CN114306577B - 一种门冬胰岛素30混悬液的制备方法 - Google Patents
一种门冬胰岛素30混悬液的制备方法 Download PDFInfo
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- CN114306577B CN114306577B CN202011088818.5A CN202011088818A CN114306577B CN 114306577 B CN114306577 B CN 114306577B CN 202011088818 A CN202011088818 A CN 202011088818A CN 114306577 B CN114306577 B CN 114306577B
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- insulin aspart
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- stirring
- phenol
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 42
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
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- KDQPSPMLNJTZAL-UHFFFAOYSA-L disodium hydrogenphosphate dihydrate Chemical compound O.O.[Na+].[Na+].OP([O-])([O-])=O KDQPSPMLNJTZAL-UHFFFAOYSA-L 0.000 claims description 14
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- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 6
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/CN2020/126395 WO2022073275A1 (fr) | 2020-10-10 | 2020-11-04 | Procédé de préparation d'une suspension d'insuline asparte 30 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2896375A1 (fr) * | 2013-02-04 | 2014-08-07 | Sanofi | Formulations pharmaceutiques stabilisees d'analogues d'insuline et/ou de derives d'insuline |
| CN105899190A (zh) * | 2014-01-09 | 2016-08-24 | 赛诺菲 | 门冬胰岛素的稳定化药物制剂 |
| CN108096185A (zh) * | 2017-12-20 | 2018-06-01 | 珠海冀百康生物科技有限公司 | 一种速效胰岛素制剂及其制备方法 |
| CN108114270A (zh) * | 2018-02-06 | 2018-06-05 | 美药星（南京）制药有限公司 | 一种门冬胰岛素注射液的制备方法 |
| CN108778246A (zh) * | 2016-01-07 | 2018-11-09 | 美药星制药股份有限公司 | 胰岛素和胰岛素类似物的高纯度可吸入颗粒及其高效制备方法 |
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| DK72793D0 (da) * | 1993-06-21 | 1993-06-21 | Novo Nordisk As | Nyt produkt |
| CO4970787A1 (es) * | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
| JP4933455B2 (ja) * | 2005-02-02 | 2012-05-16 | ノヴォ ノルディスク アー／エス | 新規のインスリン誘導体 |
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- 2020-11-04 WO PCT/CN2020/126395 patent/WO2022073275A1/fr active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2896375A1 (fr) * | 2013-02-04 | 2014-08-07 | Sanofi | Formulations pharmaceutiques stabilisees d'analogues d'insuline et/ou de derives d'insuline |
| CN105899190A (zh) * | 2014-01-09 | 2016-08-24 | 赛诺菲 | 门冬胰岛素的稳定化药物制剂 |
| CN108778246A (zh) * | 2016-01-07 | 2018-11-09 | 美药星制药股份有限公司 | 胰岛素和胰岛素类似物的高纯度可吸入颗粒及其高效制备方法 |
| CN108096185A (zh) * | 2017-12-20 | 2018-06-01 | 珠海冀百康生物科技有限公司 | 一种速效胰岛素制剂及其制备方法 |
| CN108114270A (zh) * | 2018-02-06 | 2018-06-05 | 美药星（南京）制药有限公司 | 一种门冬胰岛素注射液的制备方法 |
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| WO2022073275A1 (fr) | 2022-04-14 |
| CN114306577A (zh) | 2022-04-12 |
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