CN114340584B - 包含二取代的对苯二甲酸酯以及光防护滤光物质、除臭剂和/或止汗剂活性成分的组合物 - Google Patents
包含二取代的对苯二甲酸酯以及光防护滤光物质、除臭剂和/或止汗剂活性成分的组合物 Download PDFInfo
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- CN114340584B CN114340584B CN202080062196.0A CN202080062196A CN114340584B CN 114340584 B CN114340584 B CN 114340584B CN 202080062196 A CN202080062196 A CN 202080062196A CN 114340584 B CN114340584 B CN 114340584B
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- ethylhexyl
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- 239000000203 mixture Substances 0.000 title claims abstract description 62
- 239000000463 material Substances 0.000 title claims abstract description 7
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- 239000003213 antiperspirant Substances 0.000 title abstract description 11
- 239000002781 deodorant agent Substances 0.000 title abstract description 11
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical class OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 title abstract description 10
- 230000003711 photoprotective effect Effects 0.000 title abstract description 6
- -1 diethyl hexyl butyryl Chemical group 0.000 claims description 30
- 239000000126 substance Substances 0.000 claims description 30
- 239000002904 solvent Substances 0.000 claims description 15
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims description 11
- 238000012216 screening Methods 0.000 claims description 11
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims description 8
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
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- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 claims description 3
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- ZMPFVMSHKCGRFH-UHFFFAOYSA-N hexyl 3-(diethylamino)-2-hydroxybenzoate Chemical compound CCCCCCOC(=O)C1=CC=CC(N(CC)CC)=C1O ZMPFVMSHKCGRFH-UHFFFAOYSA-N 0.000 claims 1
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Abstract
本发明涉及包含二取代的对苯二甲酸酯以及光防护滤光物质、除臭剂和/或止汗剂活性成分的组合物。
Description
发明领域
本发明涉及包含二取代的对苯二甲酸酯以及光防护滤光物质(light protectionfilter substances)、除臭剂和/或止汗剂活性成分的组合物。
现有技术
在频繁或大面积施用防晒制剂的情况下，不能排除将以克为单位的量的高剂量防紫外光滤光物质施用于皮肤。必须将这些量的防紫外光滤光物质均匀且稳定地掺入并溶解到制剂中。
为了溶解这些防紫外光滤光物质，通常使用对防紫外光滤光物质具有良好溶解能力的油性组分。所用的具有良好溶解能力的一类化合物是脂族苯甲酸酯。此类化合物的典型代表是苯甲酸C12-C15烷酯，它在世界范围内已被确定为防晒制剂的成分。
EP2165696公开了C6-C12烷基-和环烷基羧酸的苯氧基烷酯用于制备化妆品、皮肤病制剂或药物制剂中的用途，以及作为至少一种防紫外光滤光物质的增溶剂或溶剂的用途。
EP2062566公开了苯甲酸异壬酯用于制备化妆品、皮肤病制剂或药物制剂中的用途，以及作为至少一种防紫外光滤光物质的增溶剂或溶剂的用途。
由于消费者健康意识的提高和休闲行为的不断增长，需要在防紫外光滤光物质方面的高浓缩的防晒制剂。
本发明的目的是提供不仅对防紫外光滤光物质而且对除臭剂和止汗剂活性成分具有良好溶解能力的物质。
发明描述
令人意外的是，已发现二取代的对苯二甲酸酯不仅对防紫外光滤光物质以及对除臭剂和止汗剂活性成分具有优异的溶解性能。
因此，本发明涉及如权利要求1所述的包含二取代的对苯二甲酸酯以及光防护滤光物质、除臭剂和/或止汗剂活性成分的组合物。
本发明还涉及所述二取代的对苯二甲酸酯在化妆品或药物组合物中作为增溶剂或溶剂的用途。
本发明的一个优点是所述二取代的对苯二甲酸酯在宽温度范围内容易地溶解针对不同UV范围的防光滤光剂。
本发明的另一个优点是，当施用于皮肤时，与包含苯甲酸C12-15烷酯的防晒制剂相比，所述包含二取代的对苯二甲酸酯的防晒制剂的特征在于相对较少的油腻性和吸收良好的皮肤感觉。
本发明的另一个优点是，与包含苯甲酸C12-15烷酯的防晒制剂相比，所述包含二取代的对苯二甲酸酯的防晒制剂具有更高的储存稳定性，并因此具有更长的保质期。
本发明的另一个优点是，所述二取代的对苯二甲酸酯稳定地分散无机颜料，并且因此也适用于制备包含除臭剂和/或止汗剂活性成分的组合物。
本发明的另一个优点是，所述二取代的对苯二甲酸酯具有良好的铺展性并因此实现了防光因子在皮肤上的均匀分布。
除非另有说明，否则所有给出的百分比(％)均为质量百分比。
因此，本发明涉及一种组合物，其包含
A)至少一种通式(I)的物质
其中R1和R2各自独立地相同或不同，选自包含2至18个碳原子的有机基团，优选脂族基团，尤其是烷基，特别优选包含4至8个碳原子的烷基；和
B)至少一种选自防紫外光滤光物质、除臭剂和止汗剂活性成分的物质，尤其是防紫外光滤光物质。
通式(I)的物质例如可如EP3351526中所述通过合成方式获得。
根据本发明，R1和R2各自独立地相同或不同，选自支链烷基，特别优选包含4至8个碳原子，尤其是异戊基。
存在的防紫外光滤光物质例如可以是能够吸收紫外辐射并以较长波辐射(例如热)的形式再次发射所吸收的能量的有机物质。
UVB滤光剂可以是油溶性或水溶性的。油溶性防UVB光滤光剂包括例如：3-亚苄基樟脑衍生物，例如3-(4-甲基亚苄基)樟脑(INCI：4-甲基亚苄基樟脑)；4-氨基苯甲酸衍生物，例如4-(二甲基氨基)苯甲酸2-乙基己酯(INCI：乙基己基二甲基PABA(EthylhexylDimethyl PABA))、4-{双[2-(2-羟基乙氧基)乙基]氨基}苯甲酸2-羟乙酯(INCI：PEG-25PABA)；肉桂酸的酯，例如4-甲氧基肉桂酸2-乙基己酯(INCI：甲氧基肉桂酸乙基己酯(Ethylhexyl Methoxycinnamate))、4-甲氧基肉桂酸异戊酯(INCI：对甲氧基肉桂酸异戊酯(Isoamyl p-Methoxycinnamate))、2-氰基-3,3-二苯基丙烯酸2-乙基己酯(INCI：奥克立林)；水杨酸的酯，例如水杨酸2-乙基己酯(INCI：水杨酸乙基己酯(EthylhexylSalicylate))、homomenthyl salicylate(INCI：薄荷醇水杨酸酯(Menthyl Salicylate))、水杨酸3,3,5-三甲基环己酯(INCI：胡莫柳酯)、2-羟基苯甲酸2,2',2”-次氮基三乙醇(1:1)(INCI：TEA-水杨酸酯(TEA-Salicylate))；二苯甲酮的衍生物，例如2-羟基-4-甲氧基二苯甲酮(INCI：二苯甲酮-3(Benzophenone-3))、2,2'-二羟基-4-甲氧基二苯甲酮(INCI：二苯甲酮-8(Benzophenone-8))、2-羟基-4-甲氧基-4'-甲基二苯甲酮(INCI：二苯甲酮-10(Benzophenone-10))；三嗪衍生物，例如4,4',4”-(1,3,5-三嗪-2,4,6-三基三亚氨基)三苯甲酸三(2-乙基己酯)(INCI：乙基己基三嗪酮(Ethylhexyl Triazone)，例如以商品名Uvinul T 150得自BASF)、Iscotrizinole(INCI：二乙基己基丁酰胺基三嗪酮(Diethylhexyl Butamido Triazone))和2,4,6-三(4-联苯基)-1,3,5-三嗪(INCI：三联苯基三嗪(Tris-Biphenyl Triazine))。
另一种UVB滤光剂是3-(4-(2,2-二乙氧基羰基乙烯基)苯氧基)丙烯基)甲氧基硅氧烷/二甲基硅氧烷共聚物(INCI：聚硅氧烷-15(Polysilicone-15))，例如可以商品名Parsol SLX获得。
可能的水溶性防UVB光滤光剂例如是：2-苯基苯并咪唑-5-磺酸的盐，诸如其碱金属盐、碱土金属盐、铵盐、烷基铵盐、烷醇铵盐和葡萄糖铵盐；以及INCI名称为苯基苯并咪唑磺酸(Phenylbenzimidazole Sulfonic Acid)的磺酸本身；二苯甲酮的磺酸衍生物，例如5-苯甲酰-4-羟基-2-甲氧基苯磺酸(INCI：二苯甲酮-4(Benzophenone-4))及其盐；3-亚苄基樟脑的苯磺酸衍生物，例如4-[(E)-(4,7,7-三甲基-3-氧代二环[2.2.1]庚-2-叉基)甲基]苯磺酸(INCI：亚苄基樟脑磺酸(Benzylidene Camphor Sulfonic Acid))及其盐。
典型的合适的油溶性广谱防UVA光滤光剂例如是：苯甲酰甲烷的衍生物，例如1-(4-甲氧基苯基)-3-[4-(2-甲基-2-丙基)苯基]-1,3-丙二酮(INCI：丁基甲氧基二苯甲酰甲烷(Butyl Methoxydibenzoylmethane))、1-(4-异丙基苯基)-3-苯基-1,3-丙二酮(INCI：异丙基二苯甲酰甲烷(Isopropyl Dibenzoylmethane))；三嗪衍生物，例如2,2'-[6-(4-甲氧基苯基)-1,3,5-三嗪-2,4-二基]双{5-[(2-乙基己基)氧基]苯酚}(INCI：双-乙基己基氧基苯酚甲氧基苯基三嗪(Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine)，例如可从BASF以商品名Tinosorb S获得)、N,N'-双[4-[5-(1,1-二甲基丙基)-2-苯并噁唑基]苯基]-N”-(2-乙基己基)-1,3,5-三嗪-2,4,6-三胺(INCI：乙基己基双-异戊基苯并噁唑基苯基三聚氰胺，可从3V Sigma以商品名Uvasorb K2A获得)；以及二苯甲酮的衍生物，例如2-(4-二乙基氨基-2-羟基苯甲酰)苯甲酸己酯(INCI：二乙氨羟苯甲酰基苯甲酸己酯(DiethylaminoHydroxybenzoyl Hexyl Benzoate))。
可能的水溶性广谱防UVA光滤光剂例如为：3,3'-(1,4-苯二亚甲基)双(7,7-二甲基-2-氧代-双环[2.2.1]庚-1-基甲磺酸)(也称为苯-1,4-二(2-氧代-3-冰片叉基甲基-10-磺酸)且INCI名称为对苯二亚甲基二樟脑磺酸(Terephthalylidene Dicamphor SulfonicAcid)，以商品名Mexoryl SX获得)及其盐，尤其是相应的钠盐、钾盐或三乙醇铵盐；2,2'-(1,4-亚苯基)双(6-磺基-1H-苯并咪唑-4-磺酸)及其盐(相应的钠盐、钾盐或三乙醇铵盐)，例如2,2'-(1,4-亚苯基)双(6-磺基-1H-苯并咪唑-4-磺酸)二钠，INCI名称为苯基二苯并咪唑四磺酸二钠(Disodium Phenyl Dibenzimidazole Tetrasulfonate)，商品名例如为NeoHeliopan AP。
其他广谱UVA滤光剂例如为2,2'-亚甲基双[6-(2H-苯并三唑-2-基)-4-(2,4,4-三甲基-2-戊基)苯酚](INCI：亚甲基双-苯并三唑基四甲基丁基苯酚(亚甲基双-苯并三唑基四甲基丁基酚)，例如可从BASF以商品名Tinosorb M获得)、2-(2H-苯并三唑-2-基)-4-甲基-6-[2-甲基-3-[1,3,3,3-四甲基-1-[(三甲基甲硅烷基)氧基]二硅氧烷基]丙基]苯酚(INCI：甲酚曲唑三硅氧烷(Drometrizole Trisiloxane)，商品名：Mexoryl XL)、(1R,2S,5R)-2-氨基苯甲酸-2-异丙基-5-甲基环己酯(INCI：薄荷醇邻氨基苯甲酸酯(MenthylAnthanilate))和(2E)-3-(4-甲氧基苯基))丙烯酸2-乙氧基乙酯(INCI：Cinoxate)。
显然UV滤光剂也可以混合物形式存在于根据本发明的组合物中。
除了规定的可溶性物质外，不溶性颜料也适用于此目的，不溶性颜料即细分散的金属氧化物或盐，例如二氧化钛、氧化锌、氧化铁、氧化铝、氧化铈、氧化锆、硅酸盐(滑石)、硫酸钡和硬脂酸锌。此处的颗粒应具有小于100nm的平均直径，例如在5-50nm之间，特别是在15-30nm之间。它们可以具有球形形状，尽管也可以使用具有椭圆形或以其他某种方式偏离球形的形状的那些颗粒。然而，微粉化的有机颜料也是可能的，例如2,2'-亚甲基双[6-(2H-苯并三唑-2-基)-4-(2,4,4-三甲基-2-戊基)苯酚](INCI：亚甲基双-苯并三唑基四甲基丁基苯酚(亚甲基双-苯并三唑基四甲基丁基酚)，例如可从BASF以商品名Tinosorb M获得)，具有小于200nm的粒度，其例如可以作为50％的水分散体获得。
此外，可以在P.Finkel,-Journal 122,543(1996)的概述或N.A.Shaath,Principles and Practice of Photoprotection的The Chemistry of UltravioletFilters章节，S.Q.Wang,H.W.Lim(编辑),Springer International PublishingSwitzerland 2016中找到其他适合的防紫外光滤光剂。
根据本发明，优选根据本发明的组合物的组分B)选自至少两种、优选至少三种、特别优选至少四种防紫外光滤光物质。
根据本发明，优选根据本发明的组合物的组分B)选自有机防紫外光滤光物质，尤其是选自三嗪衍生物。
根据本发明，特别优选根据本发明的组合物的组分B)选自包括以下物质、优选由以下物质组成的防紫外光滤光物质：丁基甲氧基二苯甲酰甲烷、乙基己基三嗪酮、双-乙基己基氧基苯酚甲氧基苯基三嗪、二乙基己基丁酰胺基三嗪酮、二乙氨羟苯甲酰基苯甲酸己酯、二苯甲酮-3、4-甲基亚苄基樟脑。
根据本发明进一步优选根据本发明的组合物的组分B)选自除臭剂和止汗剂活性成分的群组，所述除臭剂和止汗剂活性成分包括以下物质、优选由以下物质组成：收敛剂，优选铝盐、锌盐和铝-锆络合物。在这些群组中，特别优选存在碱性氯化铝诸如水合氯化铝(“ACH”)或铝-锆-甘氨酸盐(“ZAG”)。
根据本发明的一种优选的组合物的特征在于
组分A)以0.1重量％至60重量％、优选0.5重量％至30重量％、特别优选1重量％至20重量％的量存在，和
组分B)以0.1重量％至50重量％、优选1重量％至40重量％、特别优选3重量％至30重量％的量存在。
根据本发明的组合物可以包含例如至少一种选自以下群组的另外的附加组分：润肤剂、助乳化剂、增稠剂/粘度调节剂/稳定剂、抗氧化剂、水溶助长剂(或多元醇)、固体和填充剂、珠光添加剂、驱虫剂、自黝黑剂、防腐剂、调理剂、香料、染料、化妆品活性成分、护理添加剂、超脂剂(superfatting agent)、溶剂。
可以用作各个群组的示例性代表的物质是本领域技术人员已知的并且例如可以在德国申请DE 102008001788.4中找到。该专利申请在此作为参考并入并因此构成本公开的一部分。
关于其他任选的组分和这些组分的用量，明确参考本领域技术人员已知的相关手册，例如K.Schrader,"Grundlagen und Rezepturen der Kosmetika[Fundamentals andformulations of cosmetics]",第2版,329-341页,Hüthig Buch Verlag Heidelberg。
具体添加剂的量由预期用途决定。
针对相应应用的典型的界定制剂是已知的现有技术并且包含在例如特定的基础成分和活性成分的制造商的手册中。通常可以原封不动地采用这些现有制剂。但是，如果需要的话，为了调整和优化，可以通过简单的试验进行所需修改，而不会很复杂。
根据本发明的组合物可以例如用作皮肤护理、面部护理、头部护理、身体护理、私密护理、足部护理、毛发护理、指甲护理、牙齿护理或口腔护理产品。
根据本发明的组合物可以例如以乳液、悬浮液、溶液、乳膏、软膏、糊膏、凝胶、油、粉末、气雾剂、棒、喷剂、清洁产品、美容或防晒制剂或面部爽肤水的形式使用。
本发明还涉及至少一种通式(I)的物质作为化妆品或药物组合物中的增溶剂或溶剂、特别是作为至少一种选自防紫外光滤光物质、除臭剂和止汗剂活性成分的物质、尤其是防紫外光滤光物质的增溶剂或溶剂的用途，
其中R1和R2各自独立地相同或不同，选自包含2至18个碳原子的有机基团，优选脂族基团，尤其是烷基，特别优选包含4至8个碳原子的烷基。
在根据本发明的用途中，优选使用以上规定的组分作为优选存在于根据本发明的组合物的上下文中的组分。
以下实施例通过实例的方式描述了本发明，但无意将本发明限制于实施例中引用的实施方案，本发明的范围从整个说明书和权利要求书显而易见。
附图说明
下图是实施例的一部分：
图1：乳液的感官评价
图2：乳液的感官评价
具体实施方式
实施例：
实施例1：对防紫外光滤光剂的溶解能力
为了测试对防紫外光滤光剂的溶解能力，选择了三种代表性防UVA或UVB光滤光剂。这些滤光剂是：
·丁基甲氧基二苯甲酰甲烷(BMDM)
·乙基己基三嗪酮(EHT)
·双-乙基己基氧基苯酚甲氧基苯基三嗪(BEMT)。
为了确定对这三种防紫外光滤光剂的溶解能力，在每种情况下最初加入一定量(50g)的根据本发明的化合物之一并将温度控制在22℃。添加一定重量百分比的防紫外光滤光剂并搅拌直到该量已经完全且均匀地溶解。重复该过程直到超过防紫外光滤光剂的最大可溶量。为了在较高浓度下完全溶解，通常需要数小时的较长搅拌时间。如果以这种方式粗略地确定了最大浓度，则使用称取的较小量的防紫外光滤光剂在该最大浓度附近重复进行来精细确定该浓度范围。
使用苯甲酸C12-15烷酯和辛酸2-苯氧基乙酯作为参考物。
| BMDM | EHT | BEMT | |
| 苯甲酸C12-15烷酯 | 13％ | 4％ | 9％ |
| 辛酸2-苯氧基乙酯 | 18％ | 6％ | 11％ |
| 对苯二甲酸二(异)戊酯 | 22％ | 14％ | 13％ |
| 对苯二甲酸二(2-乙基己酯) | 20％ | 7％ | 12％ |
| 对苯二甲酸二(正)丁酯 | 23％ | 18％ | 23％ |
所使用的对苯二甲酸二烷酯比苯甲酸C12-15烷酯和辛酸2-苯氧基乙酯更能溶解所考察的防紫外光滤光剂。
特别是，所使用的对苯二甲酸二烷酯的特征在于在对EHT的溶解能力方面的优异性能。
实施例2：包含对苯二甲酸二烷酯的防晒制剂SPF50,PA++++的感官评价
制备了表1中所示的制剂。由测试小组来考察制剂对皮肤感觉的影响。向十三个人每人前臂内侧的规定测试区域施用规定的约25μl的量的两种制剂，他们不知该制剂的组成。用手指通过在测试区域中作圆周运动来铺展该制剂。在样品铺展期间评估参数油腻性和吸收性。吸收完成后，暂停，5分钟后，重新评估测试区域的皮肤感觉。
表1：水包油乳液。数字为重量百分比经典露液制剂。将A相和B相加热至85℃，将B相添加到A中并用UltraTurrax(20500rpm)均化90秒。在50℃下，加入C相并使用UltraTurrax(20500rpm)均质化30秒。在35℃下，加入D相和E相并用UltraTurrax(13500rpm)均化30秒。用氨丁三醇(三(羟甲基)氨基甲烷，30％的水溶液)将pH值调节到6.5-7.0。
图1显示，与苯甲酸C12-15烷酯相比，含有对苯二甲酸二烷酯的制剂不那么油腻并且在5分钟后吸收更好。
实施例3：包含对苯二甲酸二烷酯的防晒制剂SPF50,PA++++的感官评价
制备了表2中所示的制剂。通过测试小组研究了制剂对皮肤感觉的影响。向十四个人每人前臂内侧的规定测试区域施用规定的约25μl的量的两种制剂，他们不知该制剂的组成。用手指通过在测试区域中作圆周运动来铺展该制剂。在样品铺展期间评估参数油腻性和吸收性。吸收完成后，暂停，5分钟后，重新评估测试区域的皮肤感觉。
表2：水包油乳液。数字为重量百分比。经典露液(lotion)制剂。将A相和B相加热至85℃，将B相添加到A中并用UltraTurrax(20500rpm)均化90秒。在50℃下，加入C相并使用UltraTurrax(20500rpm)均化30秒。在35℃下，加入D相和E相并用UltraTurrax(13500rpm)均化30秒。用氨丁三醇(三(羟甲基)氨基甲烷，30％的水溶液)将pH值调节到6.5-7.0。
图2显示，与苯甲酸C12-15烷酯相比，含有对苯二甲酸二烷酯的制剂不那么油腻并且在5分钟后吸收更好。
实施例4：包含对苯二甲酸二烷酯的防晒制剂SPF50,PA的储存稳定性
制备表1中所示的水包油型防晒乳液。各制剂的粘度是相当的(7-8，或9Pa·s；Brookfield粘度，用4号转子测量，5rpm)。所有制剂均为低粘度露液。制剂在40℃和45℃下储存三个月。在40℃和45℃下储存三个月后的两种样品中包含苯甲酸C12-15烷酯的制剂表现出显著的油分离，而包含对苯二甲酸二烷酯的根据本发明的制剂则没有。
实施例5：制剂实施例
使用对苯二甲酸二(异)戊酯的制剂实施例如下所列出。
在每种情况下，所有以下列出的制剂实施例用对苯二甲酸二(新)戊酯、对苯二甲酸二(正)戊酯、对苯二甲酸(异/新)戊酯、对苯二甲酸(异/正)戊酯、对苯二甲酸(新/正)戊酯、对苯二甲酸二(异)己酯、对苯二甲酸二(2-乙基己酯)、对苯二甲酸二(正)丁酯、对苯二甲酸二(2-甲基丙酯)和对苯二甲酸正丁酯/2-甲基丙酯代替对苯二甲酸二(异)戊酯另外配制。
防晒喷雾SPF30
释油防晒露SPF 50
防晒喷剂SPF 30
透明防晒喷剂SPF 25
耐水喷剂SPF 30
| 相 | 原料 | w/w％ |
| A | 变性乙醇 | 至100 |
| 聚酯-10(和)丙二醇二苯甲酸酯 | 2.00 | |
| 二苯甲酮-3 | 5.00 | |
| 水杨酸乙基己酯 | 5.00 | |
| 甲氧基肉桂酸乙基己酯 | 7.50 | |
| 胡莫柳酯 | 10.00 | |
| 丁基甲氧基二苯甲酰甲烷 | 2.00 | |
| 对苯二甲酸二(异)戊酯 | 4.00 |
轻质O/W防晒露
干爽手部保湿霜
抗衰老BB霜SPF 15
保湿护理BB霜SPF 15
无水条棒
O/W防晒美黑用品
防晒泡沫SPF 50
W/O防晒摇动型产品(W/O Sun Protection Shake-Shake)
轻质防晒w/o摇动型产品SPF30 PA+++
W/O有机摇动型产品SPF50+PA++++
夏日天堂霜SPF 30
旅行用防紫外条棒SPF 50
透明防紫外水性喷剂SPF 30
防晒霜SPF 25
无机耐水O/W防晒品SPF 20
体感防晒喷剂SPF 50
防晒条棒
W/O快速破乳霜(Quick-Breaking Cream)SPF 15
阳光下的乐趣(Fun in the Sun)SPF 30喷剂
阳离子防晒品SPF 12
W/O防晒露SPF 8,耐水
阳离子防晒品SPF 19,耐水
阳离子防晒品SPF 15,耐水
阳离子防晒霜SPF 14
日常防晒霜(Everyday Sunshine Cream)SPF 15
高度防晒露O/W SPF 50
冰感O/W防晒露SPF 25
低粘度W/O防晒露SPF30 PA+++
O/W防晒凝胶SPF30 PA+++
防晒水凝胶SPF50+,PA++++
O/W高防晒SPF 50+霜PA+++
透明防晒条棒SPF50+,PA++++
防晒霜SPF 15
无PEG AP/Deo滚搽剂
AP/Deo条棒
W/O AP气溶胶喷剂
AP/Deo气溶胶喷剂(无水)
O/W AP/Deo滚搽剂
无PEG和ACH的AP/Deo滚搽剂
Claims (8)
1.一种组合物，其包含
A)至少一种通式(I)的物质
其中R1和R2各自独立地相同或不同，选自包含2至8个碳原子的烷基；和
B)防紫外光滤光物质，所述防紫外光滤光物质选自丁基甲氧基二苯甲酰甲烷、乙基己基三嗪酮、双-乙基己基氧基苯酚甲氧基苯基三嗪、二乙基己基丁酰胺基三嗪酮、二乙氨羟苯甲酰基苯甲酸己酯。
2.根据权利要求1所述的组合物，其特征在于
组分A)以0.1重量％至60重量％的量存在，和
组分B)以0.1重量％至50重量％的量存在。
3.根据权利要求2所述的组合物，其特征在于
组分A)以0.5重量％至30重量％的量存在。
4.根据权利要求2所述的组合物，其特征在于
组分A)以1重量％至20重量％的量存在。
5.根据权利要求2所述的组合物，其特征在于
组分B)以1重量％至40重量％的量存在。
6.根据权利要求2所述的组合物，其特征在于
组分B)以3重量％至30重量％的量存在。
7.至少一种通式(I)的物质作为包含防紫外光滤光物质的化妆品或药物组合物中的增溶剂或溶剂的用途，
其中R1和R2各自独立地相同或不同，选自包含2至8个碳原子的烷基，所述防紫外光滤光物质选自丁基甲氧基二苯甲酰甲烷、乙基己基三嗪酮、双-乙基己基氧基苯酚甲氧基苯基三嗪、二乙基己基丁酰胺基三嗪酮、二乙氨羟苯甲酰基苯甲酸己酯。
8.至少一种通式(I)的物质作为防紫外光滤光物质的增溶剂或溶剂的用途，
其中R1和R2各自独立地相同或不同，选自包含2至8个碳原子的烷基，所述防紫外光滤光物质选自丁基甲氧基二苯甲酰甲烷、乙基己基三嗪酮、双-乙基己基氧基苯酚甲氧基苯基三嗪、二乙基己基丁酰胺基三嗪酮、二乙氨羟苯甲酰基苯甲酸己酯。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19195485.8 | 2019-09-05 | ||
| EP19195485 | 2019-09-05 | ||
| PCT/EP2020/073921 WO2021043656A1 (de) | 2019-09-05 | 2020-08-27 | Zusammensetzungen enthaltend di-substituierte terephthalate sowie lichtschutzfiltersubstanzen, deodorant- und/oder antitranspirantwirkstoffe |
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| Publication Number | Publication Date |
|---|---|
| CN114340584A CN114340584A (zh) | 2022-04-12 |
| CN114340584B true CN114340584B (zh) | 2024-07-19 |
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| CN202080062196.0A Active CN114340584B (zh) | 2019-09-05 | 2020-08-27 | 包含二取代的对苯二甲酸酯以及光防护滤光物质、除臭剂和/或止汗剂活性成分的组合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220323325A1 (zh) |
| EP (1) | EP4025177A1 (zh) |
| CN (1) | CN114340584B (zh) |
| WO (1) | WO2021043656A1 (zh) |
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| AU2022348925A1 (en) * | 2021-09-23 | 2024-04-04 | Edgewell Personal Care Brands, Llc | Sunscreen composition with crystalline organic sunscreen filters |
| FR3146067A1 (fr) * | 2023-02-28 | 2024-08-30 | L'oreal | Composition cosmetique a base d'oxyde de zinc et de bisethyhexyloxyphenol methoxyphenyl triazine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1543335A (zh) * | 2001-06-22 | 2004-11-03 | 荷兰联合利华有限公司 | 化妆用组合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2063857A2 (en) * | 2006-08-30 | 2009-06-03 | Eastman Chemical Company | Fragrance fixatives |
| DE102007055483A1 (de) | 2007-11-21 | 2009-05-28 | Evonik Goldschmidt Gmbh | Kosmetische und dermatologische Formulierungen enthaltend Isononylbenzoat |
| DE102008042149A1 (de) | 2008-09-17 | 2010-03-18 | Evonik Goldschmidt Gmbh | Kosmetische und dermatologische Formulierungen enthaltend Phenoxyalkylester |
| EP2542212B1 (de) * | 2010-03-05 | 2018-02-21 | Covestro Deutschland AG | Sonnenschutz-zusammensetzungen |
| JP2015521161A (ja) * | 2012-04-25 | 2015-07-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 抗微生物特性を有するジシクロヘキシルメタノール誘導体の使用 |
| US9370191B2 (en) * | 2012-08-07 | 2016-06-21 | Pardis Kelly | Cosmetic formulation |
| EP3284735A1 (de) * | 2015-02-18 | 2018-02-21 | Evonik Degussa GmbH | Pentyl-nonyl-terephthalate |
| JP6851366B2 (ja) * | 2015-08-03 | 2021-03-31 | アイエスピー インヴェストメンツ エルエルシー | ビニルアルコールエーテルから誘導されたポリマーを含むパーソナルケア組成物、およびその用途 |
| ES2837112T3 (es) | 2017-01-20 | 2021-06-29 | Evonik Operations Gmbh | Tereftalato de diisopentilo |
| US11499030B2 (en) * | 2017-02-10 | 2022-11-15 | Lg Chem, Ltd. | Plasticizer composition and resin composition including the same |
| US12115290B2 (en) * | 2017-10-11 | 2024-10-15 | Microban Products Company | Odor control composition and carpet having a durable odor control property |
-
2020
- 2020-08-27 EP EP20764618.3A patent/EP4025177A1/de active Pending
- 2020-08-27 CN CN202080062196.0A patent/CN114340584B/zh active Active
- 2020-08-27 US US17/753,446 patent/US20220323325A1/en active Pending
- 2020-08-27 WO PCT/EP2020/073921 patent/WO2021043656A1/de unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1543335A (zh) * | 2001-06-22 | 2004-11-03 | 荷兰联合利华有限公司 | 化妆用组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220323325A1 (en) | 2022-10-13 |
| CN114340584A (zh) | 2022-04-12 |
| WO2021043656A1 (de) | 2021-03-11 |
| EP4025177A1 (de) | 2022-07-13 |
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