CN114259520A - Formula for promoting sleep and improving sleep and sleep-promoting essential oil - Google Patents
Formula for promoting sleep and improving sleep and sleep-promoting essential oil Download PDFInfo
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Abstract
The invention relates to a sleeping-aiding formula and sleeping essential oil, wherein the sleeping-aiding formula comprises lavender oil, evening primrose oil, jasmine oil, bergamot oil, sea buckthorn oil and ylang-ylang flower oil, and is a combined formula of essential oil extracted from natural edible plant medicines, and can relieve emotion, calm and calm the nerves and shorten sleeping time. The hypnotic essential oil can effectively improve sleep quality, has the effects of enriching blood, soothing nerves, removing stagnation of qi, clearing away heart-fire, tranquilizing and hypnotizing, and aims to solve the problem of insomnia caused by emotional anxiety, restlessness, difficulty in falling asleep and the like.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a sleeping-aiding formula and sleeping essential oil.
Background
The data show that sleep dysfunction is present in about one third of all people worldwide, and sleep problems can have a large negative impact on the physiology and psychology of people. And as socio-economic development and competition become more intense, the number of patients with sleep disorders tends to increase every year. In order to solve the above problems, various medicines, health products, and daily products having functions of improving sleep quality and treating sleep disorders have been developed and applied in succession.
At present, methods for treating insomnia include drug therapy, muscle relaxation, hypnosis, suggestive therapy, behavioral therapy, and the like, and at present, drug therapy, i.e., administration of hypnotics or similar sedatives, is mainly used in medicine. Although hypnotics or similar sedatives have a sedative effect on the central nervous system of the brain, the drugs are short in duration, need to be taken for a long time, and cause side effects, and also cause toxic effects on the central nervous system after long-term administration, thereby causing morbid phenomena such as listlessness, difficult excitation, memory decline, inappetence and the like. In addition, the hypnotic enters the human body through oral administration, enters blood through gastric digestion, and then enters the brain through blood circulation to exert the drug effect, so that the whole process needs a long time and has great hysteresis. The traditional Chinese medicine mainly comprises plant extracts, can achieve the effect of improving sleep quality through traditional Chinese medicine therapy, does not cause medicine dependence, and does not cause iatrogenic diseases. The Chinese patent with publication number CN106729068A provides an external energy oil which can help sleep, the effect of improving sleep can be achieved only after the external energy oil is continuously used for a long time, and the improvement effect is not obvious. Therefore, the development of a sleep-aiding product which has small side effect and can quickly and effectively improve the sleep quality is urgently needed.
Disclosure of Invention
The invention aims to provide a sleeping-aiding formula, the components of the formula are extracted from natural plants, and the sleeping-aiding formula can relieve emotion, calm and calm nerves and shorten sleeping time. And further develops the hypnotic essential oil which can enrich the blood, calm the nerves, condense qi, clear away the heart and promote sleep.
The invention aims to provide a sleeping-aiding formula.
The invention also aims to provide the sleep-improving essential oil.
The above object of the present invention is achieved by the following technical solutions:
a composition for improving sleep comprises oleum Lavandula Angustifolia, evening primrose oil, jasmine oil, bergamot oil, oleum Hippophae and cananga oil.
In the formula, the effects of the components are as follows:
lavender oil: the lavender is called 'the king of all grass', has fresh and elegant fragrance and mild property, and is a plant which is acknowledged to have the effects of calming, soothing and hypnotizing. The oleum Lavandula Angustifolia has effects of relieving nervous mood, calming mind, and calming.
Evening primrose oil: can be used for treating various sclerosis, diabetes, obesity, rheumatic arthritis and schizophrenia, and also has effect in inhibiting cancer cell growth in laboratory. Clinically, the special-effect medicine is prepared by utilizing the characteristic that the evening primrose oil can prevent cardiovascular obstruction and reduce cholesterol, and is used for preventing and treating cardiovascular diseases. Evening primrose oil contains a large amount of gamma-linolenic acid (GLA), an essential fatty acid, which is ten times more active than linoleic acid, and the diseases to be treated are multiple sclerosis, atopic dermatitis, and rheumatoid arthritis.
Jasmine oil: pungent, sweet and warm. Regulating qi, resolving stagnation, removing filth, and regulating the middle warmer. It can be used for treating abdominal pain due to dysentery, conjunctival congestion, red swelling, and sore. Flos Jasmini sambac, leaf and root can be used for treating diseases, wherein the root has effects of inhibiting central nervous system, clearing heat and toxic substances, and removing dampness.
Bergamot oil: pungent, bitter, sweet, warm and nontoxic; it has the functions of regulating qi, eliminating phlegm, stopping vomiting, relieving flatulence, soothing liver, strengthening spleen, regulating stomach and other medicinal functions. Has obvious relieving effect on tracheitis and asthma of the old; has more obvious curative effect on dyspepsia and chest and abdomen swelling and stuffiness of general people.
Sea buckthorn oil: the sea-buckthorn oil contains a large amount of vitamin E, vitamin A, flavone and SOD active ingredients which can effectively prevent free radicals so as to achieve the anti-aging effect, so the sea-buckthorn is used as an important high-grade cosmetic raw material by the cosmetic industry. Its efficacy is numerous, including: reducing blood lipid, relieving cough and eliminating phlegm; regulating digestion and promoting ulcer healing; enhancing immunity; anti-tumor; improving cardiovascular system function; promoting hematopoiesis function; reducing the viscosity of whole blood; inhibiting platelet aggregation; reducing serum total cholesterol, increasing serum high density lipoprotein cholesterol and liver total cholesterol; inhibiting the formation of a test thrombus; protecting liver; anti-gastric ulcer; anti-inflammatory; oxidation resistance; anti-allergic; increasing the phagocytic function of the reticuloendothelial system.
Cananga odorata flower oil: it has the functions of relieving anxiety, hypertension, tension, etc. in nervous system. It not only can balance hormone, but also has good health promotion effect on cardiovascular diseases, and can alleviate tachypnea and tachycardia, and has tranquilizing effect. Ylang oil also has anti-inflammatory properties on skin, and is also commonly used in oily skin treatments because ylang oil inhibits sebaceous gland secretion.
Preferably, the sleep-aiding component comprises the following components in parts by weight: 20-30 parts of lavender oil, 5-10 parts of evening primrose oil, 10-15 parts of jasmine oil, 10-30 parts of bergamot oil, 5-10 parts of sea buckthorn oil and 10-20 parts of ylang-ylang flower oil.
More preferably, the sleep aiding and promoting composition comprises the following components in parts by weight: 28 parts of lavender oil, 8 parts of evening primrose oil, 12 parts of jasmine oil, 25 parts of bergamot oil, 7 parts of sea buckthorn oil and 14 parts of ylang-ylang flower oil.
The components in the sleep-aiding formula can be obtained commercially or prepared by self.
As a preferred possible embodiment, the lavender oil, evening primrose oil, jasmine oil, bergamot oil, sea buckthorn oil, and ylang-ylang oil are extracted by steam distillation.
The invention also provides the hypnotic essential oil containing the hypnotic sleep-aiding formula, and the hypnotic essential oil comprises the hypnotic sleep-aiding formula and absolute ethyl alcohol.
Preferably, the hypnotic essential oil consists of the following components in parts by weight: 20-30 parts of lavender oil, 5-10 parts of evening primrose oil, 10-15 parts of jasmine oil, 10-30 parts of bergamot oil, 5-10 parts of sea buckthorn oil, 10-20 parts of ylang-ylang flower oil and 50-100 parts of absolute ethyl alcohol.
More preferably, the hypnotic essential oil consists of the following components in parts by weight: 28 parts of lavender oil, 8 parts of evening primrose oil, 12 parts of jasmine oil, 25 parts of bergamot oil, 7 parts of sea buckthorn oil, 14 parts of ylang oil and 100 parts of absolute ethyl alcohol.
The invention also provides a preparation method of any one of the sleep-improving essential oils, which comprises the following steps:
s1, extracting essential oil of lavender, evening primrose, jasmine, bergamot, sea buckthorn and ylang-ylang by a steam distillation method respectively.
S2, uniformly mixing the essential oil extracted in the step S1 and absolute ethyl alcohol under the stirring condition to obtain the essential oil.
Preferably, the distillation time of the steam distillation method in the step S1 is 2-4 h.
Preferably, the rotation speed of the stirring condition in the step S2 is 900-1000 r/min.
Preferably, the stirring condition in the step S2 is performed for 2-5 min.
Compared with the prior art, the invention has the following beneficial effects:
(1) the invention provides a sleeping-aiding formula which is a combined formula of essential oil extracted from natural edible plant medicines with sleeping-aiding effect, has the effects of relieving anxiety, calming the nerves, tranquilizing the mind and improving cardiovascular functions, and is green, environment-friendly, safe, non-toxic and free of side effects.
(2) The invention also provides the hypnotic essential oil, the essential oil of each component in the hypnotic essential oil has a synergistic effect, has the effects of enriching blood and soothing nerves, condensing qi and clearing away heart-fire, promoting sleep and improving sleep quality, can achieve the effect of calming and soothing nerves, and has no toxic or side effect.
Detailed Description
The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.
Unless otherwise indicated, reagents and materials used in the following examples are commercially available.
Example 1 sleep-promoting composition and preparation thereof
1. Preparation of each formula for improving sleep
The lavender oil, the evening primrose oil, the jasmine oil, the bergamot oil, the sea buckthorn oil and the ylang-ylang flower oil are extracted by a steam distillation method, and the specific extraction steps are as follows:
(1) 200g of the pulverized sample powder was weighed and placed in a 5000mL round-bottom flask.
(2) 3500mL of deionized water is added for soaking for 12 h.
(3) Distilling with water vapor for 4 hr to obtain oleum Lavandula Angustifolia, evening primrose oil, jasmine oil, bergamot oil, oleum Hippophae and cananga oil.
(4) And stirring and mixing the obtained essential oil uniformly according to different proportions, wherein the rotating speed of the stirring condition is 900r/min, and the stirring time is 3 min.
2. Sleep-aiding formula prepared according to dosage in table 1
TABLE 1 formula ratio of sleep-aiding and sleep-aiding components
| Component (g) | Lavender oil | Evening primrose oil | Jasmine oil | Bergamot oil | Sea buckthorn oil | Cananga oil |
| Composition 1 | 28 | 8 | 12 | 25 | 7 | 14 |
| Composition 2 | 25 | 5 | 15 | 15 | 9 | 15 |
| Composition 3 | 20 | 10 | 11 | 10 | 5 | 19 |
| Composition 4 | 30 | 10 | 13 | 30 | 10 | 10 |
| Composition 5 | 28 | 8 | 12 | 25 | 0 | 20 |
| Composition 6 | 28 | 8 | 12 | 0 | 7 | 20 |
| Composition 7 | 28 | 8 | 0 | 25 | 7 | 20 |
| Composition 8 | 28 | 0 | 12 | 25 | 7 | 20 |
| Composition 9 | 0 | 8 | 12 | 25 | 7 | 20 |
| Composition 10 | 15 | 12 | 17 | 20 | 3 | 15 |
| Composition 11 | 35 | 3 | 8 | 32 | 12 | 25 |
Example 2 sleep-promoting essential oil and preparation thereof
1. Sleep improving essential oil prepared according to the dosage of table 2
TABLE 2 sleep-promoting essential oil ratio
2. Preparation method of hypnotic essential oil
(1) 200g of the pulverized sample powder was weighed and placed in a 5000mL round-bottom flask.
(2) 3500mL of deionized water is added for soaking for 12 h.
(3) Distilling with water vapor for 4 hr to obtain oleum Lavandula Angustifolia, evening primrose oil, jasmine oil, bergamot oil, oleum Hippophae and cananga oil.
(4) Mixing the obtained oleum Lavandula Angustifolia, oleum Oenotherae Erythrosepalae, jasmine oil, Olium Citri Sarcodactylis, oleum Hippophae, cananga odorata flower oil and anhydrous alcohol at different ratio under stirring condition of rotation speed of 1000r/min for 5 min.
Example 3 efficacy testing of hypnotic essential oil
The positive effect of the present invention in improving sleep is further illustrated by animal experimental data.
1. Experimental animal ICR grade male BALB/C mouse, the weight average of body is between 20-22 g, provided by Guangdong province medical experimental animal center. Mice were housed in independent ventilated positive and negative pressure animal cages, maintained at controlled temperature (20 + -2 deg.C) and humidity (60 + -15%), and maintained on a 12 hour light/dark cycle. Food and water were freely available during the feeding period and acclimatized 7 days prior to the official experiment.
2. Drug management: 1-11 parts of sleep-improving essential oil prepared according to the formula shown in Table 2.
3. Animal administration: mice were randomly divided into 12 groups by weight, each: control group and experimental drug group. The experimental drug groups were separately gavage with the corresponding hypnotic essential oil, and the control group was gavage with distilled water, and the gavage volume was 0.2ml/10g body weight, once a day for 21 consecutive days.
4. The experimental method comprises the following steps: the influence of the hypnotic essential oil on the sleep incidence, sleep time and sleep latency of the pentobarbital sodium-induced mice is analyzed by using a pentobarbital sodium-induced mouse experiment (refer to handbook for health food inspection and evaluation technical specifications (2003 edition)).
a. Experiment on influence of sleep incidence on mice induced by subthreshold dose of sodium pentobarbital
1h after the last administration of each group, 0.1mg/10g of the body weight of each mouse is injected into the abdominal cavity of each mouse, 1min after the disappearance of the righting reflex is taken as an index of falling asleep, the mice are placed on a warm blanket to relieve the tension degree, and the sleep incidence rate of the mice within 30min is recorded.
And (4) analyzing results: compared with the control group, the sleep incidence rate of the mice in the essential oil 1-4 groups is very different (P <0.01), and the incidence rate of the mice in the essential oil 1 group reaches the highest value (see table 3).
TABLE 3 Effect of hypnotic essential oil in combination with sodium pentobarbital on the incidence of sleep in mice
| Group of | Dosage form | Number of | Incidence of sleep (%) |
| Control group | - | 5 | 30.31 |
| Essential oil 1 | 1.5 | 5 | 75.24# |
| Essential oil 2 | 1.5 | 5 | 73.45# |
| Essential oil 3 | 1.5 | 5 | 65.81# |
| Essential oil 4 | 1.5 | 5 | 68.43# |
| Essential oil 5 | 1.5 | 5 | 59.14* |
| Essential oil 6 | 1.5 | 5 | 60.97* |
| Essential oil 7 | 1.5 | 5 | 53.34* |
| Essential oil 8 | 1.5 | 5 | 57.29* |
| Essential oil 9 | 1.5 | 5 | 46.57* |
| Essential oil 10 | 1.5 | 5 | 40.53* |
| Essential oil 11 | 1.5 | 5 | 45.21* |
Note: p <0.05 and P <0.01 (tables 3, 4, 5, supra) compared to the control group.
b. Experiment for prolonging influence of sodium pentobarbital on sleep time of mice induced by sodium pentobarbital
Each mouse was injected intraperitoneally with pentobarbital sodium solution (50mg/kg) at 0.1mg/10g body weight 1h after the last dose. Taking 1min after the righting reflex disappears as an index of falling asleep, placing the mice on a warm blanket to relieve the tension degree, and recording the sleep time of each group of mice, wherein the sleep time of the mice is calculated by 120min when the sleep time of the mice exceeds 120 min.
And (4) analyzing results: compared with the control group, the mice of the essential oil 1 group, the essential oil 2 group and the essential oil 3 group have very significant difference in sleeping time (P <0.01), and show significant sedation and hypnosis synergy (see Table 4).
TABLE 4 Effect of hypnotic essential oil in combination with sodium pentobarbital on sleep time in mice
| Group of | Dosage form | Number of | Sleep time (min) |
| Control group | - | 5 | 21.16 |
| Essential oil 1 | 1.5 | 5 | 38.21# |
| Essential oil 2 | 1.5 | 5 | 37.43# |
| Essential oil 3 | 1.5 | 5 | 35.73# |
| Essential oil 4 | 1.5 | 5 | 34.67* |
| Essential oil 5 | 1.5 | 5 | 33.71* |
| Essential oil 6 | 1.5 | 5 | 30.02* |
| Essential oil 7 | 1.5 | 5 | 29.37* |
| Essential oil 8 | 1.5 | 5 | 28.86* |
| Essential oil 9 | 1.5 | 5 | 25.95* |
| Essential oil 10 | 1.5 | 5 | 22.13 |
| Essential oil 11 | 1.5 | 5 | 21.41 |
c. Experiment on influence of barbiturate sodium on sleep latency of mice
1h after the last administration, each mouse was injected with 0.1mg/10g of body weight of barbital sodium solution (250mg/kg) intraperitoneally. Taking disappearance of righting reflex as an index, placing the mice on a warm blanket to relieve the tension degree of the mice, recording the time from administration to disappearance of righting reflex of each group of mice, and calculating the sleeping time of the mice for more than 60min by 60 min.
And (4) analyzing results: the combined effect of essential oil 1, essential oil 2 and essential oil 4 groups with barbiturate sodium had a very significant effect on the sleep latency of mice compared to the control group (P < 0.01). Mice had a reduction in sleep latency of approximately 10min in groups of essential oil 1, essential oil 2 and essential oil 4 compared to the control group (see table 5). The sleep latency time of the mice in the essential oil groups 1, 2 and 4 is shorter than that of the mice in other essential oil groups, and the results show that the hypnotic essential oil groups 1, 2 and 4 are more effective in shortening the sleeping time of the mice and have better hypnotic effect on the mice.
TABLE 5 Effect of hypnotic essential oil in combination with barbiturate sodium on sleep latency in mice
| Group of | Dosage form | Number of | Sleep latency (min) |
| Control group | - | 5 | 36.38 |
| Essential oil 1 | 1.5 | 5 | 25.21# |
| Essential oil 2 | 1.5 | 5 | 26.72# |
| Essential oil 3 | 1.5 | 5 | 28.17* |
| Essential oil 4 | 1.5 | 5 | 27.91# |
| Essential oil 5 | 1.5 | 5 | 30.42* |
| Essential oil 6 | 1.5 | 5 | 32.16 |
| Essential oil 7 | 1.5 | 5 | 29.67* |
| Essential oil 8 | 1.5 | 5 | 32.98 |
| Essential oil 9 | 1.5 | 5 | 33.03 |
| Essential oil 10 | 1.5 | 5 | 35.91 |
| Essential oil 11 | 1.5 | 5 | 34.12 |
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. The sleep-aiding prescription for improving sleep is characterized by comprising the following components: lavender oil, evening primrose oil, jasmine oil, bergamot oil, sea buckthorn oil and ylang-ylang flower oil.
2. The sleep-aiding and sleep-improving composition according to claim 1, which comprises the following components in parts by weight: 20-30 parts of lavender oil, 5-10 parts of evening primrose oil, 10-15 parts of jasmine oil, 10-30 parts of bergamot oil, 5-10 parts of sea buckthorn oil and 10-20 parts of ylang-ylang flower oil.
3. The sleep-aiding and sleep-improving composition according to claim 2, which comprises the following components in parts by weight: 28 parts of lavender oil, 8 parts of evening primrose oil, 12 parts of jasmine oil, 25 parts of bergamot oil, 7 parts of sea buckthorn oil and 14 parts of ylang-ylang flower oil.
4. A sleeping essential oil comprising the sleeping aid composition according to any one of claims 1 to 3.
5. The hypnotic essential oil according to claim 4, which is characterized by comprising the following components in parts by weight: 20-30 parts of lavender oil, 5-10 parts of evening primrose oil, 10-15 parts of jasmine oil, 10-30 parts of bergamot oil, 5-10 parts of sea buckthorn oil, 10-20 parts of ylang-ylang flower oil and 50-100 parts of absolute ethyl alcohol.
6. A sleep-improving essential oil as claimed in claim 4, which is prepared from the following components in parts by weight: 28 parts of lavender oil, 8 parts of evening primrose oil, 12 parts of jasmine oil, 25 parts of bergamot oil, 7 parts of sea buckthorn oil, 14 parts of ylang oil and 100 parts of absolute ethyl alcohol.
7. A method for preparing a hypnotic essential oil according to any one of claims 4 to 6, characterized by comprising the following steps:
s1, extracting essential oil of lavender, evening primrose, jasmine, bergamot, sea buckthorn and ylang-ylang by a steam distillation method respectively.
S2, uniformly mixing the essential oil extracted in the step S1 and absolute ethyl alcohol under the stirring condition to obtain the essential oil.
8. The method according to claim 7, wherein the steam distillation in step S1 is performed for 2-4 h.
9. The method according to claim 7, wherein the stirring condition of step S2 is at a rotation speed of 900 to 1000 r/min.
10. The method according to claim 7, wherein the stirring condition of step S2 is carried out for 2-5 min.
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