CN114230566A - Optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces - Google Patents
Optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces Download PDFInfo
- Publication number
- CN114230566A CN114230566A CN202111610253.7A CN202111610253A CN114230566A CN 114230566 A CN114230566 A CN 114230566A CN 202111610253 A CN202111610253 A CN 202111610253A CN 114230566 A CN114230566 A CN 114230566A
- Authority
- CN
- China
- Prior art keywords
- phellodendron amurense
- decoction pieces
- extraction
- berberine hydrochloride
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention relates to the technical field of phellodendron amurense extraction, and provides an optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces, which comprises the following steps: taking phellodendron amurense decoction pieces, naturally drying, sieving the crushed powder, and mixing dilute sulfuric acid, beta-glucanase and cellulase with water for later use; respectively loading the phellodendron amurense powder and sulfuric acid obtained in the step 1 into a feeding device, adding the feeding device into different extraction tanks, and performing reflux extraction; mixing all filtrates, concentrating, and adjusting pH with dilute hydrochloric acid; cooling, adding saturated NaCl solution, storing at 4 deg.C overnight, filtering, and drying. According to the extraction process of berberine hydrochloride in the optimized phellodendron amurense decoction pieces, the activity of enzyme is improved through dilute sulfuric acid, the beta-glucanase and cellulase can thoroughly damage plant cell walls, and effective components are more fully extracted, so that the effects of accelerated extraction, full extraction and high extraction rate are achieved.
Description
Technical Field
The invention relates to the technical field of extraction of phellodendron amurense, in particular to an optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces.
Background
The cortex phellodendri amurensis schneid is cortex phellodendri amurensis schneid, an arbor plant of phellodendron of Rutaceae, bark cracks, no cork layer, yellow inner layer, viscosity, thick twigs, smoothness, no hair, single feather shaped compound leaf pair, rectangular round needle shaped to rectangular round egg shaped, parthenocarpy, male and female plants, arranged into top generation conical inflorescence, berry shaped stone fruit shaped ball shaped, dense, black, nucleated, the bioactive components of the cortex phellodendri amurensis schneid are pariphylline hydrochloride as the main active component except the extract and the total alkaloids, and the cortex phellodendri amurensis schneid has better steaming effect and wide clinical application.
The existing berberine extraction method mainly comprises the following steps: the dilute sulfuric acid method mainly utilizes sulfate in the berberine to be dissolved in an acid solution, the berberine is firstly converted into the sulfate to be dissolved in acid, then hydrochloric acid is added to be converted into hydrochloride to be separated out, the method has the advantages of cheap materials and simple process, but in the extraction process, the material-liquid ratio is single, the raw materials with multiple groups of material-liquid ratios are inconvenient to process simultaneously, the extraction rate is low, meanwhile, the material-liquid ratio is usually manually weighed and then matched, the manual weighing is low in precision, the weighing speed is low, and the extraction efficiency is low.
Disclosure of Invention
In order to realize the purposes of multi-material-liquid ratio extraction, reduction of proportioning error, acceleration of extraction, full extraction and high extraction rate, the invention is realized by the following technical scheme: an optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces comprises the following steps:
s1, taking the phellodendron amurense decoction pieces, naturally drying, sieving the crushed powder, and mixing dilute sulfuric acid, beta-glucanase and cellulase with water for later use;
s2, respectively loading the phellodendron amurense powder and sulfuric acid obtained in the step 1 into a feeding device, dividing the phellodendron amurense powder and the mixed solution into three groups by the feeding device, adding the three groups into different extraction tanks, and carrying out reflux extraction;
s3, after reflux extraction, cooling to room temperature and soaking, extracting residues, and treating the filter residues again by repeating the steps;
s4, combining all filtrates, concentrating, and adjusting the pH value with dilute hydrochloric acid; cooling, adding saturated NaCl solution, storing at 4 deg.C overnight, filtering, and drying.
Furthermore, the sieving number in the step 1 is 40-60 meshes, and the ratio of the dilute sulfuric acid to the beta-glucanase to the cellulase to the water is 10:0.1: 1.
Further, the feed-liquid ratio of the phellodendron amurense powder and the sulfuric acid in the step 2 is 1:12, 1:13 and 1:14 respectively.
Further, the concentration of the sulfuric acid in the step 2 is 2% -3%.
Further, the soaking time in the step 3 is 65-85 min.
Further, the filtrate obtained in the step 4 is concentrated to the specific gravity of 1.20-1.31, and the pH value is adjusted to 2-3 by using dilute hydrochloric acid.
A feeding device for extracting berberine hydrochloride in optimized phellodendron amurense decoction pieces comprises a feeding mechanism, wherein the feeding mechanism comprises a feeding pipe, a trough and a liquid cavity are formed in the feeding pipe, a material valve is inserted in the bottom of the trough, a material spoon is fixedly connected to the outer side of the material valve, a top bag is fixedly connected to the inner side of the material valve, a sliding block is fixedly connected to the bottom of the top bag, a liquid adding pipe is inserted in the bottom of the liquid cavity, a liquid valve is inserted in the liquid adding pipe, a baffle is hinged in the liquid valve, an adjusting rod is inserted in the back of the baffle, a positioning rod is fixedly connected to one side, close to the liquid valve, of the adjusting rod, an adjusting spring is sleeved on the outer side of the adjusting rod, a locking block is fixedly connected to the inner wall of the liquid valve, an air pipe is inserted in the top of the feeding pipe, an air cavity is formed in the feeding pipe, and a toothed rod is slidably connected to the inner part of the air cavity, the top fixedly connected with reset spring of ratch, the meshing of the bottom of ratch has the drive wheel, the top of reinforced mechanism articulates there is actuating mechanism, actuating mechanism is including the apron, the apron articulates the top at the filling tube, the top of apron articulates there is the stripper plate, the top fixedly connected with drive bag of apron, the outside of apron articulates there is the jack catch, the jack catch is close to one side fixedly connected with jump ring of apron.
Furthermore, the material of the material spoon is a rubber pad, and the sliding block is in transmission connection with the material spoon through a pull rope.
Furthermore, the air pipe is respectively connected with the air cavity, the top sac, the liquid cavity and the driving sac through a guide pipe.
Furthermore, the driving wheel is respectively in transmission connection with the material valve and the material spoon through a transmission belt.
Compared with the prior art, the invention has the following beneficial effects:
1. this extraction technology of berberine hydrochloride in optimizing phellodendron amurense decoction pieces, through adding phellodendron amurense powder and mixed liquid in the frame material pipe, and peg graft the filling tube on extracting the jar, then through extrusion drive bag with phellodendron amurense powder and mixed liquid ration's the addition extract jar in, add the back of accomplishing, the pulling is adjusted the pole and is removed, and rotate the regulation pole, it rotates to adjust the relative baffle of pole, it changes to adjust the restriction that the pole made regulating spring give the baffle, when the baffle made the liquid valve open, the velocity of flow changes, and then changed the material-liquid ratio, make feeding device can be quick to extracting the jar in the material liquid of different ratios, draw through the material liquid to different ratios in step again, thereby reached and to have carried out many material-liquid ratio and drawn, reduce the effect of ratio error.
2. According to the extraction process of berberine hydrochloride in the optimized phellodendron amurense decoction pieces, dilute sulfuric acid, beta-glucanase and cellulase are mixed with water to form a mixed solution, the activity of the enzyme is improved by the dilute sulfuric acid, the beta-glucanase and the cellulase can thoroughly damage plant cell walls, and effective components are more sufficiently extracted, so that the effects of accelerated extraction, sufficient extraction and high extraction rate are achieved.
Drawings
FIG. 1 is a schematic side view of the overall charging device of the present invention;
FIG. 2 is an overall elevational schematic view of the charging device of the present invention;
FIG. 3 is an enlarged view of part A of FIG. 2;
FIG. 4 is a schematic view of a structural charging mechanism of the present invention;
FIG. 5 is a schematic view of a portion of a material valve according to the present invention;
FIG. 6 is an enlarged view of B in FIG. 4 according to the present invention;
FIG. 7 is a schematic left side cross-sectional view of a structural fluid valve portion of the present invention;
FIG. 8 is a rear view of a fluid valve according to the present invention.
In the figure: 1. a feeding mechanism; 11. a feed tube; 12. a trough; 13. a liquid chamber; 14. a material valve; 15. a material spoon; 16. ejecting a bag; 17. a slider; 18. a liquid feeding pipe; 19. a liquid valve; 110. a baffle plate; 111. adjusting a rod; 112. positioning a rod; 113. adjusting the spring; 114. a locking block; 115. an air tube; 116. an air cavity; 117. a rack bar; 118. a return spring; 119. a driving wheel; 2. a drive mechanism; 21. a cover plate; 22. a pressing plate; 23. a drive bladder; 24. a claw; 25. and a clamp spring.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment of the extraction process for optimizing berberine hydrochloride in the phellodendron amurense decoction pieces comprises the following steps:
example one
An optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces comprises the following steps:
s1, taking the phellodendron amurense decoction pieces, naturally drying, sieving the crushed powder, and mixing dilute sulfuric acid, beta-glucanase and cellulase with water for later use;
s2, respectively loading the phellodendron amurense powder and sulfuric acid obtained in the step 1 into a feeding device, dividing the phellodendron amurense powder and the mixed solution into three groups by the feeding device, adding the three groups into different extraction tanks, and carrying out reflux extraction;
s3, after reflux extraction, cooling to room temperature and soaking, extracting residues, and treating the filter residues again by repeating the steps;
s4, combining all filtrates, concentrating, and adjusting the pH value with dilute hydrochloric acid; cooling, adding saturated NaCl solution, storing at 4 deg.C overnight, filtering, and drying.
The sieving number in the step 1 is 40 meshes, and the ratio of the dilute sulfuric acid to the beta-glucanase to the cellulase to the water is 10:0.1: 1.
In the step 2, the material-to-liquid ratios of the three groups of phellodendron amurense powder and the sulfuric acid are respectively 1:12, 1:13 and 1: 14.
The concentration of sulfuric acid in step 2 was 2%.
The soaking time in step 3 is 65 min.
In step 4, the filtrate is concentrated to a specific gravity of 1.20, and the pH is adjusted to 2 by using dilute hydrochloric acid.
Example two
An optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces comprises the following steps:
s1, taking the phellodendron amurense decoction pieces, naturally drying, sieving the crushed powder, and mixing dilute sulfuric acid, beta-glucanase and cellulase with water for later use;
s2, respectively loading the phellodendron amurense powder and sulfuric acid obtained in the step 1 into a feeding device, dividing the phellodendron amurense powder and the mixed solution into three groups by the feeding device, adding the three groups into different extraction tanks, and carrying out reflux extraction;
s3, after reflux extraction, cooling to room temperature and soaking, extracting residues, and treating the filter residues again by repeating the steps.
S4, combining all filtrates, concentrating, and adjusting the pH value with dilute hydrochloric acid; cooling, adding saturated NaCl solution, storing at 4 deg.C overnight, filtering, and drying.
The sieving number in the step 1 is 60 meshes, and the ratio of the dilute sulfuric acid to the beta-glucanase to the cellulase to the water is 10:0.1: 1.
In the step 2, the material-to-liquid ratios of the three groups of phellodendron amurense powder and the sulfuric acid are respectively 1:12, 1:13 and 1: 14.
The concentration of sulfuric acid in step 2 was 3%.
The soaking time in step 3 is 85 min.
In step 4, the filtrate is concentrated to a specific gravity of 1.31, and the pH is adjusted to 3 by using dilute hydrochloric acid.
EXAMPLE III
Referring to fig. 1-8, an optimized extraction process of berberine hydrochloride from phellodendron amurense decoction pieces includes the following steps:
s1, taking the phellodendron amurense decoction pieces, naturally drying, sieving the crushed powder, and mixing dilute sulfuric acid, beta-glucanase and cellulase with water for later use;
s2, respectively loading the phellodendron amurense powder and sulfuric acid obtained in the step 1 into a feeding device, dividing the phellodendron amurense powder and the mixed solution into three groups by the feeding device, adding the three groups into different extraction tanks, and carrying out reflux extraction;
s3, after reflux extraction, cooling to room temperature and soaking, extracting residues, and treating the filter residues again by repeating the steps.
S4, combining all filtrates, concentrating, and adjusting the pH value with dilute hydrochloric acid; cooling, adding saturated NaCl solution, storing at 4 deg.C overnight, filtering, and drying.
The sieving number in the step 1 is 40-60 meshes, and the ratio of the dilute sulfuric acid to the beta-glucanase to the cellulase to the water is 10:0.1: 1.
In the step 2, the material-to-liquid ratios of the three groups of phellodendron amurense powder and the sulfuric acid are respectively 1:12, 1:13 and 1: 14.
The concentration of the sulfuric acid in the step 2 is 2% -3%.
The soaking time in the step 3 is 65-85 min.
And (4) concentrating the filtrate in the step (4) until the specific gravity is 1.20-1.31, and adjusting the pH value to 2-3 by using dilute hydrochloric acid.
A feeding device for extracting berberine hydrochloride in optimized phellodendron amurense decoction pieces comprises a feeding mechanism 1, wherein the feeding mechanism 1 comprises a feeding pipe 11, a clamping block is fixedly connected to the outer side of the feeding pipe 11 and matched with a clamping jaw 24 for use, a trough 12 and a liquid cavity 13 are formed in the feeding pipe 11, a one-way valve is inserted into the top of the liquid cavity 13 and used for feeding liquid, a material valve 14 is inserted into the bottom of the trough 12, a groove is formed in one side, close to a material spoon 15, of the material valve 14, the material spoon 15 is convenient to stretch, the material spoon 15 is fixedly connected to the outer side of the material valve 14, the material spoon 15 is made of a rubber pad, a sliding block 17 is in transmission connection with the material spoon 15 through a pull rope, a top bag 16 is fixedly connected to the inner part of the material valve 14, a sliding block 17 is fixedly connected to the bottom of the top bag 16, a liquid feeding pipe 18 is inserted into the bottom of the liquid cavity 13, a liquid valve 19 is inserted into the liquid feeding pipe 18, a positioning groove is formed in the back of the liquid valve 19, and the liquid ratio can be convenient to adjust, a baffle 110 is hinged inside the liquid valve 19, an adjusting rod 111 is inserted into the back of the baffle 110, a positioning rod 112 is fixedly connected to one side of the adjusting rod 111 close to the liquid valve 19, an adjusting spring 113 is sleeved outside the adjusting rod 111, the adjusting spring 113 is connected with the baffle 110, a locking block 114 is fixedly connected to the inner wall of the liquid valve 19, the locking block 114 can limit the swing direction of the baffle 110 while facilitating the adjustment of the baffle 110, an air pipe 115 is inserted into the top of the feed pipe 11, the air pipe 115 is respectively connected with an air chamber 116, a top bag 16, a liquid chamber 13 and a driving bag 23 through a guide pipe, an air chamber 116 is arranged inside the feed pipe 11, a toothed bar 117 is slidably connected inside the air chamber 116, a return spring 118 is fixedly connected to the top of the toothed bar 117, a driving wheel 119 is meshed at the bottom of the toothed bar 117, the driving wheel 119 is respectively connected with the material valve 14 and the material spoon 15 through a driving belt, and a driving mechanism 2 is hinged to the top of the feed mechanism 1, actuating mechanism 2 is including lapping 21, and lapping 21 articulates at the top of filling tube 11, and the top of lapping 21 articulates there is stripper plate 22, and stripper plate 22 can guarantee that the extrusion degree of driving bag 23 at every turn is the same, and can control the volume of adding material through controlling stripper plate 22 swing angle, and the top fixedly connected with of lapping 21 drives bag 23, and the outside of lapping 21 articulates there is jack catch 24, and jack catch 24 is close to one side fixedly connected with jump ring 25 of lapping 21.
When the device is used, the claw 24 is pressed, the cover plate 21 is pushed to be opened, enough phellodendron amurense powder is added into the trough 12, enough mixed liquid is added through the one-way valve at the top of the liquid cavity 13, the cover plate 21 is closed, the feeding pipe 11 is inserted into the extraction tank, the extrusion plate 22 is pushed to swing at the moment, the extrusion plate 22 extrudes the driving bag 23, the driving bag 23 enables the air pipe 115 to intake air through the guide pipe, the air pipe 115 respectively enables the air cavity 116, the top bag 16 and the liquid cavity 13 to intake air through the guide pipe, the top bag 16 enables the air to inflate and expand, the top bag 16 pushes the sliding block 17 to slide, the sliding block 17 drives the material spoon 15 to dent towards the interior of the material valve 14 through the pull rope, the phellodendron amurense powder falls on the material spoon 15, the air of the air cavity 116 enables the toothed rod 117 to descend under the action of air pressure, the toothed rod 117 descends to drive the driving wheel 119, the driving wheel 119 drives the material valve 14 and the liquid valve 19 to rotate, the material valve 14 to pour the phellodendron the extraction tank, the liquid valve 19 rotates to open the liquid adding pipe 18, the mixed liquid enters the extracting tank through the liquid adding pipe 18 under the action of air pressure, after the adding is completed, the extruding plate 22 is loosened, the driving bag 23 resets, the driving bag 23 shrinks the top bag 16, the material spoon 15 resets under the action of self elasticity, the material spoon 15 resets and shakes, the situation that phellodendron amurense powder cannot remain on the material spoon 15 is guaranteed, the adding precision is further guaranteed, meanwhile, the reset spring 118 drives the toothed bar 117 to reset, the toothed bar 117 drives the transmission wheel 119 to rotate reversely, the transmission wheel 119 enables the material valve 14 and the liquid valve 19 to reset, then the adjusting rod 111 is pulled to slide relative to the baffle plate 110, the adjusting rod 111 drives the positioning rod 112 to be away from the positioning groove on the back side of the liquid valve 19, the adjusting rod 111 rotates at the moment, the adjusting rod 111 winds the adjusting spring 113, meanwhile, the baffle plate 110 cannot rotate under the action of the locking block 114, the restriction change given by the adjusting spring 113 to the baffle plate 110, when the liquid valve 19 is opened again, baffle 110 changes through the confining force that adjusting spring 113 gave mixed liquid to change mixed liquid addition, thereby change the feed liquid ratio, make feeding device can be quick extract the feed liquid of jar interpolation different ratios to the difference, draw in step through the feed liquid to different ratios again, thereby reduce the ratio error, improved the extraction rate.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. An optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces is characterized by comprising the following steps:
s1, taking the phellodendron amurense decoction pieces, naturally drying, sieving the crushed powder, and mixing dilute sulfuric acid, beta-glucanase and cellulase with water for later use;
s2, respectively loading the phellodendron amurense powder and sulfuric acid obtained in the step 1 into a feeding device, dividing the phellodendron amurense powder and the mixed solution into three groups by the feeding device, adding the three groups into different extraction tanks, and carrying out reflux extraction;
s3, after reflux extraction, cooling to room temperature and soaking, extracting residues, and treating the filter residues again by repeating the steps;
s4, combining all filtrates, concentrating, and adjusting the pH value with dilute hydrochloric acid; cooling, adding saturated NaCl solution, storing at 4 deg.C overnight, filtering, and drying.
2. The optimized extraction process of berberine hydrochloride from phellodendron amurense decoction pieces according to claim 1, which is characterized in that: the sieving number in the step 1 is 40-60 meshes, and the ratio of the dilute sulfuric acid to the beta-glucanase to the cellulase to the water is 10:0.1: 1.
3. The optimized extraction process of berberine hydrochloride from phellodendron amurense decoction pieces according to claim 1, which is characterized in that: the material-to-liquid ratio of the phellodendron amurense powder and the sulfuric acid in the step 2 is 1:12, 1:13 and 1:14 respectively.
4. The optimized extraction process of berberine hydrochloride from phellodendron amurense decoction pieces according to claim 1, which is characterized in that: the concentration of the sulfuric acid in the step 2 is 2% -3%.
5. The optimized extraction process of berberine hydrochloride from phellodendron amurense decoction pieces according to claim 1, which is characterized in that: the soaking time in the step 3 is 65-85 min.
6. The optimized extraction process of berberine hydrochloride from phellodendron amurense decoction pieces according to claim 1, which is characterized in that: and (4) concentrating the filtrate in the step (4) until the specific gravity is 1.20-1.31, and adjusting the pH value to 2-3 by using dilute hydrochloric acid.
7. A feeding device for optimizing berberine hydrochloride extraction in phellodendron amurense decoction pieces is applied to the process for optimizing berberine hydrochloride extraction in phellodendron amurense decoction pieces according to any one of claims 1 to 6, and comprises a feeding mechanism (1), and is characterized in that: the feeding mechanism (1) comprises a feeding pipe (11), a trough (12) and a liquid cavity (13) are arranged inside the feeding pipe (11), a material valve (14) is inserted into the bottom of the trough (12), a material spoon (15) is fixedly connected to the outer side of the material valve (14), a top bag (16) is fixedly connected to the inner part of the material valve (14), a sliding block (17) is fixedly connected to the bottom of the top bag (16), a liquid feeding pipe (18) is inserted into the bottom of the liquid cavity (13), a liquid valve (19) is inserted into the inner part of the liquid feeding pipe (18), a baffle (110) is hinged to the inner part of the liquid valve (19), an adjusting rod (111) is inserted into the back of the baffle (110), a positioning rod (112) is fixedly connected to one side, close to the liquid valve (19), of the adjusting rod (111), and an adjusting spring (113) is sleeved on the outer side of the adjusting rod (111), the inner wall of the liquid valve (19) is fixedly connected with a locking block (114), the top of the feed pipe (11) is inserted with an air pipe (115), an air cavity (116) is arranged inside the charging pipe (11), a toothed bar (117) is connected inside the air cavity (116) in a sliding way, the top of the toothed bar (117) is fixedly connected with a return spring (118), the bottom of the toothed bar (117) is engaged with a driving wheel (119), the top of the feeding mechanism (1) is hinged with a driving mechanism (2), the driving mechanism (2) comprises a cover plate (21), the cover plate (21) is hinged on the top of the charging pipe (11), the top of the cover plate (21) is hinged with an extrusion plate (22), the top of the cover plate (21) is fixedly connected with a driving bag (23), the outer side of the cover plate (21) is hinged with a claw (24), one side of the clamping jaw (24) close to the cover plate (21) is fixedly connected with a clamping spring (25).
8. The optimized feeding device for extracting berberine hydrochloride from phellodendron amurense decoction pieces according to claim 7, wherein the feeding device comprises: the material of the material spoon (15) is a rubber pad, and the sliding block (17) is in transmission connection with the material spoon (15) through a pull rope.
9. The optimized feeding device for extracting berberine hydrochloride from phellodendron amurense decoction pieces according to claim 7, wherein the feeding device comprises: the air pipe (115) is respectively connected with the air cavity (116), the top sac (16), the liquid cavity (13) and the driving sac (23) through a guide pipe.
10. The optimized feeding device for extracting berberine hydrochloride from phellodendron amurense decoction pieces according to claim 7, wherein the feeding device comprises: the driving wheel (119) is respectively in transmission connection with the material valve (14) and the material spoon (15) through a transmission belt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111610253.7A CN114230566A (en) | 2021-12-27 | 2021-12-27 | Optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111610253.7A CN114230566A (en) | 2021-12-27 | 2021-12-27 | Optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114230566A true CN114230566A (en) | 2022-03-25 |
Family
ID=80763244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111610253.7A Pending CN114230566A (en) | 2021-12-27 | 2021-12-27 | Optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114230566A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435194A (en) * | 2014-12-17 | 2015-03-25 | 鼎正动物药业（天津）有限公司 | Extraction method of berberine |
| CN207694617U (en) * | 2017-11-22 | 2018-08-07 | 李宇婷 | A kind of solid and liquid automatic quantitation mixing arrangement |
| CN210302491U (en) * | 2019-04-04 | 2020-04-14 | 四川维尔康动物药业有限公司 | Traditional Chinese medicine extraction device capable of quantitatively adding medicines |
| CN111266156A (en) * | 2020-03-21 | 2020-06-12 | 嵊州向合纺织科技有限公司 | Cochineal pigment extractor with fixed material-liquid ratio |
| CN112175737A (en) * | 2020-10-29 | 2021-01-05 | 张辉 | Extraction device and extraction method for cosmetic plant essential oil |
-
2021
- 2021-12-27 CN CN202111610253.7A patent/CN114230566A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435194A (en) * | 2014-12-17 | 2015-03-25 | 鼎正动物药业（天津）有限公司 | Extraction method of berberine |
| CN207694617U (en) * | 2017-11-22 | 2018-08-07 | 李宇婷 | A kind of solid and liquid automatic quantitation mixing arrangement |
| CN210302491U (en) * | 2019-04-04 | 2020-04-14 | 四川维尔康动物药业有限公司 | Traditional Chinese medicine extraction device capable of quantitatively adding medicines |
| CN111266156A (en) * | 2020-03-21 | 2020-06-12 | 嵊州向合纺织科技有限公司 | Cochineal pigment extractor with fixed material-liquid ratio |
| CN112175737A (en) * | 2020-10-29 | 2021-01-05 | 张辉 | Extraction device and extraction method for cosmetic plant essential oil |
Non-Patent Citations (1)
| Title |
|---|
| 张福维, 关崇新, 高坤: "盐酸小檗碱提取实验的改进", 大学化学, vol. 18, no. 04, pages 47 - 49 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112190972A (en) | Special traditional Chinese medicine fragmentation extraction device and use method thereof | |
| CN114230566A (en) | Optimized extraction process of berberine hydrochloride in phellodendron amurense decoction pieces | |
| CN109806617B (en) | Device for preparing dye from natural raw materials | |
| CN209616414U (en) | A kind of tea-seed oil pressing device | |
| CN106833883B (en) | Double-kettle turnover supercritical fluid extraction device | |
| CN206659685U (en) | A kind of espresso machine | |
| CN106799082A (en) | A kind of grape extraction juice filter plant | |
| CN113546442B (en) | Reinforced pinellia ternata of ration soaks pond | |
| CN111990672A (en) | Automatic intelligent all-in-one that separates of passion fruit pulp, peel, fruit seed | |
| CN108541436A (en) | A kind of planting unit convenient for lotus rhizome fertilising | |
| CN210569805U (en) | Processing equipment is used in tea-seed oil production with dry function of disturbance | |
| CN208527291U (en) | A kind of Rice enriched-Se intensive processing adjustable device of rice husk separation | |
| CN207385944U (en) | A kind of seed screening plant | |
| CN103877142B (en) | The method that microorganism auxiliary sloughs snake gourd fruit pulp | |
| CN114314900A (en) | Sewage treatment device and using method thereof | |
| CN208925157U (en) | A kind of fruit juice keeps in fresh-keeping oxidation | |
| CN220056751U (en) | Wine preprocessing device is za to tree peony | |
| CN110078690B (en) | Vitamin C solution extraction method and device, and metasilicic acid solution preparation method and device | |
| CN110777000A (en) | Tea-seed oil filter equipment | |
| CN114082220B (en) | Device and process for removing plasticizer from cowberry extract | |
| CN216457024U (en) | Tower type countercurrent leaching device for instant tea | |
| CN208191870U (en) | A kind of natural honey primary filter solid impurity device | |
| CN114405058B (en) | Supercritical carbon dioxide extraction device capable of improving material replacement efficiency | |
| CN210960374U (en) | Feed processing device containing plant extracts | |
| CN204350580U (en) | A kind of moistening device for seed pelleting |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |