CN115350350A

CN115350350A - Blood return control method for blood purification apparatus, and computer-readable storage medium

Info

Publication number: CN115350350A
Application number: CN202211002733.XA
Authority: CN
Inventors: 董凡; 吴少海; 阮彬鑫; 刘冠贤
Original assignee: Jafron Biomedical Co Ltd
Current assignee: Jafron Biomedical Co Ltd
Priority date: 2022-08-18
Filing date: 2022-08-18
Publication date: 2022-11-18

Abstract

The invention provides a blood return control method of a blood purification device, the blood purification device and a computer readable storage medium, wherein the blood return control method of the blood purification device comprises the following steps: controlling the blood purification equipment to enter a blood returning stage; detecting the accumulated reduction Q of the back flushing liquid in the liquid storage bag; judging whether the accumulated reduction quantity Q is larger than a preset safety quantity delta Q1, if so, detecting the color of the liquid in the venous pipeline; and judging whether the color of the liquid in the venous pipeline is red or not, if not, controlling the blood purification equipment to stop connecting the liquid storage bag to finish the blood returning stage operation. The blood return control method of the blood purification equipment can perform double judgment on the fact that the blood purification equipment obtains sufficient blood return in the blood return stage according to the accumulated reduction amount of the back flushing liquid in the liquid storage bag and the color of the liquid in the venous pipeline, can accurately control the blood purification equipment to perform the blood return stage operation, improves the blood purification treatment effect, and enables the blood purification treatment to be safer and more reliable.

Description

Blood return control method for blood purification apparatus, and computer-readable storage medium

Technical Field

The present invention relates to the technical field of control of blood purification equipment, and in particular, to a blood return control method for blood purification equipment, blood purification equipment for implementing the blood return control method, and a computer-readable storage medium.

Background

Blood purification equipment belongs to a medical instrument, when blood purification equipment uses in the clinic, takes out blood from the patient through blood purification equipment and carries to the extracorporeal circulation return circuit to export patient's blood to the blood clarifier, utilize the blood clarifier to purify patient's blood, in order to clear away the specific material in patient's blood, then with the blood feedback after the purification to the patient internal, in order to accomplish the blood purification process, in order to reach the purpose of purifying blood, treatment disease. Different blood purification treatment modes can be achieved by the blood purification device, such as: the blood purification treatment device comprises a blood purification treatment device, a blood filtration device, a blood circulation device, a blood exchange device, a blood purification treatment device and an immunoadsorption treatment device.

When the blood purification equipment is clinically applied, the control flow of the blood purification equipment can be divided into the following steps in sequence: starting up, self-checking, pre-flushing, purifying treatment, blood returning and shutting down, and after controlling the blood purifying equipment to carry out purifying treatment on the blood of a patient, the blood returning operation is required. The blood purification equipment is specifically operated in the blood returning stage, and blood left in an extracorporeal circulation pipeline of the blood purification equipment and a blood purifier is completely returned to the human body, so that the phenomenon of blood waste of a patient in the blood purification treatment process is avoided.

However, when the blood return control is performed on the blood purification apparatus in the prior art, the blood return time and the blood return amount are manually set by the medical staff through experience, which easily causes the operation deviation of the blood return stage of the blood purification apparatus. For example, when the amount of blood returned is too large, too much residual liquid is injected into the human body, which affects the blood purification treatment effect of the patient; when the blood returning amount is too small, insufficient blood returning can be caused, blood waste is caused, and the safety of a human body is damaged. Therefore, the blood return time and the blood return amount are manually set by medical staff at present through experience, and the proper blood return amount is difficult to accurately set, so that the blood return effect of the blood purification equipment is poor.

Disclosure of Invention

The invention aims to provide a blood return control method of a blood purification device, which can perform double judgment on full blood return of the blood purification device in a blood return stage according to the accumulated reduction amount of a back flushing liquid and the color of liquid in a venous pipeline, and solves the problems of overlarge blood return amount or insufficient blood return amount caused by manually setting blood return time and blood return amount by virtue of experience of medical workers in the prior art, so that the blood purification device can be accurately controlled to perform blood return stage operation, the blood purification treatment effect is improved, and the blood purification treatment is safer and more reliable.

A second object of the present invention is to provide a blood purification apparatus that implements the above-described flashback-controlling method.

A third object of the present invention is to provide a computer-readable storage medium for implementing the above-mentioned blood return control method.

In order to achieve the first object of the present invention, the present invention provides a method for controlling blood return of a blood purification apparatus, the extracorporeal circulation circuit of the blood purification apparatus includes a liquid storage bag, an arterial line, a blood purifier and a venous line, an input end of the arterial line is connected to an artery of a human body, an output end of the arterial line is connected to an input end of the blood purifier, an output end of the blood purifier is connected to an input end of the venous line, an output end of the venous line is connected to a vein of the human body, the venous line is provided with a blood detector for detecting a color of a liquid, the liquid storage bag is connected to one of the input end of the arterial line, the input end of the blood purifier and the input end of the venous line, the liquid storage bag stores a back flushing liquid, the method for controlling blood return of the blood purification apparatus includes: when the continuous purification time of the blood purifier is greater than or equal to the preset purification time, controlling the liquid storage bag to be communicated with one of the input end of the arterial pipeline, the input end of the blood purifier and the input end of the venous pipeline so as to enable the blood purification equipment to enter a blood return stage for operation; detecting the accumulated reduction Q of the back flushing liquid in the liquid storage bag; judging whether the accumulated reduction quantity Q is larger than a preset safety quantity delta Q1, if so, detecting the color of the liquid in the venous pipeline; and judging whether the color of the liquid in the venous pipeline is red or not, if not, controlling the blood purification equipment to stop connecting the liquid storage bag to finish the blood returning stage operation.

According to the scheme, the blood return control method of the blood purification equipment can perform double judgment on full blood return of the blood purification equipment in the blood return stage according to the accumulated reduction quantity Q of the return liquid in the liquid storage bag and the color of the liquid in the venous pipeline, and solves the problems of overlarge blood return quantity or insufficient blood return caused by manually setting the blood return time and the blood return quantity by depending on experience of medical workers at present, so that the blood purification equipment can be accurately controlled to perform the blood return stage operation, the blood purification treatment effect is improved, and the blood purification treatment is safer and more reliable.

In a preferred embodiment, when the reservoir bag is connected to the input end of the arterial line for the blood return phase operation, the blood return control method of the blood purification apparatus further comprises: detecting a first detection flow Q1 of the arterial pipeline access backwash liquid, and acquiring a preset safety quantity delta Q1 according to the first detection flow Q1, wherein the preset safety quantity delta Q1 and the first detection flow Q1 form a positive correlation; or detecting a first detection flow Q1 of the arterial pipeline access backwash liquid, and controlling the first detection flow Q1 to decrease progressively according to a preset decreasing rule.

In a further aspect, the blood return control method of the blood purification apparatus further includes: when the continuous purification time of the blood purifier is less than the preset purification time, detecting the blood flow of an artery accessed to the human body by the arterial line to obtain a second detection flow Q2; calculating to obtain preset constant flow

When the continuous purification time of the blood purifier is longer than or equal to the preset purification time and when the liquid storage bag is communicated with the input end of the arterial pipeline for blood returning stage operation, the arterial pipeline is controlled to be connected into the backwash liquid at a preset constant flow delta Q2.

In a further aspect, the blood return control method of the blood purification apparatus further includes: when the color of the liquid in the venous pipeline is red, controlling the blood purification equipment to send a blood return fault alarm signal, and detecting the liquid flow of the venous pipeline to obtain a third detection flow Q3; judging whether the third detection flow Q3 is smaller than a preset minimum flow; if so, controlling the blood purification equipment to send out a venous line blockage fault signal; if not, obtaining a blood return calibration quantity delta Q3 of the blood purification equipment according to the color RGB value of the liquid in the venous pipeline, then judging whether Q is more than delta Q1+ delta Q3, and if so, controlling the blood purification equipment to stop connecting the liquid storage bag to finish the blood return stage operation; wherein, the calibration quantity delta Q3 of the blood returning and the color RGB value of the liquid in the venous pipeline form a positive correlation relationship.

Further, the inner bore diameter of the arterial line is equal to the inner bore diameter of the venous line, and the blood return control method of the blood purification device further comprises: detecting the length L1 of the arterial pipeline and the length L2 of the venous pipeline; when L1> L2 is satisfied, judging whether the accumulated reduction quantity Q is smaller than the blood volume Q1 of the arterial pipeline; if yes, the liquid storage bag is controlled to be communicated with the input end of the arterial pipeline; if not, the liquid storage bag is controlled to be communicated with the input end of the blood purifier.

In a further aspect, the blood return control method of the blood purification apparatus further includes: when Q is less than or equal to Q1, controlling the liquid storage bag to be communicated with the input end of the arterial pipeline, and controlling the arterial pipeline to be connected into the backwash liquid at a first preset liquid flow rate, wherein Q1 is the blood volume of the arterial pipeline; when Q1< Q is less than or equal to Q1+ Q2, controlling the liquid storage bag to be communicated with the input end of the blood purifier, controlling the blood purifier to be connected into the backwash liquid at a second preset liquid flow rate, and controlling the multifunctional hammer to knock the input end of the blood purifier or the output end of the blood purifier at a preset knocking frequency, wherein Q2 is the blood volume of the blood purifier; when Q1+ Q2< Q < delta Q1, controlling the liquid storage bag to be communicated with the input end of the venous pipeline, and controlling the venous pipeline to be connected into the backwash liquid at a third preset liquid flow rate; the first preset liquid flow is larger than the second preset liquid flow, and the second preset liquid flow is larger than the third preset liquid flow.

In a further aspect, when the reservoir bag is connected to the input end of the arterial line for the blood return phase operation, the blood return control method of the blood purification apparatus further comprises: detecting the temperature of the back flushing liquid in the liquid storage bag to obtain a first detection temperature T1, and detecting the temperature of the liquid in the venous pipeline to obtain a second detection temperature T2; judging whether T2-T1 is greater than delta T, if so, controlling the blood purification equipment to send a back flushing liquid temperature fault signal; wherein Δ T is a preset temperature difference.

The blood purifier is a plasma separator, the input end of a venous pipeline is provided with a venous pot, the blood cell output end of the plasma separator is communicated with the first inlet end of the venous pot through a first branch, the plasma output end of the plasma separator is communicated with the second inlet end of the venous pot through a second branch, the second branch is provided with an adsorption column and a filtration pump, the first branch is provided with a first on-off clamp at the position close to the blood cell output end of the plasma separator, and the second branch is provided with a second on-off clamp at the position close to the plasma output end of the plasma separator; the blood return control method of the blood purification apparatus further includes: calculating to obtain a first safety quantity Δ q1= q1+ q2+ q4 and a second safety quantity Δ q2= q5+ q6+ q3, where q1 is the blood volume of the arterial line, q2 is the blood volume of the blood purifier, q3 is the blood volume of the venous line, q4 is the blood volume of the first branch, q5 is the blood volume of the second branch, and q6 is the blood volume of the venous pot; when the Q is judged to be less than or equal to delta Q1, the liquid storage bag is controlled to be communicated with the input end of the arterial pipeline, the arterial pipeline is controlled to be connected into the backwash liquid at a first preset flow rate, and the first on-off clamp is controlled to be opened and the second on-off clamp is controlled to be closed; when the condition that delta q1 is larger than or equal to q and is not larger than delta q1+ delta q2 is met, controlling the liquid storage bag to be connected with the input end of the arterial pipeline, controlling the arterial pipeline to be connected into the backwash liquid at a second preset flow rate, controlling the second on-off clamp to be opened and the first on-off clamp to be closed, detecting the liquid temperature of the venous pipeline to obtain a second detection temperature T2, and when the second detection temperature T2 is smaller than a preset safety temperature, controlling the blood purification equipment to send temperature prompt information, wherein the first preset flow rate is larger than the second preset flow rate; when it is judged that q > Δ q1+ Δ q2 is satisfied, it is judged whether the color of the liquid in the intravenous line is red.

In order to achieve the second objective of the present invention, the present invention provides a blood purification apparatus, which includes a host and a display screen, wherein a circuit board capable of implementing interactive communication with the display screen is disposed in the host, a processor and a memory are disposed on the circuit board, the memory stores a computer program, and when the computer program is executed by the processor, the steps of the blood return control method of the blood purification apparatus are implemented.

In order to achieve the third object of the present invention, the present invention provides a computer-readable storage medium having stored thereon a computer program which, when being executed by a processor, realizes the respective steps of the blood return control method of the blood purification apparatus described above.

Drawings

Fig. 1 is a structural view of an embodiment of the blood purification apparatus of the present invention.

Fig. 2 is a schematic diagram of the operation of an embodiment of the blood purification apparatus of the present invention.

Fig. 3 is a flowchart of an embodiment of the blood return control method of the blood purification apparatus of the present invention.

Fig. 4 is a graph showing the correspondence between the preset safety amount and the flow rate of the arterial line access flush liquid in the embodiment of the blood return control method of the blood purification apparatus of the present invention.

Fig. 5 is a schematic diagram of the multifunctional hammer knocking blood purifier in the embodiment of the blood returning control method of the blood purifying device of the present invention.

FIG. 6 is a schematic diagram of the operation of the blood purifier as a plasma separator in the embodiment of the blood purification apparatus of the present invention.

The invention is further explained with reference to the drawings and the embodiments.

Detailed Description

The embodiment of the blood return control method of the blood purification equipment comprises the following steps:

the blood return control method of the blood purification device of the embodiment is applied to the blood purification device, see fig. 1, the blood purification device includes components such as a host 1 and a display screen 2, the display screen 2 is a human-computer interactive touch screen, a circuit board capable of achieving interactive communication with the display screen 2 is arranged in the host 1, a processor and a memory are arranged on the circuit board, the memory stores a computer program, when the computer program is executed by the processor, each step of the blood return control method of the blood purification device of the embodiment is achieved, so that interactive communication can be achieved between the display screen 2 and the host 1, a medical worker can input an instruction on the display screen 2, so that the blood purification device executes each step of the blood return control method of the blood purification device of the embodiment according to an operation requirement of the medical worker, and safety of blood purification treatment of a patient is guaranteed.

Referring to fig. 2, the extracorporeal circulation circuit of the blood purification apparatus includes a liquid storage bag, an arterial clamp 31, a blood pump 32, a heparin pump 33 (i.e., an anticoagulation pump), a blood purifier 34, a venous pot 36, a liquid level detector 35, a bubble detector 37, a blood detector 38, a venous clamp 39, an arterial line 310 and a venous line 311, an input end of the arterial line 310 is used for communicating with an artery of a human body, an output end of the arterial line 310 is communicated with an input end of the blood purifier 34, an output end of the blood purifier 34 is communicated with an input end of the venous line 311 through the venous pot 36, an output end of the venous line 311 is used for communicating with a vein of the human body, and the blood detector 38 is used for detecting a color of liquid in the venous line 311. The arterial line 310 outputs the blood of the human body to the blood purifier 34, the blood pump 32 is adopted to provide driving force, so that the blood circulates between the arterial line 310 and the venous line 311, when the blood passes through the blood purifier 34, the blood purifier 34 can filter and purify specific molecular substances in the blood, and then the purified blood is returned to the human body through the venous line 311, so that the purposes of purifying the blood and treating diseases are achieved. Specifically, the present embodiment can be connected to one of the input of the arterial line 310, the input of the blood purifier 34, and the input of the venous line 311, and the reservoir can contain a back flush fluid. It should be noted that the input end of the arterial line 310 is connected to the artery of the human body only when the blood purification apparatus is in the blood purification stage, and the input end of the arterial line 310 is not connected to the artery of the human body in the blood returning stage, and the input end of the arterial line 310 may be connected to the reservoir bag.

The blood purification device of the present embodiment can implement a plurality of blood purification treatment modes, such as hemodialysis, hemofiltration, hemodiafiltration, hemoperfusion, plasmapheresis, immunoadsorption, and other treatment modes. When the blood purification apparatus is in different blood purification treatment modes, the types of the blood purifiers 34 will be different, for example, in the blood perfusion treatment mode, the blood purifiers 34 are blood perfusion devices, and in the hemodialysis treatment mode, the blood purifiers 34 are dialyzers, etc. The components of the extracorporeal circuit of the blood purification apparatus may also change when the blood purification apparatus is in different blood purification treatment modes, wherein fig. 2 shows a most basic structural schematic of the extracorporeal circuit of the blood purification apparatus, and the extracorporeal circuit of the blood purification apparatus may be modified or modified from fig. 2 when the blood purification apparatus is in different blood purification treatment modes.

Referring to fig. 3, fig. 3 is a flowchart of the blood return control method of the blood purification apparatus of the present embodiment, and the specific implementation steps of the blood return control method of the blood purification apparatus of the present embodiment are as follows.

Step S1, the blood purification apparatus is judged to be in the blood purification stage, and step S2 is executed.

Specifically, the working process of the blood purification device at least comprises the following steps: a priming stage, a blood-drawing stage, a blood purification stage and a blood returning stage. In the pre-flushing stage, the arterial pipeline 310, the blood purifier 34 and the venous pipeline 311 are sequentially flushed by pre-flushing liquid so as to remove impurities and gas in the arterial pipeline 310, the blood purifier 34 and the venous pipeline 311; during the priming phase, the patient's blood is drawn into the arterial line 310; in the blood purification stage, the blood of the patient is subjected to normal blood purification by the blood purifier 34; in the blood return phase, when the blood purification treatment of the patient is about to be completed, the blood remaining in the arterial line 310, the blood purifier 34, and the venous line 311 needs to be returned to the patient.

Step S2, judging whether the continuous purification time of the blood purifier 34 is less than the preset purification time, if so, executing the step S3; if not, step S5 is executed.

Step S3, when the continuous purification time of the blood purifier 34 is judged to be less than the preset purification time in step S2, the step S3 judges whether the continuous purification time of the blood purifier 34 is less than the preset safe time, if so, step S1 is executed, and the blood purification apparatus continues to perform the blood purification operation; if not, executing step S4.

And S4, when the continuous purification time of the blood purifier 34 is judged to be greater than or equal to the preset safe time in the step S3, controlling the blood purification equipment to emit an indicating light source to prompt the blood purification equipment to enter a blood returning stage in the step S4. Wherein the preset safe time is less than the preset purifying time.

Specifically, the continuous purification time of the blood purifier 34 represents the continuous time of the blood purification apparatus in the blood purification stage, and the continuous purification time of the blood purifier 34 can be obtained by detecting the time when the input end of the arterial line 310 is continuously connected to the blood of the human body. The preset purifying time represents the total time of blood purifying treatment required to be set by a user, generally, the user sets the total time according to clinical treatment requirements, generally, the continuous purifying time is 12 hours to 24 hours, and only when the continuous purifying time of the blood purifier 34 is less than the preset purifying time, the blood purifying equipment can be operated in a safe blood purifying stage without sending a blood returning control signal. When the continuous purification time of the blood purifier 34 is greater than or equal to the preset purification time, a blood return control signal is sent, and the blood storage bag is controlled to be connected with one of the input end of the arterial pipeline 310, the input end of the blood purifier 34 and the input end of the venous pipeline 311 through the blood return control signal, so that the blood purification equipment enters the blood return stage operation, namely step S5, and the blood purification equipment can be ensured to normally operate.

Whether the blood purification equipment is about to enter a blood returning stage or not can be identified by presetting safe time, wherein the presetting safe time is less than the presetting purifying time, for example, the presetting safe time is 1195min, the presetting purifying time is 1200min, when the continuous purifying time of the blood purifier 34 is more than or equal to 1195min and is less than 1200min, the blood purification equipment is controlled to emit an indicating light source, and a user can be prompted through the indicating light source: the blood purification equipment is about to enter the blood return stage, and the user can make preparation work before the blood return stage as soon as seeing the indicating light source, so that the blood purification equipment is switched to the blood return stage from the blood purification stage, and the control safety of the blood purification equipment is guaranteed. The blood return control method of the blood purification equipment controls the blood purification equipment to send the indicating light source to prompt the blood purification equipment to enter the blood return stage, so that the blood purification equipment has higher control simplicity.

It should be noted that the preset safe time is set in advance according to the experience value of clinical treatment, and usually, the preset safe time is less than the preset purge time by 5min, for example, the preset purge time is 1000min, and the preset safe time is 995min.

And step S5, when the continuous purification time of the blood purifier 34 is judged to be greater than or equal to the preset purification time in the step S2, the step S5 controls the liquid storage bag to be communicated with one of the input end of the arterial pipeline 310, the input end of the blood purifier 34 and the input end of the venous pipeline 311, so that the blood purification equipment enters a blood return phase operation, namely, the step S5 controls the blood purification equipment to enter a blood return phase.

When the liquid storage bag is communicated with the input end of the arterial pipeline 310, the backflushing liquid in the liquid storage bag flushes the arterial pipeline 310, the blood purifier 34 and the venous pipeline 311 in sequence, and the residual blood in the arterial pipeline 310, the residual blood in the blood purifier 34 and the residual blood in the venous pipeline 311 are all flushed to the veins of the human body through the backflushing liquid so as to realize the blood backflushing operation; when the liquid storage bag is communicated with the input end of the blood purifier 34, the blood purifier 34 and the venous pipeline 311 are washed in sequence by the back flushing liquid in the liquid storage bag, and the blood remained in the blood purifier 34 and the blood remained in the venous pipeline 311 are all washed to the veins of the human body by the back flushing liquid so as to realize the blood return operation; when the liquid storage bag is communicated with the input end of the venous pipeline 311, the backflushing liquid in the liquid storage bag directly washes the venous pipeline 311, and the residual blood in the venous pipeline 311 is completely washed to the veins of the human body through the backflushing liquid so as to realize the blood returning operation.

Wherein, the stock solution bag prestores the recoil liquid of certain volume, for example the stock solution bag prestores 2L's recoil liquid, and the recoil liquid can be water for injection.

And S6, detecting the accumulated reduction Q of the back flushing liquid in the liquid storage bag. Specifically, when the reservoir bag is connected to one of the input end of the arterial line 310, the input end of the blood purifier 34, and the input end of the venous line 311, the volume of the back flushing liquid in the reservoir bag gradually decreases, and the cumulative decrease Q of the back flushing liquid in the reservoir bag represents the volume of the back flushing liquid connected to the blood purification apparatus, for example, the cumulative decrease Q of the back flushing liquid in the reservoir bag is 300ml, which represents that the blood purification apparatus has connected 300ml of back flushing liquid.

S7, judging whether the accumulated reduction quantity Q is larger than a preset safety quantity delta Q1, if so, executing the step S14; if not, step S8 is executed.

Step S8, when the accumulated reduction quantity Q is judged to be less than or equal to the preset safety quantity delta Q1 in the step S7, the step S8 judges whether Q is less than or equal to Q1, if so, the step S9 is executed; if not, step S10 is executed. Where q1 is the blood volume of arterial line 310.

Specifically, the preset safety amount Δ Q1 represents a safety amount used by the blood purification apparatus during the blood returning phase, where the preset safety amount Δ Q1 is determined by a pipeline structure of the blood purification apparatus, and when the blood purification apparatus implements different blood purification treatment modes, the pipeline structure of the blood purification apparatus is not the same, and generally, the more complicated the pipeline structure of the blood purification apparatus is, the larger the preset safety amount Δ Q1 is, for example, for the pipeline structure in the blood perfusion treatment mode, the preset safety amount Δ Q1 is generally 600ml, and when the cumulative reduction amount Q of the back flushing liquid in the liquid storage bag is greater than 600ml, it is indicated that the volume of the back flushing liquid accessed by the blood purification apparatus exceeds the safety amount during the blood returning phase, and it is also required to determine whether the blood purification apparatus has sufficiently returned blood by detecting the color of the liquid in the venous line 311.

And S9, when the condition that Q is not more than Q1 is judged in the step S8, controlling the liquid storage bag to be communicated with the input end of the arterial pipeline 310 and controlling the arterial pipeline 310 to be connected into the backwash liquid at a first preset liquid flow rate, and then executing a step S6 to detect the accumulated reduction Q of the backwash liquid in the liquid storage bag in real time.

Step S10, when the step S8 judges that Q is not more than Q1, the step S10 judges whether Q1< Q not more than Q1+ Q2 is satisfied, if so, the step S11 is executed; if not, step S12 is executed. Wherein q2 is the blood volume of the blood purifier 34.

And S11, when the step S10 judges that Q1 is more than or equal to Q1 and less than or equal to Q1 and Q2, the step S11 controls the liquid storage bag to be communicated with the input end of the blood purifier 34, controls the blood purifier 34 to be connected into the backwash liquid at a second preset liquid flow rate, and then executes the step S6 to detect the accumulated reduction quantity Q of the backwash liquid in the liquid storage bag in real time.

Step S12, when the step S10 judges that Q1< Q ≦ Q1+ Q2 is not satisfied, the step S12 judges whether Q1+ Q2< Q ≦ Δ Q1 is satisfied, if yes, the step S13 is executed; if not, executing step S6, and detecting the accumulated reduction Q of the back flushing liquid in the liquid storage bag in real time.

Step S13, when it is determined in step S12 that Q1+ Q2< Q > is not greater than Δ Q1, step S13 controls the liquid storage bag to be connected to the input end of the venous line 311, and controls the venous line 311 to access the backwash liquid at a third preset liquid flow rate, and then step S6 is executed to detect an accumulated reduction amount Q of the backwash liquid in the liquid storage bag in real time.

The first preset liquid flow is larger than the second preset liquid flow, and the second preset liquid flow is larger than the third preset liquid flow.

Specifically, before entering the return phase, the blood volume q1 of the arterial line 310, the blood volume q2 of the blood purifier 34, and the blood volume q3 of the venous line 311 are detected, and the total volume q = q1+ q2+ q3 of the blood purification apparatus is calculated. The blood volume q1 of the arterial line 310 represents the volume of the maximum liquid that the arterial line 310 can hold, the blood volume q3 of the venous line 311 represents the volume of the maximum liquid that the venous line 311 can hold, and the blood volume q2 of the blood purifier 34 represents the volume of the maximum liquid that the blood purifier 34 can hold. Since biochemical materials such as an adsorbent and a hollow fiber membrane are present inside the blood purifier 34, the volume of the maximum liquid that can be stored in the blood purifier 34 means the volume that can also store the maximum liquid after the biochemical materials are stored inside the blood purifier 34, and for example, the volume of the biochemical materials stored inside the blood purifier 34 is 500ml (biochemical materials are stored in the form of a solution), and the volume of the maximum liquid that can be stored in the blood purifier 34 is 300ml, and thus the blood volume q2 of the blood purifier 34 is 300ml. The total volume q of the blood purification apparatus represents the maximum liquid volume that the blood purification apparatus can store, and during the blood purification stage, the total volume q represents the maximum blood volume that the blood purification apparatus can store, such as the total volume q is 1000ml.

The present embodiment divides the blood return stage of the blood purification apparatus into a first process, a second process and a third process in sequence, which are as follows:

in the first process, when Q is less than or equal to Q1, the liquid storage bag is controlled to be communicated with the input end of the arterial pipeline 310, the arterial pipeline 310 is controlled to be connected into the backwash liquid at a first preset liquid flow rate, the backwash liquid enters the arterial pipeline 310 at the first preset liquid flow rate for flushing, and the blood remaining in the arterial pipeline 310, the blood remaining in the blood purifier 34 and the blood remaining in the venous pipeline 311 are all flushed to veins of a human body through the backwash liquid, so that the blood return operation in the first process is realized, and the arterial pipeline 310 is mainly flushed;

in the second process, when Q1< Q is less than or equal to Q1+ Q2, the liquid storage bag is controlled to be communicated with the input end of the blood purifier 34, the blood purifier 34 is controlled to be connected into the backwash liquid at a second preset liquid flow rate, the backwash liquid enters the blood purifier 34 at the second preset liquid flow rate for washing, and the residual blood in the blood purifier 34 and the residual blood in the venous pipeline 311 are all washed to the veins of the human body through the backwash liquid, so that the blood return operation in the second process is realized, and the blood purifier 34 is mainly washed;

in the third process, when Q1+ Q2 is greater than or equal to Q and is less than or equal to Δ Q1, the liquid storage bag is controlled to be communicated with the input end of the venous pipeline 311, the venous pipeline 311 is controlled to be connected with the back flushing liquid at a third preset liquid flow rate, the back flushing liquid enters the venous pipeline 311 at the third preset liquid flow rate for flushing, and all blood remaining in the venous pipeline 311 is flushed to veins of a human body through the back flushing liquid, so that the blood returning operation in the third process is realized, and only the venous pipeline 311 is flushed.

In each process, the blood return control method of the blood purification equipment performs blood return operation on each part of the extracorporeal circulation circuit of the blood purification equipment independently, so that the problem of insufficient blood return is solved, the parts can be subjected to efficient blood return through the backwash liquid, and the blood purification equipment can realize efficient and sufficient blood return.

It should be noted that, in the blood return control method of the blood purification apparatus in this embodiment, the first preset liquid flow rate is greater than the second preset liquid flow rate, and the second preset liquid flow rate is greater than the third preset liquid flow rate, so that it can be ensured that the flow rate of the backwash liquid is gradually reduced in the blood return stage, and the optimum blood return effect of the backwash liquid on the component can be achieved in the later stage. Generally, the difficulty of flushing the venous line 311 is the greatest, the difficulty of flushing the arterial line 310 is the least, and therefore the third predetermined fluid flow is the least, and the optimal blood return effect can be achieved for the venous line 311 by the flushing fluid at the third predetermined fluid flow.

And S14, when the accumulated reduction Q of the back flushing liquid in the liquid storage bag is judged to be larger than the preset safety quantity delta Q1 in the step S7, the color of the liquid in the venous pipeline 311 is detected in the step S14.

Step S15, judging whether the color of the liquid in the venous pipeline 311 is red, if so, executing step S16; if not, step S21 is executed to control the blood purification apparatus to stop connecting the liquid storage bag to complete the blood return stage operation.

Step S16, when the color of the liquid in the venous line 311 is determined to be red in step S15, step S16 controls the blood purification apparatus to send a blood return failure alarm signal, and detects the liquid flow rate in the venous line 311 to obtain a third detected flow rate Q3.

Step S17, judging whether the third detection flow Q3 is smaller than the preset lowest flow, if so, executing step S18; if not, step S19 is executed.

And S18, when the third detection flow Q3 is smaller than the preset minimum flow in the step S17, controlling the blood purification equipment to send out a blockage fault signal of the venous line 311 in the step S18.

Specifically, when the color of the liquid in the venous line 311 is red, it indicates that the blood purification apparatus has not returned blood sufficiently, and a part of blood remains in the venous line 311, the blood purification apparatus is controlled to send an audible and visual alarm message to the user through the blood return fault alarm signal, and the user can know that the blood purification apparatus has a blood return fault upon receiving the blood return fault alarm signal.

The blood return control method of the blood purification apparatus of this embodiment determines whether a blockage fault occurs in the venous line 311 according to the flow rate of the liquid in the venous line 311, and specifically, compares the third detected flow rate Q3 of the liquid in the venous line 311 with a preset minimum flow rate (usually, the preset minimum flow rate is 1 ml/min), and further determines whether a blockage fault occurs in the venous line 311. When the third detected flow Q3 of the liquid in the venous line 311 is smaller than the preset minimum flow, it is determined that the venous line 311 has a blockage fault.

It should be noted that when the cumulative decrease Q of the back flushing fluid is greater than Δ Q1, the venous line 311 may not be flushed clean, and the failure is usually a blockage in the venous line 311. Therefore, in step S17, by determining whether the third detected flow Q3 of the liquid in the venous line 311 is smaller than the preset minimum flow, it can be determined whether the venous line 311 is blocked, so that the specific reason why the blood purification apparatus does not return blood sufficiently can be determined.

Step S19, when the third detected flow Q3 is greater than or equal to the preset minimum flow in step S17, step S19 obtains the calibrated blood return amount Δ Q3 of the blood purification apparatus according to the color RGB value of the liquid in the venous line 311.

Step S20, judging whether Q > delta Q1+ delta Q3 is met, if yes, executing step S21; if not, step S19 is executed to obtain the blood return calibration quantity Δ Q3 of the blood purification apparatus in real time according to the color RGB value of the liquid in the venous line 311. Wherein, the calibration quantity Δ Q3 of the blood returning has a positive correlation with the color RGB value of the liquid in the venous line 311.

And step S21, controlling the blood purification equipment to stop connecting the liquid storage bag to finish the blood returning stage operation.

Specifically, the back flushing liquid in the liquid storage bag is usually colorless or white, and the color of the blood of the human body is red. When the arterial line 310, the blood purifier 34 and the venous line 311 are returned by the flushing liquid, if the color of the liquid in the venous line 311 is red, the venous line 311 still contains blood, and the blood purification equipment does not return blood sufficiently; when the color of the liquid in the venous line 311 is not red, it indicates that only the back flushing liquid exists in the venous line 311, the blood remaining in the venous line 311 is completely returned to the human body, and the blood purification device has returned blood sufficiently. Therefore, when the blood return control method of the blood purification apparatus of the present embodiment detects that the color of the liquid in the venous line 311 is not red, which indicates that the blood purification apparatus has returned blood sufficiently, the blood purification apparatus is controlled to stop connecting the liquid storage bag to complete the blood return stage operation.

The blood detector 38 provided in the venous line 311 determines whether the color of the liquid in the venous line 311 is red based on the principle of light sensing, and the blood detector 38 can detect the color of the liquid in the venous line 311 and convert the color into RGB values, and quantitatively determine whether the color of the liquid in the venous line 311 is red based on the RGB values. The RGB values include three color channels, R represents red, G represents green, and B represents blue, and the shade of the color can be quantitatively determined according to the RGB values, for example, the RGB values are (200, 10, 30). When the venous line 311 is judged not to be blocked, the reason why the venous line 311 does not return blood sufficiently is as follows: if the preset safety amount Δ Q1 is set unreasonably or the flow rate of the back flushing fluid is set unreasonably, the venous line 311 needs to be flushed continuously by the back flushing fluid to ensure that the venous line 311 can return blood sufficiently. Therefore, when the accumulated reduction amount Q of the back flushing liquid is greater than the preset safety amount Δ Q1, the blood purification apparatus will be continuously flushed by the back flushing liquid until Q > Δ Q1+ Δ Q3 is satisfied, and the blood purification apparatus will be controlled to stop connecting the liquid storage bag to complete the blood return stage operation.

It should be noted that there is a one-to-one correspondence relationship between the color RGB value of the liquid in the venous line 311 and the blood return calibration amount Δ Q3, and when the color RGB value of the liquid in the venous line 311 is deeper, the higher the residual degree of the blood in the venous line 311 is, the larger the blood return calibration amount Δ Q3 is, and the longer the blood return time of the venous line 311 is.

Therefore, the blood return control method of the blood purification device of the embodiment can perform double judgment on the blood purification device to obtain sufficient blood return in the blood return stage according to the accumulated reduction quantity Q of the return liquid in the liquid storage bag and the color of the liquid in the venous pipeline 311, and overcomes the problem that the blood return amount is too large or the blood return amount is insufficient due to the fact that the blood return time and the blood return amount are manually set by medical workers through experience in the prior art, so that the blood purification device can be accurately controlled to perform the blood return stage operation, the blood purification treatment effect is further improved, and the blood purification treatment is safer and more reliable.

During the blood return phase, the flow rate of the back flushing liquid has a certain influence on the blood return effect of the arterial line 310, the blood purifier 34 and the venous line 311. According to clinical practice, when the flow rate of the back flushing liquid is smaller, the flow rate of the back flushing liquid in the arterial line 310, the venous line 311 and the blood purifier 34 is slower, the time of the back flushing liquid staying in the lines is longer, and the washing effect of the back flushing liquid on the residual blood in the arterial line 310, the venous line 311 and the blood purifier 34 is better. The blood return control method of the blood purification apparatus of this embodiment may calibrate the total volume Q of the blood purification apparatus according to the flow rate of the flushing liquid introduced to the input end of the arterial line 310, where the calibrated total volume Q is the preset safety amount Δ Q1. Further, the blood return control method of the blood purification apparatus of the present embodiment may acquire the preset safety amount Δ Q1 from the first detected flow rate Q1, i.e., perform step S22.

Step S22, detecting a first detection flow Q1 of the arterial line 310 accessing the back flushing liquid, and obtaining a preset safety amount Δ Q1 according to the first detection flow Q1. For example, the total volume Q of the blood purification apparatus is 300ml, and a relationship curve between the preset safety amount Δ Q1 obtained after a technician performs a plurality of clinical technical experiments and the first detection flow Q1 of the arterial line 310 accessing the back flushing liquid is shown in fig. 4, when the flow rate of the arterial line 310 accessing the back flushing liquid is smaller, the preset safety amount Δ Q1 is smaller, and the arterial line 310, the venous line 311 and the blood purifier 34 can be fully back-flushed by the back flushing liquid with a smaller flow rate. Therefore, the blood return control method of the blood purification apparatus of the present embodiment can obtain the corresponding preset safety amount Δ Q1 according to the curve shown in fig. 4 according to the first detection flow Q1 of the arterial line 310 accessing the back flushing liquid, and can accurately determine whether to sufficiently return blood to the blood purification apparatus according to the preset safety amount Δ Q1. As shown in fig. 4, the predetermined safety amount Δ Q1 is generally smaller than the total capacity Q of the blood purification apparatus because the blood purifier 34 and the venous line 311 are not filled with blood during the blood purification stage, the venous pot 36 is disposed at the input end of the venous line 311, the venous pot 36 is not completely filled with blood, and half of the air is present inside the venous pot 36, so the predetermined safety amount Δ Q1 is smaller than the total capacity Q of the blood purification apparatus.

When the input end of the arterial line 310 is connected to the backwash liquid, the flow rate of the arterial line 310 connected to the backwash liquid may be fixed or variable.

In step S23, when the continuous purification time of the blood purifier 34 is less than the preset purification time, the step S23 detects the blood flow rate of the artery connected to the human body through the arterial line 310 to obtain a second detected flow rate Q2.

Step S24, calculating to obtain a preset constant flow

Step S25, when the continuous purification time of the blood purifier 34 is greater than or equal to the preset purification time and the reservoir bag is connected to the input end of the arterial line 310 for the blood returning phase operation, step S25 controls the arterial line 310 to access the back flushing liquid at the preset constant flow Δ Q2.

Specifically, the second detection flow Q2 is an average flow of blood in the arterial line 310, and a flow of the backwash liquid in the arterial line 310 in the blood return stage is smaller than a flow of blood in the arterial line 310 in the blood purification stage, so that sufficient pre-flushing of the blood purification apparatus by the backwash liquid is ensured, and in the blood return stage, the flow of the backwash liquid in the arterial line 310 is always kept unchanged, that is, is always a preset constant flow Δ Q2, thereby simplifying a blood return rate control step of the blood purification apparatus.

Step S26, when the liquid storage bag is connected to the input end of the arterial tube 310 for blood returning operation, step S26 detects a first detection flow Q1 of the arterial tube 310 for accessing the flushing liquid, and controls the first detection flow Q1 to decrease progressively according to a preset decreasing rule.

Specifically, when the liquid storage bag is connected with the input end of the arterial tube 310 for blood return phase operation, the first detection flow Q1 of the arterial tube 310 connected to the return liquid decreases progressively according to a preset decreasing rule, which is favorable for exerting the blood return effect of the return liquid, and especially in the latter half of the blood return phase, the slow flowing return liquid can play a better blood return effect on the blood purification equipment, so that the arterial tube 310, the blood purifier 34 and the venous tube 311 are fully washed. For example, the preset decreasing rule may be to decrease the first detection flow Q1 of the arterial line 310 into the backwash liquid in an equal ratio series manner, for example, taking 30s as a period, where the first detection flow Q1 of the arterial line 310 into the backwash liquid in the next period is 3/4 of the first detection flow Q1 of the arterial line 310 into the backwash liquid in the previous period, and gradually decrease the first detection flow Q1 of the arterial line 310 into the backwash liquid according to the preset decreasing rule, so as to improve the blood return efficiency of the blood purification apparatus, and flush the arterial line 310, the blood purifier 34, and the venous line 311 more cleanly.

In one embodiment, the diameter of the inner bore of the arterial line 310 is equal to the diameter of the inner bore of the venous line 311, and the following steps are performed during the step S6 of detecting the cumulative decrease Q of the back-flushing fluid in the fluid storage bag.

In step S27, the length L1 of the arterial line 310 is detected, and the length L2 of the venous line 311 is detected.

Step S28, when L1> L2 is satisfied, step S28 determines whether the cumulative decrease amount Q is smaller than the blood volume Q1 of the arterial line 310, if so, step S29 is executed; if not, step S30 is executed.

And step S29, controlling the liquid storage bag to be communicated with the input end of the arterial pipeline 310.

And step S30, controlling the liquid storage bag to be communicated with the input end of the blood purifier 34.

Specifically, the inner lumen diameter of arterial line 310 is equal to the inner lumen diameter of venous line 311, and the length L1 of arterial line 310 is greater than the length L2 of venous line 311, indicating that the blood volume q1 of arterial line 310 is greater than the blood volume q3 of venous line 311. When the backwash liquid is introduced into the input end of the arterial line 310, the flow time of the backwash liquid in the arterial line 310 is relatively long, and the backwash liquid encounters a relatively large blocking force when flowing in the arterial line 310. When the accumulated reduction Q is judged to be greater than or equal to the blood volume Q1 of the arterial line 310, it is indicated that sufficient blood return is performed on the arterial line 310, the reservoir bag is directly communicated with the input end of the blood purifier 34, the reservoir bag directly outputs the return liquid to the input end of the blood purifier 34, the blood purifier 34 and the venous line 311 continue to be returned by the return liquid, the return liquid does not need to flow through the arterial line 310, the blood purifier 34 and the venous line 311 are washed by the return liquid, the flow of the return liquid in the blood purifier 34 and the venous line 311 is smoother, and the washing performance of the return liquid is improved.

For example, when the input end of the arterial line 310 is connected to the reservoir, the amount of reduction of the back flushing liquid in the reservoir is 100ml, and when the input end of the blood purifier 34 is connected to the reservoir, the amount of reduction of the back flushing liquid in the reservoir is: 200ml, the cumulative decrease Q of the back flushing liquid in the liquid storage bag is 300ml.

Therefore, in the blood return control method of the blood purification apparatus of the present embodiment, the length L1 of the arterial line 310 and the length L2 of the venous line 311 are compared, so as to change the connection mode of the reservoir bag, and improve the efficiency of flushing the blood purifier 34 and the venous line 311 with the flushing liquid.

When the reservoir is connected to the input of the arterial line 310 for the blood return phase, the following steps may be performed.

In step S31, the temperature of the refill liquid in the liquid storage bag is detected to obtain a first detected temperature T1, and the temperature of the liquid in the venous line 311 is detected to obtain a second detected temperature T2.

Step S32, judging whether T2-T1> delta T is met, if yes, executing step S33; if not, step S31 is executed. Wherein Δ T is a predetermined temperature difference.

And step S33, controlling the blood purification equipment to send a back flushing liquid temperature fault signal.

Specifically, the temperature of the flashback fluid in the fluid reservoir represents the temperature of the flashback fluid connected to the input end of the arterial line 310, the temperature of the fluid in the venous line 311 represents the temperature of the fluid returned to the veins of the human body, and whether the flashback fluid is in the temperature failure state at the flashback stage is determined according to the first detection temperature T1 and the second detection temperature T2. For example, when the temperature T2-T1 is judged to be more than 3 ℃, the temperature of the back flushing liquid in the liquid storage bag is judged to be too low, the temperature of the back flushing liquid in the liquid storage bag is judged to be in a temperature failure state, and the blood temperature in the blood returning stage is too low after the back flushing liquid with the too low temperature is mixed with the blood in the pipeline, so that the patient generates uncomfortable symptoms.

The blood return control method of the blood purification apparatus of the present embodiment accurately identifies whether the temperature of the back liquid in the liquid storage bag is in a temperature failure state according to the difference between the first detected temperature T1 and the second detected temperature T2, thereby preventing the temperature of the back liquid from being in the failure state in the blood return stage.

After controlling the blood purifier 34 to introduce the back flushing fluid at the second predetermined fluid flow rate, the following steps may be further performed.

And step S34, controlling the multifunctional hammer 4 to knock the input end of the blood purifier 34 or the output end of the blood purifier 34 at a preset knocking frequency.

Specifically, referring to fig. 5, in the blood returning stage, the back flushing liquid directly flows into the blood purifier 34, that is, when the blood returning stage of the blood purifying apparatus is in the second process, the input end of the blood purifier 34 directly connects to the back flushing liquid, and by knocking the input end of the blood purifier 34 or the output end of the blood purifier 34, the impact force generated by the knocking can make the back flushing liquid fill each position inside the blood purifier 34, so that the blood hidden in the corners inside the blood purifier 34 can also be flushed to the output end of the blood purifier 34, so as to fully return the inside of the blood purifier 34.

It should be noted that, in step S34, the multifunctional hammer 4 performs the striking on the input end of the blood purifier 34 or the output end of the blood purifier 34 according to a preset striking frequency, wherein the preset striking frequency can be set according to the specific type and structure of the blood purifier 34, for example, when the blood purifier 34 is a plasma separator, the preset striking frequency is 5 times/minute, the amount of residual blood attached inside the plasma separator is not large, and the striking frequency of the multifunctional hammer 4 can be slower; for example, when the blood purifier 34 is a blood perfusion device, the preset knocking frequency is 10 times/minute, so that the blood residue phenomenon is more likely to occur inside the blood perfusion device, and the knocking frequency of the multifunctional hammer 4 can be faster, so that the backwash liquid can be filled into each corner inside the blood perfusion device, and the blood returning efficiency of the blood perfusion device is improved.

Referring to fig. 6, the blood purifier 34 of this embodiment is a plasma separator 341, the input end of the venous line 311 is provided with a venous pot 36, the blood cell output end of the plasma separator 341 is connected with the first input end of the venous pot 36 through a first branch 312, the plasma output end of the plasma separator 341 is connected with the second input end of the venous pot 36 through a second branch 313, the second branch 313 is provided with an adsorption column 315, a filtration pump 314 and a heater 316, the first branch 312 is provided with a first on-off clamp at a position close to the blood cell output end of the plasma separator 341, and the second branch 313 is provided with a second on-off clamp at a position close to the plasma output end of the plasma separator 341. The plasma separator 341 has a plasma separation function, when the arterial line 310 outputs the blood of the human body to the plasma separator 341, the blood of the human body is separated into blood cells and plasma by the plasma separator 341, the first branch 312 outputs the blood cells to the first inlet end of the venous pot 36, the second branch 313 outputs the plasma purified by the adsorption column 315 to the second inlet end of the venous pot 36, the purified plasma and the blood cells are mixed in the venous pot 36 to obtain purified blood, and the venous line 311 returns the purified blood to the vein of the human body to complete the blood purification treatment. The blood purifier 34 of the present embodiment performs the following steps for the plasma separator 341.

In step S34, a first safety volume Δ q1= q1+ q2+ q4 and a second safety volume Δ q2= q5+ q6+ q3 are calculated, where q1 is the blood volume of the arterial line 310, q2 is the blood volume of the blood purifier 34, q3 is the blood volume of the venous line 311, q4 is the blood volume of the first branch 312, q5 is the blood volume of the second branch 313, and q6 is the blood volume of the venous pot 36.

Step S35, when the condition that Q is less than or equal to delta Q1 is judged, the step S35 controls the liquid storage bag to be connected with the input end of the artery pipeline 310, controls the artery pipeline 310 to be connected with the back flushing liquid at a first preset flow rate, and controls the first on-off clamp to be opened and the second on-off clamp to be closed.

Specifically, when the cumulative reduction Q of the back flushing liquid in the liquid storage bag is less than or equal to the first safety amount Δ Q1, the arterial line 310 is controlled to be connected to the back flushing liquid at the first preset flow rate, and the first on-off clamp is opened and the second on-off clamp is closed, so that the back flushing liquid flows through the arterial line 310, the blood purifier 34 and the first branch 312 for blood return operation, and the back flushing liquid does not flow through the second branch 313.

And S36, when the condition that the delta q1 is less than or equal to the delta q1 and the delta q2 is judged to be met, the step S36 controls the liquid storage bag to be communicated with the input end of the arterial pipeline 310, controls the arterial pipeline 310 to be communicated with the back flushing liquid at a second preset flow rate, and controls the second on-off clamp to be opened and the first on-off clamp to be closed. The first preset flow is larger than the second preset flow.

Step S37, when it is determined that q > Δ q1+ Δ q2 is satisfied, step S37 determines whether the color of the liquid in the venous line 311 is red, if so, step S14 is executed to detect the color of the liquid in the venous line 311 in real time; if not, step S21 is executed to control the blood purification apparatus to stop connecting the liquid storage bag to complete the blood return stage operation.

Specifically, when it is determined that Δ q1< q ≦ Δ q1+ Δ q2 is satisfied, the arterial line 310 is controlled to access the backwash liquid at a second preset flow rate, and the second on-off clamp is controlled to open and the first on-off clamp is controlled to close. Wherein, the first predetermined flow rate is greater than the second predetermined flow rate, the back flushing liquid flows through the second branch 313, the venous pot 36 and the venous pipeline 311 in sequence, so that the second branch 313, the venous pot 36 and the venous pipeline 311 are filled with the back flushing liquid for blood returning operation.

The back-flow control of the blood plasma in the second branch 313 after the back-flow operation of the arterial line 310, the blood purifier 34 and the first branch 312 is performed, so that the blood in the arterial line 310, the venous line 311, the first branch 312 and the second branch 313 can be fully back-flowed, coagulation failure caused by untimely back-flow of blood cells separated by the blood plasma separator 341 can be avoided, and the safety of the blood return of a patient can be greatly guaranteed.

When it is determined that Q is equal to or less than Δ Q1, the arterial line 310 is connected to the flushing liquid at a first preset flow rate, which may accelerate the blood return rate, and the blood cells in the first branch 312 are not easily attached to the inner wall of the line, so that the first branch 312 can be flushed clean by the flushing liquid at the first preset flow rate. The plasma in the second branch 313 is easy to adhere to the inner wall of the tube, so the flow rate of the back flushing liquid in the second branch 313 needs to be as small as possible, and the plasma in the second branch 313 is completely flushed away by the back flushing liquid with a second preset small flow rate. Therefore, the blood return control method of the blood purification device of the embodiment sets the first preset flow to be larger than the second preset flow, which is beneficial to improving the blood return efficiency of the blood purification device and greatly reduces the blood return control time of the blood purification device.

Wherein, the preset safety amount Δ Q1= Δ Q1+ Δ Q2 in the above step.

Step S38, after controlling the arterial line 310 to access the back flushing fluid at the second preset flow rate and controlling the second on-off clamp to open and the first on-off clamp to close, step S38 detects the fluid temperature of the venous line 311 to obtain a second detected temperature T2.

And S39, when the second detection temperature T2 is judged to be less than the preset safe temperature, controlling the blood purification equipment to send out temperature prompt information in the step S39.

Specifically, when the second branch 313 is returned with the back flushing liquid, the second branch 313 is returned only when it is determined that Δ q1< q ≦ Δ q1+ Δ q2, which may cause the second branch 313 to wait for a long time before the blood return operation is started, and may cause the plasma temperature in the second branch 313 to decrease. If the plasma temperature in the second branch 313 is too low, this may cause the patient to experience symptoms. The preset safe temperature is the lowest liquid temperature of the venous line 311 returned to the human body, wherein the preset safe temperature is preset by a technician, for example, the preset safe temperature is 30 ℃, and the liquid returned to the human body by the venous line 311 is in a safe state only when the liquid temperature of the venous line 311 is greater than or equal to the preset safe temperature; conversely, when the temperature of the liquid in the venous line 311 (the second detected temperature T2) is lower than the preset safety temperature, it indicates that the temperature of the liquid in the second branch 313 is too low, which causes the liquid returned from the venous line 311 to the human body to cause discomfort to the human body and even endanger the life safety of the patient.

When the second detection temperature T2 is judged to be less than the preset safety temperature, a prompt is sent to a user through temperature prompt information: the temperature of the liquid in the second branch 313 is too low. Therefore, the user, upon receiving the temperature indication information, will deal with the temperature failure of the second branch 313 during the blood returning stage.

Blood purification apparatus embodiment:

the blood purification device comprises a host machine 1, a display screen 2 and other components, wherein the display screen 2 is a human-computer interactive touch screen, a circuit board which can realize interactive communication with the display screen 2 is arranged in the host machine 1, a processor and a memory are arranged on the circuit board, a computer program is stored in the memory, and each step of the blood return control method of the blood purification device is realized when the computer program is executed by the processor.

For example, a computer program may be partitioned into one or more modules that are stored in a memory and executed by a processor to implement the modules of the present invention. One or more of the modules may be a series of computer program instruction segments capable of performing certain functions, which are used to describe the execution of the computer program in the terminal device.

The Processor referred to in the present invention may be a Central Processing Unit (CPU), other general purpose Processor, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), an off-the-shelf Programmable Gate Array (FPGA) or other Programmable logic device, discrete Gate or transistor logic device, discrete hardware component, etc. The general purpose processor may be a microprocessor or the processor may be any conventional processor or the like, the processor being the control center of the appliance and connected to the various parts of the overall appliance by various interfaces and lines.

The memory may be used to store computer programs and/or modules, and the processor may implement various functions of the appliance by operating or executing the computer programs and/or modules stored in the memory and calling data stored in the memory. The memory may mainly include a storage program area and a storage data area, wherein the storage program area may store an operating system, an application program required for at least one function, and the like; the storage data area may store data created according to use of the appliance, and the like. In addition, the memory may include high speed random access memory, and may also include non-volatile memory, such as a hard disk, a memory, a plug-in hard disk, a Smart Media Card (SMC), a Secure Digital (SD) Card, a Flash memory Card (Flash Card), at least one magnetic disk storage device, a Flash memory device, or other volatile solid state storage device.

Computer-readable storage medium embodiments:

the computer program stored in the memory of the blood purification apparatus may be stored in a computer-readable storage medium if it is implemented in the form of a software functional unit and sold or used as a separate product. Based on such understanding, all or part of the processes in the above-described embodiment methods can be implemented by a computer program, which can be stored in a computer readable storage medium, and can implement the steps of the blood return control method of the blood purification apparatus when the computer program is executed by a processor.

Wherein the computer program comprises computer program code, which may be in the form of source code, object code, an executable file or some intermediate form, etc. The computer readable medium may include: any entity or device capable of carrying computer program code, recording medium, U.S. disk, removable hard disk, magnetic disk, optical disk, computer Memory, read-Only Memory (ROM), random Access Memory (RAM), electrical carrier wave signals, telecommunications signals, software distribution media, and the like. It should be noted that the computer-readable medium may contain suitable additions or subtractions depending on the requirements of legislation and patent practice in jurisdictions, for example, in some jurisdictions, computer-readable media may not include electrical carrier signals or telecommunication signals in accordance with legislation and patent practice.

The above embodiments are merely preferred examples of the present invention, and not intended to limit the scope of the invention, so that equivalent changes or modifications made based on the structure, characteristics and principles of the invention as claimed should be included in the claims of the present invention.

Claims

1. The blood return control method of the blood purification equipment comprises a liquid storage bag, an artery pipeline, a blood purifier and a vein pipeline, wherein the input end of the artery pipeline is communicated with an artery of a human body, the output end of the artery pipeline is communicated with the input end of the blood purifier, the output end of the blood purifier is communicated with the input end of the vein pipeline, the output end of the vein pipeline is communicated with a vein of the human body, and the vein pipeline is provided with a blood detector for detecting the color of liquid;

the liquid storage bag can be communicated with one of the input end of the arterial pipeline, the input end of the blood purifier and the input end of the venous pipeline, and the liquid storage bag is internally stored with a back flushing liquid, and the blood purification device is characterized in that:

the blood return control method of the blood purification device comprises the following steps:

when the continuous purification time of the blood purifier is greater than or equal to the preset purification time, controlling the liquid storage bag to be communicated with one of the input end of the arterial pipeline, the input end of the blood purifier and the input end of the venous pipeline so that the blood purification equipment enters a blood return stage operation;

detecting the accumulated reduction Q of the back flushing liquid in the liquid storage bag;

judging whether the accumulated reduction quantity Q is larger than a preset safety quantity delta Q1, if so, detecting the color of the liquid in the venous pipeline;

and judging whether the color of the liquid in the venous pipeline is red or not, if not, controlling the blood purification equipment to stop connecting the liquid storage bag to finish the operation of the blood returning stage.

2. The method of controlling blood return of a blood purification apparatus according to claim 1, characterized in that:

when the liquid storage bag is communicated with the input end of the arterial pipeline for blood return stage operation, the blood return control method of the blood purification device further comprises the following steps:

detecting a first detection flow Q1 of the arterial pipeline accessed to the back flushing liquid, and acquiring the preset safety quantity delta Q1 according to the first detection flow Q1, wherein the preset safety quantity delta Q1 and the first detection flow Q1 form a positive correlation;

or detecting a first detection flow Q1 of the arterial pipeline connected into the backwash liquid, and controlling the first detection flow Q1 to decrease progressively according to a preset decreasing rule.

3. The method of controlling blood return of a blood purification apparatus according to claim 1, characterized in that:

the blood return control method of the blood purification apparatus further includes:

when the continuous purification time of the blood purifier is less than the preset purification time, detecting the blood flow of the artery accessed to the human body by the arterial line to obtain a second detection flow Q2;

calculating to obtain preset constant flow

And when the continuous purification time of the blood purifier is longer than or equal to the preset purification time and when the liquid storage bag is communicated with the input end of the arterial pipeline for blood returning stage operation, controlling the arterial pipeline to be connected into the back flushing liquid at the preset constant flow delta Q2.

4. The blood return control method of a blood purification apparatus according to claim 1, characterized in that:

when the color of the liquid in the venous pipeline is red, controlling the blood purification equipment to send a blood return fault alarm signal, and detecting the liquid flow of the venous pipeline to obtain a third detection flow Q3;

judging whether the third detection flow Q3 is smaller than a preset minimum flow;

if so, controlling the blood purification equipment to send out a venous line blockage fault signal;

if not, obtaining a blood return calibration quantity delta Q3 of the blood purification equipment according to the color RGB value of the liquid in the venous pipeline, then judging whether Q is more than delta Q1+ delta Q3, if so, controlling the blood purification equipment to stop connecting the liquid storage bag to finish the blood return stage operation;

wherein the calibration quantity Δ Q3 of the blood returning is in positive correlation with the RGB value of the color of the liquid in the intravenous line.

5. The method of controlling blood return of a blood purification apparatus according to claim 1, characterized in that:

the inner bore pipe diameter of the artery pipeline is equal to the inner bore pipe diameter of the vein pipeline, and the blood return control method of the blood purification equipment further comprises the following steps:

detecting the length L1 of the arterial line and detecting the length L2 of the venous line;

when L1> L2 is satisfied, judging whether the accumulated reduction amount Q is smaller than the blood volume Q1 of the arterial line; if yes, controlling the liquid storage bag to be communicated with the input end of the arterial pipeline; if not, controlling the liquid storage bag to be communicated with the input end of the blood purifier.

6. The method of controlling blood return of a blood purification apparatus according to claim 1, characterized in that:

when Q is not more than Q1, controlling the liquid storage bag to be communicated with the input end of the arterial pipeline, and controlling the arterial pipeline to be connected into the backwash liquid at a first preset liquid flow rate, wherein Q1 is the blood volume of the arterial pipeline;

when Q1< Q is less than or equal to Q1+ Q2, controlling the liquid storage bag to be communicated with the input end of the blood purifier, controlling the blood purifier to be connected into the backwash liquid at a second preset liquid flow rate, and controlling a multifunctional hammer to knock the input end of the blood purifier or the output end of the blood purifier at a preset knocking frequency, wherein Q2 is the blood volume of the blood purifier;

when Q1+ Q2< Q < delta Q1, controlling the liquid storage bag to be communicated with the input end of the venous pipeline, and controlling the venous pipeline to be connected into the backwash liquid at a third preset liquid flow rate;

7. The blood return control method of a blood purification apparatus according to claim 1, characterized in that:

detecting the temperature of the flushing liquid in the liquid storage bag to obtain a first detection temperature T1, and detecting the temperature of the liquid in the venous pipeline to obtain a second detection temperature T2;

judging whether T2-T1 is greater than delta T, if so, controlling the blood purification equipment to send a backwash liquid temperature fault signal;

wherein Δ T is a preset temperature difference.

8. The method of controlling blood return of a blood purification apparatus according to claim 1, characterized in that:

the blood purifier is a plasma separator, the input end of the venous pipeline is provided with a venous pot, the blood cell output end of the plasma separator is communicated with the first inlet end of the venous pot through a first branch, the plasma output end of the plasma separator is communicated with the second inlet end of the venous pot through a second branch, the second branch is provided with an adsorption column and a filter pump, a first on-off clamp is arranged at the position, close to the blood cell output end of the plasma separator, of the first branch, and a second on-off clamp is arranged at the position, close to the plasma output end of the plasma separator, of the second branch;

calculating a first safety quantity Δ q1= q1+ q2+ q4 and a second safety quantity Δ q2= q5+ q6+ q3, where q1 is the blood volume of the arterial line, q2 is the blood volume of the blood purifier, q3 is the blood volume of the venous line, q4 is the blood volume of the first branch, q5 is the blood volume of the second branch, and q6 is the blood volume of the venous pot;

when Q is judged to be less than or equal to delta Q1, controlling the liquid storage bag to be communicated with the input end of the arterial pipeline, controlling the arterial pipeline to be connected into the backwash liquid at a first preset flow rate, and controlling the first on-off clamp to be opened and the second on-off clamp to be closed;

when the condition that the delta q1< q is not more than delta q1+ delta q2 is met, controlling the liquid storage bag to be communicated with the input end of the arterial pipeline, controlling the arterial pipeline to be connected into the backwash liquid at a second preset flow rate, controlling the second on-off clamp to be opened and the first on-off clamp to be closed, detecting the liquid temperature of the venous pipeline to obtain a second detection temperature T2, and controlling the blood purification equipment to send temperature prompt information when the second detection temperature T2 is judged to be less than a preset safety temperature, wherein the first preset flow rate is more than the second preset flow rate;

when it is judged that q > Δ q1+ Δ q2 are satisfied, it is judged whether the color of the liquid in the intravenous line is red.

9. Blood purification equipment, characterized by, including host computer and display screen, be provided with the circuit board that can realize interactive communication with the display screen in the host computer, be provided with treater and memory on the circuit board, the memory stores computer program, computer program realizes each step of the blood return control method of blood purification equipment of above-mentioned claim 1 to 8 when being executed by the treater.

10. A computer-readable storage medium having stored thereon a computer program, characterized in that:

the computer program, when executed by a processor, implements the steps of the method for controlling blood return of a blood purification apparatus according to any one of claims 1 to 8.