CN114259480A - Antipyretic patch and preparation method thereof - Google Patents
Antipyretic patch and preparation method thereof Download PDFInfo
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- CN114259480A CN114259480A CN202210086545.3A CN202210086545A CN114259480A CN 114259480 A CN114259480 A CN 114259480A CN 202210086545 A CN202210086545 A CN 202210086545A CN 114259480 A CN114259480 A CN 114259480A
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- 230000001754 anti-pyretic effect Effects 0.000 title claims abstract description 14
- 239000002221 antipyretic Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000010410 layer Substances 0.000 claims abstract description 50
- 238000001816 cooling Methods 0.000 claims abstract description 37
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000011241 protective layer Substances 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 7
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 7
- 230000017525 heat dissipation Effects 0.000 claims abstract description 7
- 229940041616 menthol Drugs 0.000 claims abstract description 7
- 239000008213 purified water Substances 0.000 claims abstract description 7
- 239000000600 sorbitol Substances 0.000 claims abstract description 7
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 6
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 229920000642 polymer Polymers 0.000 claims description 12
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical group COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 claims description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 229940095102 methyl benzoate Drugs 0.000 claims description 5
- 238000010008 shearing Methods 0.000 claims description 5
- 241000205585 Aquilegia canadensis Species 0.000 claims description 3
- 240000001972 Gardenia jasminoides Species 0.000 claims description 3
- 235000011201 Ginkgo Nutrition 0.000 claims description 3
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 3
- 241000951473 Schizonepeta Species 0.000 claims description 3
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- -1 polyethylene Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 244000194101 Ginkgo biloba Species 0.000 claims 1
- 240000001949 Taraxacum officinale Species 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 206010037660 Pyrexia Diseases 0.000 description 10
- 239000000499 gel Substances 0.000 description 10
- 239000012071 phase Substances 0.000 description 7
- 238000000137 annealing Methods 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- 241000218628 Ginkgo Species 0.000 description 2
- 241000245665 Taraxacum Species 0.000 description 2
- UTUUIUQHGDRVPU-UHFFFAOYSA-K aluminum;2-aminoacetate;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Al+3].NCC([O-])=O UTUUIUQHGDRVPU-UHFFFAOYSA-K 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000001061 forehead Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 1
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention discloses an antipyretic patch and a preparation method thereof, wherein the antipyretic patch comprises a back lining layer, a antipyretic layer and a protective layer which are sequentially arranged, wherein the antipyretic layer comprises the following components in parts by weight: 15-25 parts of menthol, 25-35 parts of a phase-change heat-dissipation material, 1-8 parts of a temperature-sensitive color-changing powder, 5-10 parts of ethanol, 1-5 parts of a bacteriostatic agent, 1-5 parts of a cross-linking agent, 5-10 parts of glycerol, 10-15 parts of sorbitol and 50-60 parts of purified water. Compared with the prior art, the cooling paste provided by the invention has a good cooling effect, can be used for multiple times, and can judge whether a user is cooling through the color of the cooling paste.
Description
Technical Field
The invention relates to the technical field of medical supplies, in particular to an antipyretic patch and a preparation method thereof.
Background
In daily life, people often suffer from fever caused by various reasons, particularly exogenous fever, and timely physical cooling is a measure taken firstly, the physical cooling is realized by rubbing bath of alcohol on the back, face, abdomen, armpit and the like of a patient, the alcohol cooling only has a single cooling and antipyretic effect and cannot radically eliminate the cause of disease, in addition, antipyretic and analgesic drugs can be taken, but the drugs can bring very large side effects to human bodies, and particularly, antibiotics are not suitable for special crowds such as pregnant women, infants and the like.
The defervesce plaster belongs to a physical cooling article and is widely applied to the conditions of fever, summer heat and high-temperature operation of children, etc. The traditional cooling paste has a simple structure, is prepared by taking polymer hydrogel as a main component, and adopts the principle that liquid water is locked by the polymer gel in the gel layer, and the liquid water is converted into water vapor after absorbing heat on the forehead surface, so that the temperature of the head is locally reduced. However, the conventional cooling patch has the following disadvantages:
1) the antipyretic patch is a disposable article, cannot be used for the second time, has low resource utilization rate and is not beneficial to sustainable development.
2) The function is single, and the user can not judge whether the user defervesces through the color of the defervescing paste.
In view of the above, there is a need to improve the existing cooling patch and the preparation thereof.
Disclosure of Invention
In view of the problems in the related art, an object of the present application is to provide an antipyretic patch, which has a better cooling effect, can be used for multiple times, and can determine whether a user has fever through the color of the antipyretic patch.
In order to achieve the purpose, the application provides an annealing paste which comprises a back lining layer, an annealing layer and a protective layer, wherein the back lining layer, the annealing layer and the protective layer are sequentially arranged, and the annealing layer comprises the following components in parts by weight:
preferably, the heat-release layer comprises the following components in parts by weight:
preferably, the heat-clearing layer further comprises a traditional Chinese medicine extracting solution, wherein the traditional Chinese medicine extracting solution comprises, by weight, 10-15 parts of honeysuckle, 10-15 parts of radix bupleuri, 5-10 parts of schizonepeta and 5-10 parts of ginkgo leaves. The Chinese medicinal extractive solution has good heat and toxic materials clearing away effect.
Preferably, the heat-clearing layer further comprises a traditional Chinese medicine extracting solution, wherein the traditional Chinese medicine extracting solution comprises, by weight, 5-10 parts of dandelion, 10-15 parts of gardenia, 10-15 parts of rhizoma picrorhizae and 5-10 parts of fructus forsythiae. The Chinese medicinal extractive solution has good effects of clearing heat and reducing dryness.
Preferably, the bacteriostatic agent is methyl benzoate;
preferably, the cross-linking agent is at least one of aluminum glyceroxide and aluminum hydroxide.
Preferably, the protective layer is a polyethylene film.
Preferably, the backing layer is a breathable nonwoven material.
Preferably, the phase change heat dissipation material is polyethylene glycol with average relative molecular mass of 950-1000. The polyethylene glycol is an organic solid-solid phase change material (a solid ordered molecular connection structure is changed into a solid disordered molecular connection structure), and the phase change temperature of the polyethylene glycol is increased along with the increase of the polymerization degree, so that the average relative molecular weight of the polyethylene glycol cannot be too high or too low, and when the polyethylene glycol reaches the phase change temperature (37-39 ℃), solid-solid phase change can be generated, and heat can be absorbed or released.
In addition, the application also provides a preparation method of the cooling paste, which comprises the following steps:
1) adding the menthol, the cross-linking agent and the phase-change heat dissipation material into purified water, and stirring for 20-30 minutes to obtain a first mixture;
2) adding the temperature-sensitive color-changing powder, ethanol, a bacteriostatic agent and sorbitol into glycerol, and stirring for 10-20 minutes to obtain a second mixture;
3) adding the first mixture prepared in the step 1) into the second mixture prepared in the step 2), and stirring for 5-10 minutes to obtain polymer gel;
4) and coating the polymer gel prepared in the step 3) on the upper surface of the back lining layer to obtain the heat-removing layer, then covering the protective layer on the upper surface of the heat-removing layer, and then forming, shearing and curing to obtain the heat-removing paste.
The technical scheme provided by the application can achieve the following beneficial effects: the application provides a subsides of bringing down a fever, including back sheet, the layer of bringing down a fever and the protective layer that sets gradually, the layer of bringing down a fever includes the composition of following parts by weight: 15-25 parts of menthol, 25-35 parts of a phase-change heat-dissipation material, 1-8 parts of a temperature-sensitive color-changing powder, 5-10 parts of ethanol, 1-5 parts of a bacteriostatic agent, 1-5 parts of a cross-linking agent, 5-10 parts of glycerol, 10-15 parts of sorbitol and 50-60 parts of purified water. Compared with the prior art, the cooling effect that the subsides of bringing down a fever that this application provided have the preferred can repetitious usage, can also judge whether the user brings down a fever through the subsides colour of bringing down a fever simultaneously. The phase change heat dissipation material is added, when the phase change temperature is reached, the phase change occurs to absorb the heat on the forehead surface, so that the cooling effect is achieved, and after the cooling is finished, the energy is released to the outside through the phase change, so that the cooling patch manufactured by the invention can be used for many times, the resource utilization rate is improved, and the production cost is reduced; in addition, by adding the temperature-sensitive color-changing powder, when the temperature of the cooling paste exceeds 37 ℃, the temperature-sensitive color-changing powder becomes colorless, and when the temperature of the cooling paste is lower than 37 ℃, the temperature-sensitive color-changing powder returns dark blue, so that people can visually judge whether the user is cooling through the color of the cooling paste.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is further described in detail with reference to specific embodiments below. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.
Example 1
The heat-removing paste comprises a back lining layer, a heat-removing layer and a protective layer which are sequentially arranged, wherein the heat-removing layer comprises the following components in parts by weight:
the preparation method of the cooling paste comprises the following steps:
1) adding menthol, dihydroxyaluminum glycinate and polyethylene glycol 950 into purified water, and stirring for 20-30 minutes to obtain a first mixture;
2) adding the temperature-sensitive discoloring powder, ethanol, methyl benzoate and sorbitol into glycerol, and stirring for 10-20 minutes to obtain a second mixture;
3) adding the first mixture prepared in the step 1) into the second mixture prepared in the step 2), and stirring for 5-10 minutes to obtain polymer gel;
4) and coating the polymer gel prepared in the step 3) on the upper surface of the back lining layer to obtain the heat-removing layer, then covering the protective layer on the upper surface of the heat-removing layer, and then forming, shearing and curing to obtain the heat-removing paste.
Example 2
Different from the embodiment 1, the heat-release layer comprises the following components in parts by weight:
the rest is the same as embodiment 1, and the description is omitted here.
Example 3
Different from the embodiment 1, the heat-release layer comprises the following components in parts by weight:
the heat-removing layer comprises the following components in parts by weight:
the rest is the same as embodiment 1, and the description is omitted here.
Example 4
The heat-removing paste comprises a back lining layer, a heat-removing layer and a protective layer which are sequentially arranged, wherein the heat-removing layer comprises the following components in parts by weight:
40 parts of traditional Chinese medicine extracting solution; wherein the traditional Chinese medicine extracting solution comprises 12 parts of honeysuckle, 12 parts of radix bupleuri, 8 parts of schizonepeta and 8 parts of ginkgo leaves.
The preparation method of the cooling paste comprises the following steps:
1) adding menthol, dihydroxyaluminium aminoacetate, polyethylene glycol 980 and the traditional Chinese medicine extract into purified water, and stirring for 20-30 minutes to obtain a first mixture;
2) adding the temperature-sensitive discoloring powder, ethanol, methyl benzoate and sorbitol into glycerol, and stirring for 10-20 minutes to obtain a second mixture;
3) adding the first mixture prepared in the step 1) into the second mixture prepared in the step 2), and stirring for 5-10 minutes to obtain polymer gel;
4) and coating the polymer gel prepared in the step 3) on the upper surface of the back lining layer to obtain the heat-removing layer, then covering the protective layer on the upper surface of the heat-removing layer, and then forming, shearing and curing to obtain the heat-removing paste.
Example 5
The heat-removing paste comprises a back lining layer, a heat-removing layer and a protective layer which are sequentially arranged, wherein the heat-removing layer comprises the following components in parts by weight:
40 parts of traditional Chinese medicine extracting solution; wherein the traditional Chinese medicine extracting solution comprises 8 parts of dandelion, 12 parts of gardenia, 12 parts of rhizoma picrorhizae and 8 parts of fructus forsythiae.
The preparation method of the cooling paste comprises the following steps:
1) adding menthol, dihydroxyaluminium aminoacetate, polyethylene glycol 980 and the traditional Chinese medicine extract into purified water, and stirring for 20-30 minutes to obtain a first mixture;
2) adding the temperature-sensitive discoloring powder, ethanol, methyl benzoate and sorbitol into glycerol, and stirring for 10-20 minutes to obtain a second mixture;
3) adding the first mixture prepared in the step 1) into the second mixture prepared in the step 2), and stirring for 5-10 minutes to obtain polymer gel;
4) and coating the polymer gel prepared in the step 3) on the upper surface of the back lining layer to obtain the heat-removing layer, then covering the protective layer on the upper surface of the heat-removing layer, and then forming, shearing and curing to obtain the heat-removing paste.
The cooling pastes of examples 1 to 5 were subjected to cooling performance tests:
the test method comprises the following steps: marking a PC plate with the length of 20cm, the width of 10cm and the thickness of 5cm as a point 1 at a position 4cm away from the length direction, sequentially spacing 4cm as a point 2, a point 3 and a point 4, wherein the point 1, the point 2, the point 3 and the point 4 are on a straight line, and at the center position of the plate, heating the PC plate to 40 ℃, attaching the heat-removing pastes of the embodiment and the comparative example, and calculating after a certain time to obtain the average temperature on the PC plate, wherein the average temperature is the sum/4 of the temperatures tested at each point, and the certain time is 1min, 5min, 10min and 20 min.
The test results were as follows:
| group of | 1min | 5min | 10min | 20min |
| Example 1 | 38.8 | 36.5 | 34.3 | 31.8 |
| Example 2 | 38.5 | 36.2 | 34.0 | 31.2 |
| Example 3 | 37.6 | 35.5 | 33.8 | 30.5 |
| Example 4 | 37.2 | 34.8 | 32.8 | 30.2 |
| Example 5 | 37.0 | 34.5 | 32.6 | 30.0 |
The test results in the table show that the cooling patch of the invention has better cooling effect.
Variations and modifications to the above-described embodiments may also occur to those skilled in the art, which fall within the scope of the invention as disclosed and taught herein. Therefore, the present invention is not limited to the above-mentioned embodiments, and any obvious improvement, replacement or modification made by those skilled in the art based on the present invention is within the protection scope of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.
Claims (10)
1. An antipyretic patch, which is characterized in that: the heat-insulating layer comprises a back lining layer, a heat-insulating layer and a protective layer which are sequentially arranged, wherein the heat-insulating layer comprises the following components in parts by weight:
2. the cooling patch as claimed in claim 1, wherein: the heat-removing layer comprises the following components in parts by weight:
3. the cooling patch as claimed in claim 1, wherein: the heat-reducing layer further comprises a traditional Chinese medicine extracting solution, wherein the traditional Chinese medicine extracting solution comprises, by weight, 10-15 parts of honeysuckle, 10-15 parts of radix bupleuri, 5-10 parts of schizonepeta and 5-10 parts of ginkgo leaves.
4. The cooling patch as claimed in claim 1, wherein: the heat-reducing layer further comprises a traditional Chinese medicine extracting solution, wherein the traditional Chinese medicine extracting solution comprises, by weight, 5-10 parts of dandelion, 10-15 parts of gardenia, 10-15 parts of rhizoma picrorhizae and 5-10 parts of fructus forsythiae.
5. The cooling patch as claimed in claim 1, wherein: the bacteriostatic agent is methyl benzoate.
6. The cooling patch as claimed in claim 1, wherein: the cross-linking agent is at least one of aluminum glycollate and aluminum hydroxide.
7. The cooling patch as claimed in claim 1, wherein: the protective layer is a polyethylene film.
8. The cooling patch as claimed in claim 1, wherein: the back lining layer is made of breathable non-woven fabric material.
9. The cooling patch as claimed in claim 1, wherein: the phase change heat dissipation material is polyethylene glycol with average relative molecular mass of 950-1000.
10. The preparation method of the antipyretic patch according to claim 1, characterized by comprising the following steps:
1) adding the menthol, the cross-linking agent and the phase-change heat dissipation material into purified water, and stirring for 20-30 minutes to obtain a first mixture;
2) adding the temperature-sensitive color-changing powder, ethanol, a bacteriostatic agent and sorbitol into glycerol, and stirring for 10-20 minutes to obtain a second mixture;
3) adding the first mixture prepared in the step 1) into the second mixture prepared in the step 2), and stirring for 5-10 minutes to obtain polymer gel;
4) and coating the polymer gel prepared in the step 3) on the upper surface of the back lining layer to obtain the heat-removing layer, then covering the protective layer on the upper surface of the heat-removing layer, and then forming, shearing and curing to obtain the heat-removing paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210086545.3A CN114259480A (en) | 2022-01-25 | 2022-01-25 | Antipyretic patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210086545.3A CN114259480A (en) | 2022-01-25 | 2022-01-25 | Antipyretic patch and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN114259480A true CN114259480A (en) | 2022-04-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210086545.3A Pending CN114259480A (en) | 2022-01-25 | 2022-01-25 | Antipyretic patch and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN114259480A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109762130A (en) * | 2019-01-21 | 2019-05-17 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | One kind can be recycled defervescence plaster used |
| CN111035501A (en) * | 2018-10-15 | 2020-04-21 | 广州市雨纯生物科技有限公司 | Medical cooling patch and preparation method thereof |
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2022
- 2022-01-25 CN CN202210086545.3A patent/CN114259480A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111035501A (en) * | 2018-10-15 | 2020-04-21 | 广州市雨纯生物科技有限公司 | Medical cooling patch and preparation method thereof |
| CN109762130A (en) * | 2019-01-21 | 2019-05-17 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | One kind can be recycled defervescence plaster used |
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