CN107412883A - A kind of hydrophilic superslide coating for medical apparatus surface and preparation method thereof - Google Patents
A kind of hydrophilic superslide coating for medical apparatus surface and preparation method thereof Download PDFInfo
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- CN107412883A CN107412883A CN201710284736.XA CN201710284736A CN107412883A CN 107412883 A CN107412883 A CN 107412883A CN 201710284736 A CN201710284736 A CN 201710284736A CN 107412883 A CN107412883 A CN 107412883A
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- hydrophilic
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- subbing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Abstract
The present invention provides a kind of hydrophilic superslide coating for medical apparatus surface and preparation method thereof, the hydrophilic superslide coating includes bottom and surface layer, utilize the principle of similar compatibility, by bottom and base material strong bonded, the chemical bond and intermolecular force formed using uv photo initiated grafting, surface layer is firmly connected with bottom.Using the technology of Best-Effort request, medical apparatus surface is first impregnated in bottom solution, carried out using ultraviolet radiation partially cured；The medicine equipment of partially cured bottom is impregnated in investment precoat again, after being fully cured under ultraviolet light, surface layer uniformly, stable be distributed on bottom.The hydrophilic superslide coating of the present invention under ultraviolet light can rapid curing, obtained hydrophilic coating has excellent lubricity and persistence, it can effectively reduce and friction and the damage to tissue are produced in insertion process, and the hydrophilic superslide coating material is easy to get, is cheap.
Description
Technical field
The invention belongs to medical instruments field, is related to a kind of hydrophilic superslide coating and preparation method thereof.
Background technology
Interventional medicine is a kind of low wound or minimal invasive techniques, has formd the three big clinical medicine arranged side by side with surgery, internal medicine
One of, and image documentation equipment and intervention apparatus are the pillars of interventional medicine.
Lubricity is one of intervention apparatus (conduit, seal wire) highly important performance.When inserting or pull out human body, it is desirable to this
A little equipment surfaces have lubricity, to reduce damage and adhesion to tissue, mitigate patient's pain.There is two ways solution at present
The problem of lubricity, one kind is to use lubricating oil, but the lubricity that this processing method obtains is poor, it is lasting and unfavorable to be difficult to
In operation.A kind of is to form one layer of hydrophilic coating with lubricity in equipment surfaces.
Because intervention apparatus is moved and stayed for some time in vivo, therefore, the hydrophilic coating on intervention apparatus must be taken into account
Hydrophilic lubrication performance and stability, i.e. coating will not fallen off after rubbing repeatedly, maintain good combination property.It is generally logical
Certain fixation can be played to hydrophilic compounds by crossing the means such as chemical key connection or physical entanglement, and such technology is also gradual
It is widely used.
Domestic at present very few to the hydrophilic superslide coating product for medical apparatus surface, the product is mostly external monopolization.
The content of the invention
The problem of existing for prior art, the present invention provide a kind of hydrophilic superslide coating for medical apparatus surface and
Its preparation method.
The technical scheme is that：A kind of hydrophilic superslide coating includes bottom and surface layer, passes through chemical bond between two layers
Connected with intermolecular force.The bottom is cross-linked network structure, is the articulamentum that bonding cross-linking point is provided for surface layer, by curing
Treat equipment surfaces and be impregnated in subbing, solidify to obtain by ultraviolet light.The surface layer is hydrophilic layer, is with interpenetrating networks knot
The hydrogel coating of structure, investment precoat is impregnated in by the medical apparatus surface for scribbling bottom, solidifies to obtain by ultraviolet light.Bottom
The principle strong bonded of similar compatibility is utilized between base material.
Described subbing is by urethane acrylate, reactive diluent, the first light trigger and the first organic solvent
Composition.The mass ratio of urethane acrylate and reactive diluent is 1:0.1-10, the first light trigger solidify for subbing
The 2%-8% of gross mass afterwards, the quality of the first organic solvent are the 70%-99% of subbing gross mass.
Described investment precoat by can be carried out with two and the above functional group of photopolymerization monomer and/or polymer,
The hydrophilic polymer of biocompatibility, the second light trigger and the second organic solvent composition.Monomer and/or polymerization with functional group
The mass ratio of the hydrophilic polymer of thing and biocompatibility is 1:0.1-10, the second light trigger are total matter after investment precoat solidification
The 0.5%-5% of amount, the quality of the second organic solvent are the 60%-99% of investment precoat gross mass.
The preparation method of above-mentioned hydrophilic superslide coating, comprises the following steps：
The first step, prepare subbing
1.1) polyurethane acrylate prepolymer is prepared
Method one：Under mechanical stirring, diisocyanate and acrylic acid hydroxyl ester are added into reactor, at 15-60 DEG C
2-24h is reacted, obtains intermediate；60-90 DEG C is warming up to again, polyethers/ester dihydric alcohol, octoate catalyst stannous is added, in octanoic acid
1-24h is reacted in the presence of stannous, obtains polyurethane acrylate prepolymer.
Method two：Under mechanical stirring, diisocyanate and polyethers/ester dihydric alcohol are added into reactor, at 60-90 DEG C
Lower reaction 1-24h, obtains intermediate；15-60 DEG C is cooled to again, adds acrylic acid hydroxyl ester, octoate catalyst stannous, sad sub-
2-24h is reacted in the presence of tin, obtains polyurethane acrylate prepolymer.
Diisocyanate described in two methods includes：2,4 toluene diisocyanate, isoflurane chalcone diisocyanate,
One kind in hexa-methylene -1,6- diisocyanate, methyl diphenylene diisocyanate.Described acrylic acid hydroxyl ester includes：(first
Base) hydroxy-ethyl acrylate, (methyl) hydroxypropyl acrylate, the one or more in (methyl) hy-droxybutyl.Described is poly-
Ether/ester dihydric alcohol includes：Polyethylene glycol, polypropylene glycol, polytetrahydrofuran diol, PCDL, polycaprolactone binary
One or more in alcohol, number-average molecular weight is in the range of 200-200000.
1.2) polyurethane acrylate prepolymer, reactive diluent and the first light trigger are dissolved in the first organic solvent
In, at room temperature, formation viscosity is 1-10mm after lucifuge stirs 1~2h2/ s transparent homogeneous bottom solution, produce bottom painting
Material.Described urethane acrylate and the mass ratio of reactive diluent are
1:(0.1-10)；First light trigger is the 2%-8% of gross mass after subbing solidification, the first organic solvent
Quality is the 70%-99% of subbing gross mass.
Described reactive diluent has been selected from tri (propylene glycol) diacrylate, polyethyleneglycol diacrylate, 1,6-
Omega-diol diacrylate, pentaerythritol triacrylate, the one or more of tetramethylol methane tetraacrylate.Described first
Organic solvent is selected from more than one or both of water, ethanol, isopropanol, acetone, butanone, ethyl acetate.The first described light
Initiator is selected from 2- hydroxyls -4 ' (2- hydroxy ethoxies) -2- methyl phenyl ketones (Irgacure 2959), 1- hydroxyls cyclohexyl phenyl third
Ketone (Irgacure 184), 2-hydroxyl-2-methyl-1-phenylacetone (Irgacure 1173), 2- methyl isophthalic acids-[4- (methylthio phenyls
Base) -2 morpholinyl -1- acetone] (Irgacure 907), 2- phenyl benzyl -2- dimethyl amines -1- (4- morpholine benzyls phenyl) butanone
In (Irgacure 369), phenyl double (2,4,6- trimethylbenzoyls) phosphine oxide (Irgacure 819), benzophenone etc.
One or more.
Second step, prepare investment precoat
To can be carried out with two or more the functional group of photopolymerization monomer and/or polymer, biocompatibility it is hydrophilic
Polymer, the second light trigger are dissolved in the second organic solvent, and at room temperature, formation viscosity is 17- after lucifuge stirs 1~2h
55mm2/ s transparent homogeneous surface layer solution, that is, obtain investment precoat.The monomer and/or polymer of described band functional group with
The mass ratio of the hydrophilic polymer of biocompatibility is 1:(0.1-10), the second light trigger are gross mass after investment precoat solidification
0.5%-5%, the quality of the second organic solvent is the 60%-99% of investment precoat gross mass.
The monomer and/or polymer of the described functional group that photopolymerization can be carried out with two or more are selected from undersaturated ester
Class and undersaturated ethers such as tri (propylene glycol) diacrylate, polyethyleneglycol diacrylate, 1,6- hexylene glycol dipropyls
Olefin(e) acid ester, pentaerythritol triacrylate, tetramethylol methane tetraacrylate.The hydrophilic polymer of described biocompatibility be selected from
Polyvinylpyrrolidone, polyvinyl alcohol, polyurethane, polyethylene glycol, Sodium Polyacrylate, polyacrylamide, polyacrylic acid-acryloyl
It is more than one or both of amine moiety sodium salt, starch, cellulose, alginic acid, hyaluronic acid, chitosan, collagen；Hydrophilic polymeric
The number-average molecular weight of thing is in the range of 2000-5000000.The second described organic solvent be selected from water, ethanol, isopropanol, acetone,
It is more than one or both of butanone, ethyl acetate.The second described light trigger be selected from 2- hydroxyls -4 ' (2- hydroxy ethoxies) -
2- methyl phenyl ketones (Irgacure 2959), 1- hydroxyl cyclohexyl benzene benzylacetones (Irgacure 184), the methyl isophthalic acid of 2- hydroxyls-2-
Phenylacetone (Irgacure 1173), 2- methyl isophthalic acids-[morpholinyl -1- acetone of 4- (methyl mercapto phenyl) -2] (Irgacure
907), double (the 2,4,6- front threes of 2- phenyl benzyl -2- dimethyl amines -1- (4- morpholine benzyls phenyl) butanone (Irgacure 369), phenyl
Base benzoyl) it is more than one or both of phosphine oxide (Irgacure 819), benzophenone etc..
3rd step, prepare hydrophilic superslide coating
Subbing is coated on medical apparatus surface, 1~60s of ultraviolet radiation, in Medical treatment device after subbing solidification
Tool surface forms bottom, then by investment precoat coated on bottom, 60~360s of ultraviolet radiation, investment precoat solidifies,
Medical apparatus surface forms hydrophilic superslide coating.Uv energy density is 10mw/cm2~120mw/cm2。
Described coating method is dipping-lifting mode, and dip time is 1-30s, and pull rate is 5-150mm/
min.Described bottom and surface layer are solidified by the way of rotation, rotary speed 3-60rpm/min.
Beneficial effects of the present invention are：
Hydrophilic superslide coating of the present invention and preparation method thereof, by building double-deck (bottom and surface layer) coating system, bottom
Layer is used as intermediate connecting layer, is on the one hand firmly attached to by active force caused by similar compatibility on base material, is on the one hand face
Layer provides bonding cross-linking point.And again due to containing same composition in subbing and investment precoat so that two layers because of phase patibhaga-nimitta
Intermolecular force hold and caused combines more firm.So that hydrophilic coating both has excellent hydrophilic lubrication performance simultaneously
There is excellent adhesive force again.
The present invention utilizes ultra-violet curing technology, can will foreshorten to a few minutes hardening time, production efficiency is greatly increased, had
Beneficial to reduction production cost.
The present invention is one layer of transparent membrane in dry state, is easy to pack and stores.
Embodiment
In order that technical scheme and advantage are more clearly understood, it is further described below by way of example,
But the limitation to this patent is not indicated that.
Prepare embodiment
Prepare polyurethane acrylate prepolymer 1
10.45g 2,4 toluene diisocyanate and 30g PolyTHF 1000 (number-average molecular weight 1000) are added
Enter in reactor, obtain intermediate after 60 DEG C of mechanic whirl-nett reaction 4h, be cooled to 40 DEG C, add 7.69g (methyl) acrylic acid
The stannous octoate of hydroxy butyl ester and 0.077g, 3h is reacted, obtains polyurethane acrylate prepolymer 1.
Prepare polyurethane acrylate prepolymer 2
10.45g 2,4- toluene di-isocyanate(TDI)s and 7.69g (methyl) hy-droxybutyl are added in reactor,
Intermediate pre-polymer is obtained after 40 DEG C of mechanical agitation 3h, is warming up to 60 DEG C, adds the 60g (number-average molecular weight of PolyTHF 2000
For the 2000) stannous octoate with 0.077g, 6h is reacted, obtains polyurethane acrylate prepolymer 2.
Prepare polyurethane acrylate prepolymer 3
13.34g isoflurane chalcone diisocyanate and 60g polyethylene glycol 2000 are added in reactor, 60 DEG C of machineries
Intermediate pre-polymer is obtained after stirring 6h, 40 DEG C is cooled to, adds 7.809g hydroxyethyl methacrylate and 0.078g octanoic acid
Stannous, 3h is reacted, obtains polyurethane acrylate prepolymer 3.
Prepare polyurethane acrylate prepolymer 4
13.34g g isoflurane chalcone diisocyanate and 30g cetomacrogol 1000 are added in reactor, 60 DEG C of machines
Tool stirring 4h after obtain intermediate pre-polymer, be cooled to 40 DEG C, add 7.809g hydroxyethyl methacrylate and 0.078g it is pungent
Sour stannous, 3h is reacted, obtains polyurethane acrylate prepolymer 4.
Example 1 below -3 is using the urethane acrylate for preparing to prepare in embodiment as reaction raw materials.
Embodiment 1
(1) (it is 1000 by number-average molecular weight by polyurethane acrylate prepolymer 1, polyethylene glycol dipropionate 1000
Polyethylene glycol blocks to obtain), Irgacure 2959 be dissolved in the in the mixed solvent of ethanol and deionized water, room temperature lucifuge stirring 1-
2h, obtain subbing；The mass ratio of wherein urethane acrylate and polyethylene glycol dipropionate 1000 is 2:1,
Irgacure 2959 accounts for 5% of gross mass after subbing solidifies, and ethanol accounts for the 94% of subbing quality with water.
By polyethyleneglycol diacrylate 1000, PEG 20000 (number-average molecular weight 20000), Irgacure
2959 are dissolved in deionized water, room temperature lucifuge stirring 1-2h, obtain investment precoat；Wherein polyethyleneglycol diacrylate 1000 with
PEG 20000 mass ratio is 1:4, light trigger is 3% of gross mass after investment precoat solidifies, and deionized water accounts for surface layer painting
The 80% of material.
(2) subbing is coated on medical apparatus surface, ultraviolet radiation 10s, afterwards by investment precoat coated in solid
On bottom after change, ultra-violet curing 300s.Required coating can be obtained in medical apparatus surface.
Lubricity is tested：The medicine equipment for scribbling hydrophilic coating is placed on the universal testing machine of self-control repacking, one end is solid
It is scheduled on and applies in the fixture for accommodating power, one end is connected with sensor, is tested at room temperature, and blessing power is 5N, and tested media is
Water.Contrasted with uncoated sample, the difference size of friction value reflects the hydrophilic lubrication performance of hydrophilic coating.
Persistence is tested：Be repeatedly detected greasy property, the reappearance of frictional force reflect hydrophilic coating enduring quality and
Anti-wear performance.
Test result shows：After medical apparatus surface in this embodiment prepares hydrophilic coating, frictional force amplitude reduces
More than 95%, illustrate that the coating has excellent lubricity, repeatedly after friction, frictional force amount of decrease illustrates the painting still greater than 95%
Layer has excellent persistence and wearability.
Embodiment 2
(1) polyurethane acrylate prepolymer 2, tetramethylol methane tetraacrylate, benzophenone are dissolved in ethanol, room temperature
Lucifuge stirs 1-2h, obtains subbing；Wherein the mass ratio of urethane acrylate and tetramethylol methane tetraacrylate is 1:
1, light trigger is 5% of gross mass after subbing solidifies, and ethanol accounts for the 85% of subbing quality.
By tetramethylol methane tetraacrylate, PVP K30 (number-average molecular weight 45000-58000), hexichol
Ketone, Irgacure 1173 are dissolved in ionized water, room temperature lucifuge stirring 1-2h, obtain investment precoat；Wherein pentaerythrite 4 third
Olefin(e) acid ester is 3 with polyvinylpyrrolidone mass ratio:1, deionized water accounts for the 85% of investment precoat.
(2) subbing is coated on medical apparatus surface, ultraviolet radiation 20s, afterwards by investment precoat coated in solid
On bottom after change, ultra-violet curing 320s.Required coating can be obtained in medical apparatus surface.
Lubricity and persistence method of testing are identical with embodiment 1 in this example, and test result shows：This embodiment
In medical apparatus surface prepare hydrophilic coating after, frictional force amplitude reduce more than 95%, illustrate that the coating has excellent profit
Slip, repeatedly after friction, frictional force amount of decrease illustrates that the coating has excellent persistence and wearability still greater than 95%.
Embodiment 3
(1) polyurethane acrylate prepolymer 3, polyethyleneglycol diacrylate 600, benzophenone are dissolved in ethanol,
Room temperature lucifuge stirs 1-2h, obtains subbing；The wherein quality of urethane acrylate and polyethyleneglycol diacrylate 600
Than for 1:1, benzophenone is 4% after subbing solidification, and ethanol accounts for the 75% of subbing quality.
Polyethyleneglycol diacrylate 600, polyacrylic acid-acrylamide partial sodium salt, benzophenone are dissolved in ionized water
In alcohol mixed solvent, room temperature lucifuge stirring 1-2h, investment precoat is obtained；Wherein polyethyleneglycol diacrylate 600 is with gathering
Acrylic acid-acrylamide partial sodium salt mass ratio is 1:4, light trigger is 4% of gross mass after investment precoat solidification, deionization
Water and ethanol account for the 93% of investment precoat, and the mass ratio of deionized water and ethanol is 1:1.
The wherein production for polyacrylic acid-acrylamide partial sodium salt is Sigma-Aldrich, number-average molecular weight is 150000
Product.
(2) subbing is coated on medical apparatus surface, ultraviolet radiation 15s, afterwards by investment precoat coated in solid
On bottom after change, ultra-violet curing 360s.Required coating can be obtained in medical apparatus surface.
Lubricity and persistence method of testing are identical with embodiment 1 in this example, and test result shows：This embodiment
In medical apparatus surface prepare hydrophilic coating after, frictional force amplitude reduce more than 95%, illustrate that the coating has excellent profit
Slip, repeatedly after friction, frictional force amount of decrease illustrates that the coating has excellent persistence and wearability still greater than 95%.
Claims (10)
- A kind of 1. hydrophilic superslide coating for medical apparatus surface, it is characterised in that the hydrophilic superslide coating include bottom and Surface layer, the chemical bond formed by ultraviolet radiation graft between two layers connect with intermolecular force；The bottom is cross-linked network Structure, for providing the articulamentum of bonding cross-linking point for surface layer, subbing is impregnated in by medical apparatus surface, passes through ultraviolet light Solidification obtains；The surface layer is hydrophilic layer, is the hydrogel coating with inierpeneirating network structure, by the medicine equipment for scribbling bottom Surface is impregnated in investment precoat, solidifies to obtain by ultraviolet light；Described subbing is made up of urethane acrylate, reactive diluent, the first light trigger and the first organic solvent；Described investment precoat is by that can carry out the monomer and/or polymer, biology of the functional group of photopolymerization with two and the above The hydrophilic polymer of compatibility, the second light trigger and the second organic solvent composition.
- A kind of 2. hydrophilic superslide coating for medical apparatus surface according to claim 1, it is characterised in that the bottom Coating viscosity is 1-10mm2The mass ratio of/s, described urethane acrylate and reactive diluent is 1:0.1-10, first Light trigger is the 2%-8% of gross mass after subbing solidification, and the quality of organic solvent is the 70%- of subbing gross mass 99%.
- 3. a kind of hydrophilic superslide coating for medical apparatus surface according to claim 2, it is characterised in that described Investment precoat viscosity is 17-55mm2/ s, the monomer and/or polymer of described band functional group and the hydrophilic of biocompatibility gather The mass ratio of compound is 1:0.1-10, the second light trigger are the 0.5%-5% of gross mass after investment precoat solidification, and second is organic The quality of solvent is the 60%-99% of investment precoat gross mass.
- A kind of 4. preparation method of the hydrophilic superslide coating described in claim 3, it is characterised in that following steps：The first step, prepare subbing1.1) polyurethane acrylate prepolymer is preparedMethod one：After diisocyanate and acrylic acid hydroxyl ester are well mixed, 2-24h is reacted under the conditions of 15-60 DEG C, obtains centre Body；60-90 DEG C is warming up to again, adds polyethers/ester dihydric alcohol, octoate catalyst stannous, and polyurethane propylene is obtained after reacting 1-24h Acid esters prepolymer；Method two：Diisocyanate and polyethers/ester dihydric alcohol, react 1-24h at 60-90 DEG C, obtain intermediate；It is cooled to again 15-60 DEG C, acrylic acid hydroxyl ester, octoate catalyst stannous are added, polyurethane acrylate prepolymer is obtained after reacting 2-24h；1.2) polyurethane acrylate prepolymer, reactive diluent and the first light trigger are dissolved in the first organic solvent, room Under temperature, lucifuge forms bottom solution after stirring 1~2h, produces subbing；Described urethane acrylate and activity are dilute The mass ratio for releasing agent is 1:0.1-10；First light trigger is the 2%-8% of gross mass after subbing solidification, and first is organic molten The quality of agent is the 70%-99% of subbing gross mass；Second step, prepare investment precoatThe monomer and/or polymer, the hydrophilic polymeric of biocompatibility of the functional group of photopolymerization will can be carried out with two or more Thing, the second light trigger are dissolved in the second organic solvent, and at room temperature, lucifuge forms surface layer solution after stirring 1~2h, that is, obtains face Coating；The monomer of described band functional group and/or the mass ratio of the hydrophilic polymer of polymer and biocompatibility are 1: 0.1-10, the second light trigger are the 0.5%-5% of gross mass after investment precoat solidification, and the quality of the second organic solvent is surface layer The 60%-99% of coating gross mass；The monomer and/or polymer of the described functional group that photopolymerization can be carried out with two or more be selected from undersaturated esters and Undersaturated ethers such as tri (propylene glycol) diacrylate, polyethyleneglycol diacrylate, 1,6- hexanediyls Ester, pentaerythritol triacrylate, tetramethylol methane tetraacrylate；3rd step, prepare hydrophilic superslide coatingSubbing is coated on medical apparatus surface, 1~60s of ultraviolet radiation, in medicine equipment table after subbing solidification Face forms bottom；Again by investment precoat coated on bottom, 60~360s of ultraviolet radiation, investment precoat solidifies, in medical treatment Equipment surfaces form hydrophilic superslide coating；Uv energy density is 10mw/cm2~120mw/cm2。
- 5. the preparation method of hydrophilic superslide coating according to claim 4, it is characterised in that prepared by first step step 1.1) Diisocyanate described in the two methods of polyurethane acrylate prepolymer includes：2,4 toluene diisocyanate, different fluorine One kind in your ketone diisocyanate, hexa-methylene -1,6- diisocyanate, methyl diphenylene diisocyanate；Described third Olefin(e) acid hydroxyl ester includes：One kind in (methyl) hydroxy-ethyl acrylate, (methyl) hydroxypropyl acrylate, (methyl) hy-droxybutyl It is or several；Described polyethers/ester dihydric alcohol includes：Polyethylene glycol, polypropylene glycol, polytetrahydrofuran diol, makrolon binary One or more in alcohol, polycaprolactone diols, number-average molecular weight is in the range of 200-200000.
- 6. the preparation method of hydrophilic superslide coating according to claim 5, it is characterised in that institute in first step step 1.2) The reactive diluent stated is selected from tri (propylene glycol) diacrylate, polyethyleneglycol diacrylate, the propylene of 1,6- hexylene glycols two Acid esters, pentaerythritol triacrylate, the one or more of tetramethylol methane tetraacrylate.
- 7. the preparation method of hydrophilic superslide coating according to claim 6, it is characterised in that the biology described in second step The hydrophilic polymer of compatibility is selected from and polyvinylpyrrolidone, polyvinyl alcohol, polyurethane, polyethylene glycol, Sodium Polyacrylate, poly- In acrylamide, polyacrylic acid-acrylamide partial sodium salt, starch, cellulose, alginic acid, hyaluronic acid, chitosan, collagen One or more, the number-average molecular weight of hydrophilic polymer is in the range of 2000-5000000.
- 8. the preparation method of hydrophilic superslide coating according to claim 7, it is characterised in that the first described organic solvent It is selected from more than one or both of water, ethanol, isopropanol, acetone, butanone, ethyl acetate with the second organic solvent.
- 9. the preparation method of hydrophilic superslide coating according to claim 8, it is characterised in that the first described light trigger 2- hydroxyls -4 ' (2- hydroxy ethoxies) -2- methyl phenyl ketones, 1- hydroxyl cyclohexyl benzenes benzylacetone, 2- are selected from the second light trigger The methyl isophthalic acid of hydroxyl-2-phenylacetone, 2- methyl isophthalic acids-[morpholinyl-1- acetone of 4- (methyl mercapto phenyl)-2], 2- phenyl benzyls-2- two In double (2,4,6- trimethylbenzoyls) phosphine oxide, benzophenone of methyl amine -1- (4- morpholine benzyls phenyl) butanone, phenyl etc. It is one or more kinds of.
- 10. the preparation method of hydrophilic superslide coating according to claim 9, it is characterised in that the coating described in the 3rd step Mode is dipping-lifting mode, and dip time is 1-30s, and pull rate is 5-150mm/min；Bottom described in 3rd step Layer and surface layer are solidified by the way of rotation, rotary speed 3-60rpm/min.
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