=O)C=2C(=CC=CC=2)C2(O)CCCCC2)C=1C1(O)CCCCC1 MQDJYUACMFCOFT-UHFFFAOYSA-N 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 abstract description 4
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 239000000178 monomer Substances 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- 238000003786 synthesis reaction Methods 0.000 abstract description 3
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 150000003951 lactams Chemical group 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000004506 ultrasonic cleaning Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/46—Polymerisation initiated by wave energy or particle radiation
- C08F2/48—Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
- C08F271/02—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00 on to polymers of monomers containing heterocyclic nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a hydrophilic coating special for a polyurethane medical catheter and a manufacturing method thereof, and particularly relates to the technical field of medical catheters, wherein the hydrophilic coating comprises 5-8% of hydrophilic lubricant, 1-3% of polyfunctional acrylate cross-linking agent, 3-5% of active diluent, 0.1-0.8% of photoinitiator and 83-90% of diluent, the hydrophilic lubricant is polyvinylpyrrolidone, the molecular content is 10-100 ten thousand, the preparation method of the hydrophilic coating is simple, all materials are added and stirred uniformly, the condition that the residues of monomers which do not participate in reaction in synthesis cause harm to people is prevented, the lubricity of the medical catheter is improved, and the pain of patients is reduced.
Description
Technical Field
The invention relates to the field of medical catheters, in particular to a hydrophilic coating special for a polyurethane medical catheter and a manufacturing method thereof.
Background
The polyurethane material has stable physical property, chemical property and biological safety property, and can be widely applied to various medical instruments as a medical catheter, and common products comprise a nasogastric tube and a PICC central venous catheter. When the material is used as an interventional catheter, because the surface of the material contains a large number of carbamate units, the polarity of the surface of the material is large, and macroscopically, the material has strong adsorbability on a human body, so that a large friction force is generated in the sliding process, mucous membrane damage in blood vessels or natural cavities is easily caused, infection is caused, and the pain of a patient is increased.
Disclosure of Invention
The invention aims to provide a hydrophilic coating special for a polyurethane medical catheter and a manufacturing method thereof, so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a hydrophilic coating special for a polyurethane medical catheter comprises 5-8% of hydrophilic lubricant, 1-3% of polyfunctional acrylate cross-linking agent, 3-5% of reactive diluent, 0.1-0.8% of photoinitiator and 83-90% of diluent, wherein the hydrophilic lubricant is polyvinylpyrrolidone, and the molecular content is 10-100 ten thousand.
Preferably, the multifunctional acrylate crosslinking agent is one or more of a difunctional crosslinking agent and a trifunctional crosslinking agent.
Preferably, the multifunctional acrylate crosslinking agent is one or more of ethylene glycol dimethacrylate, 1, 6-hexanediol diacrylate and ethoxylated trimethylolpropane triacrylate.
Preferably, the reactive diluent is one or more of 4-hydroxybutyl acrylate, hydroxypropyl methacrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate and hydroxyethyl acrylate.
Preferably, the photoinitiator is one or more of 2-hydroxy-4' - (2-hydroxyethoxy) -2-methyl propiophenone, 1-hydroxycyclohexyl phenyl ketone and benzophenone.
Preferably, the diluent is one or more of water, ethanol, isopropanol and N-methylpyrrolidone.
A manufacturing method of a hydrophilic coating special for a polyurethane medical catheter comprises the following steps:
s1, weighing 5-8% of hydrophilic lubricating matter, 1-3% of multifunctional acrylate cross-linking agent, 3-5% of reactive diluent, 0.1-0.8% of photoinitiator and 83-90% of diluent according to a proportion, pouring the mixture into a beaker, and stirring the mixture uniformly by using a glass rod in a light-tight environment;
s2, pouring the prepared hydrophilic coating solution into an opaque PE solution pipe, immersing the TPU catheter into the coating solution, and soaking for 10-60 s;
s3, pulling out the TPU catheter soaked in the S2, airing for 5-10min, removing redundant solution on the surface, and irradiating for 2-10min by using a 365nm wavelength LED ultraviolet light source;
s4, washing the manufactured hydrophilic coating catheter with a solution containing 0.1% sodium dodecyl benzene sulfonate for 10 minutes by ultrasonic waves, removing unreacted substances on the surface, washing the catheter with purified water, and airing the catheter at room temperature or drying the catheter for 30 minutes at 60 ℃.
Compared with the prior art, the invention has the beneficial effects that:
1. by utilizing the characteristic that-NH in a TPU carbamate unit is easy to dehydrogenize to form an active reaction point, a cross-linking agent is introduced into the surface, and the other end of the cross-linking agent is connected with polyvinylpyrrolidone (PVP) hydrophilic lubricating molecules, namely PVP-cross-linking agent-PVP are sequentially and alternately connected, so that linear PVP forms cross-linked mesh PVP. Because the PVP is fixed on the surface of the TPU through a chemical bond, the PVP is not easy to fall off in the using process;
2. the PVP molecule main chain side group has a large amount of lactam groups, and can form a large amount of hydrogen bonds with water to form hydrates, so that each molecule oleophylic main chain (lubricating property source) of the PVP is separated and expanded to form gel, namely, the lubricating hydrogel is formed on the surface of the catheter, and therefore, the friction force can be effectively reduced in the sliding process of the coated catheter in a human body;
3. the preparation method of the hydrophilic coating is simple, and only all materials are added and uniformly stirred, so that the monomer residues which do not participate in the reaction in the synthesis are prevented from causing harm to people.
Detailed Description
Examples
The materials are weighed according to the proportion and poured into a beaker, a glass rod is used for stirring uniformly in a dark environment, the prepared hydrophilic coating solution is poured into a lightproof PE solution tube, a TPU catheter is immersed in the coating solution for 10s, the TPU catheter is lifted out, air-dried for 10min, the redundant solution on the surface is removed, and an LED ultraviolet light source with the wavelength of 365nm is used for irradiating for 5 min. And washing the prepared hydrophilic coating catheter by using a solution containing 0.1% sodium dodecyl benzene sulfonate for ultrasonic cleaning for 10 minutes, removing unreacted substances on the surface, washing the catheter by using purified water, and airing the catheter at room temperature.
The prepared catheter is placed into a 37 ℃ water solution to be soaked for 60s, a friction tester is used, the holding force is 300g, the stretching speed is set to be 10mm/s, 25 times of repeated pulling are carried out, and the test data of each formula are as follows:
uncoated catheter friction average friction was about 400N.
The formula I is as follows: the average friction is 11N, and the friction coefficient is reduced by 97.25%;
and a second formula: the average friction is 9N, and the friction coefficient is reduced by 97.75 percent;
and a second formula: the average friction force is 6N, and the friction coefficient is reduced by 98.5 percent.
In general, the preparation method of the hydrophilic coating provided by the scheme is simple, and only all materials are required to be added and uniformly stirred, so that the monomer residues which do not participate in the reaction in the synthesis process are prevented from causing harm to people, the lubrication degree of the medical catheter is improved, and the pain of a patient is reduced.
Claims (7)
1. A special hydrophilic coating for a polyurethane medical catheter is characterized in that: the multifunctional acrylate water-based lubricant comprises 5-8% of a hydrophilic lubricant, 1-3% of a multifunctional acrylate cross-linking agent, 3-5% of an active diluent, 0.1-0.8% of a photoinitiator and 83-90% of a diluent, wherein the hydrophilic lubricant is polyvinylpyrrolidone, and the molecular content is 10-100 ten thousand.
2. The hydrophilic coating special for polyurethane medical catheters as claimed in claim 1, wherein: the multifunctional acrylate crosslinking agent is one or more of difunctional crosslinking agents and trifunctional crosslinking agents.
3. The hydrophilic coating special for polyurethane medical catheters as claimed in claim 3, wherein: the multifunctional acrylate crosslinking agent is one or more of ethylene glycol dimethacrylate, 1, 6-hexanediol diacrylate and ethoxylated trimethylolpropane triacrylate.
4. The hydrophilic coating special for polyurethane medical catheters as claimed in claim 1, wherein: the reactive diluent is one or more of 4-hydroxybutyl acrylate, hydroxypropyl methacrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate and hydroxyethyl acrylate.
5. The hydrophilic coating special for polyurethane medical catheters as claimed in claim 1, wherein: the photoinitiator is one or more of 2-hydroxy-4' - (2-hydroxyethoxy) -2-methyl propiophenone, 1-hydroxycyclohexyl phenyl ketone and benzophenone.
6. The hydrophilic coating special for polyurethane medical catheters as claimed in claim 1, wherein: the diluent is one or more of water, ethanol, isopropanol and N-methylpyrrolidone.
7. A manufacturing method of a hydrophilic coating special for a polyurethane medical catheter is characterized by comprising the following steps: the method comprises the following steps:
s1, weighing 5-8% of hydrophilic lubricating substance, 1-3% of multifunctional acrylate cross-linking agent, 3-5% of reactive diluent, 0.1-0.8% of photoinitiator and 83-90% of diluent according to a proportion, pouring the weighed materials into a beaker, and uniformly stirring the materials by using a glass rod in a light-proof environment;
s2, pouring the prepared hydrophilic coating solution into a lightproof PE solution tube, and soaking the TPU catheter into the coating solution for 10-60 s;
s3, pulling out the TPU catheter soaked in the S2, airing for 5-10min, removing redundant solution on the surface, and irradiating for 2-10min by using a 365nm wavelength LED ultraviolet light source;
s4, washing the prepared hydrophilic coating catheter with a solution containing 0.1% sodium dodecyl benzene sulfonate for 10 minutes by ultrasonic waves, removing unreacted substances on the surface, washing the catheter with purified water, and airing the catheter at room temperature or drying the catheter for 30 minutes at 60 ℃.
Priority Applications (1)
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CN202210804699.1A CN115089769A (en) | 2022-07-08 | 2022-07-08 | Hydrophilic coating special for polyurethane medical catheter and manufacturing method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN202210804699.1A CN115089769A (en) | 2022-07-08 | 2022-07-08 | Hydrophilic coating special for polyurethane medical catheter and manufacturing method thereof |
Publications (1)
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CN115089769A true CN115089769A (en) | 2022-09-23 |
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Family Applications (1)
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CN202210804699.1A Pending CN115089769A (en) | 2022-07-08 | 2022-07-08 | Hydrophilic coating special for polyurethane medical catheter and manufacturing method thereof |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4100309A (en) * | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
US20150018431A1 (en) * | 2013-07-15 | 2015-01-15 | Boston Scientific Scimed, Inc. | Lubricious Coating Compositions |
CN109966560A (en) * | 2019-03-13 | 2019-07-05 | 业聚医疗器械(深圳)有限公司 | A kind of medical catheter hydrophilic lubrication coating of photocuring and preparation method thereof |
CN110075364A (en) * | 2019-03-18 | 2019-08-02 | 科塞尔医疗科技(苏州)有限公司 | A kind of hydrophilic coating solution of interposing catheter and preparation method thereof and application method |
CN113786519A (en) * | 2021-10-11 | 2021-12-14 | 浙江海圣医疗器械股份有限公司 | Preparation method of photocuring hydrophilic coating |
-
2022
- 2022-07-08 CN CN202210804699.1A patent/CN115089769A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4100309A (en) * | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
US20150018431A1 (en) * | 2013-07-15 | 2015-01-15 | Boston Scientific Scimed, Inc. | Lubricious Coating Compositions |
CN109966560A (en) * | 2019-03-13 | 2019-07-05 | 业聚医疗器械(深圳)有限公司 | A kind of medical catheter hydrophilic lubrication coating of photocuring and preparation method thereof |
CN110075364A (en) * | 2019-03-18 | 2019-08-02 | 科塞尔医疗科技(苏州)有限公司 | A kind of hydrophilic coating solution of interposing catheter and preparation method thereof and application method |
CN113786519A (en) * | 2021-10-11 | 2021-12-14 | 浙江海圣医疗器械股份有限公司 | Preparation method of photocuring hydrophilic coating |
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