CN114225795A - Micro-fluidic chip structure and method for automatically preparing two alcohol concentrations - Google Patents
Micro-fluidic chip structure and method for automatically preparing two alcohol concentrations Download PDFInfo
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- CN114225795A CN114225795A CN202111570138.1A CN202111570138A CN114225795A CN 114225795 A CN114225795 A CN 114225795A CN 202111570138 A CN202111570138 A CN 202111570138A CN 114225795 A CN114225795 A CN 114225795A
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 65
- 238000000034 method Methods 0.000 title claims abstract description 11
- 239000012530 fluid Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 238000005086 pumping Methods 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- -1 polydimethylsiloxane Polymers 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 18
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 15
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000005457 optimization Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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Abstract
The invention discloses a micro-fluidic chip structure and a method for automatically preparing two alcohol concentrations, belonging to the technical field of reagent preparation and micro-nano flow; the technical problems that manual preparation is time-consuming, labor-consuming, accurate and low in chemical reagent concentration preparation at present and multiple reagent concentrations cannot be prepared simultaneously are solved; the technical scheme is as follows: the micro-fluidic chip structure comprises a solution inlet, a solution inlet flow channel, a micro-fluidic channel, a U-shaped resistance channel, a resistance plate, a solution outlet I and a solution outlet II; the control method comprises the following steps: two alcohol solutions with different concentrations are obtained by controlling the pressure of the pumped solution, the number of the U-shaped channels of the U-shaped resistance channels and the number of the resistance plates. The invention has the beneficial effects that: the invention realizes the automatic preparation of a plurality of different reagent concentrations.
Description
Technical Field
The invention relates to the technical field of reagent preparation and micro-nano flow, in particular to a micro-fluidic chip structure and a method for automatically preparing two alcohol concentrations.
Background
In industrial and agricultural production and scientific research, the solution with certain amount and concentration of a substance is often required to be accurately prepared, the preparation of the concentration of a reagent is difficult, each link of the preparation needs to be strictly controlled, the manual preparation is mostly carried out at present, the manual preparation wastes time and energy, the accuracy is low, the preparation of various reagent concentrations cannot be carried out simultaneously, and the reagent with one concentration can only be prepared at one time. When in preparation, the protective measures of operators are improper, and personal injury accidents are easy to happen. Manual preparation also easily results in reagent contamination, and operators need to use multiple instruments to complete the preparation, which is inefficient and easily affects precision. Therefore, it is necessary to develop a solution preparing apparatus with high preparing efficiency, safety, time saving and labor saving.
Disclosure of Invention
In order to solve the technical problems, the invention provides a micro-fluidic chip structure and a method for automatically preparing two alcohol concentrations, and aims to realize the automation of reagent preparation, and the preparation of various reagent concentrations can be automatically carried out simultaneously only by adjusting various factors of a chip, and the preparation of various reagent concentrations can also be carried out simultaneously.
The invention is realized by the following measures, and the microfluidic chip structure for automatically preparing two alcohol concentrations comprises a solution inlet I, a solution inlet II and a microfluidic channel, wherein one end of the microfluidic channel is communicated with the solution inlet I, the other end of the microfluidic channel is respectively communicated with a microfluidic channel II and a microfluidic channel III, the lower ends of the microfluidic channel II and the microfluidic channel III are respectively connected with a U-shaped resistance channel, and the lower ends of the two resistance U-shaped channels are respectively connected with a solution outlet I and a solution outlet II through the microfluidic channel.
The first solution outlet and the second solution outlet are respectively communicated with a fourth microfluidic channel and a fifth microfluidic channel, the upper ends of the fourth microfluidic channel and the fifth microfluidic channel are communicated with a sixth microfluidic channel, and the sixth microfluidic channel is communicated with the second solution inlet.
As a further optimization scheme of the structure of the micro-fluidic chip for automatically preparing two alcohol concentrations, the resistance U-shaped channel comprises a plurality of U-shaped tubes which are sequentially communicated end to end and a plurality of resistance plates which are arranged on two transverse inner walls of the U-shaped tubes at equal intervals, and the height of each resistance plate is half of the diameter of the U-shaped tube.
As a further optimization scheme of the structure of the micro-fluidic chip for automatically preparing two alcohol concentrations, the number of the U-shaped channels connected with the lower ends of the two micro-fluidic channels is 2 times that of the U-shaped channels connected with the lower ends of the three micro-fluidic channels.
As a further optimization scheme of the structure of the micro-fluidic chip for automatically preparing two alcohol concentrations, the first solution inlet and the second solution inlet are positioned on the same horizontal plane.
As a further optimization scheme of the structure of the micro-fluidic chip for automatically preparing two alcohol concentrations, the position of the first solution outlet is higher than the position of the second solution outlet.
As a further optimization scheme of the structure of the micro-fluidic chip for automatically preparing two alcohol concentrations, the micro-fluidic channel is made of polydimethylsiloxane materials.
In order to better achieve the above object, the present invention further provides a method for automatically preparing a microfluidic chip structure with two alcohol concentrations, comprising the following steps:
s1, pumping a certain amount of pure alcohol from the solution inlet I through the program pump, and pumping a certain amount of water from the solution inlet II through the program pump;
s2, alcohol pumped from the solution inlet I flows into a microflow channel, the microflow channel is provided with a microflow channel II and a microflow channel III which are provided with two branches, a U-shaped channel is arranged in the microflow channel of each branch, and a resistance plate in the U-shaped channel generates resistance to fluid;
s3, water pumped by the solution inlet II flows into a micro-flow channel six, the micro-flow channel six also has two branch micro-flow channels four and five, because the micro-flow channels four and five are internally provided with U-shaped channels and resistance plates, the resistance borne by the fluid of the micro-flow channel four and the fluid of the micro-flow channel five are the same, and the flow rates of the two branch channels are the same;
s4, because of the difference of resistance of the three fluids of the branch microfluidic channel II and the microfluidic channel, the alcohol flow entering the two branch channels from the solution inlet I is different;
because the resistance borne by the fluid in the branch microfluidic channel four is the same as that borne by the fluid in the microfluidic channel five, the water flow entering the two branch channels from the solution inlet two at one time is the same;
pure alcohol in the branch microfluidic channel II is mixed with water in the branch microfluidic channel III in the microfluidic channel to obtain alcohol solution with a certain concentration, and the alcohol solution flows out of the solution outlet II;
two alcohol solutions with different concentration contents are obtained at the solution outlet I and the solution outlet II by controlling the inlet flow of alcohol and water, adjusting the number of U-shaped channels of the microfluidic channel II and the microfluidic channel III of the two branches of the microfluidic channel and adjusting the size and the number of the resistance plates.
Compared with the prior art, the invention has the beneficial effects that:
1. the invention automatically prepares the micro-fluidic structure of the micro-fluidic chip structure with two alcohol concentrations, has high automation in implementation and high time-saving, labor-saving and precision.
2. The invention discloses a micro-fluidic structure of a micro-fluidic chip structure for automatically preparing two alcohol concentrations, which is provided with a U-shaped channel, wherein a resistance plate is arranged in the U-shaped channel and can apply resistance to fluid.
3. The micro-fluidic structure of the micro-fluidic chip structure for automatically preparing the alcohol solutions with two alcohol concentrations is provided with the U-shaped channels with different numbers in the flow channel branch channels, so that the flow rate difference of the fluids in different flow channels can be realized, and the alcohol solutions with different concentrations can be obtained.
4. The invention automatically prepares the micro-fluidic structure of the micro-fluidic chip structure with two alcohol concentrations, can be modified highly, and can obtain two specific alcohol solutions with different concentration contents at the outlets of the two solutions by controlling the inlet flow of alcohol and water, changing the number of U-shaped channels of two branch channels of the channel and adjusting the size, the position and the number of the resistance plates; further increasing the number of branch channels of the channel, adjusting the number of U-shaped channels and adjusting the speed of a fluid inlet to obtain alcohol solutions with various specific concentrations. Furthermore, the number of inlets can be increased, other different fluids can be introduced into each inlet, the number of branch channels, the number of U-shaped channels and the flow rate of the fluids are changed, and various specific solutions with different preparation concentrations are obtained.
5. The micro-fluidic structure of the micro-fluidic chip structure for automatically preparing the two alcohol concentrations can be used for reagent concentration preparation, can also be used for chemical reactions between different reagents and reagents with different contents, can quickly obtain two specific alcohol solutions with different concentrations, and is time-saving, labor-saving, high in accuracy, high in automation degree, low in cost and simple in operation.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention.
Fig. 1 is a schematic diagram of a micro-fluidic chip structure for automatically preparing two alcohol concentrations according to the present invention.
Fig. 2 is a schematic diagram of a position relationship between a U-shaped channel and a resistance plate therein in a micro-fluidic chip structure for automatically preparing two alcohol concentrations according to the present invention.
Wherein the reference numerals are: 1. a first solution inlet; 1-1, a microfluidic channel II; 1-2, a microfluidic channel III; 2. a second solution inlet; 3. a microfluidic channel; 4. a U-shaped resistance channel; 40. a U-shaped channel; 41. a resistance plate; 5. a first solution outlet; 6. a second solution outlet; 7. a microfluidic channel IV; 8. a micro-flow channel V; 9. and a microfluidic channel six.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1 and 2, the invention provides a micro-fluidic chip structure and a method for automatically preparing two alcohol concentrations, the micro-fluidic chip structure for automatically preparing two alcohol concentrations comprises a solution inlet I1, a solution inlet II 2, a micro-flow channel 3 with one end communicated with the solution inlet I1, the other end of the micro-flow channel 3 is respectively communicated with the micro-flow channel II 1-1 and the micro-flow channel III 1-2, the lower ends of the micro-flow channel II 1-1 and the micro-flow channel III 1-2 are respectively connected with a U-shaped resistance channel 4, and the lower ends of the two resistance U-shaped channels 4 are respectively connected with a solution outlet I5 and a solution outlet II 6 through the micro-flow channels;
the solution outlet I5 and the solution outlet II 6 are respectively communicated with a micro-flow channel IV 7 and a micro-flow channel V8, the upper ends of the micro-flow channel IV 7 and the micro-flow channel V8 are communicated with a micro-flow channel VI 9, and the micro-flow channel VI 9 is communicated with the solution inlet II 2.
Preferably, the resistance U-shaped channel 4 comprises a plurality of U-shaped tubes 40 which are sequentially communicated end to end and a plurality of resistance plates 41 which are arranged on two transverse inner walls of the U-shaped tubes at equal intervals, and the height of each resistance plate 41 is half of the diameter of the U-shaped tube.
Preferably, the number of the U-shaped channels 40 connected to the lower end of the second microfluidic channel 1-1 by one U-shaped resistance channel 4 is 2 times that of the U-shaped channels 40 connected to the lower end of the third microfluidic channel 1-2 by one U-shaped resistance channel 4.
Preferably, the solution inlet I1 and the solution inlet II 2 are positioned on the same horizontal plane.
Preferably, the position of the solution outlet one 5 is higher than the position of the solution outlet two 6.
Preferably, the microfluidic channel is made of polydimethylsiloxane.
The working principle of the invention is as follows: pumping a certain amount of pure alcohol from a solution inlet I1 through a program pump, pumping a certain amount of water from a solution inlet II 2 through a program pump, enabling the alcohol pumped from the solution inlet I1 to flow into a microfluidic channel 3, wherein the microfluidic channel 3 is provided with two branch microfluidic channels II 1-1 and three microfluidic channels III 1-2, a U-shaped channel 40 is arranged in the microfluidic channel of each branch, and a resistance plate 41 in the U-shaped channel 40 generates resistance to fluid; the water pumped by the solution inlet II 2 flows into the micro-flow channel six 9, the micro-flow channel six 9 also has two branch micro-flow channels four 7 and five micro-flow channels five 8, because the micro-flow channels four 7 and five micro-flow channels five 8 are internally provided with U-shaped channels and resistance plates, the fluid resistance of the micro-flow channels four 7 and five micro-flow channels five 8 is the same, and the flow rates of the two branch channels are the same; because of the difference of the resistance borne by the fluid of the branch microfluidic channel II 1-1 and the microfluidic channel III 1-2, the alcohol flow entering the two branch channels from the solution inlet I1 is different; because the resistance borne by the fluid in the branch microfluidic channel four 7 is the same as that borne by the fluid in the microfluidic channel five 8, the water flow entering the two branch channels from the solution inlet two 2 at one time is the same; pure alcohol of the branch microfluidic channel II 1-1 is mixed with water of the branch microfluidic channel III 1-2 in the microfluidic channel to obtain alcohol solution with a certain concentration, the alcohol solution flows out of the solution outlet II 6, the pure alcohol of the branch microfluidic channel III 1-2 is mixed with water of the branch microfluidic channel IV 7 in the microfluidic channel to obtain alcohol solution with another concentration, and the alcohol solution flows out of the solution outlet I5; two alcohol solutions with different concentration contents are obtained at the solution outlet I5 and the solution outlet II 6 by controlling the inlet flow rates of alcohol and water, adjusting the number of the U-shaped channels 40 of the micro-flow channel II 1-1 and the micro-flow channel III 1-2 of the two branches of the micro-flow channel 3 and adjusting the size and the number of the resistance plates 41.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (7)
1. The utility model provides an automatic prepare micro-fluidic chip structure of two kinds of alcohol concentration which characterized in that: the device comprises a solution inlet I (1), a solution inlet II (2) and a micro-flow channel (3) with one end communicated with the solution inlet I (1), wherein the other end of the micro-flow channel (3) is respectively communicated with a micro-flow channel II (1-1) and a micro-flow channel III (1-2), the lower ends of the micro-flow channel II (1-1) and the micro-flow channel III (1-2) are respectively connected with a U-shaped resistance channel (4), and the lower ends of the two resistance U-shaped channels (4) are respectively connected with a solution outlet I (5) and a solution outlet II (6) through the micro-flow channels;
the first solution outlet (5) and the second solution outlet (6) are respectively communicated with a fourth microfluidic channel (7) and a fifth microfluidic channel (8), the upper ends of the fourth microfluidic channel (7) and the fifth microfluidic channel (8) are communicated with a sixth microfluidic channel (9), and the sixth microfluidic channel (9) is communicated with the second solution inlet (2).
2. The microfluidic chip structure for automatically dispensing two alcohol concentrations according to claim 1, wherein: resistance U-shaped passageway (4) include U-shaped pipe (40) and equidistant a plurality of resistance board (41) of setting on two horizontal inner walls of U-shaped pipe that a plurality of head and the tail communicate in proper order, the height of resistance board (41) is half of U-shaped pipe diameter.
3. The microfluidic chip structure for automatically dispensing two alcohol concentrations according to claim 1, wherein: the number of the U-shaped channels (40) connected with the lower end of the microfluidic channel II (1-1) and provided with one U-shaped resistance channel (4) is 2 times that of the U-shaped channels (40) of the U-shaped resistance channel (4) connected with the lower end of the microfluidic channel III (1-2).
4. The microfluidic chip structure for automatically dispensing two alcohol concentrations according to claim 1, wherein: the solution inlet I (1) and the solution inlet II (2) are positioned on the same horizontal plane.
5. The microfluidic chip structure for automatically dispensing two alcohol concentrations according to claim 1, wherein: the position of the solution outlet I (5) is higher than that of the solution outlet II (6).
6. The microfluidic chip structure for automatically dispensing two alcohol concentrations according to claim 1, wherein: the microfluidic channel is made of polydimethylsiloxane material.
7. The method for preparing a microfluidic chip structure for automatically preparing two alcohol concentrations according to claim 1, wherein the method comprises the following steps: the method comprises the following steps:
s1, pumping a certain amount of pure alcohol from the solution inlet I (1) through a program pump, and pumping a certain amount of water from the solution inlet II (2) through a program pump;
s2, alcohol pumped from the solution inlet I (1) flows into the microfluidic channel (3), the microfluidic channel (3) is provided with two branch microfluidic channels II (1-1) and three microfluidic channels III (1-2), a U-shaped channel (40) is arranged in the microfluidic channel of each branch, a resistance plate (41) in the U-shaped channel (40) generates resistance to fluid, the flow rates of the two branch microfluidic channels are different due to the fact that the U-shaped channels (40) in the two branch microfluidic channels are different in number and the resistance of the two branch microfluidic channels to fluid is different, and the flow rate of the branch microfluidic channel III (1-2) is larger than that of the microfluidic channel III (1-1);
s3, water pumped by the solution inlet II (2) flows into a micro-flow channel six (9), the micro-flow channel six (9) is provided with two branch micro-flow channels four (7) and five (8), and because the micro-flow channels four (7) and five (8) are internally provided with U-shaped channels and resistance plates, the fluid resistance of the micro-flow channels four (7) and five (8) is the same, and the flow rates of the two branch channels are the same;
s4, because of the difference of the resistance of the fluid in the branch microfluidic channel II (1-1) and the microfluidic channel III (1-2), the alcohol flow entering the two branch channels from the solution inlet I (1) is different;
because the resistance borne by the fluid of the branch microfluidic channel four (7) is the same as that borne by the fluid of the microfluidic channel five (8), the water flow entering the two branch channels from the solution inlet two (2) at one time is the same;
pure alcohol in the branch microfluidic channel II (1-1) is mixed with water in the branch microfluidic channel III (1-2) in the microfluidic channel to obtain alcohol solution with a certain concentration, and the alcohol solution flows out of the solution outlet II (6), and the pure alcohol in the branch microfluidic channel III (1-2) is mixed with water in the branch microfluidic channel IV (7) in the microfluidic channel to obtain alcohol solution with another concentration, and the alcohol solution flows out of the solution outlet I (5);
two alcohol solutions with different concentration contents are obtained at the solution outlet I (5) and the solution outlet II (6) by controlling the inlet flow rates of alcohol and water, adjusting the number of U-shaped channels (40) of the microfluidic channel II (1-1) and the microfluidic channel III (1-2) of the two branches of the microfluidic channel (3) and adjusting the size and the number of the resistance plates (41).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111570138.1A CN114225795B (en) | 2021-12-21 | Micro-fluidic chip structure and method for automatically preparing two alcohol concentrations |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111570138.1A CN114225795B (en) | 2021-12-21 | Micro-fluidic chip structure and method for automatically preparing two alcohol concentrations |
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| CN114225795A true CN114225795A (en) | 2022-03-25 |
| CN114225795B CN114225795B (en) | 2024-05-24 |
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| US20070122819A1 (en) * | 2005-11-25 | 2007-05-31 | Industrial Technology Research Institute | Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same |
| JP2008239902A (en) * | 2007-03-28 | 2008-10-09 | Fujifilm Corp | Polymer fine particle and method for producing the same |
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