CN114306520A - Traditional Chinese medicine ointment formula for treating Parkinson's disease dysphagia and preparation method thereof - Google Patents
Traditional Chinese medicine ointment formula for treating Parkinson's disease dysphagia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine ointment formula for treating Parkinson's disease dysphagia and a preparation method thereof, wherein the ointment formula is prepared from the following raw materials in parts by weight: 10-20 parts of scutellaria baicalensis, 10-15 parts of inula flower, 5-10 parts of prepared rehmannia root, 3-5 parts of blumea balsamifera, 10-15 parts of oldenlandia diffusa, 5-10 parts of fructus gleditsiae, 10-15 parts of radix angelicae, 5-10 parts of rhodiola rosea, 10-20 parts of gastrodia elata, 10-20 parts of salvia chinensis, 5-10 parts of fennel, 8-10 parts of trichosanthes kirilowii maxim, 5-10 parts of pseudo-ginseng, 5-10 parts of mint and 5-10 parts of isomaltooligosaccharide. The traditional Chinese medicine composition has the effects of lowering adverse qi, reducing phlegm, tonifying qi, harmonizing stomach, protecting brain, strengthening tendons, removing blood stasis, dredging collaterals, promoting blood circulation, removing stasis, effectively promoting recovery and reconstruction of swallowing reflex arcs, remarkably improving swallowing disorder symptoms of PD patients, and simultaneously remarkably slowing down progress of swallowing disorder diseases of PD patients.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine ointment formula for treating dysphagia of Parkinson's disease and a preparation method thereof.
Background
Parkinson's Disease (PD) is a common neurodegenerative disease. Swallowing dysfunction is a common symptom of PD, severely affecting the prognosis and quality of life of patients, and is also a major cause of death in patients due to aspiration pneumonia. It is found that with the development of the disease, swallowing difficulty and speech disorder appear in nearly 90% of patients, and inhalation pneumonia is caused by choking and aspiration in 25% -50% of patients.
In recent years, a great deal of medical research at home and abroad proves that early systemic therapeutic intervention can obviously slow down the progress of the dysphagia of PD patients and obviously improve the dysphagia symptoms of the PD patients.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine ointment formula for treating the dysphagia of the Parkinson disease and a preparation method thereof, and the traditional Chinese medicine ointment formula has the effects of lowering adverse qi, reducing phlegm, tonifying qi, harmonizing stomach, protecting brain, strengthening tendons, removing blood stasis, dredging collaterals, promoting blood circulation and resolving masses, can effectively promote the recovery and reconstruction of swallowing reflex arcs, obviously improve the symptoms of the dysphagia of PD patients, and simultaneously obviously slow down the progress of the dysphagia of the PD patients.
In order to achieve the purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine ointment formula for treating Parkinson's disease dysphagia is prepared from the following raw materials in parts by weight:
10-20 parts of scutellaria baicalensis, 10-15 parts of inula flower, 5-10 parts of prepared rehmannia root, 3-5 parts of blumea balsamifera, 10-15 parts of oldenlandia diffusa, 5-10 parts of fructus gleditsiae, 10-15 parts of radix angelicae, 5-10 parts of rhodiola rosea, 10-20 parts of gastrodia elata, 10-20 parts of salvia chinensis, 5-10 parts of fennel, 8-10 parts of trichosanthes kirilowii maxim, 5-10 parts of pseudo-ginseng, 5-10 parts of mint and 5-10 parts of isomaltooligosaccharide.
Preferably, the feed additive is prepared from the following raw materials in parts by weight:
10 parts of scutellaria baicalensis, 10 parts of inula flower, 5 parts of prepared rehmannia root, 3 parts of blumea balsamifera, 10 parts of oldenlandia diffusa, 5 parts of fructus gleditsiae, 10 parts of angelica dahurica, 5 parts of rhodiola rosea, 10 parts of gastrodia elata, 10 parts of salvia chinensis, 5 parts of fennel, 8 parts of fructus trichosanthis, 5 parts of pseudo-ginseng, 5 parts of mint and 5 parts of isomaltooligosaccharide.
Preferably, the feed additive is prepared from the following raw materials in parts by weight:
20 parts of scutellaria baicalensis, 15 parts of inula flower, 10 parts of prepared rehmannia root, 5 parts of blumea balsamifera, 15 parts of oldenlandia diffusa, 10 parts of fructus gleditsiae, 15 parts of angelica dahurica, 10 parts of rhodiola rosea, 20 parts of gastrodia elata, 20 parts of salvia chinensis, 10 parts of fennel, 10 parts of fructus trichosanthis, 10 parts of pseudo-ginseng, 10 parts of mint and 10 parts of isomaltooligosaccharide.
Preferably, the feed additive is prepared from the following raw materials in parts by weight:
15 parts of scutellaria baicalensis, 12.5 parts of inula flower, 7.5 parts of prepared rehmannia root, 4 parts of blumea balsamifera, 12.5 parts of oldenlandia diffusa, 7.5 parts of fructus gleditsiae, 12.5 parts of angelica dahurica, 7.5 parts of rhodiola rosea, 15 parts of gastrodia elata, 15 parts of salvia chinensis, 7.5 parts of fennel, 9 parts of fructus trichosanthis, 7.5 parts of pseudo-ginseng, 7.5 parts of mint and 7.5 parts of isomaltooligosaccharide.
The invention also provides a preparation method of the traditional Chinese medicine ointment for treating dysphagia of Parkinson's disease, which comprises the following steps:
s1, weighing the components according to the formula;
s2, respectively pulverizing the weighed radix Scutellariae, Inulae flos, radix rehmanniae Preparata, herba Blumeae Balsamiferae, herba Hedyotidis Diffusae, fructus Gleditsiae Abnormalis, radix Angelicae Dahuricae, radix Rhodiolae, rhizoma Gastrodiae, herba Salviae chinensis, fructus Foeniculi, fructus Trichosanthis, radix Notoginseng, and herba Menthae into 200 mesh powder for use;
s3, mixing and stirring Scutellaria baicalensis powder, Inula flower powder, rehmannia glutinosa powder, blumea balsamifera powder, oldenlandia diffusa powder, Saponaria officinalis powder, angelica dahurica powder, rhodiola rosea powder, rhizoma gastrodiae powder, Chinese sage powder, fennel powder, trichosanthes kirilowii Maxim powder and pseudo-ginseng powder, ultrasonically extracting for 2 hours by 6 times of ethanol solution with the volume concentration of 75% and ethanol solution with the volume concentration of 90% at 90 ℃ respectively at 110w, filtering, collecting filtrate, merging, distilling under reduced pressure and recovering ethanol, concentrating to obtain clear paste, and stopping concentrating for later use;
s6, putting the clear paste into an electric frying pan, heating with an electromagnetic oven while stirring, and adding peppermint powder and isomaltooligosaccharide at the same time until flag hanging occurs.
The traditional Chinese medicine composition has the effects of lowering adverse qi, reducing phlegm, tonifying qi, harmonizing stomach, protecting brain, strengthening tendons, removing blood stasis, dredging collaterals, promoting blood circulation, removing stasis, effectively promoting recovery and reconstruction of swallowing reflex arcs, remarkably improving swallowing disorder symptoms of PD patients, and simultaneously remarkably slowing down progress of swallowing disorder diseases of PD patients.
Modern pharmacological research shows that the formula has the effects of effectively improving the expression of neurotrophic factor (BDNF, GDNF) mRNA in the brain, protecting neuron cells, inhibiting apoptosis of damaged neurons, relieving neuron paralysis, promoting blood circulation of deglutition muscle groups and deglutition auxiliary muscle groups, effectively promoting recovery and reconstruction of deglutition reflex arcs, obviously improving the symptoms of the deglutition disorder of PD patients and simultaneously obviously slowing the progress of the deglutition disorder of the PD patients.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.
Example 1
A traditional Chinese medicine ointment formula for treating Parkinson's disease dysphagia is prepared by the following steps:
s1, weighing the following components in parts by weight: 10 parts of scutellaria baicalensis, 10 parts of inula flower, 5 parts of prepared rehmannia root, 3 parts of blumea balsamifera, 10 parts of oldenlandia diffusa, 5 parts of fructus gleditsiae, 10 parts of angelica dahurica, 5 parts of rhodiola rosea, 10 parts of gastrodia elata, 10 parts of Chinese sage herb, 5 parts of fennel, 8 parts of trichosanthes kirilowii maxim, 5 parts of pseudo-ginseng, 5 parts of mint and 5 parts of isomaltooligosaccharide;
s2, respectively pulverizing the weighed radix Scutellariae, Inulae flos, radix rehmanniae Preparata, herba Blumeae Balsamiferae, herba Hedyotidis Diffusae, fructus Gleditsiae Abnormalis, radix Angelicae Dahuricae, radix Rhodiolae, rhizoma Gastrodiae, herba Salviae chinensis, fructus Foeniculi, fructus Trichosanthis, radix Notoginseng, and herba Menthae into 200 mesh powder for use;
s3, mixing and stirring Scutellaria baicalensis powder, Inula flower powder, rehmannia glutinosa powder, blumea balsamifera powder, oldenlandia diffusa powder, Saponaria officinalis powder, angelica dahurica powder, rhodiola rosea powder, rhizoma gastrodiae powder, Chinese sage powder, fennel powder, trichosanthes kirilowii Maxim powder and pseudo-ginseng powder, ultrasonically extracting for 2 hours by 6 times of ethanol solution with the volume concentration of 75% and ethanol solution with the volume concentration of 90% at 90 ℃ respectively at 110w, filtering, collecting filtrate, merging, distilling under reduced pressure and recovering ethanol, concentrating to obtain clear paste, and stopping concentrating for later use;
s6, putting the clear paste into an electric frying pan, heating with an electromagnetic oven while stirring, and adding peppermint powder and isomaltooligosaccharide at the same time until flag hanging occurs.
Example 2
A traditional Chinese medicine ointment formula for treating Parkinson's disease dysphagia is prepared by the following steps:
s1, weighing the following components in parts by weight: 20 parts of scutellaria baicalensis, 15 parts of inula flower, 10 parts of prepared rehmannia root, 5 parts of blumea balsamifera, 15 parts of oldenlandia diffusa, 10 parts of fructus gleditsiae, 15 parts of angelica dahurica, 10 parts of rhodiola rosea, 20 parts of gastrodia elata, 20 parts of salvia chinensis, 10 parts of fennel, 10 parts of fructus trichosanthis, 10 parts of pseudo-ginseng, 10 parts of mint and 10 parts of isomaltooligosaccharide;
s2, respectively pulverizing the weighed radix Scutellariae, Inulae flos, radix rehmanniae Preparata, herba Blumeae Balsamiferae, herba Hedyotidis Diffusae, fructus Gleditsiae Abnormalis, radix Angelicae Dahuricae, radix Rhodiolae, rhizoma Gastrodiae, herba Salviae chinensis, fructus Foeniculi, fructus Trichosanthis, radix Notoginseng, and herba Menthae into 200 mesh powder for use;
s3, mixing and stirring Scutellaria baicalensis powder, Inula flower powder, rehmannia glutinosa powder, blumea balsamifera powder, oldenlandia diffusa powder, Saponaria officinalis powder, angelica dahurica powder, rhodiola rosea powder, rhizoma gastrodiae powder, Chinese sage powder, fennel powder, trichosanthes kirilowii Maxim powder and pseudo-ginseng powder, ultrasonically extracting for 2 hours by 6 times of ethanol solution with the volume concentration of 75% and ethanol solution with the volume concentration of 90% at 90 ℃ respectively at 110w, filtering, collecting filtrate, merging, distilling under reduced pressure and recovering ethanol, concentrating to obtain clear paste, and stopping concentrating for later use;
s6, putting the clear paste into an electric frying pan, heating with an electromagnetic oven while stirring, and adding peppermint powder and isomaltooligosaccharide at the same time until flag hanging occurs.
Example 3
A traditional Chinese medicine ointment formula for treating Parkinson's disease dysphagia is prepared by the following steps:
s1, weighing the following components in parts by weight: 15 parts of scutellaria baicalensis, 12.5 parts of inula flower, 7.5 parts of prepared rehmannia root, 4 parts of blumea balsamifera, 12.5 parts of oldenlandia diffusa, 7.5 parts of fructus gleditsiae, 12.5 parts of angelica dahurica, 7.5 parts of rhodiola rosea, 15 parts of gastrodia elata, 15 parts of salvia chinensis, 7.5 parts of fennel, 9 parts of fructus trichosanthis, 7.5 parts of pseudo-ginseng, 7.5 parts of mint and 7.5 parts of isomaltooligosaccharide.
S2, respectively pulverizing the weighed radix Scutellariae, Inulae flos, radix rehmanniae Preparata, herba Blumeae Balsamiferae, herba Hedyotidis Diffusae, fructus Gleditsiae Abnormalis, radix Angelicae Dahuricae, radix Rhodiolae, rhizoma Gastrodiae, herba Salviae chinensis, fructus Foeniculi, fructus Trichosanthis, radix Notoginseng, and herba Menthae into 200 mesh powder for use;
s3, mixing and stirring Scutellaria baicalensis powder, Inula flower powder, rehmannia glutinosa powder, blumea balsamifera powder, oldenlandia diffusa powder, Saponaria officinalis powder, angelica dahurica powder, rhodiola rosea powder, rhizoma gastrodiae powder, Chinese sage powder, fennel powder, trichosanthes kirilowii Maxim powder and pseudo-ginseng powder, ultrasonically extracting for 2 hours by 6 times of ethanol solution with the volume concentration of 75% and ethanol solution with the volume concentration of 90% at 90 ℃ respectively at 110w, filtering, collecting filtrate, merging, distilling under reduced pressure and recovering ethanol, concentrating to obtain clear paste, and stopping concentrating for later use;
s6, putting the clear paste into an electric frying pan, heating with an electromagnetic oven while stirring, and adding peppermint powder and isomaltooligosaccharide at the same time until flag hanging occurs.
Clinical data:
80 patients with Parkinson severe dysphagia are divided into a test group 1, a test group 2, a test group 3 and a control group by random grouping software, and no obvious difference exists among the four groups in terms of age, weight and physical quality level state.
Control group: electrical swallow stimulation and conventional swallowing training was given:
test group 1: swallow electrical stimulation and conventional swallowing training are given, and the ointment formula prepared in example 1 is matched, wherein the dosage is 15mL each time, three times a day, and 2 weeks/treatment course;
test group 2: swallow electrical stimulation and conventional swallowing training are given, and the paste formula prepared in the example 2 is matched, wherein the amount of the paste formula is 15mL each time, three times a day, and 2 weeks/course of treatment;
test group 3: swallow electrical stimulation and conventional swallowing training are given, and the paste formula prepared in the example 2 is matched, wherein the amount of the paste formula is 15mL each time, three times a day, and 2 weeks/course of treatment;
after two treatment courses, the curative effect judgment is carried out, and the statistics of data is completed, wherein the curative effect judgment standard is as follows:
and (3) healing: the swallowing function is close to normal, and the depression field drinking water test evaluates that the grade 1 or the Tengchangyi swallowing score is 10; or a swallow X-ray fluoroscopy score of 9.
The method has the following advantages: the dysphagia is obviously improved, and the swallow difficulty is improved by 1 grade or more than 1 grade or the Tengdao swallowing score is improved by more than or equal to 2 points compared with the swallow before treatment or the swallow X-ray television fluoroscopy score is improved by more than or equal to 2 points compared with the swallow before treatment according to the assessment of the hollow field drinking water test;
and (4) invalidation: the dysphagia is not obviously improved, the drinking test or the Tengchangyi swallowing score is not changed or the score is reduced compared with that of a patient before treatment, or the swallowing X-ray television fluoroscopy score is lower than 4.
As a result:
the cure rate of the control group is 45%, and the total effective rate is 85%.
The cure rate of the test group 1 is 85%, and the total effective rate is 95%.
The cure rate of the test group 2 is 90%, and the total effective rate is 95%.
The cure rate of the test group 3 is 90%, and the total effective rate is 100%.
In the whole treatment process, the blood and urine of the test group 1, the test group 2 and the test group 3 are conventional, the functions of heart, liver and kidney are not abnormally changed, and no obvious adverse reaction is seen.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.
Claims (5)
1. The traditional Chinese medicine ointment formula for treating dysphagia of Parkinson disease is characterized by being prepared from the following raw materials in parts by weight:
10-20 parts of scutellaria baicalensis, 10-15 parts of inula flower, 5-10 parts of prepared rehmannia root, 3-5 parts of blumea balsamifera, 10-15 parts of oldenlandia diffusa, 5-10 parts of fructus gleditsiae, 10-15 parts of radix angelicae, 5-10 parts of rhodiola rosea, 10-20 parts of gastrodia elata, 10-20 parts of salvia chinensis, 5-10 parts of fennel, 8-10 parts of trichosanthes kirilowii maxim, 5-10 parts of pseudo-ginseng, 5-10 parts of mint and 5-10 parts of isomaltooligosaccharide.
2. The traditional Chinese medicine ointment formula for treating swallowing disorder in Parkinson's disease according to claim 1, which is prepared from the following raw materials in parts by weight:
10 parts of scutellaria baicalensis, 10 parts of inula flower, 5 parts of prepared rehmannia root, 3 parts of blumea balsamifera, 10 parts of oldenlandia diffusa, 5 parts of fructus gleditsiae, 10 parts of angelica dahurica, 5 parts of rhodiola rosea, 10 parts of gastrodia elata, 10 parts of salvia chinensis, 5 parts of fennel, 8 parts of fructus trichosanthis, 5 parts of pseudo-ginseng, 5 parts of mint and 5 parts of isomaltooligosaccharide.
3. The traditional Chinese medicine ointment formula for treating swallowing disorder in Parkinson's disease according to claim 1, which is prepared from the following raw materials in parts by weight:
20 parts of scutellaria baicalensis, 15 parts of inula flower, 10 parts of prepared rehmannia root, 5 parts of blumea balsamifera, 15 parts of oldenlandia diffusa, 10 parts of fructus gleditsiae, 15 parts of angelica dahurica, 10 parts of rhodiola rosea, 20 parts of gastrodia elata, 20 parts of salvia chinensis, 10 parts of fennel, 10 parts of fructus trichosanthis, 10 parts of pseudo-ginseng, 10 parts of mint and 10 parts of isomaltooligosaccharide.
4. The traditional Chinese medicine ointment formula for treating swallowing disorder in Parkinson's disease according to claim 1, which is prepared from the following raw materials in parts by weight:
15 parts of scutellaria baicalensis, 12.5 parts of inula flower, 7.5 parts of prepared rehmannia root, 4 parts of blumea balsamifera, 12.5 parts of oldenlandia diffusa, 7.5 parts of fructus gleditsiae, 12.5 parts of angelica dahurica, 7.5 parts of rhodiola rosea, 15 parts of gastrodia elata, 15 parts of salvia chinensis, 7.5 parts of fennel, 9 parts of fructus trichosanthis, 7.5 parts of pseudo-ginseng, 7.5 parts of mint and 7.5 parts of isomaltooligosaccharide.
5. A preparation method of a traditional Chinese medicine ointment formula for treating dysphagia of Parkinson disease is characterized by comprising the following steps:
s1, weighing the components according to the formula of any one of claims 1 to 4;
s2, respectively pulverizing the weighed radix Scutellariae, Inulae flos, radix rehmanniae Preparata, herba Blumeae Balsamiferae, herba Hedyotidis Diffusae, fructus Gleditsiae Abnormalis, radix Angelicae Dahuricae, radix Rhodiolae, rhizoma Gastrodiae, herba Salviae chinensis, fructus Foeniculi, fructus Trichosanthis, radix Notoginseng, and herba Menthae into 200 mesh powder for use;
s3, mixing and stirring Scutellaria baicalensis powder, Inula flower powder, rehmannia glutinosa powder, blumea balsamifera powder, oldenlandia diffusa powder, Saponaria officinalis powder, angelica dahurica powder, rhodiola rosea powder, rhizoma gastrodiae powder, Chinese sage powder, fennel powder, trichosanthes kirilowii Maxim powder and pseudo-ginseng powder, ultrasonically extracting for 2 hours by 6 times of ethanol solution with the volume concentration of 75% and ethanol solution with the volume concentration of 90% at 90 ℃ respectively at 110w, filtering, collecting filtrate, merging, distilling under reduced pressure and recovering ethanol, concentrating to obtain clear paste, and stopping concentrating for later use;
s6, putting the clear paste into an electric frying pan, heating with an electromagnetic oven while stirring, and adding peppermint powder and isomaltooligosaccharide at the same time until flag hanging occurs.
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