CN114286674A - 用于治疗患有包括自杀倾向在内的重性抑郁障碍的患者的艾司氯胺酮 - Google Patents

用于治疗患有包括自杀倾向在内的重性抑郁障碍的患者的艾司氯胺酮 Download PDF

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Publication number
CN114286674A
CN114286674A CN202080061186.5A CN202080061186A CN114286674A CN 114286674 A CN114286674 A CN 114286674A CN 202080061186 A CN202080061186 A CN 202080061186A CN 114286674 A CN114286674 A CN 114286674A
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CN
China
Prior art keywords
esketamine
treatment
patient
suicide
standard
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Pending
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CN202080061186.5A
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English (en)
Chinese (zh)
Inventor
C·M·卡努索
D-J·付
D·F·约内斯库
R·莱恩
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Janssen Pharmaceuticals Inc
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Janssen Pharmaceuticals Inc
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Publication of CN114286674A publication Critical patent/CN114286674A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202080061186.5A 2019-08-28 2020-08-28 用于治疗患有包括自杀倾向在内的重性抑郁障碍的患者的艾司氯胺酮 Pending CN114286674A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962892841P 2019-08-28 2019-08-28
US62/892841 2019-08-28
US201962897593P 2019-09-09 2019-09-09
US62/897593 2019-09-09
PCT/IB2020/058030 WO2021038500A2 (en) 2019-08-28 2020-08-28 Esketamine for the treatment of patients with major depressive disorder, including suicidality

Publications (1)

Publication Number Publication Date
CN114286674A true CN114286674A (zh) 2022-04-05

Family

ID=74685267

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080061186.5A Pending CN114286674A (zh) 2019-08-28 2020-08-28 用于治疗患有包括自杀倾向在内的重性抑郁障碍的患者的艾司氯胺酮

Country Status (5)

Country Link
US (1) US20220304950A1 (https=)
EP (1) EP4021432A4 (https=)
JP (1) JP2022546456A (https=)
CN (1) CN114286674A (https=)
WO (1) WO2021038500A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2907692T3 (es) 2017-12-29 2022-04-26 Celon Pharma Sa Composición de ketamina de polvo seco para su administración por vía pulmonar en la depresión resistente al tratamiento
AU2022283967A1 (en) * 2021-06-03 2024-01-18 Arcadia Medicine, Inc. Enantiomeric entactogen compositions and methods of their use
WO2025057111A1 (en) * 2023-09-12 2025-03-20 Clexio Biosciences Ltd. Esketamine or a pharmaceutical salt thereof for use in a method of treating major depressive disorder
WO2025256585A1 (zh) * 2024-06-12 2025-12-18 江苏恩华药业股份有限公司 R-氯胺酮在治疗伴急性自杀意念或行为的抑郁症中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016172672A1 (en) * 2015-04-24 2016-10-27 Icahn School Of Medicine At Mount Sinai Method for treating suicidal ideation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19723133A1 (de) 1997-06-03 1998-12-10 Caideil M P Teoranta Tourmakea Austragvorrichtung für Medien
DE10306686A1 (de) 2003-02-12 2004-08-26 Ing. Erich Pfeiffer Gmbh Austragvorrichtung zur manuellen Erzeugung eines Volumenstroms
JP2008514612A (ja) * 2004-09-23 2008-05-08 ミシャロウ、アレクサンダー 対抗適応を誘発することにより神経伝達物質系を調節する方法
TW200735878A (en) * 2005-11-18 2007-10-01 Astrazeneca Ab Pharmaceutical compositions
WO2013138322A1 (en) * 2012-03-12 2013-09-19 Janssen Pharmaceutica Nv Esketamine for the treatment of treatment-refractory or treatment-resistant depression
FR3003481B1 (fr) 2013-03-19 2020-05-15 Aptar France Sas Dispositif de distribution de produit fluide.
AU2015318123A1 (en) * 2014-09-15 2017-03-30 Janssen Pharmaceutica Nv Val66Met (SNP rs6265) genotype specific dosing regimens and methods for the treatment of depression
US20160338977A1 (en) * 2015-05-20 2016-11-24 Janssen Pharmaceutica Nv Methods and kits for treating depression
KR20240011237A (ko) * 2017-12-22 2024-01-25 얀센 파마슈티카 엔브이 우울증 치료를 위한 에스케타민

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016172672A1 (en) * 2015-04-24 2016-10-27 Icahn School Of Medicine At Mount Sinai Method for treating suicidal ideation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CARLA M. CANUSO等: "Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study", AM J PSYCHIATRY, pages 29 - 2 *

Also Published As

Publication number Publication date
US20220304950A1 (en) 2022-09-29
JP2022546456A (ja) 2022-11-04
WO2021038500A2 (en) 2021-03-04
WO2021038500A3 (en) 2021-04-22
EP4021432A4 (en) 2023-08-16
EP4021432A2 (en) 2022-07-06

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