CN114366697A - Preparation method of liquid soap containing gingko extracting solution - Google Patents

Preparation method of liquid soap containing gingko extracting solution Download PDF

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Publication number
CN114366697A
CN114366697A CN202111419615.4A CN202111419615A CN114366697A CN 114366697 A CN114366697 A CN 114366697A CN 202111419615 A CN202111419615 A CN 202111419615A CN 114366697 A CN114366697 A CN 114366697A
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CN
China
Prior art keywords
mixing
mixture
stirring
mixer
extracting solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202111419615.4A
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Chinese (zh)
Inventor
何福林
邵金华
袁志辉
张祖姣
陈小明
吕敬崑
魏允武
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HUNAN HENGWEI PHARMACEUTICAL CO Ltd
Hunan University of Science and Engineering
Original Assignee
HUNAN HENGWEI PHARMACEUTICAL CO Ltd
Hunan University of Science and Engineering
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Publication date
Application filed by HUNAN HENGWEI PHARMACEUTICAL CO Ltd, Hunan University of Science and Engineering filed Critical HUNAN HENGWEI PHARMACEUTICAL CO Ltd
Priority to CN202111419615.4A priority Critical patent/CN114366697A/en
Publication of CN114366697A publication Critical patent/CN114366697A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9771Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations

Abstract

The invention provides a preparation method of a hand sanitizer containing ginkgo extract, which comprises the following materials, by weight, 1-5% of a ginkgo concentrated extract, 3-7% of glycerol, 0.5-1.5% of phenoxyethanol, 5-10% of a biological bactericide, 1-5% of carboxymethyl cellulose, 10-15% of a surfactant, 0.1-0.5% of essence, 2-5% of propylene glycol and 65-80% of deionized water.

Description

Preparation method of liquid soap containing gingko extracting solution
Technical Field
The invention belongs to the technical field of plant extraction, and particularly relates to a preparation method of a liquid soap containing a gingko extracting solution.
Background
The whole body of ginkgo is treasure, the chemical components of the leaves, roots and bark of ginkgo are complex, only 30 kinds of flavone elements exist, 17 kinds of monoterpene and sesquiterpene, 6 kinds of terpene lactone, 9 kinds of alkyl phenol and phenol of polyisoprene and 12 kinds of fatty acid and 11 kinds of organic acid. Experiments prove that ginkgolic acid and ginkgol with relatively high content have antibacterial and bactericidal effects, the ginkgo water-soaking agent has different degrees of inhibition effects on various fungi and can relieve itching and treat tinea, the ginkgo testa contains a large amount of hydroginkgolic acid and ginkgetin, the effective rate of the exocarp alcohol intermediate on the inhibition of 22 clinical common pathogenic fungi is 81%, and the effective rate of 0.1% of hydroginkgolic acid on the inhibition of 25 clinical pathogenic fungi is 92%.
The hand sanitizer gradually replaces the traditional soap for cleaning hands due to the advantages of convenience, sanitation and the like, and most of the hand sanitizers in the market use chemically synthesized bactericides to kill bacteria on the hands, so that no novel hand sanitizer taking ginkgo active substances as disinfectants exists at present.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a method for preparing a liquid soap containing a gingko extracting solution.
In order to achieve the purpose, the invention provides the following technical scheme:
a method for preparing a hand sanitizer containing ginkgo biloba extract comprises the following materials, by weight, 1-5% of ginkgo biloba concentrated extract, 3-7% of glycerol, 0.5-1.5% of phenoxyethanol, 5-10% of a biological bactericide, 1-5% of carboxymethyl cellulose, 10-15% of a surfactant, 0.1-0.5% of essence, 2-5% of propylene glycol and 65-80% of deionized water.
Preferably, the preparation steps are as follows: putting the ginkgo concentrated extract and glycerol into a container according to a ratio, uniformly stirring, then placing into a mixer, adding phenoxyethanol to obtain a primary mixture, selecting a sealed mixer with glass as an outer wall and a stainless steel inner mixing rod for mixing, operating at a high speed in the mixing process, prolonging the mixing time, fully mixing the ginkgo concentrated extract, the glycerol and the phenoxyethanol to obtain a primary mixture, then putting a biological bactericide, carboxymethyl cellulose and a surfactant into the container, uniformly stirring to obtain a secondary mixture, selecting the glass container for mixing in the mixing process, mixing the secondary mixture by stirring in the mixing process, fully mixing essence, propylene glycol and deionized water, selecting the glass container for mixing in the mixing process, mixing the tertiary mixture by stirring in the mixing process, and (3) obtaining a third mixture, putting the first mixture, the second mixture and the third mixture into a stirrer for mixing and stirring, pouring the first mixture, the second mixture and the third mixture into the stirrer to be uniformly mixed in the stirring process, starting the stirrer for stirring after pouring, and starting a mixing machine for mixing to obtain the hand sanitizer.
Preferably, the surfactant is one or more of alkyl glycoside, polyethylene glycol and fatty alcohol-polyoxyethylene ether.
Preferably, the biological bactericide consists of 75-85 wt% of propolis flavone and 15-25 wt% of apple polyphenol.
Preferably, the stirring speed of the mixer is 5500-.
Preferably, in the primary mixing step, the stirring speed of the mixer is 5500-.
Preferably, in the secondary mixing step, the stirring speed of the mixer is 6600-8000r/min, and the time of single stirring is 15-25 min.
Preferably, in the third mixing step, the stirring speed of the mixer is 8000-.
Compared with the prior art, the invention provides a preparation method of the hand sanitizer containing the gingko extracting solution, which has the following beneficial effects: the bactericidal effect of the ginkgo biloba extract is utilized and added into the hand sanitizer, so that the efficacy and the components of the hand sanitizer are enriched, the application of the ginkgo biloba crude extract is expanded, the use of a large amount of chemically synthesized bactericidal preservatives with strong irritation is avoided, the product components are more natural, the irritation is small, and the product has unique smell without adding essence.
Detailed Description
Example 1:
a method for preparing a hand sanitizer containing ginkgo biloba extract comprises the following materials, by weight, 3% of ginkgo biloba concentrated extract, 5% of glycerol, 1% of phenoxyethanol, 8% of a biological bactericide, 1% of carboxymethyl cellulose, 12% of a surfactant, 0.3% of an essence, 3% of propylene glycol and 66.7% of deionized water.
Material preparation: putting the ginkgo concentrated extract and glycerol into a container according to a ratio, uniformly stirring, then placing into a mixer, adding phenoxyethanol to obtain a primary mixture, selecting a sealed mixer with glass as an outer wall and a stainless steel inner mixing rod for mixing, operating at a high speed in the mixing process, prolonging the mixing time, fully mixing the ginkgo concentrated extract, the glycerol and the phenoxyethanol to obtain a primary mixture, then putting a biological bactericide, carboxymethyl cellulose and a surfactant into the container, uniformly stirring to obtain a secondary mixture, selecting the glass container for mixing in the mixing process, mixing the secondary mixture by stirring in the mixing process, fully mixing essence, propylene glycol and deionized water, selecting the glass container for mixing in the mixing process, mixing the tertiary mixture by stirring in the mixing process, and (3) obtaining a third mixture, putting the first mixture, the second mixture and the third mixture into a stirrer for mixing and stirring, pouring the first mixture, the second mixture and the third mixture into the stirrer to be uniformly mixed in the stirring process, starting the stirrer for stirring after pouring, and starting a mixing machine for mixing to obtain the hand sanitizer.
The surfactant is one or more of alkyl glycoside, polyethylene glycol and fatty alcohol-polyoxyethylene ether.
The biological bactericide consists of propolis flavone 80 wt% and apple polyphenol 20 wt%.
In the primary mixing step, the stirring speed of the mixer is 7000r/min, and the time of the primary stirring is 12 min.
In the first mixing step, the stirring speed of the mixer is 6500r/min, and the single stirring time is 13 min.
In the secondary mixing step, the stirring speed of the mixer is 7200r/min, and the single stirring time is 20 min.
In the third mixing step, the stirring speed of the mixer is 10000r/min, and the single stirring time is 30 min.
Example 1: the bactericidal effect of the ginkgo biloba extract is utilized and added into the hand sanitizer, so that the efficacy and the components of the hand sanitizer are enriched, the application of the ginkgo biloba crude extract is expanded, the use of a large amount of chemically synthesized bactericidal preservatives with strong irritation is avoided, the product components are more natural, the irritation is small, essence is not required to be added, the product has unique smell, and the good evaluation rate of the selling client is 97.5%.
Example 2:
a method for preparing a hand sanitizer containing ginkgo biloba extract comprises the following materials, by weight, 4% of ginkgo biloba concentrated extract, 6% of glycerol, 1.2% of phenoxyethanol, 9% of a biological bactericide, 2% of carboxymethyl cellulose, 13% of a surfactant, 0.3% of an essence, 4% of propylene glycol and 60.5% of deionized water.
Material preparation: putting the ginkgo concentrated extract and glycerol into a container according to a ratio, uniformly stirring, then placing into a mixer, adding phenoxyethanol to obtain a primary mixture, selecting a sealed mixer with glass as an outer wall and a stainless steel inner mixing rod for mixing, operating at a high speed in the mixing process, prolonging the mixing time, fully mixing the ginkgo concentrated extract, the glycerol and the phenoxyethanol to obtain a primary mixture, then putting a biological bactericide, carboxymethyl cellulose and a surfactant into the container, uniformly stirring to obtain a secondary mixture, selecting the glass container for mixing in the mixing process, mixing the secondary mixture by stirring in the mixing process, fully mixing essence, propylene glycol and deionized water, selecting the glass container for mixing in the mixing process, mixing the tertiary mixture by stirring in the mixing process, and (3) obtaining a third mixture, putting the first mixture, the second mixture and the third mixture into a stirrer for mixing and stirring, pouring the first mixture, the second mixture and the third mixture into the stirrer to be uniformly mixed in the stirring process, starting the stirrer for stirring after pouring, and starting a mixing machine for mixing to obtain the hand sanitizer.
The surfactant is one or more of alkyl glycoside, polyethylene glycol and fatty alcohol-polyoxyethylene ether.
The biological bactericide consists of 75 wt% of propolis flavone and 23 wt% of apple polyphenol.
In the primary mixing step, the stirring speed of the mixer is 7300r/min, and the single stirring time is 12 min.
In the primary mixing step, the stirring speed of the mixer is 7000r/min, and the time of the primary stirring is 13 min.
In the secondary mixing step, the stirring speed of the mixer is 7500r/min, and the single stirring time is 20 min.
In the third mixing step, the stirring speed of the mixer is 10100r/min, and the single stirring time is 30 min.
Example 2: the bactericidal effect of the ginkgo biloba extract is utilized and added into the hand sanitizer, so that the efficacy and the components of the hand sanitizer are enriched, the application of the ginkgo biloba crude extract is expanded, the use of a large amount of chemically synthesized bactericidal preservatives with strong irritation is avoided, the product components are more natural, the irritation is small, essence is not required to be added, the product has unique smell, and the good evaluation rate of sold customers is 99.5%.
Example 3:
a method for preparing a hand sanitizer containing ginkgo biloba extract comprises the following materials, by weight, 3% of ginkgo biloba concentrated extract, 5% of glycerol, 1.3% of phenoxyethanol, 10% of a biological bactericide, 3% of carboxymethyl cellulose, 12% of a surfactant, 0.3% of an essence, 5% of propylene glycol and 60.4% of deionized water.
Material preparation: putting the ginkgo concentrated extract and glycerol into a container according to a ratio, uniformly stirring, then placing into a mixer, adding phenoxyethanol to obtain a primary mixture, selecting a sealed mixer with glass as an outer wall and a stainless steel inner mixing rod for mixing, operating at a high speed in the mixing process, prolonging the mixing time, fully mixing the ginkgo concentrated extract, the glycerol and the phenoxyethanol to obtain a primary mixture, then putting a biological bactericide, carboxymethyl cellulose and a surfactant into the container, uniformly stirring to obtain a secondary mixture, selecting the glass container for mixing in the mixing process, mixing the secondary mixture by stirring in the mixing process, fully mixing essence, propylene glycol and deionized water, selecting the glass container for mixing in the mixing process, mixing the tertiary mixture by stirring in the mixing process, and (3) obtaining a third mixture, putting the first mixture, the second mixture and the third mixture into a stirrer for mixing and stirring, pouring the first mixture, the second mixture and the third mixture into the stirrer to be uniformly mixed in the stirring process, starting the stirrer for stirring after pouring, and starting a mixing machine for mixing to obtain the hand sanitizer.
The surfactant is one or more of alkyl glycoside, polyethylene glycol and fatty alcohol-polyoxyethylene ether.
The biological bactericide consists of 75 wt% of propolis flavone and 23 wt% of apple polyphenol.
In the primary mixing step, the stirring speed of the mixer is 7300r/min, and the single stirring time is 12 min.
In the primary mixing step, the stirring speed of the mixer is 7000r/min, and the time of the primary stirring is 13 min.
In the secondary mixing step, the stirring speed of the mixer is 7500r/min, and the single stirring time is 20 min.
In the third mixing step, the stirring speed of the mixer is 10100r/min, and the single stirring time is 30min
Example 3: the bactericidal effect of the ginkgo biloba extract is utilized and added into the hand sanitizer, so that the efficacy and the components of the hand sanitizer are enriched, the application of the ginkgo biloba crude extract is expanded, the use of a large amount of chemically synthesized bactericidal preservatives with strong irritation is avoided, the product components are more natural, the irritation is small, essence is not required to be added, the product has unique smell, and the good evaluation rate of the selling client is 97.5%.
Example 4:
a method for preparing a hand sanitizer containing ginkgo biloba extract comprises the following materials, by weight, 4% of ginkgo biloba concentrated extract, 4% of glycerol, 1% of phenoxyethanol, 6% of a biological bactericide, 3% of carboxymethyl cellulose, 11% of a surfactant, 0.4% of an essence, 3% of propylene glycol and 67.6% of deionized water.
Material preparation: putting the ginkgo concentrated extract and glycerol into a container according to a ratio, uniformly stirring, then placing into a mixer, adding phenoxyethanol to obtain a primary mixture, selecting a sealed mixer with glass as an outer wall and a stainless steel inner mixing rod for mixing, operating at a high speed in the mixing process, prolonging the mixing time, fully mixing the ginkgo concentrated extract, the glycerol and the phenoxyethanol to obtain a primary mixture, then putting a biological bactericide, carboxymethyl cellulose and a surfactant into the container, uniformly stirring to obtain a secondary mixture, selecting the glass container for mixing in the mixing process, mixing the secondary mixture by stirring in the mixing process, fully mixing essence, propylene glycol and deionized water, selecting the glass container for mixing in the mixing process, mixing the tertiary mixture by stirring in the mixing process, and (3) obtaining a third mixture, putting the first mixture, the second mixture and the third mixture into a stirrer for mixing and stirring, pouring the first mixture, the second mixture and the third mixture into the stirrer to be uniformly mixed in the stirring process, starting the stirrer for stirring after pouring, and starting a mixing machine for mixing to obtain the hand sanitizer.
The surfactant is one or more of alkyl glycoside, polyethylene glycol and fatty alcohol-polyoxyethylene ether.
The biological bactericide consists of 78 wt% of propolis flavone and 24 wt% of apple polyphenol.
In the primary mixing step, the stirring speed of the mixer is 7500r/min, and the single stirring time is 12 min.
In the primary mixing step, the stirring speed of the mixer is 7300r/min, and the single stirring time is 13 min.
In the secondary mixing step, the stirring speed of the mixer is 7800r/min, and the single stirring time is 20 min.
In the third mixing step, the stirring speed of the mixer is 10300r/min, and the single stirring time is 30min
Example 4: the bactericidal effect of the ginkgo biloba extract is utilized and added into the hand sanitizer, so that the efficacy and the components of the hand sanitizer are enriched, the application of the ginkgo biloba crude extract is expanded, the use of a large amount of chemically synthesized bactericidal preservatives with strong irritation is avoided, the product components are more natural, the irritation is small, essence is not required to be added, the product has unique smell, and the high evaluation rate of the sold customers is 98.5%.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical scope of the present invention and the equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention within the technical scope of the present invention.

Claims (8)

1. A preparation method of a hand sanitizer containing gingko extracting solution is characterized by comprising the following steps: comprises the following materials, by weight, 1-5% of a ginkgo concentrated extract, 3-7% of glycerol, 0.5-1.5% of phenoxyethanol, 5-10% of a biological bactericide, 1-5% of carboxymethyl cellulose, 10-15% of a surfactant, 0.1-0.5% of an essence, 2-5% of propylene glycol and 65-80% of deionized water.
2. The preparation method of the hand sanitizer containing the gingko extracting solution is characterized by comprising the following steps: material preparation: putting the ginkgo concentrated extract and glycerol into a container according to a ratio, uniformly stirring, then placing into a mixer, adding phenoxyethanol to obtain a primary mixture, selecting a sealed mixer with glass as an outer wall and a stainless steel inner mixing rod for mixing, operating at a high speed in the mixing process, prolonging the mixing time, fully mixing the ginkgo concentrated extract, the glycerol and the phenoxyethanol to obtain a primary mixture, then putting a biological bactericide, carboxymethyl cellulose and a surfactant into the container, uniformly stirring to obtain a secondary mixture, selecting the glass container for mixing in the mixing process, mixing the secondary mixture by stirring in the mixing process, fully mixing essence, propylene glycol and deionized water, selecting the glass container for mixing in the mixing process, mixing the tertiary mixture by stirring in the mixing process, and (3) obtaining a third mixture, putting the first mixture, the second mixture and the third mixture into a stirrer for mixing and stirring, pouring the first mixture, the second mixture and the third mixture into the stirrer to be uniformly mixed in the stirring process, starting the stirrer for stirring after pouring, and starting a mixing machine for mixing to obtain the hand sanitizer.
3. The method for preparing the liquid soap containing the gingko extracting solution according to the claim 1, which is characterized in that: the surfactant is one or more of alkyl glycoside, polyethylene glycol and fatty alcohol-polyoxyethylene ether.
4. The method for preparing the liquid soap containing the gingko extracting solution according to the claim 1, which is characterized in that: the biological bactericide consists of propolis flavone 75-85 wt% and apple polyphenol 15-25 wt%.
5. The method for preparing the liquid soap containing the gingko extracting solution according to the claim 1, which is characterized in that: in the primary mixing step, the stirring speed of the mixer is 5500-.
6. The method for preparing the liquid soap containing the gingko extracting solution according to the claim 1, which is characterized in that: in the primary mixing step, the stirring speed of the mixer is 5500-.
7. The method for preparing the liquid soap containing the gingko extracting solution according to the claim 1, which is characterized in that: in the secondary mixing step, the stirring speed of the mixer is 6600-8000r/min, and the time of single stirring is 15-25 min.
8. The method for preparing the liquid soap containing the gingko extracting solution according to the claim 1, which is characterized in that: in the secondary mixing step, in the third mixing step, the stirring speed of the mixer is 8000-11000r/min, and the time of single stirring is 20-35 min.
CN202111419615.4A 2021-11-26 2021-11-26 Preparation method of liquid soap containing gingko extracting solution Pending CN114366697A (en)

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CN202111419615.4A CN114366697A (en) 2021-11-26 2021-11-26 Preparation method of liquid soap containing gingko extracting solution

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Application Number Priority Date Filing Date Title
CN202111419615.4A CN114366697A (en) 2021-11-26 2021-11-26 Preparation method of liquid soap containing gingko extracting solution

Publications (1)

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CN114366697A true CN114366697A (en) 2022-04-19

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107616960A (en) * 2017-09-30 2018-01-23 张建仁 Biological antibiotic hand cleanser and its production technology
CN108261355A (en) * 2016-12-30 2018-07-10 孝感市森茂激光数控设备有限公司 A kind of hand cleanser of containing gingko extract

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108261355A (en) * 2016-12-30 2018-07-10 孝感市森茂激光数控设备有限公司 A kind of hand cleanser of containing gingko extract
CN107616960A (en) * 2017-09-30 2018-01-23 张建仁 Biological antibiotic hand cleanser and its production technology

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Application publication date: 20220419