CN114344596B

CN114344596B - Exhaust control system of blood perfusion device

Info

Publication number: CN114344596B
Application number: CN202111618267.3A
Authority: CN
Inventors: 董凡; 宁偲偲; 周峰; 谭明圆
Original assignee: Jafron Biomedical Co Ltd
Current assignee: Jafron Biomedical Co Ltd
Priority date: 2021-12-27
Filing date: 2021-12-27
Publication date: 2023-07-25
Anticipated expiration: 2041-12-27
Also published as: CN114344596A

Abstract

The invention discloses an exhaust control system of a blood perfusion device, which is characterized in that a first detection module is used for detecting the bubble quantity of liquid on a venous line, and a time detection module is used for detecting the pre-flushing exhaust time of an adsorption column; the state of the pre-flush fluid venting phase is monitored in combination with both the amount of bubbles in the fluid on the venous line and the pre-flush venting time of the adsorption column and a determination is made as to whether or not to terminate the venting phase. In addition, in the pre-flushing liquid flowing exhaust stage or after the pre-flushing liquid flowing exhaust stage is finished, the angle of the adsorption column can be adjusted through the holding module, or the adsorption column is knocked through the knocking module, or the adsorption column is rotated through the rotating module, or the adsorption column and the knocking module are combined, so that bubbles hidden in all corners of the adsorption column are further exhausted; the method is very suitable for exhaust control of the cytokine adsorption column by using the resin with small particles, light weight and strong hydrophobicity as the adsorbent, and effectively improves the exhaust effect of the cytokine adsorption column.

Description

Exhaust control system of blood perfusion device

Technical Field

The invention belongs to the technical field of medical appliances, and particularly relates to an exhaust control system of a blood perfusion device.

Background

The blood perfusion device is an instrument used in a blood purification treatment mode, and the working principle is as follows: the method comprises the steps of drawing out the blood of a patient, enabling the blood to be in contact with an adsorbent in a hemoperfusion apparatus, removing some exogenous or endogenous toxins in an adsorption mode, and returning the purified blood to the patient, so that the treatment purpose of purifying the blood is achieved.

Figure 1 shows a schematic diagram of the tubing of one embodiment of a blood perfusion apparatus for clinical treatment, wherein extracorporeal circulation tubing (including arterial tubing and venous tubing) is used to transport blood and the blood perfusion apparatus is used to remove some exogenous or endogenous toxins from the blood. There are a number of different types of hemodynamics that differ primarily in terms of the clinical symptoms of the patient: the adsorbents filled inside the hemodynamic machines are different and can be roughly divided into: disposable blood perfusion device, disposable endotoxin absorber, disposable plasma bilirubin absorber, DNA immunity adsorption column, etc. Further, taking the apparatus of the medical science and technology group, inc. as an example, the disposable hemoperfusion apparatus can be further divided into: HA60 disposable hemodiafiltration device, HA130 disposable hemodiafiltration device, HA230 disposable hemodiafiltration device, HA330 disposable hemodiafiltration device, etc.; these HA-series hemodynamic machines of the health sail biotechnology group limited are applicable to a variety of different types of blood perfusion treatments.

Referring to fig. 1, before a patient is treated by hemoperfusion, the hemoperfusion apparatus and the extracorporeal circulation circuit need to be completely purged of gases and impurities, this step is called: and (5) exhausting. In the exhaust method described in patent document CN106215265B, the gas and impurities in the blood perfusion apparatus are completely removed by changing the inclined position of the blood perfusion apparatus and performing the exhaust step by step.

Wherein, the blood perfusion device mainly depends on the chemical characteristics of the adsorbent to realize the blood purification function; generally, the adsorbent in the blood perfusion device in the prior art is mainly neutral macroporous adsorption resin synthesized by taking polystyrene-divinylbenzene porous microspheres as a matrix; taking the HA series hemoperfusion apparatus mentioned above as an example, the surface of the material of the neutral macroporous adsorption resin HAs hydrophilicity, and the diameter of the resin particles is larger, so that in the process of exhausting the hemoperfusion apparatus, medical staff only needs to set a short time (such as 1 minute) to pre-flush the HA series hemoperfusion apparatus by adopting pre-flushing liquid such as physiological saline, and the like, so that the air and impurities of the adsorption column can be completely exhausted.

However, with continuous research on clinical treatment of hemodiafiltration, technicians have gradually developed new types of hemodiafiltration; blood perfusion device newly developed by the Jianshan Biotechnology group Co., ltd.): compared with the HA series blood perfusion device in the traditional technology, the cytokine adsorption column (CA series product of Jianfan biotechnology group Co., ltd.) is exemplified, the adsorbent in the cytokine adsorption column adopts resin with small particles, light weight and strong hydrophobicity, and the loading of the cytokine adsorption column is full; if the traditional exhaust method is still adopted, the exhaust degree can not be monitored, insufficient exhaust is easily caused, residual bubbles can reduce the contact between blood and resin, the coagulation risk in the treatment process is increased, the effectiveness and the safety of the cytokine adsorption column in the blood perfusion treatment process are reduced, and the clinical application of the adsorption column is influenced.

Disclosure of Invention

The invention aims to provide a brand new exhaust control mode, which can monitor the state of an exhaust process (called pre-flushing liquid flowing exhaust stage for short) for flushing the inside of an adsorption column through the pre-flushing liquid flowing continuously and control the stopping of the exhaust stage. The invention is realized by the following technical scheme:

an exhaust control system of a blood perfusion device, the blood perfusion device comprises an adsorption column, wherein the adsorption column is filled with resin adsorbent and is provided with an inlet end connected with an arterial pipeline and an outlet end connected with a venous pipeline; characterized in that the exhaust gas control system includes:

the pre-flushing module is connected with the arterial pipeline and used for outputting pre-flushing liquid into the adsorption column through the arterial pipeline when the arterial pipeline is conducted;

the first detection module is arranged on the venous pipeline and is used for detecting the bubble quantity of the liquid on the venous pipeline and generating a first voltage value;

the time detection module is used for detecting the accumulated conduction time of the arterial pipeline and generating a second voltage value;

the comparison module is connected with the first detection module and the time detection module and is used for detecting that the first voltage value is smaller than a first preset voltage value and the second voltage value is larger than a second preset voltage value and generating a turn-off control signal for turning off the arterial pipeline.

Preferably, the exhaust gas control system further includes:

the switch control module is arranged on the arterial pipeline, connected with the time detection module and the comparison module, and used for conducting the arterial pipeline according to a conducting control signal and switching off the arterial pipeline according to a switching-off control signal.

Preferably, the exhaust gas control system further includes: and the clamping module is connected with the comparison module and used for adjusting the angle between the axial direction of the adsorption column and the horizontal plane according to the turn-off control signal.

Specifically, the clamping module includes:

the first angle adjusting module is connected with the switch control module and is used for outputting a first adjusting signal according to the conduction control signal;

the second angle adjusting module is connected with the comparing module and is used for outputting a second adjusting signal according to the turn-off control signal;

the clamping component is connected with the first angle adjusting module and the second angle adjusting module and is used for clamping the adsorption column and setting the axial opposite horizontal surfaces of the adsorption column to be at a first preset angle according to the first adjusting signal; setting the axial phase of the adsorption column to be a second preset angle along with the horizontal plane according to the second adjusting signal;

The inlet end of the adsorption column is lower than the outlet end, and the first preset angle is larger than the second preset angle.

Preferably, the exhaust gas control system further includes:

the first flow detection module is arranged on the arterial circuit and used for detecting the flow of the pre-flushing liquid in the arterial circuit.

Preferably, the exhaust gas control system further includes:

the second flow detection module is arranged on the intravenous line and connected with the switch control module and is used for detecting the flow of the pre-flushing liquid in the intravenous line according to the conduction control signal;

and the blocking detection module is connected with the first flow detection module and the second flow detection module and is used for judging whether pre-flushing liquid in the adsorption column is blocked or not according to the difference value between the flow detection value of the first flow detection module and the flow detection value of the second flow detection module.

Preferably, the exhaust gas control system further includes:

and the knocking module is connected with the comparison module and used for adjusting the knocking frequency and the knocking area of the shell of the adsorption column according to the turn-off control signal.

Specifically, the tapping module includes:

The first direction adjusting module is connected with the switch control module and is used for outputting a third adjusting signal according to the conduction control signal;

the second direction adjusting module is connected with the comparing module and is used for outputting a fourth adjusting signal according to the turn-off control signal;

the knocking component is connected with the first direction adjusting module and the second direction adjusting module and is used for knocking the inlet end of the adsorption column according to the third adjusting signal and the first knocking frequency and knocking the outlet end of the adsorption column according to the fourth adjusting signal and the second knocking frequency;

the inlet end of the adsorption column is lower than the outlet end, and the second knocking frequency is higher than the first knocking frequency.

Specifically, the tapping module further comprises:

the angle indicating module is connected with the knocking component and is used for setting a first knocking domain of the inlet end of the adsorption column according to the first preset angle and setting a second knocking domain of the outlet end of the adsorption column according to the second preset angle;

the knocking component is specifically configured to knock a first knocking domain of an inlet end of the adsorption column according to the first knocking frequency according to the third adjusting signal, and knock a second knocking domain of an outlet end of the adsorption column according to the second knocking frequency according to the fourth adjusting signal.

Preferably, the second preset angle is 0 degrees; the exhaust gas control system further includes:

and the rotating module is connected with the comparing module and used for controlling the adsorption column to rotate at a constant speed on the horizontal plane by taking the axial midpoint of the adsorption column as a rotating center according to the turn-off control signal.

Preferably, the exhaust gas control system further includes:

the standing module is connected with the rotating module and the clamping component and is used for detecting the accumulated time of the adsorption column rotating at a constant speed, controlling the adsorption column to stop rotating when the accumulated time of the adsorption column rotating at the constant speed is greater than a preset rotating time and outputting a standing adjustment signal;

the clamping part is also used for setting the axial opposite horizontal surfaces of the adsorption column at a third preset angle according to the standing adjustment signal;

the first preset angle is larger than the third preset angle, and the third preset angle is larger than the second preset angle.

An exhaust control method of a blood perfusion device comprises an adsorption column, wherein resin adsorbent is filled in the adsorption column, and the adsorption column is provided with an inlet end connected with an arterial pipeline and an outlet end connected with a venous pipeline; the exhaust gas control method is characterized by comprising the following steps: the pre-flushing liquid flowing exhaust stage is that the pre-flushing liquid is continuously connected to the adsorption column through the arterial pipeline, the inside of the adsorption column is flushed, and the pre-flushing liquid, bubbles and impurities are continuously discharged outwards through the venous pipeline; the method is characterized in that: judging the state of the pre-flushing fluid flowing exhaust stage by detecting the bubble quantity of the liquid on the venous pipeline and the accumulated conduction time of the arterial pipeline; and when the air bubble quantity is lower than a first preset value and the accumulated on time is higher than a second preset value, generating an off control signal for turning off the arterial pipeline.

Preferably, after the pre-flushing liquid flowing and exhausting stage or after the pre-flushing liquid flowing and exhausting stage is finished, bubbles hidden in corners of the adsorption column are exhausted by adjusting the angle adjustment of the adsorption column, or by knocking the adsorption column, or by rotating the adsorption column.

Preferably, after the pre-flushing liquid flowing and exhausting stage or after the pre-flushing liquid flowing and exhausting stage is finished, at least two modes of adjusting the angle of the adsorption column, knocking the adsorption column and rotating the adsorption column are combined, so that bubbles hidden in corners of the adsorption column are exhausted.

The invention has the beneficial effects that:

1. detecting the bubble quantity of the liquid on the venous line through a first detection module, and detecting the pre-flushing exhaust time of the adsorption column through a time detection module; and the state of the pre-flushing liquid flowing and exhausting stage of the adsorption column is monitored by combining the bubble quantity of the liquid on the venous line and the pre-flushing and exhausting time of the adsorption column, and whether the pre-flushing liquid flowing and exhausting stage of the adsorption column is needed to be stopped or not is judged.

2. After the pre-flushing liquid flowing and exhausting stage or the pre-flushing liquid flowing and exhausting stage is finished, the angle of the adsorption column can be adjusted through the holding module, or the adsorption column is knocked through the knocking module, or the adsorption column is rotated through the rotating module, so that bubbles hidden in all corners of the adsorption column are further exhausted; the cytokine adsorption column is very suitable for safe exhaust control by adopting the cytokine adsorption column with small particles, light weight and strong hydrophobicity as the adsorbent, improves the exhaust effect of the cytokine adsorption column, ensures the safety and effectiveness of the blood perfusion treatment of patients, and is favorable for the popularization and use of the blood perfusion device of the cytokine adsorption column.

3. The invention fully considers the problems that the adsorbent particles of the cytokine adsorption column are small, the weight is light, the hydrophobicity is strong, and the residual small bubbles of the resin adsorbent in the adsorption column are easy to cause, and combines the adjustment of the inclination angle of the adsorption column and the knocking frequency of the adsorption column to jointly adjust the exhaust state of the blood perfusion device, thereby preventing the residual bubbles in the cytokine adsorption column.

Drawings

Fig. 1 is a schematic diagram of a circuit of one embodiment in a clinical application of a blood perfusion apparatus.

FIG. 2 is a block diagram of an exhaust control system of the blood perfusion apparatus according to the present invention;

FIG. 3 is a specific circuit configuration diagram of the first detection module according to the present invention;

FIG. 4 is a specific circuit configuration diagram of the switch control circuit of the present invention;

FIG. 5 is a specific circuit block diagram of the RC charge circuit of the present invention;

FIG. 6 is a specific circuit block diagram of the comparison module shown in the present invention;

FIG. 7 is a circuit diagram of a first angle adjustment module according to the present invention;

FIG. 8 is a specific circuit block diagram of the indication module of the present invention;

FIG. 9 is a specific circuit block diagram of a first flow detection module according to the present invention;

FIG. 10 is a specific circuit block diagram of the jam detection module of the present invention;

FIG. 11 is a schematic illustration of a tapping component of the present invention tapping;

FIG. 12 is a schematic view of the strike zones of the inlet and outlet ends of an adsorption column according to the present invention;

fig. 13 is a schematic view showing the rotation of the adsorption column according to the present invention.

Detailed Description

In order to better illustrate the embodiments of the present invention, the hemoperfusion apparatus described in this embodiment adopts a mechanical structure of the hemoperfusion apparatus in CN201211354Y patent document or a similar structure, that is, the hemoperfusion apparatus includes an adsorption column, the adsorption column has a hollow filter chamber, the filter chamber is filled with a resin adsorbent, wherein both ends of the adsorption column are provided with an inlet end and an outlet end for connecting an arterial line and a venous line, respectively. The process and principle of the blood perfusion device for purifying blood are as follows: with reference to fig. 1, the arterial line is driven by the blood pump to introduce the blood of the human body into the inlet end of the blood perfusion device, the blood is in direct contact with the solid adsorbent in the adsorption column, the middle molecular or macromolecular toxins in the blood are removed in an adsorption manner, then the purified blood flows out from the outlet end of the blood perfusion device to the venous line and reaches the venous pot, the gas in the purified blood is removed through the venous pot, and then the blood is returned into the vein of the human body, so that the blood perfusion treatment process is completed.

The embodiment adopts the blood perfusion device of the cytokine adsorption column type because the exhaust of the cytokine adsorption column is more difficult to control and the expected effect is more difficult to achieve, and the exhaust control system in the invention is applied to the cytokine adsorption column and can more prominently embody the technical effect. However, it is not excluded that the exhaust control system provided by the present invention may also be applied to the exhaust of a hemoperfusion cartridge of a non-cytokine adsorption column.

The exhaust control system provided in this embodiment is used for exhausting the blood perfusion apparatus, that is, before the blood perfusion apparatus formally purifies blood, gas and impurities in a cytokine adsorption column (hereinafter referred to as adsorption column) are removed, so that the blood perfusion apparatus can normally and effectively purify blood when purifying blood subsequently.

In the exhaust control process of the embodiment, the inlet end of the adsorption column is connected with a storage bag (filled with pre-flushing liquid) through an arterial pipeline, and the outlet end of the adsorption column is connected with a waste liquid bag through a venous pipeline; the arterial pipeline outputs the pre-flushing liquid to the inlet end of the adsorption column when being conducted, and the venous pipeline discharges the pre-flushing liquid or bubbles in the adsorption column when being conducted.

The exhaust control system provided in this embodiment can realize exhaust control in three stages: 1. a pre-flushing fluid flowing exhaust stage; 2. a pre-flushing non-flowing exhaust stage; 3. and (3) standing and exhausting. The pre-flushing liquid flowing and exhausting stage is to continuously connect pre-flushing liquid (from a liquid storage bag) to the adsorption column through an arterial pipeline, flush the inside of the adsorption column and continuously exhaust the pre-flushing liquid, bubbles and impurities outwards (for example, a waste liquid bag) through a venous pipeline; the pre-flushing non-flowing exhaust stage refers to a stage that an arterial pipeline is shut off, the pre-flushing is not connected to the adsorption column, the pre-flushing is reserved in the adsorption column, and bubbles in the adsorption column are exhausted outwards from a venous pipeline through other auxiliary means (such as angle adjustment, knocking and or rotation of the adsorption column); the stage of standing and exhausting refers to a stage of standing the adsorption column so that bubbles inside the adsorption column are exhausted to the outlet end of the adsorption column.

In this embodiment, the above three exhaust phases are sequentially performed, and only the pre-flushing fluid flowing exhaust phase, or only the pre-flushing fluid flowing exhaust phase and the pre-flushing fluid non-flowing exhaust phase may be performed. The respective control modules involved are described below for the different exhaust phases.

As shown in fig. 2, the exhaust gas control system provided in this embodiment includes: a first detection module 101, a switch control module 102, a pre-flush module 103, a time detection module 104, and a comparison module 105.

The first detection module 101 is disposed on the venous line, and is configured to detect a bubble amount of the liquid on the venous line, generate a first voltage value according to the bubble amount, and obtain the bubble amount of the liquid on the venous line through the first voltage value; when the adsorption column is exhausted, judging whether the pre-flushing liquid flowing and exhausting stage is exhausted or not according to the bubble quantity of the liquid on the monitoring vein pipeline; for example, when the bubble amount of the liquid on the venous line is detected to be larger, the fact that more air remains in the adsorption column is indicated, and the adsorption column is required to continue exhausting.

Specifically, fig. 3 shows a specific circuit configuration of the first detection module 101, and the first detection module 101 includes: the infrared light is irradiated on the bubble or the infrared light transmission quantity generated by irradiating the bubble on the liquid is different when the bubble exists in the liquid in the vein pipeline, the infrared light received by the light receiver of the infrared light tube is also changed, and the resistance value of the light receiver of the infrared light tube is changed, which is shown as follows: the resistance of the light receiver of the infrared photoelectric tube also changes, the voltage output by the light receiver of the infrared photoelectric tube also changes, and the voltage is amplified by the operational amplifier to obtain a first voltage value; therefore, the present embodiment uses the infrared photoelectric tube to perform infrared detection on the bubble amount of the liquid on the venous line, so as to obtain the first voltage value. It can be seen that there is a correspondence between the bubble amount of the liquid in the venous line and the magnitude of the first voltage value, for example, when the bubble amount of the liquid on the venous line is greater, the larger the diameter of the bubble is, the larger the first voltage value is; therefore, by using the circuit structure of the first detection module 101 in fig. 3, it is possible to convert the non-electric quantity into the electric quantity by the air bubble quantity of the liquid on the venous line, and the detection accuracy of the air bubble quantity is higher.

The switch control module 102 comprises a switch control circuit and a clip, wherein the clip comprises an arterial clip and a venous clip (shown in combination with fig. 1), and the arterial clip is arranged on an arterial circuit and used for controlling the on or off of the arterial circuit under the drive of the switch control module 102; the venous clip is arranged on the venous line and used for controlling the on-off of the venous line, but the on-off control of the venous clip is mainly used in blood purification, and the venous line is kept on in the exhaust stage. When the switch control module 102 conducts the arterial line according to the conduction control signal, the arterial line outputs the pre-flushing liquid to the adsorption column, and when the switch control module 102 turns off the arterial line according to the turn-off control signal, the arterial line is not connected to the pre-flushing liquid.

Specifically, fig. 4 shows a specific circuit structure of the switch control circuit provided in this embodiment, where the switch control circuit includes electronic components such as a triode and a resistor, and the turn-off control signal and the turn-on control signal respectively represent high and low levels, and when the switch control circuit is connected to the turn-on control signal or the turn-off control signal, the triode can be controlled to be turned off or turned on by the turn-on control signal or the turn-off control signal, so that the clip can be powered on or powered off; for example, when the clamp is powered on, the clamp conducts the arterial line; when the clamp is powered off, the clamp turns off the arterial pipeline so as to realize the automatic on-off control function of the clamp. It should be noted that, the clip is a clip in the prior art, and the clip can be automatically opened or automatically closed by controlling the power on or power off of the clip.

The pre-flushing module 103 is connected with an arterial pipeline, and is used for outputting pre-flushing liquid into the adsorption column through the arterial pipeline when the arterial pipeline is conducted. Referring to fig. 2, the pre-die block 103 includes: a first storage bag 1031 and peristaltic pump 1032; the first storage bag 1031 is connected with an arterial line and is used for storing a pre-flushing liquid with a certain volume, so that the pre-flushing liquid can be conveniently output to the inlet end of the adsorption column in real time when the adsorption column of the hemoperfusion apparatus is exhausted. Peristaltic pump 1032 sets up on arterial line for provide the driving force to arterial line, so that arterial line transmission advance towards liquid, make the inside inflow of adsorption column advance towards liquid, then in will adsorbing the post advance towards liquid discharge to the waste liquid bag (wherein advance towards liquid in the adsorption column belongs to the waste liquid through the venous line), in order to exhaust the adsorption column. The peristaltic pump 1032 is a peristaltic pump structure in the prior art, and a specific structure of the peristaltic pump in the patent document CN203548140U may be referred to specifically.

The time detection module 104 is configured to detect a time when the arterial line is accumulatively turned on, and generate a second voltage value according to the detected turn-on time. When the arterial catheter is conducted, the adsorption column is connected with pre-flushing liquid, and the adsorption column is exhausted through the pre-flushing liquid; when the arterial line is shut off, the adsorption column cannot be connected with the pre-flushing liquid; therefore, the time for which the arterial line is cumulatively turned on is equal to the time for which the adsorption column is cumulatively flushed with pre-flush air; converting the accumulated flushing exhaust time of the blood perfusion apparatus into a second voltage value by the time detection module 104 to realize conversion of the non-electric quantity signal into an electric quantity signal; the accumulated exhaust time of the blood perfusion device and the second voltage value have a one-to-one correspondence, and the invention can further process the second voltage value.

Specifically, the time detection module 104 may be implemented by an RC charging circuit in the conventional technology, for example, referring to fig. 5, fig. 5 shows a most simplified circuit structure of the RC charging circuit, and the working principle thereof is as follows: when the switch control module 102 is turned on, the switch control module 102 outputs a high level and charges the capacitor, and the time when the capacitor is charged is the time when the switch control module 102 outputs the high level (i.e. the time when the arterial line is accumulatively turned on), and the longer the time when the capacitor is charged, the larger the second voltage value output by the capacitor is, so that the time when the arterial line is accumulatively turned on can be represented by the magnitude of the second voltage value, and further, according to the second voltage value, the following steps are obtained: the adsorption column is pre-flushed with pre-flush fluid for a cumulative purge time. The RC charging circuit shown in fig. 5 belongs to the simplest circuit structure, and is mainly used for explaining the working principle of the time detection module 104, and in a specific application process, the RC charging circuit can be extended based on the circuit structure in fig. 5, for example, a part of electronic components are added, which is not limited herein too much.

The comparison module 105 is connected to the first detection module 101 and the time detection module 104, and is capable of comparing the magnitude between the first voltage value and the first preset voltage value through the comparison module 105, and is capable of comparing the magnitude between the second voltage value and the second preset voltage value through the comparison module 105. And generating a turn-off control signal when the first voltage value is detected to be smaller than a first preset voltage value and the second voltage value is detected to be larger than a second preset voltage value. That is, when the bubble amount of the liquid on the venous line is smaller than the preset bubble amount, the comparison module 105 detects that the first voltage is smaller than the first preset voltage value; when the time that the arterial line is turned on is greater than the first preset time, the comparison module 105 detects that the second voltage value is greater than the second preset voltage value, and only when the bubble amount of the liquid on the venous line is less than the preset bubble amount and the time that the arterial line is turned on is greater than the first preset time, the pre-flushing flow exhaust stage of the blood perfusion device can be ended and other stages can be entered; conversely, if the time that the arterial line is turned on is less than or equal to the first preset time and/or the air bubble amount of the liquid on the venous line is greater than or equal to the preset air bubble amount, it is indicated that the adsorption column has not been sufficiently exhausted by the pre-flushing liquid. As can be seen from the above, the present embodiment can monitor the state of the pre-flushing fluid flowing exhaust stage in real time, and the monitoring result is used as a dividing standard for different stages of the blood perfusion apparatus.

Specifically, fig. 6 shows a specific circuit configuration of the comparison module 105, and the comparison module 105 includes: the electronic components such as a comparator, an AND gate, a resistor and the like mainly utilize the working principle of the comparator: when the voltage of the non-inverting input end of the comparator is larger than the voltage of the inverting input end of the comparator, the level of the output end of the comparator is high; and in fig. 6, the output terminal of the and gate outputs a high level (i.e., turns off the control signal) only when both the output terminal of the comparator CMP1 and the output terminal of the comparator CMP2 are high levels; thus ensuring that: the first voltage value is smaller than a first preset voltage value, the second voltage value is larger than a second preset voltage value, and when the two conditions are met simultaneously, the comparison module 105 outputs a turn-off control signal to drive the switch control module 102 to turn off the arterial line.

The comparison module 105 in this embodiment can quantitatively determine whether the blood perfusion device is fully exhausted by the pre-flushing liquid by adopting a voltage comparison mode, and only when the air bubble amount of the liquid on the venous pipeline is smaller than the preset air bubble amount and the accumulated conduction time of the arterial pipeline is longer than the first preset time, the two conditions are satisfied simultaneously, the blood perfusion device can be determined to be fully exhausted by the pre-flushing liquid, so that the problem of insufficient exhaust of the adsorbent in the adsorption column is avoided, and the method is particularly suitable for the exhaust process of the cytokine adsorption column which adopts the resin with small particles, light weight and strong hydrophobicity as the adsorption material, and has wider application range and better applicability.

The exhaust control system provided in this embodiment further includes a clamping module 106, where the clamping module 106 is connected to the switch control module 102, and is used to clamp the adsorption column and adjust an angle of an axial direction Z (see fig. 11 and 12) of the adsorption column with respect to a horizontal plane. The angle adjustment of the adsorption column is performed when switching from the pre-flush fluid flow off-take stage to the pre-flush fluid non-flow off-take stage. Of course, the angle adjustment of the adsorption column may be performed in the pre-flushing liquid flowing exhaust stage or in the pre-flushing liquid non-flowing exhaust stage.

The angle adjustment of the adsorption column has the advantages that: since a large number of bubbles exist in the adsorption column before the adsorption column is not exhausted, the bubbles are uniformly distributed in each space in the adsorption column; when the inclination angles of the adsorption columns are different, the efficiency of discharging bubbles hidden in the adsorption columns is also different; if the inclination angle of the adsorption column is kept unchanged all the time in the exhaust process, bubbles hidden in corners of the adsorption column are easily omitted, so that insufficient exhaust in the adsorption column is caused; in the exhaust process of the adsorption column, the inclination angle of the adsorption column is flexibly adjusted at different stages in the exhaust process through the clamping module 106, so that the adsorption column can perform the exhaust operation while maintaining the optimum inclination angle.

Further, when the clamping module 106 clamps the adsorption column, the outlet end of the adsorption column is kept above the inlet end, so that when the inlet end of the adsorption column is connected with the pre-flushing liquid and the pre-flushing liquid is discharged through the outlet end of the adsorption column, the pre-flushing liquid can keep the flow direction from bottom to top in the adsorption column, and bubbles and impurities in the adsorption column can be completely and rapidly discharged through the pre-flushing liquid; so as to prevent the problem that bubbles hidden in the inner corners of the adsorption columns cannot be discharged due to improper arrangement of the inclination angle.

In this embodiment, the switching from the pre-flushing fluid flowing exhaust stage to the pre-flushing fluid non-flowing exhaust stage is performed by adjusting an angle of the axial direction of the adsorption column relative to a horizontal plane according to the turn-off control signal. Specifically, when the comparison module 105 detects that the first voltage value is smaller than the first preset voltage value and the second voltage value is larger than the second preset voltage value, the comparison module 105 outputs a turn-off control signal to stop the pre-flushing fluid flowing exhaust stage, and at this time, the inclination angle of the blood perfusion device is adjusted; the bubbles distributed at all corners inside the adsorption column can be completely discharged, so that the application safety of the hemoperfusion apparatus in the future hemoperfusion treatment process is further improved.

It should be noted that the above-mentioned suspension of the pre-flush fluid flow venting phase is only the end of one phase, and the entire venting process for the adsorption column of the hemodiayer is continued, i.e. the pre-flush fluid non-flow venting phase may be entered (this phase may include the part of the adsorption column angle adjustment described above for the venting of air bubbles, and may also include the part of the venting of air bubbles by knocking or rotating the adsorption column, which will be described below). In addition, the venous line is always connected no matter in the pre-flushing liquid flowing exhaust stage or in the pre-flushing liquid non-flowing exhaust stage, and then the bubbles in the adsorption column can be discharged to the waste liquid bag through the venous line.

Referring to fig. 2, the clamping module 106 specifically includes: a first angle adjustment module 1061, a second angle adjustment module 1062, and a clamping member 1063. The first angle adjustment module 1061 is connected to the switch control module 102, and configured to output a first adjustment signal according to the on control signal. The second angle adjustment module 1062 is connected to the comparison module 105, and configured to output a second adjustment signal according to the turn-off control signal. The clamping component 1063 is connected to the first angle adjustment module 1061 and the second angle adjustment module 1062, and forms a first preset angle between the adsorption column and the horizontal plane along the axial direction according to the first adjustment signal; or, according to the second adjusting signal, the adsorption column is subjected to a second preset angle with the horizontal plane along the axial direction; wherein the first preset angle is greater than the second preset angle.

In the present embodiment, the first preset angle is 90 degrees (see fig. 11), and the second preset angle is 60 degrees (see fig. 12); then in the stage of the flow and exhaust of the pre-flushing liquid, the axis of the adsorption column is consistent with the vertical direction, and when the pre-flushing liquid flows in the adsorption column from bottom to top, the flowing pre-flushing liquid can flush bubbles in the adsorption column at a faster speed, so that the exhaust efficiency and the exhaust effect of the pre-flushing liquid in the adsorption column are improved. In this embodiment, the second preset angle is 60 degrees, when the pre-flushing liquid flowing exhaust stage is switched to the pre-flushing liquid non-flowing exhaust stage, the pre-flushing liquid in the adsorption column is rocked by the switching of the angles, so that each angle in the adsorption column is flushed, and especially, bubbles hidden on the inlet end of the adsorption column and the wall of the adsorption column are completely exhausted, so that the defect that bubbles hidden at corners of the adsorption column cannot be completely exhausted in the first stage is overcome, and the method is favorable for playing a better exhaust effect on the resin with small particles, light weight and strong hydrophobicity in the adsorption column, and is particularly suitable for a cytokine adsorption column, and the exhaust effect is better.

Referring to the mechanical structure of the clamping members in both CN211214654U and CN204170171U, in the above embodiment, the principle of angle control on the clamping module 106 is equivalent to the control on the mechanical arm in the prior art, which is mainly implemented by a motor driving circuit, and the first angle adjusting module 1061 may be implemented by a motor driving circuit, where fig. 7 shows a specific circuit structure of the motor driving circuit, and in fig. 7, the first angle adjusting module 1061 includes: triode (PNP triode), diode, electronic components such as resistance can change triode conduction time through switching on control signal to realize PWM (Pulse Width Modulation ) regulatory function to the motor, change rotational speed and the rotation time of motor, and then adjust the rotation state of clamping part 1063, so that the adsorption column personally submits first default angle along axial direction and level, realized the drive control function of clamping module 106. It should be noted that fig. 7 only shows the simplest control principle of the motor driving circuit, which is mainly used to illustrate the control principle of the first angle adjusting module 1061, and in a specific application process, the control principle may be extended on the basis of fig. 7, for example, the control principle may be extended into an H-bridge motor driving circuit, so as to adjust the speed and the steering of the motor. In addition, the second angle adjusting module 1062 may also be implemented by the circuit structure in fig. 7, and the control principle thereof is similar to that of the first angle adjusting module 1061, which will not be described herein.

Optionally, referring to fig. 2, the exhaust gas control system further includes: the alarm module 107 is connected with the comparison module 105, and is used for performing audible and visual alarm according to the turn-off control signal; when the comparison module 105 outputs the turn-off control signal, it is indicated that the inclination angle of the adsorption column needs to be adjusted, so that the exhaust process of the hemoperfusion apparatus enters another stage, and at this time, the alarm module 107 performs an audible and visual alarm to prompt the user: the inclination angle of the blood perfusion device is changed, so that the exhaust process of the blood perfusion device is prevented from being failed.

Optionally, referring to fig. 2, the exhaust gas control system further includes: the first flow detection module 109 is arranged on the arterial circuit and is used for detecting the flow of pre-flushing liquid in the arterial circuit; the first flow detection module 109 can detect the flow of the pre-flushing liquid in the arterial line so as to facilitate the user to know the pre-flushing exhaust state of the blood perfusion device; for example, when the arterial line is on, the flow detected by the first flow detection module 109 is: 10ml/min, when the arterial line is shut off, the flow detected by the first flow detection module 109 should be: 0ml/min.

Preferably, referring to fig. 2, the exhaust gas control system further includes: the display module 110, the display module 110 is connected with the first flow detection module 109, and the display module 110 is used for displaying the flow of the pre-flushing liquid in the arterial line, so that the user can review in real time.

Optionally, referring to fig. 2, the exhaust gas control system further includes: the indication module 111 is connected to the switch control module 102, and is configured to send out a first indication light source according to the on control signal. By way of example, fig. 8 shows a specific circuit structure of the indication module 111, and the indication module 111 includes: when the switch control module 102 conducts the arterial line according to the conduction control signal, the base electrode of the triode is connected with the driving voltage so as to conduct the triode, and the light emitting diode is powered on and emits a first indication light source; once the user sees the light emitting diode to emit the first indication light source, the user can know that: the adsorption column is adopting pre-flushing liquid for exhaust control, so that the user can check conveniently.

Optionally, referring to fig. 2, the exhaust gas control system further includes: the second flow detection module 112 is disposed on the venous line, and connected to the switch control module 102, and is configured to detect a flow of the pre-flushing liquid in the venous line according to the on control signal. Only when the switch control module 102 turns on the arterial line according to the on control signal, the second flow detection module 112 detects the flow of the pre-flushing liquid in the venous line, so that it can determine whether the liquid flow state in the blood perfusion apparatus is in a fault state according to the flow detection difference between the first flow detection module 109 and the second flow detection module 112, so as to monitor the exhaust control process of the blood perfusion apparatus in real time. For example, in the process of adopting the pre-flushing liquid to carry out exhaust flushing on the blood perfusion device, under normal conditions, the flow of the pre-flushing liquid in the arterial pipeline is not too different from the flow of the pre-flushing liquid in the venous pipeline; thus, when the flow detection values of both the first flow detection module 109 and the second flow detection module 112 differ too much, it is indicated that the pre-flush flow condition within the adsorption column is malfunctioning.

Specifically, the first flow detection module 109 is implemented using a flow sensor, and fig. 9 illustrates a circuit structure of the first flow detection module 109, where the first flow detection module 109 includes: electronic components such as a resistor, a comparator and the like, and the resistance strain gauge can convert mechanical pressure into resistance change; the four resistance strain gauges RV1, RV2, RV3 and RV4 form a Wheatstone bridge, wherein the resistance strain gauges RV1 and RV3 form a group and are arranged at one position of an arterial pipeline; the resistance strain gauges RV2 and RV4 form another group and are arranged at the other part of the arterial pipeline; the line pressure at these two points will vary and will vary as the flow of fluid in the arterial line varies; the pressure difference can be converted through the sensing of the Wheatstone bridge to output a voltage signal, the voltage signal is used for representing the flow of the pre-flushing liquid in the arterial line, the three comparators amplify the voltage signal and then output the amplified voltage signal, and even if the flow of the pre-flushing liquid in the arterial line is slightly changed, the voltage signal with a specific amplitude can be output after the voltage is amplified; therefore, in this embodiment, the first flow detection module 109 converts the flow change of the pre-flushing liquid in the arterial line into a voltage change, so that the flow of the pre-flushing liquid in the arterial line can be obtained according to the voltage output by the first flow detection module 109.

It should be noted that, the circuit structure of the second flow rate detection module 112 may refer to the circuit structure of the first flow rate detection module 109, and thus the circuit structure of the second flow rate detection module 112 may refer to the circuit structure in fig. 9, which is not described herein.

Preferably, the exhaust gas control system further includes: the blocking detection module 113, the blocking detection module 113 is connected to the first flow detection module 109 and the second flow detection module 112, and is configured to determine whether the pre-flushing liquid in the adsorption column is blocked according to a difference between a flow detection value of the first flow detection module 109 and a flow detection value of the second flow detection module 112. Specifically, when the blockage detection module 113 detects that the difference between the flow detection value of the first flow detection module 109 and the flow detection value of the second flow detection module 112 is greater than the preset error, it indicates that the pre-flushing liquid in the adsorption column is blocked (various reasons for blocking occur therein, such as that a filter screen in the adsorption column is damaged, so that the adsorbent molecule blocks an inlet end of the adsorption column or an outlet end of the adsorption column), and then the flow difference between the inflow liquid and the outflow liquid of the adsorption column determines whether the pre-flushing liquid in the adsorption column is blocked, which is favorable for removing the pre-flushing liquid flow fault of the blood perfusion apparatus in the exhaust control process.

As described above, the flow detection value of the first flow detection module 109 is represented by a voltage value, and the flow detection value of the second flow detection module 112 is also represented by a voltage value, and then the blocking detection module 113 in this embodiment obtains the flow detection difference value of both the first flow detection module 109 and the second flow detection module 112 by using a voltage comparison method; by way of example, fig. 10 shows a specific circuit configuration of the jam detection module 113, the jam detection module 113 including: electronic components such as an operational amplifier and a resistor, and the like, the difference value of the voltages is compared by the operational amplifier, so that the voltage output by the output end of the operational amplifier can represent the difference value between the flow detection value of the first flow detection module 109 and the flow detection value of the second flow detection module 112, and when the voltage output by the output end of the operational amplifier is larger, the difference value between the flow detection value of the first flow detection module 109 and the flow detection value of the second flow detection module 112 is larger; preferably, in fig. 10, the second flow rate detection module 112 further includes: when the voltage output by the output end of the operational amplifier is increased, the triode Q4 is driven to be conducted, and the loudspeaker gives out an alarm; once the loudspeaker gives out an alarm, the pre-flushing liquid in the adsorption column is indicated to be blocked, and the sensitive judgment on whether the adsorption column is blocked or not in the exhaust control process of the blood perfusion device is realized.

Optionally, referring to fig. 2, the exhaust gas control system further includes: a weight sensing module 114 and a weight comparison module 115; the weight sensing module 114 is connected with the comparing module 105 and is used for detecting the weight of the adsorption column according to the turn-off control signal. As described above, when the comparison module 105 determines that the pre-flushing flow exhaust stage of the adsorption column is completed, the comparison module 105 outputs the off control signal, interrupting the pre-flushing access operation of the adsorption column; at this time, the pre-flushing liquid is contained in the adsorption column, and compared with the adsorption column when the adsorption column is not exhausted, the weight of the adsorption column after the adsorption column is exhausted can be obviously increased; therefore, by comparing the difference between the weight of the adsorption column after the pre-flushing fluid flowing exhaust phase and the weight of the adsorption column when not exhausting, the weight comparison module 115 can determine whether the adsorption column is in a fault state. For example, when the weight comparison module 115 detects: the difference between the weight detection result of the weight sensing module 114 and the weight of the adsorption column when not exhausting is smaller than a normal value, which indicates that the adsorption column fails (the reasons for the failure of the adsorption column are various, such as that the pipe wall of the adsorption column is damaged, and the end cover of the blood perfusion device is leaked, etc.).

Optionally, referring to fig. 2, the exhaust gas control system further includes: the pressure detection module 116 is disposed on the venous line, and is connected to the switch control module 102, and is configured to detect a pressure of the venous line according to the on control signal. Specifically, the pressure of the venous line is detected by the pressure detection module 116 to monitor the flow state of the pre-flushing liquid in the venous line, so as to obtain the safety of the exhaust control of the pre-flushing liquid in the adsorption column.

Therefore, the present embodiment can monitor the flow rate of the pre-flushing liquid in the venous line and the pressure of the venous line simultaneously, so as to prevent the flow failure of the pre-flushing liquid in the venous line when the pre-flushing liquid performs the exhaust control on the blood perfusion device.

Optionally, referring to fig. 2, the exhaust gas control system further includes: the key module 117 and the power module 118, wherein the key module 117 is connected with the switch control module 102 and is used for outputting the conduction control signal according to a trigger signal output by a user; when the user needs to start the venting process of the hemodynamic perfusion, the user outputs a trigger signal to start the pre-flush flow venting phase (equivalent to pneumatic whole venting process).

The power module 118 is connected to the key module 117 and the peristaltic pump 1032, and is configured to supply power to the peristaltic pump according to the on control signal. When the user triggers the button module 117, the power module 118 can perform rated power supply to the peristaltic pump 1032, the peristaltic pump 1032 is electrically started, the switch control module 102 conducts the arterial line according to the conducting control signal, the peristaltic pump 1032 provides driving force to the arterial line, and the arterial line transmits pre-flushing liquid to the inlet end of the adsorption column so as to start the pre-flushing exhaust process of the adsorption column; therefore, the peristaltic pump 1032 in this embodiment is powered on and the switch control module 102 conducts the arterial line simultaneously, which not only improves the exhaust control efficiency of the blood perfusion apparatus, but also prevents the peristaltic pump 1032 from generating excessive electric energy loss. Further, the power module 118 is further connected to the comparing module 105, and the power module controls the peristaltic pump 1032 to lose power according to the turn-off control signal.

As described above, the off control signal is generated by the comparison module 105, and the on control signal is generated by the switch control module according to the trigger signal of the key module 117. In the above implementation, when the comparison module 105 outputs the turn-off control signal, the power module 118 controls the peristaltic pump 1032 to be powered off, and the switch control module 102 turns off the arterial line according to the turn-off control signal, so that two events of the power failure of the peristaltic pump 1032 and the turn-off of the arterial line occur simultaneously, the pre-flushing and exhausting process of the adsorption column is interrupted, and the flow control precision and the control safety of pre-flushing liquid in the arterial line are improved.

In this embodiment, when the comparison module 105 outputs the turn-off control signal to the switch control module 102, and the switch control module 102 turns off the arterial line according to the turn-off control signal, the pre-flushing liquid cannot be connected into the adsorption column, and the pre-flushing liquid (but does not continuously flow) is contained in the adsorption column. Of course, the pre-flushing liquid flowing exhaust stage can be combined with knocking or rotating the adsorption column, so that the air bubble exhaust can be accelerated.

Based on this, referring to fig. 2, the exhaust gas control system further includes: the knocking module 119 is connected with the comparing module 105, and is used for adjusting the knocking frequency and the knocking area of the shell of the adsorption column according to the difference between the pre-flushing liquid flowing exhaust stage and the pre-flushing liquid non-flowing exhaust stage.

Specifically, when the hemoperfusion apparatus is exhausting, the vibration force can be applied to the adsorption column by knocking the outer shell of the adsorption column, so that bubbles hidden at the inner corners of the adsorption column can be completely discharged out of the adsorption column. Therefore, in the pre-flushing liquid flowing exhaust stage and the pre-flushing liquid non-flowing exhaust stage, the knocking frequency and the knocking area of the shell knocking the adsorption column can be adjusted so as to improve the exhaust efficiency of the cytokine adsorption column. In addition, the adjusting of the inclination angle of the adsorption column can be combined, so that the knocking frequency and the knocking area of the shell knocking the adsorption column can be adjusted, the exhaust mode of the blood perfusion device can be changed together, and the exhaust efficiency of the cytokine adsorption column can be improved.

Specifically, referring to fig. 2, the tapping module 119 includes: a first direction adjustment module 1191, a second direction adjustment module 1192, and a striking member 1193; the first direction adjustment module 1191 is connected to the switch control module 102, and is configured to output a third adjustment signal according to the on control signal. The second direction adjustment module 1192 is connected to the comparison module 105, and is configured to output a fourth adjustment signal according to the off control signal. The knocking component 1193 is connected to the first direction adjusting module 1191 and the second direction adjusting module 1192, and is configured to knock an inlet end of the adsorption column according to a first knocking frequency according to the third adjusting signal, and knock an outlet end of the adsorption column according to a second knocking frequency according to the fourth adjusting signal; wherein the second tap frequency is greater than the first tap frequency.

When the arterial pipeline is conducted, namely, the pre-flushing liquid flows through the adsorption column to exhaust the air, the inlet end of the adsorption column is taken as a knocking area, when the end cover at the inlet end of the adsorption column is knocked, the pre-flushing liquid flows in the adsorption column, and the knocking force generated by knocking can enable small bubbles of the end cover hidden at the inlet end to flow out to the adsorption column along with the pre-flushing liquid so as to remove all the small bubbles of the end cover at the inlet end; when the arterial pipeline is shut off, namely, when the adsorption column is subjected to the pre-flushing non-flowing exhaust stage, the outlet end of the adsorption column is used as a knocking area, and when the end cover at the outlet end of the adsorption column is knocked, small bubbles hidden in the end cover at the outlet end can quickly float in the pre-flushing liquid by knocking force generated by knocking and are output to the outside of the adsorption column. And, the second tapping frequency is greater than the first tapping frequency, for example, the second tapping frequency is: 2 beats/second, the first tap frequency is: 1 time/second, when the adsorption column is connected with the pre-flushing liquid, the knocking frequency is slower, so that the flow of the pre-flushing liquid in the adsorption column is not disturbed; when the adsorption column is not connected with the pre-flushing liquid, the knocking frequency is faster, so that small bubbles at the outlet end can be knocked into the liquid and quickly float to the venous line at the outlet end.

Note that, in this embodiment, the striking member 1193 is a multifunctional hammer for striking, and fig. 11 is an example, and the multifunctional hammer 99 may be operated by a person or may be operated automatically by a machine; for example, when the user receives the third adjustment signal or the fourth adjustment signal, the user picks up the multifunctional hammer to directly strike the end cap 911 of the inlet end 91 of the adsorption column 90 or the end cap 921 of the outlet end 92 of the adsorption column. Of course, a mechanical, automatically controlled, multi-function hammer may also be used to strike.

As an alternative embodiment, the tapping module further comprises: the angle indication module 1194, where the angle indication module 1194 is connected to the knocking component 1193, and is configured to set a first knocking domain of the inlet end of the adsorption column according to the first preset angle, and set a second knocking domain of the outlet end of the adsorption column according to the second preset angle.

The knocking component 1193 is further connected to the angle indicating module 1194, where the knocking component 1193 is specifically configured to knock a first knocking domain of the inlet end of the adsorption column according to the first knocking frequency according to the third adjusting signal, and knock a second knocking domain of the outlet end of the adsorption column according to the second knocking frequency according to the fourth adjusting signal. Wherein, the knocking field refers to: the shell of the adsorption column is used for knocking a stressed area of knocking, and the knocking part can knock the shell of the adsorption column in a knocking area; for example, using the side of the end cap near the inlet end of the adsorption column as the strike zone, then the side of the end cap near the inlet end would need to be struck by the strike member 1193; in this embodiment, the setting of the knocking domain is related to the inclination angle of the hemoperfusion apparatus, so that the small bubbles hidden at the inlet end and the outlet end of the adsorption column can be completely exhausted by knocking by the knocking component 1193, so as to achieve the best knocking exhaust effect.

For example, referring to fig. 12, if the first preset angle is 60 degrees, fig. 12 further shows that the bottom surface 913 of the end cap 911 of the inlet end 91 is circular, the circular 60-degree fan-shaped range is used as the first knocking domain 915, and when the 60-degree fan-shaped range of the bottom surface of the end cap is higher than the bottom surface of the end cap not selected as the first knocking domain, the small bubbles hidden in the corners of the end cap are more easily knocked into the pre-flushing liquid by the multifunctional hammer 99, which is beneficial to exerting the exhaust effect generated by the knocking; for example, when the first preset angle is larger, the first knocking area formed on the bottom surface of the end cover is larger, and the stress range of the bottom surface of the end cover of the adsorption column for receiving the knocking of the multifunctional hammer is larger, the area of the inlet end of the adsorption column can be knocked in real time through the knocking component 1193, and the air bubbles at the inlet end of the adsorption column can be completely discharged into the pre-flushing liquid by the impact force generated in the knocking process, and flows out into the venous pipeline along with the pre-flushing liquid.

Similarly, when the arterial line is turned off, that is, when the adsorption column is subjected to the pre-flushing non-flowing exhaust stage, the bottom surface of the end cover 921 at the outlet end 92 of the adsorption column 90 is knocked according to the second knocking frequency, and the bubbles hidden at the outlet end of the adsorption column can be completely discharged into the venous line by utilizing the density difference between the bubbles and the pre-flushing; and when the second preset angle is larger, the second knocking area formed on the bottom surface of the end cover of the outlet end of the adsorption column is larger, the stressed range of the bottom surface of the end cover of the outlet end of the adsorption column for knocking is larger, and the impact force generated in the knocking process can completely discharge bubbles hidden at the outlet end of the adsorption column into the venous pipeline so as to completely discharge the bubbles in the adsorption column into the venous pipeline, so that bubble residues are avoided inside the adsorption column.

As shown in fig. 2, the exhaust gas control system further includes: the rotating module 120 is connected to the comparing module 105, and is configured to control the adsorbing column 90 to rotate at a constant speed in a horizontal plane with an axial midpoint thereof as a rotation center according to the turn-off control signal, and meanwhile, when rotating, the clamping module 106 adjusts the second preset angle to 0 degrees, that is, the axial direction Z of the adsorbing column 90 is parallel to the horizontal plane S, see fig. 13.

Specifically, after the comparison module 105 outputs the turn-off control signal, the arterial line is turned off, and the rotation module 120 controls the adsorption column 90 to rotate at a constant speed in a horizontal plane with the axial midpoint thereof as a rotation center, for example, the rotation speed of the adsorption column is as follows: 20 turns/minute, can make the inside liquid of adsorption column flow into the inside each corner of adsorption column through rotatory centrifugal force that produces to in the bubble of hiding the adsorption column corner and the bubble of adhering to on the adsorption column pipe wall can mix in advance towards liquid in the lump, then follow in advance towards liquid and flow into the venous line in the lump, prevent the adsorption column and flow the problem of exhaust incompletely to cytokine adsorption column after the exhaust stage in advance towards liquid.

As can be seen from the above, in this embodiment, after the pre-flushing fluid flowing and exhausting stage or after the pre-flushing fluid flowing and exhausting stage is finished, the angle of the adsorption column can be adjusted by the holding module 106 to further perform exhausting; the adsorption column can be knocked through the knocking module 119 to further exhaust; the adsorption column can be rotated by the rotation module 120 to further exhaust; can also combine with each other through the three modes, and act together to further exhaust; thereby realizing the exhaust control of the pre-flushing non-flowing exhaust stage.

After the pre-flush no-flow venting phase is completed, a stationary venting phase may be entered. Accordingly, as shown in fig. 2, the exhaust gas control system further includes: the standing module 121, the standing module 121 is connected with the rotating module 120 and the clamping component 1063, and is used for detecting the accumulated time of the adsorption column rotating at a constant speed, and when the accumulated time of the adsorption column rotating at a constant speed is greater than the preset rotating time, controlling the adsorption column to stop rotating, and outputting a standing adjustment signal; as described above, when the rotation module 120 controls the adsorption column to rotate at a constant speed, the standing module 121 records the accumulated time of the adsorption column rotated at a constant speed in real time, for example, the accumulated time of the adsorption column rotated at a constant speed is 10 minutes, the preset rotation time is 9 minutes, the accumulated time of the adsorption column rotated at a constant speed (10 minutes) is greater than the preset rotation time (9 minutes), the adsorption column is controlled to stop rotating, and the standing adjustment signal is outputted, so that the adsorption column is in a standing state.

The clamping part is also used for enabling the adsorption column to form a third preset angle with the horizontal plane along the axial direction according to the standing adjusting signal. The first preset angle is larger than the third preset angle, and the third preset angle is larger than the second preset angle. Illustratively, the first preset angle is 90 degrees and the third preset angle is 60 degrees.

In summary, the exhaust control process of the present embodiment includes three stages, namely, a pre-flushing fluid flowing exhaust stage, a pre-flushing fluid non-flowing exhaust stage, and a stationary exhaust stage. The method comprises the steps of monitoring the bubble content and the flushing time in a pre-flushing liquid flowing exhaust stage, generating a turn-off control signal marking the end of the stage according to a monitoring result, starting a pre-flushing liquid non-flowing exhaust stage according to the turn-off control signal, and entering a standing exhaust stage after the pre-flushing liquid non-flowing exhaust stage is ended. The most proper air exhausting method is adopted for the adsorption column in each stage, and air bubbles in the cytokine adsorption column can be completely exhausted.

The invention also discloses an exhaust control method of the blood perfusion device, the blood perfusion device comprises an adsorption column, the adsorption column is filled with resin adsorbent, and the adsorption column is provided with an inlet end connected with an arterial pipeline and an outlet end connected with a venous pipeline; the exhaust gas control method includes: the pre-flushing liquid flowing exhaust stage is that the pre-flushing liquid is continuously connected to the adsorption column through the arterial pipeline, the inside of the adsorption column is flushed, and the pre-flushing liquid, bubbles and impurities are continuously discharged outwards through the venous pipeline; the method is characterized in that: judging the state of the pre-flushing fluid flowing exhaust stage by detecting the bubble quantity of the liquid on the venous pipeline and the accumulated conduction time of the arterial pipeline; and when the air bubble quantity is lower than a first preset value and the accumulated on time is higher than a second preset value, generating an off control signal for turning off the arterial pipeline.

As an alternative embodiment, the hidden bubbles in the corners of the adsorption column are exhausted by adjusting the angle adjustment of the adsorption column, or by knocking the adsorption column, or by rotating the adsorption column, at the end of the pre-flushing fluid flow exhaust stage or at the end of the pre-flushing fluid flow exhaust stage.

As an alternative embodiment, after the pre-flushing liquid flowing and exhausting stage or after the pre-flushing liquid flowing and exhausting stage is finished, at least two modes of adjusting the angle of the adsorption column, knocking the adsorption column and rotating the adsorption column are combined, so that bubbles hidden in corners of the adsorption column are exhausted.

The exhaust control method in this embodiment corresponds to the exhaust control system described above, and for the specific implementation of the exhaust control method in this embodiment, reference may be made to the specific implementation of the exhaust control system described above, which is not repeated herein.

The above embodiments are merely for fully disclosing the present invention, but not limiting the present invention, and substitution of equivalent technical features based on the gist of the present invention, which can be obtained without inventive effort, should be considered as the scope of the present disclosure.

Claims

1. An exhaust control system of a blood perfusion device, the blood perfusion device comprises an adsorption column, wherein the adsorption column is filled with resin adsorbent and is provided with an inlet end connected with an arterial pipeline and an outlet end connected with a venous pipeline; characterized in that the exhaust gas control system includes:

2. The exhaust gas control system according to claim 1, characterized in that the exhaust gas control system further comprises:

3. The exhaust gas control system according to claim 2, characterized in that the exhaust gas control system further comprises: and the clamping module is connected with the comparison module and used for adjusting the angle between the axial direction of the adsorption column and the horizontal plane according to the turn-off control signal.

4. The exhaust control system of claim 3, wherein the clamping module comprises:

5. The exhaust gas control system according to claim 2, characterized in that the exhaust gas control system further comprises:

6. The exhaust gas control system of claim 4, further comprising:

7. The exhaust control system of claim 6, wherein the tapping module comprises:

8. The exhaust control system of claim 7, wherein the tapping module further comprises:

9. The exhaust gas control system according to claim 7, wherein the second preset angle is 0 degrees; the exhaust gas control system further includes:

10. The exhaust gas control system of claim 9, further comprising: