CN106178136A - A kind of medical hydrophilic antimicrobial coatings and preparation method thereof - Google Patents
A kind of medical hydrophilic antimicrobial coatings and preparation method thereof Download PDFInfo
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- CN106178136A CN106178136A CN201610610252.5A CN201610610252A CN106178136A CN 106178136 A CN106178136 A CN 106178136A CN 201610610252 A CN201610610252 A CN 201610610252A CN 106178136 A CN106178136 A CN 106178136A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/10—Inorganic materials
- A61L29/106—Inorganic materials other than carbon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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Abstract
The invention discloses a kind of medical hydrophilic antimicrobial coatings, described medical hydrophilic antimicrobial coatings mainly includes supportive polymer, hydrophilic polymer, antibacterial and cross-linking agent；Described supportive polymer is the Polyetherimide (PEI) containing 2 or more than 2 carboxyl functional groups；Described hydrophilic polymer is the one of which in the natural polymer containing hydrophilic group, synthetic macromolecular compound or blend both or copolymer；Described antibacterial is the one of which in inorganic antiseptic, organic antibacterial agent or natural antibacterial agent or two or more mixing.In order to prevent to implant or get involved infections relating, at implant or inserting surface-coated antimicrobial coating, wherein loading antibacterial, be effectively increased APTT clotting time, be effectively improved anticoagulation function, anti-tampon produces；Additionally, this coating also has extraordinary lubricant effect.
Description
Technical field
The present invention relates to a kind of coating and preparation method thereof, more specifically to a kind of doctor for medical apparatus surface
With hydrophilic antimicrobial coatings and preparation method thereof.
Background technology
Modern medicine is in the diagnosis and treatment process to patient, it is desirable to the injury causing patient body is minimum, advocates " noinvasive "
Or " few wound " diagnosis and treatment method.Interventional technique is to be stretched into internal by external by various conduits, and the affected part of patient is observed, examined
Disconnected, treatment.Therefore it has fully demonstrated " noinvasive ", the spirit of " few wound " diagnosis and treatment method, has greatly promoted clinical medical development.
The conduit getting involved human body must have good biocompatibility, and due to macromolecular material, to have nontoxic, no antigen etc. excellent
Performance, therefore it is widely applied interventional therapy field.When medical macromolecular materials surface contacts with tissue, complexity can be produced
Physics chemical action, now the composition of material surface and form play pivotal role.The various conduits used in intervention diagnosis and therapy
In addition to needing good blood compatibility and histocompatibility, it is necessary to the surface with lubrication is produced to reduce in insertion process
Life rubs, tissue adherence causes damage, the misery of increase patient.Lubricated surface is possible not only to reduce the absorption of protein, blood
Sticking of platelet, moreover it is possible to antibacterium is sticked, it is to avoid infecting and the generation of various complication of wound.
At present, the hydrophilic coating product for medical material of domestic production is little, and this product mostly is external monopolization.Conventional
In hydrophilic coating material many employings polyurethane of medical material, such as, the international publication number of the Coloplast of Denmark
Patent for WO2006/037321 discloses the medical device of a kind of hydrophilic coating with moistening, and it includes comprising hydrophilic gathering
The coating composition of compound and the wetting agent containing water with one or more lubricants.Wherein said hydrophilic polymer is to be selected from
WXTANE T5410 Tecophilic HP93A100, there is Tecogel, HydroMed D640 of the molecular weight of 500-2000
With the polyurethane of Hydroslip, but above-mentioned several polyurethane materials are patented product, price is high, therefore causes by it
Holding at high price of the hydrophilic coating of preparation, the ordinary consumer being unsuitable for domestic market uses.
Additionally, in patent application at home, the patent application of Application No. 200910067936.5 discloses one
Hydrophilic coating solution being applied to medical apparatus surface and preparation method thereof, this hydrophilic coating solution includes: as matrix polymerisations
The modified polyurethane dispersion liquid of thing, hydrophilic polymer and reactivity cross-linking agent.The advantage of this hydrophilic coating solution is based on water
Gonosome system, decreases the use of solvent, decreases the injury to environment and operator, and preparation method is simple, can be applicable to multiple
Medical apparatus surface, improves the lubricity of medical apparatus surface.But, owing to the surface of existing medical apparatus and instruments mostly is polyurethane
Or the hydrophobic material such as nylon, this aqueous coating solution is the best in the fastness of the attachment of equipment surfaces, thus affects it when using
Lubricant effect.
Getting involved or in implant surgery, easily by air, the disease such as patient or the staphylococcus of patient's body surface, bacillus pyocyaneus
Pathogenic microorganism brings operative site into, thus induces implant infections relating, infects and once occurs, will bring great pain to patient
Bitter.For medical coating research in terms of anti-microbial property, in domestic patent, the practicality of Application No. 200920305801.3 is new
Disclosing a kind of antibacterial hydrophilic coating catheter in type patent, its structure is to coat one layer successively at the outer surface of urethral catheterization body to resist
Bacterium layer and one layer of hydrophilic coating, wherein antimicrobial coating is the coating comprising the composition such as chitin or Chitosan-phospholipid complex, parent
Water coating is Polyethylene Glycol, polyvinylpyrrolidone or the coating of PVP-VA hydrophilic polymer.Logical
Crossing and coat antibiotic layer and hydrophilic layer successively at catheter outer surface, catheter is implanted when, hydrophilic coating provides self-lubricating
Effect so that catheter surface lubricates, and catheter can be made to implant very easily；After catheter is implanted, hydrophilic polymer is dissolved in
Expose antibiotic layer after water, play the antibacterial action of chitin and chitosan.But, this patent but has the biggest limitation,
On the one hand, its coating needs to carry out at twice, adds workload；On the other hand, antimicrobial coating must wait hydrophilic coating to be dissolved in
Its anti-microbial property of competence exertion after water, this makes the application of this coating have significant limitation.
Summary of the invention
For the deficiencies in the prior art, it is an object of the invention to a kind of have the antibacterial and medical coating of hydrophilic interaction and
Preparation method.
The present invention solves technical problem and be the technical scheme is that a kind of medical hydrophilic antimicrobial coatings, described medical parent
Water antimicrobial coating mainly includes supportive polymer, hydrophilic polymer, antibacterial and cross-linking agent；Described supportive polymer is
Polyetherimide (PEI) containing 2 or more than 2 carboxyl functional groups；Described hydrophilic polymer is containing hydrophilic group
One of which in natural polymer, synthetic macromolecular compound or blend both or copolymer；Described
Antibacterial is the one of which in inorganic antiseptic, organic antibacterial agent or natural antibacterial agent or two or more mixing.
Further, described inorganic antiseptic is zinc oxide, copper oxide, ammonium dihydrogen phosphate, lithium carbonate, nanometer silver or silver
Ion.
Further, described organic antibacterial agent is anilid class, imidazoles, thiazoles, isothiazolone derivative, season
Ammonium salt class, double croak class, phenols, vanillin or ethyl vanillin aldehyde compound.
Further, described natural antibacterial agent is chitosan, chitosan quaternary amine, mustard, Oleum Ricini or Wasabia japonic (Euterma Wasabi).
Further, described cross-linking agent is N, N'-dicyclohexylcarbodiimide, nitrogen pyridine, carbodiimide, 1-(3-bis-
Methylaminopropyl)-3-ethyl-carbodiimide hydrochloride, Thienopyridines hydrazide derivatives.
Further, described hydrophilic polymer includes poly-lactam, polyvinyl alcohol, polyvinylether, maleic acid anhydride group
Copolymer, polyvinylamine, polymine, poly(ethylene oxide), poly-(carboxylic acid), polyamide, cellulose, heparin, dextrose
One of which in acid anhydride, polypeptide, polysaccharide, polyester or two or more mixing.
Further, described poly-lactam is polyvinyl pyrrolidone (PVP), and described cellulose is Methyl cellulose
Element, carboxymethyl cellulose, hydroxymethyl cellulose or hydroxypropyl cellulose, described polypeptide is collagen, fibrin or elastic egg
In vain, described polysaccharide is hyaluronic acid, alginic acid, gelatin or chitin, and described polyester is polylactide, PGA or poly-own interior
Ester.
Further, in parts by weight, in described medical hydrophilic antimicrobial coatings, the content of each component is: supportive is polymerized
Thing 1～30%, antibacterial 30～50%, hydrophilic polymer 20～40%, cross-linking agent 0～10%.
The preparation method of a kind of medical hydrophilic antimicrobial coatings, described preparation method mainly includes herein below: by supportive
Polymer, antibacterial, hydrophilic polymer and cross-linking agent obtain coating solution after mixing homogeneously with appropriate solvent by proportioning, by upper
State coating solution coating to thing surface to be coated；Being dried with ultraviolet radiation, thing surface to be coated just forms institute fully after drying
The hydrophilic antimicrobial coatings stated.
Further, described solvent is water, ethanol, isopropanol, ethyl acetate, chloroform, trichloro ethylene, dichloromethane, just
The mixing of one or more in hexane, heptane, toluene.
The invention has the beneficial effects as follows: in order to prevent to implant or get involved infections relating, at implant or inserting table
Topcoating covers antimicrobial coating, wherein loads antibacterial, effective bacteria growing inhibiting, prevents window from infecting, and is effectively increased APTT and coagulates
The blood time, being effectively improved anticoagulation function, anti-tampon produces；Additionally, this coating also has extraordinary lubricant effect.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
A kind of medical hydrophilic antimicrobial coatings, described medical hydrophilic antimicrobial coatings mainly includes supportive polymer, hydrophilic polymer
Thing, antibacterial and cross-linking agent；Described supportive polymer is the Polyetherimide containing 2 or more than 2 carboxyl functional groups
(PEI), molecular weight is 50000-1000000；Described hydrophilic polymer is polyvinyl pyrrolidone (PVP)；Described antibacterial
Agent is zinc oxide；Described cross-linking agent is N, N'-dicyclohexylcarbodiimide.
In described medical hydrophilic antimicrobial coatings, the content of each component is: supportive polymer 20%, antibacterial 40%, hydrophilic
Polymer 35%, cross-linking agent 5%.
The preparation method of a kind of medical hydrophilic antimicrobial coatings, described preparation method mainly includes herein below: divide by quality
Number meter, after mixing homogeneously 20% supportive polymer, 40% antibacterial, 35% hydrophilic polymer and 5% cross-linking agent with suitable quantity of water
Obtain coating solution, by the coating of above-mentioned coating solution to thing surface to be coated；Being dried with ultraviolet radiation, thing surface to be coated is filled
Divide and just form described hydrophilic antimicrobial coatings after drying.
Sample is carried out antibacterial ring test, chooses escherichia coli, it is judged that standard: inhibition zone diameter ＞ 7mm, have antibacterial work
With, repeating to test for 3 times all has bacteriostasis, and for effectively, negative control group produces without antibacterial ring.
Table 1 product is to colibacillary fungistatic effect
Embodiment 2
A kind of medical hydrophilic antimicrobial coatings, described medical hydrophilic antimicrobial coatings mainly includes supportive polymer, hydrophilic polymer
Thing, antibacterial and cross-linking agent；Described supportive polymer is the Polyetherimide containing 2 or more than 2 carboxyl functional groups
(PEI), molecular weight is 50000-1000000；Described hydrophilic polymer is poly-methylcellulose；Described antibacterial is acyl group benzene
Aminated compounds；Described cross-linking agent is carbodiimide.
In described medical hydrophilic antimicrobial coatings, the content of each component is: supportive polymer 20%, antibacterial 40%, hydrophilic
Polymer 35%, cross-linking agent 5%.
The preparation method of a kind of medical hydrophilic antimicrobial coatings, described preparation method mainly includes herein below: divide by quality
Number meter, mixs homogeneously 20% supportive polymer, 35% antibacterial, 40% hydrophilic polymer and 5% cross-linking agent with ethanol in proper amount
After obtain coating solution, by the coating of above-mentioned coating solution to thing surface to be coated；It is dried with ultraviolet radiation, thing surface to be coated
Fully just form described hydrophilic antimicrobial coatings after drying.
Sample is carried out antibacterial ring test, chooses staphylococcus aureus, it is judged that standard: inhibition zone diameter ＞ 7mm, have and press down
Bacterium effect, repeating to test for 3 times all has bacteriostasis, and for effectively, negative control group produces without antibacterial ring.
Table 2 product fungistatic effect to staphylococcus aureus
Embodiment 3
A kind of medical hydrophilic antimicrobial coatings, described medical hydrophilic antimicrobial coatings mainly includes supportive polymer, hydrophilic polymer
Thing, antibacterial and cross-linking agent；Described supportive polymer is the Polyetherimide containing 2 or more than 2 carboxyl functional groups
(PEI), molecular weight is 50000-1000000；Described hydrophilic polymer is polyvinyl alcohol；Described antibacterial is chitosan；Institute
The cross-linking agent stated is N, N'-dicyclohexylcarbodiimide.
In described medical hydrophilic antimicrobial coatings, the content of each component is: supportive polymer 25%, antibacterial 30%, hydrophilic
Polymer 40%, cross-linking agent 5%.
The preparation method of a kind of medical hydrophilic antimicrobial coatings, described preparation method mainly includes herein below: divide by quality
Number meter, mixs homogeneously 25% supportive polymer, 30% antibacterial, 40% hydrophilic polymer and 5% cross-linking agent with ethanol in proper amount
After obtain coating solution, by the coating of above-mentioned coating solution to thing surface to be coated；It is dried with ultraviolet radiation, thing surface to be coated
Fully just form described hydrophilic antimicrobial coatings after drying.
Sample is carried out antibacterial ring test, chooses escherichia coli, it is judged that standard: inhibition zone diameter ＞ 7mm, have antibacterial work
With, repeating to test for 3 times all has bacteriostasis, and for effectively, negative control group produces without antibacterial ring.
Table 3 product fungistatic effect to staphylococcus aureus
Embodiment of above is merely to illustrate the present invention, and not limitation of the present invention, about the ordinary skill of technical field
Personnel, without departing from the spirit and scope of the present invention, it is also possible to make a variety of changes and modification, the most all equivalents
Technical scheme fall within scope of the invention, the scope of patent protection of the present invention should be defined by the claims.
Claims (10)
1. a medical hydrophilic antimicrobial coatings, it is characterised in that: described medical hydrophilic antimicrobial coatings mainly includes that supportive is polymerized
Thing, hydrophilic polymer, antibacterial and cross-linking agent；Described supportive polymer is containing 2 or more than 2 carboxyl functional groups
Polyetherimide (PEI)；Described hydrophilic polymer is the natural polymer containing hydrophilic group, synthesis producing high-molecular
One of which in compound or blend both or copolymer；Described antibacterial is inorganic antiseptic, organic antibacterial agent
Or the one of which in natural antibacterial agent or two or more mixing.
A kind of medical hydrophilic antimicrobial coatings the most as claimed in claim 1, it is characterised in that: described inorganic antiseptic is oxidation
Zinc, copper oxide, ammonium dihydrogen phosphate, lithium carbonate, nanometer silver or silver ion.
A kind of medical hydrophilic antimicrobial coatings the most as claimed in claim 1, it is characterised in that: described organic antibacterial agent is acyl group
Phenyl amines, imidazoles, thiazoles, isothiazolone derivative, quaternary ammonium salt, double croak class, phenols, vanillin or ethyl vanillin aldehydes
Compound.
A kind of medical hydrophilic antimicrobial coatings the most as claimed in claim 1, it is characterised in that: described natural antibacterial agent is that shell gathers
Sugar, chitosan quaternary amine, mustard, Oleum Ricini or Wasabia japonic (Euterma Wasabi).
A kind of medical hydrophilic antimicrobial coatings the most as claimed in claim 1, it is characterised in that: described cross-linking agent is N, N'-bis-
Carbodicyclo hexylimide, nitrogen pyridine, carbodiimide, 1-(3-dimethylamino-propyl)-3-ethyl-carbodiimide hydrochloride, thieno
Pyridines hydrazide derivatives.
A kind of medical hydrophilic antimicrobial coatings the most as claimed in claim 1, it is characterised in that: described hydrophilic polymer includes
Poly-lactam, polyvinyl alcohol, polyvinylether, maleic anhydride base co-polymer, polyvinylamine, polymine, poly(ethylene oxide),
One of which or two or more in poly-(carboxylic acid), polyamide, cellulose, heparin, dextran, polypeptide, polysaccharide, polyester
Mixing.
A kind of medical hydrophilic antimicrobial coatings the most as claimed in claim 6, it is characterised in that: described poly-lactam is polyvinyl
Ketopyrrolidine (PVP), described cellulose is methylcellulose, carboxymethyl cellulose, hydroxymethyl cellulose or hydroxypropyl cellulose,
Described polypeptide is collagen, fibrin or elastin laminin, and described polysaccharide is hyaluronic acid, alginic acid, gelatin or chitin, institute
Stating polyester is polylactide, PGA or polycaprolactone.
A kind of medical hydrophilic antimicrobial coatings the most as claimed in any of claims 1 to 7 in one of claims, it is characterised in that: divide by quality
Number meter, in described medical hydrophilic antimicrobial coatings, the content of each component is: supportive polymer 1～30%, antibacterial 30～50%, parent
Waterborne polymeric 20～40%, cross-linking agent 0～10%.
9. the preparation method of a medical hydrophilic antimicrobial coatings as claimed in claim 8, it is characterised in that described preparation method
Mainly include herein below: supportive polymer, antibacterial, hydrophilic polymer and cross-linking agent are mixed with appropriate solvent by proportioning
Coating solution is obtained, by the coating of above-mentioned coating solution to thing surface to be coated after closing uniformly；It is dried with ultraviolet radiation, to be coated
Thing surface just forms described hydrophilic antimicrobial coatings fully after drying.
The preparation method of a kind of medical hydrophilic antimicrobial coatings the most as claimed in claim 9, it is characterised in that: described solvent is
One or more in water, ethanol, isopropanol, ethyl acetate, chloroform, trichloro ethylene, dichloromethane, normal hexane, heptane, toluene
Mixing.
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| CN107158485A (en) * | 2017-05-25 | 2017-09-15 | 苏州睿研纳米医学科技有限公司 | Antibiont, extracellular matrix stick coating and preparation method and application |
| CN107233227A (en) * | 2017-06-20 | 2017-10-10 | 青岛金典生化器材有限公司 | A kind of theanine is modified the preparation method of fish scale protein facial mask |
| CN107260572A (en) * | 2017-06-20 | 2017-10-20 | 青岛金典生化器材有限公司 | A kind of antibacterial fish scale protein facial mask and preparation method thereof |
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| CN115387116A (en) * | 2022-09-02 | 2022-11-25 | 浙江技立新材料股份有限公司 | Biological antibacterial dyeing nanofiber membrane and preparation method thereof |
| CN116004098A (en) * | 2023-01-09 | 2023-04-25 | 上海市徐汇区牙病防治所 | Inner wall coating of waterway pipeline of stomatology treatment table, and preparation method and application thereof |
| CN117442791A (en) * | 2023-12-22 | 2024-01-26 | 比尔安达(上海)润滑材料有限公司 | Preparation method of bending-resistant antibacterial hydrophilic coating of medical catheter and hydrophilic coating obtained by method |
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