CN111686311A - Super-lubricating coating for interventional valve delivery system and preparation method thereof - Google Patents
Super-lubricating coating for interventional valve delivery system and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
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Abstract
The invention discloses a super-lubricating coating for an interventional valve conveying system and a preparation method thereof, wherein the super-lubricating coating comprises the following raw materials in parts by mass: 2.5-16.8 parts of unsaturated oligomer, 2-8 parts of reactive diluent, 1-4.5 parts of ultraviolet initiator, 1-3 parts of organic silicon tackifier, 0.3-2.4 parts of flatting agent, 0.2-2.3 parts of 2-methacryloyloxyethyl phosphorylcholine, 1-10 parts of polyvinylpyrrolidone and 50-89 parts of solvent. The invention also provides a preparation method of the super-lubricating coating. The super-lubricating coating has good biocompatibility, can be well attached to the surface of a dilatation catheter made of polypropylene or polyethylene with low surface energy and difficult adhesion, and greatly reduces the friction force between the catheter and a sheath, so that smooth operation in the using process of a conveying system can be effectively ensured, the operation time is shortened, and the operation risk is reduced.
Description
Technical Field
The invention relates to the technical field of medical materials, in particular to a super-lubricating coating of an interventional valve conveying system and a preparation method thereof.
Background
The application of the interventional valve system to patients with valvular diseases is popularized year by year. Interventional valve systems include the main functional components of a delivery system, a valve frame, valve leaflets, and the like. At present, in the market, the interventional valve system conveying system at home and abroad mainly comprises an expansion catheter and a sheath, wherein the expansion catheter is prepared from polypropylene (PP) or Polyethylene (PE) materials. In clinical use, a large friction force exists between the dilating catheter and the sheath, which may cause the problems of unsmooth operation, prolonged operation time and the like, and increase the operation risk of patients.
The above problems can be solved by attaching a lubricious coating to the surface of the dilatation catheter. The technical measures for lubricating the surface of the catheter mainly comprise: firstly, coating paraffin oil or complex iodine on the surface of a conduit; secondly, a super-lubricating coating is formed on the surface of the conduit. Wherein the super-lubricating coating is formed on the surface of the catheter. However, as the material of the dilatation catheter of the interventional valve delivery system is PP or PE with low surface energy, a firm super-lubricating coating is difficult to form on the surface of the dilatation catheter, and the biocompatibility of the obtained coating is poor.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the super-lubricating coating for the interventional valve conveying system and the preparation method thereof, the super-lubricating coating has good biocompatibility, can be well attached to the surface of the expansion catheter made of polypropylene or polyethylene with low surface energy and difficult adhesion, and greatly reduces the friction force between the catheter and the sheath, so that smooth operation in the using process of the conveying system can be effectively ensured, the operation time is shortened, and the operation risk is reduced.
In order to achieve the purpose, the technical scheme adopted by the invention for solving the technical problems is as follows: the super-lubricating coating for the interventional valve delivery system comprises the following raw materials in parts by mass: 2.5-16.8 parts of unsaturated oligomer, 2-8 parts of reactive diluent, 1-4.5 parts of ultraviolet initiator, 1-3 parts of organic silicon tackifier, 0.3-2.4 parts of flatting agent, 0.2-2.3 parts of 2-methacryloyloxyethyl phosphorylcholine, 1-10 parts of polyvinylpyrrolidone and 50-89 parts of solvent.
Further, the super-lubricating coating of the interventional valve delivery system comprises the following raw materials in parts by mass: 12 parts of unsaturated oligomer, 2 parts of reactive diluent, 4 parts of ultraviolet initiator, 2.5 parts of organic silicon tackifier, 1 part of flatting agent, 1.5 parts of 2-methacryloyloxyethyl phosphorylcholine, 10 parts of polyvinylpyrrolidone and 60 parts of solvent.
Further, the unsaturated oligomer is at least one of monofunctional or polyfunctional epoxy acrylic resin, urethane acrylic resin, polyester acrylic resin, polyether acrylic resin, acrylated acrylate resin, and vinyl resin.
Further, the reactive diluent is at least one of monofunctional or polyfunctional acrylates, methacrylates, vinyls, vinyl ethers, or epoxies.
Further, the ultraviolet light initiator is at least one of benzoin/acyl and derivatives thereof, benzophenone and derivatives thereof, thioxanthone and derivatives thereof, anthraquinone and derivatives thereof, acetophenone derivatives, α -hydroxy/aminoketone derivatives, benzoyl formate, acylphosphine oxide, aryldiazonium salt, diaryliodonium salt, triarylsulfonium salt, ferrocenium salt, macromolecular benzophenone, macromolecular thioxanthone, macromolecular aminoacetophenone, macromolecular α -hydroxyketone, macromolecular benzoyl formate, macromolecular oxime ketone ester, macromolecular acylphosphine oxide, and macromolecular aminoalkyl ketone.
Further, the organic silicon tackifier is prepared by the following method: uniformly mixing vinyl hydroxyl silicone oil and a silane coupling agent at room temperature, dropwise adding 0.05-1 wt% of titanate compound, stirring and heating to 60-120 ℃ under the protection of nitrogen, reacting for 1-5 h, then cooling to 60-90 ℃, carrying out reduced pressure distillation for 1-5 h, and then cooling to room temperature in vacuum to obtain the organic silicon tackifier.
Further, the vinyl hydroxyl silicone oil contains 1-20 wt% of vinyl and 1-20 wt% of hydroxyl; and the molar ratio of hydroxyl in the vinyl hydroxyl silicone oil to the silane coupling agent is 1-10: 1.
Further, the silane coupling agent is at least one of vinyltrimethoxysilane, vinyltriethoxysilane, methacryloxypropyltrimethoxysilane, acryloxypropyltrimethoxysilane, methacryloxytriethoxysilane, acryloxypropyltrimethoxysilane, 3-mercaptopropyltrimethoxysilane and 3-mercaptopropyltriethoxysilane; the titanate compound is at least one of tetrabutyl titanate, tetraethyl titanate, tetraisopropyl titanate, tetra-tert-butyl titanate, diisopropyl di (acetylacetonate) titanate, isopropyl acetylacetonate complex titanate, isopropyl acetoacetate complex titanate and propylene glycol acetoacetate complex titanate.
Further, the flatting agent is at least one of polyether/polyester/aralkyl modified organic silicon polysiloxane, acrylate and fluorine modified acrylate; the solvent is at least one of methanol, ethanol, isopropanol, n-propanol, allyl alcohol, isobutanol, n-butanol and ethylene glycol monomethyl ether.
The preparation method of the super-lubricating coating of the interventional valve delivery system comprises the following steps:
at room temperature, all the raw materials are uniformly stirred and then coated on an expansion guide pipe at the concentration of 10-30 mW/cm2Curing for 0.25-30 min under the ultraviolet light intensity to obtain the super-lubricating coating intervening in the valve conveying system.
In summary, the invention has the following advantages:
1. the super-lubricating coating has good biocompatibility, can be well attached to the surface of a dilatation catheter made of polypropylene or polyethylene materials with low surface energy and difficult adhesion, and greatly reduces the friction force between the catheter and a sheath, so that smooth operation in the using process of a conveying system can be effectively ensured, the operation time is shortened, the problems of unsmooth operation, prolonged operation time and the like are avoided, and the operation risk is reduced; and when the super-lubricating coating is prepared, the super-lubricating coating is uniformly mixed, coated and ultraviolet cured in sequence, the preparation process is simple, the super-lubricating coating can be quickly prepared, the preparation efficiency is improved, and the preparation time of the super-lubricating coating is shortened.
2. In the super-lubricating coating, unsaturated oligomer is used as matrix resin and is used as a main component to participate in photocuring reaction, so that the mechanical strength of the cured coating is improved, and the adhesion capability of the coating is improved to a certain extent; the reactive diluent participates in the photocuring reaction, becomes a part of a cross-linked network structure of the coating after curing, and simultaneously adjusts the viscosity of the coating liquid; the photoinitiator can initiate polymerization, crosslinking and curing of the unsaturated oligomer, the reactive diluent and the organic silicon tackifier to promote the curing reaction; the prepared organosilicon tackifier with a novel structure contains active vinyl, sulfydryl and hydroxyl, can participate in photocuring reaction, and can improve the adhesive bonding capability of a coating cured with a base material (polypropylene or polyethylene); the leveling agent can reduce the surface energy of the coating liquid and ensure that the coating liquid is uniformly attached to the surface of the base material; 2-methacryloyloxyethyl phosphorylcholine can participate in photocuring reaction, so that the biocompatibility of the coating liquid is improved; in the cured coating, the polyvinylpyrrolidone can form hydrogel after being activated by water, so that the coating is endowed with super-lubricating property; and the solvent dissolves all components of the coating liquid to play a role in adjusting the viscosity.
3. The preparation method of the super-lubricating coating is simple and feasible, and the coating has good biocompatibility after being cured by ultraviolet light; the synthesized organic silicon tackifier used in the super-lubricating coating can obviously improve the bonding and adhering capacity of the coating after curing with the dilating catheter; after the super-lubricating coating is activated by water, the friction force between the catheter and the sheath can be greatly reduced.
Detailed Description
Example 1
The super-lubricating coating of the interventional valve delivery system comprises the following raw materials in parts by mass: 10 parts of multifunctional acrylate (Dymax BR-970), 5 parts of 1, 6-hexanediol propoxy (2) diacrylate (HD2PODA Photomer 4362), 3 parts of bifunctional alpha-hydroxy ketone oligomer, 2 parts of an organosilicon tackifier, 2.4 parts of a leveling agent (BYK-378), 0.2 part of 2-methacryloyloxyethyl phosphorylcholine, 5 parts of polyvinylpyrrolidone (K-90) and 67.4 parts of ethanol.
The organic silicon tackifier is prepared by the following method: at room temperature, 85g of vinyl hydroxyl silicone oil (containing 0.3mol of hydroxyl, the content of vinyl is 6.5 percent by weight and the content of hydroxyl is 6 percent by weight) and 8.89g of vinyl trimethoxy silane (0.06mol) are mixed uniformly, 0.047g of tetrabutyl titanate is dripped, the mixture is stirred and heated to 70 ℃ under the protection of nitrogen for reaction for 2 hours, then the temperature is reduced to 65 ℃ for reduced pressure distillation for 1.5 hours, and then the mixture is reduced to the room temperature in vacuum, thus obtaining the organic silicon tackifier.
The preparation method of the super-lubricating coating of the interventional valve delivery system comprises the following steps:
all raw materials were stirred well at room temperature and then coated on a polypropylene dilatation catheter at 25mW/cm2Curing for 10min under the ultraviolet light intensity to obtain the super-lubricating coating intervening in the valve conveying system.
Example 2
The super-lubricating coating of the interventional valve delivery system comprises the following raw materials in parts by mass: 6 parts of aliphatic polyurethane acrylate (NeoRad U-25-20D), 4 parts of fatty acid modified epoxy acrylate (AgiSyn 2020-80), 8 parts of dipropylene glycol diacrylate (DPGDA Photomer 4226), 2 parts of bifunctional alpha-hydroxyketone oligomer, 3 parts of organic silicon tackifier, 1.5 parts of flatting agent (BYK-3560), 0.5 part of 2-methacryloyloxyethyl phosphorylcholine, 2 parts of polyvinylpyrrolidone (K-120), 30 parts of isopropanol and 43 parts of ethanol.
The organic silicon tackifier is prepared by the following method: at room temperature, 85g of vinyl hydroxyl silicone oil (containing 0.15mol of hydroxyl, the content of vinyl is 3 wt percent, and the content of hydroxyl is 3 wt percent) and 28.55g of vinyl triethoxysilane (0.15mol) are mixed uniformly, 0.43g of tetraethyl titanate is dripped, the mixture is stirred and heated to 80 ℃ under the protection of nitrogen to react for 2.5h, then the temperature is reduced to 70 ℃ and reduced pressure distillation is carried out for 2h, and then the mixture is reduced to room temperature in vacuum to obtain the organic silicon tackifier.
The preparation method of the super-lubricating coating of the interventional valve delivery system comprises the following steps:
all raw materials were stirred well at room temperature and then coated on a polypropylene dilatation catheter at 10mW/cm2Curing for 20min under the ultraviolet light intensity to obtain the super-lubricating coating intervening in the valve conveying system.
Example 3
The super-lubricating coating of the interventional valve delivery system comprises the following raw materials in parts by mass: 9 parts of polyester acrylate (AgiSyn 730), 3 parts of amine modified epoxy acrylate (Photomer 3317), 6 parts of polyethylene glycol (600) diacrylate (PEG600DA AgiSyn 2835), 1 part of 2-isopropyl thioxanthone, 1 part of organic silicon tackifier, 0.8 part of flatting agent (TEGODispers 710), 0.7 part of 2-methacryloyloxyethyl phosphorylcholine, 6 parts of polyvinylpyrrolidone (K-90) and 72.5 parts of ethanol.
The organic silicon tackifier is prepared by the following method: at room temperature, 85g of vinyl hydroxyl silicone oil (containing 0.3mol of hydroxyl, the content of vinyl is 3 percent by weight and the content of hydroxyl is 6 percent by weight) and 7.44g of methacryloxy trimethoxy silane (0.03mol) are mixed uniformly, 0.92g of acetylacetone complex isopropyl titanate is dripped, the mixture is stirred and heated to 90 ℃ under the protection of nitrogen to react for 3 hours, then the mixture is cooled to 75 ℃ and distilled under reduced pressure for 2.5 hours, and then the mixture is cooled to room temperature in vacuum, thus obtaining the organic silicon tackifier.
The preparation method of the super-lubricating coating of the interventional valve delivery system comprises the following steps:
all the raw materials are stirred uniformly at room temperature and then coated on a polyethylene dilatation catheter at 30mW/cm2Curing for 5min under the ultraviolet light intensity to obtain the super-lubricating coating intervening in the valve conveying system.
Example 4
The super-lubricating coating of the interventional valve delivery system comprises the following raw materials in parts by mass: 12 parts of amine modified polyether acrylate (Photomer 5850), 2 parts of modified epoxy diacrylate (Photomer 3072), 4 parts of triethylene glycol divinyl ether (DVE-3), 4 parts of polymerized benzophenone derivative, 2.5 parts of organosilicon tackifier, 1 part of leveling agent (TEGO Dispers 672), 1.5 parts of 2-methacryloyloxyethyl phosphorylcholine, 10 parts of polyvinylpyrrolidone (K-30), 3 parts of polyvinylpyrrolidone (K-120) and 60 parts of isopropanol.
The organic silicon tackifier is prepared by the following method: at room temperature, 85g of vinyl hydroxyl silicone oil (containing 0.3mol of hydroxyl, 5 percent by weight of vinyl and 6 percent by weight of hydroxyl) and 23.4g of acryloyloxy trimethoxy silane (0.1mol) are mixed uniformly, 0.64g of tetrabutyl titanate is dripped, the mixture is stirred and heated to 100 ℃ under the protection of nitrogen to react for 3.5h, then the temperature is reduced to 80 ℃, the reduced pressure distillation is carried out for 3h, and the temperature is reduced to the room temperature in vacuum, thus obtaining the organic silicon tackifier.
The preparation method of the super-lubricating coating of the interventional valve delivery system comprises the following steps:
all the raw materials are stirred uniformly at room temperature and then coated on a polyethylene dilatation catheter at 20mW/cm2Curing for 8min under the ultraviolet light intensity to obtain the super-lubricating coating intervening in the valve conveying system.
Example 5
The super-lubricating coating of the interventional valve delivery system comprises the following raw materials in parts by mass: 7 parts of pure acrylate (AgiSyn260-163), 1 part of low-viscosity modified epoxy acrylate (Photomer 3316), 7 parts of lauric acrylate, 4.5 parts of piperazinyl-containing aminoalkyl benzophenone, 1.5 parts of an organosilicon tackifier, (BYK-UV 3500)2 parts, 1 part of 2-methacryloyloxyethyl phosphorylcholine, 2 parts of polyvinylpyrrolidone (K-90), 1 part of polyvinylpyrrolidone (K-120) and 50-89 parts of isopropanol.
The organic silicon tackifier is prepared by the following method: at room temperature, 85g of vinyl hydroxyl silicone oil (containing 0.15mol of hydroxyl, the content of vinyl is 2 percent by weight and the content of hydroxyl is 3 percent by weight) and 14.73g of mercaptopropyl trimethoxy silane (0.075mol) are mixed uniformly, 0.74g of diisopropyl di (acetylacetone) titanate is dripped, the mixture is stirred and heated to 110 ℃ under the protection of nitrogen to react for 5 hours, then the temperature is reduced to 85 ℃, reduced pressure distillation is carried out for 4 hours, and the mixture is reduced to the room temperature in vacuum, thus obtaining the organic silicon tackifier.
The preparation method of the super-lubricating coating of the interventional valve delivery system comprises the following steps:
all raw materials were stirred well at room temperature and then coated on a polypropylene dilatation catheter at 15mW/cm2Curing for 15min under the ultraviolet light intensity to obtain the super-lubricating coating intervening in the valve conveying system.
Comparative example 1
Comparative example 1 differs from the examples in that comparative example 1 lacks a silicone tackifier.
Cytotoxicity and frictional force tests were performed on the super-lubricating coatings obtained in examples 1 to 5, the coatings obtained in comparative example 1, and two blank control groups (uncoated polypropylene tube and uncoated polyethylene tube), respectively, and the results are shown in table 1.
TABLE 1 statistical table of cytotoxicity and Friction test results
Note: 1. cell viability according to GB/T16886.5-2017, part 5 of the "biological evaluation of medical devices: in vitro cytotoxicity assay.
2. The friction force is tested according to the method specified in YY/T1536-2017 Standard test model for evaluating the sliding property of the surface of the non-intravascular catheter.
As can be seen from Table 1, the super-lubricating coatings prepared in the embodiments 1-5 of the invention have high cell survival rate of the dilatation catheter, and the introduction of the coatings basically does not generate negative influence on biocompatibility; compared with the uncoated dilatation catheter, the friction force of the embodiment 1-5 is obviously reduced, and through hundreds of tests, the friction force is still lower than 0.3N, and the adhesion between the coating and the dilatation catheter is good; in contrast, in the case of the dilatation catheter of comparative example 1, the frictional force showed a significant tendency to increase with the increase of the number of tests due to no silicone tackifier added.
While the present invention has been described in detail with reference to the specific embodiments thereof, it should not be construed as limited by the scope of the present patent. Various modifications and changes may be made by those skilled in the art without inventive step within the scope of the appended claims.
Claims (10)
1. The super-lubricating coating of the interventional valve delivery system is characterized by comprising the following raw materials in parts by mass: 2.5-16.8 parts of unsaturated oligomer, 2-8 parts of reactive diluent, 1-4.5 parts of ultraviolet initiator, 1-3 parts of organic silicon tackifier, 0.3-2.4 parts of flatting agent, 0.2-2.3 parts of 2-methacryloyloxyethyl phosphorylcholine, 1-10 parts of polyvinylpyrrolidone and 50-89 parts of solvent.
2. The super-lubricating coating for the interventional valve delivery system of claim 1, which comprises the following raw materials in parts by mass: 12 parts of unsaturated oligomer, 2 parts of reactive diluent, 4 parts of ultraviolet initiator, 2.5 parts of organic silicon tackifier, 1 part of flatting agent, 1.5 parts of 2-methacryloyloxyethyl phosphorylcholine, 10 parts of polyvinylpyrrolidone and 60 parts of solvent.
3. The super-lubricious coating of the interventional valve delivery system of claim 1 or 2 wherein the unsaturated oligomer is at least one of a mono-or polyfunctional epoxy acrylic resin, a polyurethane acrylic resin, a polyester acrylic resin, a polyether acrylic resin, an acrylated acrylate resin, and a vinyl resin.
4. The super-lubricious coating of claim 1 or 2 wherein the reactive diluent is at least one of mono-or multifunctional acrylates, methacrylates, vinyls, vinyl ethers, or epoxies.
5. The super-lubricious coating for interventional valve delivery systems of claim 1 or 2 wherein the ultraviolet light initiator is at least one of benzoin/acyl and derivatives thereof, benzophenone and derivatives thereof, thioxanthone and derivatives thereof, anthraquinone and derivatives thereof, acetophenone derivatives, α -hydroxy/aminoketone derivatives, benzoyl formates, acylphosphine oxides, aryldiazonium salts, diaryliodonium salts, triarylsulfonium salts, squarylium salts, macromolecular benzophenone, macromolecular thioxanthone, macromolecular aminoacetophenone, macromolecular α -hydroxy ketones, macromolecular benzoyl formate, macromolecular oxime ketone esters, macromolecular acylphosphine oxides, and macromolecular aminoalkyl ketones.
6. The super-lubricious coating of claim 1 wherein the silicone adhesion promoter is prepared by: uniformly mixing vinyl hydroxyl silicone oil and a silane coupling agent at room temperature, dropwise adding 0.05-1 wt% of titanate compound, stirring and heating to 60-120 ℃ under the protection of nitrogen, reacting for 1-5 h, then cooling to 60-90 ℃, carrying out reduced pressure distillation for 1-5 h, and then cooling to room temperature in vacuum to obtain the organic silicon tackifier.
7. The super-lubricating coating for the interventional valve delivery system of claim 6, wherein the vinyl hydroxy silicone oil has a vinyl content of 1-20 wt% and a hydroxyl content of 1-20 wt%; and the molar ratio of hydroxyl in the vinyl hydroxyl silicone oil to the silane coupling agent is 1-10: 1.
8. The super-lubricious coating of claim 6 wherein the silane coupling agent is at least one of vinyltrimethoxysilane, vinyltriethoxysilane, methacryloxypropyltrimethoxysilane, acryloxypropyltrimethoxysilane, methacryloxytriethoxysilane, acryloxypropyltrimethoxysilane, 3-mercaptopropyltrimethoxysilane, and 3-mercaptopropyltriethoxysilane; the titanate compound is at least one of tetrabutyl titanate, tetraethyl titanate, tetraisopropyl titanate, tetra-tert-butyl titanate, diisopropyl di (acetylacetonate) titanate, isopropyl acetylacetonate complex titanate, isopropyl acetoacetate complex titanate and propylene glycol acetoacetate complex titanate.
9. The super-lubricating coating for the interventional valve delivery system according to claim 1 or 2, wherein the leveling agent is at least one of polyether/polyester/aralkyl modified silicone, acrylate, fluorine modified acrylate; the solvent is at least one of methanol, ethanol, isopropanol, n-propanol, allyl alcohol, isobutanol, n-butanol and ethylene glycol monomethyl ether.
10. The method for preparing the super-lubricating coating of the interventional valve delivery system of any one of claims 1 to 9, characterized by comprising the following steps:
at room temperature, all the raw materials are uniformly stirred and then coated on an expansion guide pipe at the concentration of 10-30 mW/cm2Curing for 0.25-30 min under the ultraviolet light intensity to obtain the super-lubricating coating intervening in the valve conveying system.
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WO2021254348A1 (en) * | 2020-06-16 | 2021-12-23 | 杭州启明医疗器械股份有限公司 | Super-lubricative coating for interventional valve delivery system and preparation method therefor |
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CN115487362A (en) * | 2022-09-21 | 2022-12-20 | 上海康德莱医疗器械股份有限公司 | Ultraviolet curing super-hydrophilic super-lubricating double-layer coating system for catheter and guide wire |
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Effective date of registration: 20220819 Address after: 310000 Room 311, 3/F, Building No. 88, Jiangling Road, Binjiang District, Hangzhou City, Zhejiang Province Patentee after: Hangzhou Qiming Medical Devices Co.,Ltd. Address before: 610064, No. 24, south section of first ring road, Chengdu, Sichuan, Wuhou District Patentee before: SICHUAN University |