CN114222761A - 一种抗cld18a2的单域抗体 - Google Patents

一种抗cld18a2的单域抗体 Download PDF

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CN114222761A
CN114222761A CN202080041701.3A CN202080041701A CN114222761A CN 114222761 A CN114222761 A CN 114222761A CN 202080041701 A CN202080041701 A CN 202080041701A CN 114222761 A CN114222761 A CN 114222761A
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amino acid
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cld18a2
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CN114222761B (zh
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黄岩山
姚高峰
董佳里
温晓芳
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Zhejiang Doer Biologics Co Ltd
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Abstract

一种抗CLD18A2的单域抗体。所述抗CLD18A2的单域抗体的互补决定区包括氨基酸序列如SEQ ID NO.4～11其中之一所示的CDR‑H1、氨基酸序列如SEQ ID NO.19～26其中之一所示的CDR‑H2、和氨基酸序列如SEQ ID NO.33～39其中之一所示的CDR‑H3。所述抗CLD18A2的单域抗体对于Claudin18.2具有良好的亲和力，且可以用于进一步构建双特异性抗体、抗体‑药物复合物、嵌合抗原受体等，且构建获得的双特异性抗体、抗体‑药物复合物、CAR‑T细胞等对于靶标细胞具有良好的靶向性和杀伤效果。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117551199A (zh) * 2023-11-16 2024-02-13 杭州荣谷生物科技有限公司 一种Claudin18.2纳米抗体的制备方法及其应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023134742A1 (zh) * 2022-01-14 2023-07-20 浙江道尔生物科技有限公司 一种三靶点抗肿瘤药物、其制备方法及其应用

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1948693A1 (en) * 2005-11-24 2008-07-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
CN101687929A (zh) * 2007-05-29 2010-03-31 加尼梅德药物公司 用于治疗癌症的抗密蛋白-18的单克隆抗体
US20130251711A1 (en) * 2010-11-22 2013-09-26 Innate Pharma Sa Nk cell modulating treatments and methods for treatment of hematological malignancies
US20150147763A1 (en) * 2012-05-09 2015-05-28 Ganymed Pharmaceuticals Ag Antibodies Against Claudin 18.2 Useful in Cancer Diagnosis
CN105315375A (zh) * 2014-07-17 2016-02-10 科济生物医药（上海）有限公司 靶向cld18a2的t淋巴细胞及其制备方法和应用
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
EP3099706A1 (en) * 2014-01-29 2016-12-07 BioNTech AG Peptide mimotopes of claudin 18.2 and uses thereof
CN109311999A (zh) * 2015-08-11 2019-02-05 南京传奇生物科技有限公司 基于单结构域抗体的嵌合抗原受体及其使用方法
CN109762067A (zh) * 2019-01-17 2019-05-17 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途
CN109790222A (zh) * 2016-07-08 2019-05-21 科济生物医药（上海）有限公司 抗密蛋白18a2的抗体及其应用
CN110606891A (zh) * 2018-06-17 2019-12-24 上海健信生物医药科技有限公司 一种针对人cldn18.2的新型抗体分子, 抗原结合片段及其医药用途
CN110857322A (zh) * 2018-08-22 2020-03-03 瑞阳(苏州)生物科技有限公司 抗人claudin 18.2单克隆抗体及其应用
CN110862454A (zh) * 2018-08-27 2020-03-06 南京圣和药业股份有限公司 一种抗Claudin18_2抗体及其应用
CN111235113A (zh) * 2020-01-21 2020-06-05 南京北恒生物科技有限公司 包含嵌合抗原受体的免疫细胞及其用途
CN111434692A (zh) * 2019-01-15 2020-07-21 浙江道尔生物科技有限公司 抗cld18a2纳米抗体及其应用
US20210214433A1 (en) * 2018-07-25 2021-07-15 Accurus Biosciences, Inc. Novel cldn 18.2-specific monoclonal antibodies and methods of use thereof
US20210230272A1 (en) * 2018-06-17 2021-07-29 L&L Biopharma Co., Ltd. Antibody targeting cldn18.2, bispecific antibody, adc, and car, and applications thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016180468A1 (en) * 2015-05-11 2016-11-17 Biontech Cell & Gene Therapies Gmbh Claudin-18.2-specific immunoreceptors and t cell epitopes

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1948693A1 (en) * 2005-11-24 2008-07-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
CN101687929A (zh) * 2007-05-29 2010-03-31 加尼梅德药物公司 用于治疗癌症的抗密蛋白-18的单克隆抗体
US20130251711A1 (en) * 2010-11-22 2013-09-26 Innate Pharma Sa Nk cell modulating treatments and methods for treatment of hematological malignancies
US20150147763A1 (en) * 2012-05-09 2015-05-28 Ganymed Pharmaceuticals Ag Antibodies Against Claudin 18.2 Useful in Cancer Diagnosis
EP3099706A1 (en) * 2014-01-29 2016-12-07 BioNTech AG Peptide mimotopes of claudin 18.2 and uses thereof
CN105315375A (zh) * 2014-07-17 2016-02-10 科济生物医药（上海）有限公司 靶向cld18a2的t淋巴细胞及其制备方法和应用
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
CN109311999A (zh) * 2015-08-11 2019-02-05 南京传奇生物科技有限公司 基于单结构域抗体的嵌合抗原受体及其使用方法
CN109790222A (zh) * 2016-07-08 2019-05-21 科济生物医药（上海）有限公司 抗密蛋白18a2的抗体及其应用
US20210230272A1 (en) * 2018-06-17 2021-07-29 L&L Biopharma Co., Ltd. Antibody targeting cldn18.2, bispecific antibody, adc, and car, and applications thereof
CN110606891A (zh) * 2018-06-17 2019-12-24 上海健信生物医药科技有限公司 一种针对人cldn18.2的新型抗体分子, 抗原结合片段及其医药用途
US20210214433A1 (en) * 2018-07-25 2021-07-15 Accurus Biosciences, Inc. Novel cldn 18.2-specific monoclonal antibodies and methods of use thereof
CN110857322A (zh) * 2018-08-22 2020-03-03 瑞阳(苏州)生物科技有限公司 抗人claudin 18.2单克隆抗体及其应用
CN110862454A (zh) * 2018-08-27 2020-03-06 南京圣和药业股份有限公司 一种抗Claudin18_2抗体及其应用
CN111434692A (zh) * 2019-01-15 2020-07-21 浙江道尔生物科技有限公司 抗cld18a2纳米抗体及其应用
CN116333141A (zh) * 2019-01-15 2023-06-27 浙江道尔生物科技有限公司 抗cld18a2纳米抗体及其应用
US10421817B1 (en) * 2019-01-17 2019-09-24 Beijing Mabworks Biotech Co., Ltd. Antibodies binding human Claudin 18.2 and uses thereof
CN109762067A (zh) * 2019-01-17 2019-05-17 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途
CN111235113A (zh) * 2020-01-21 2020-06-05 南京北恒生物科技有限公司 包含嵌合抗原受体的免疫细胞及其用途

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
GENBANK: "CAO79130.1: immunoglobulin heavy chain variable region, partial [Vicugna pacos]", 《GENBANK》 *
GENBANK: "CAQ53177.1: surface immunoglobulin M heavy chain variable region, partial [Vicugna pacos]", 《GENBANK》 *
GUOYUN ZHU等: "Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer", 《SCIENTIFIC REPORTS》, vol. 09, no. 01, pages 1 - 11 *
HUA JIANG等: "Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer", 《JOURNAL OF THE NATIONAL CANCER INSTITUTE》, vol. 111, no. 04, pages 409 - 418, XP055642983, DOI: 10.1093/jnci/djy134 *
S.E. AL-BATRAN等: "LBA-06 IMAB362: a novel immunotherapeutic antibody targeting the tight-junction protein component CLAUDIN18.2 in gastric cancer", 《ANNALS OF ONCOLOGY》, vol. 27, no. 02, pages 1 *
徐良额等: "CLDN18.2蛋白在恶性肿瘤治疗中的研究进展", 《中国肿瘤临床》, vol. 46, no. 06, pages 540 - 544 *
曹云新、张松、杨安钢: "Claudin 18在胰腺癌细胞中的表达", 《细胞与分子免疫学杂志》, vol. 25, no. 12, pages 1202 - 1203 *
邵荣光: "基于单克隆抗体的肿瘤免疫治疗", 《药学学报》, vol. 55, no. 06, pages 1110 - 1118 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117551199A (zh) * 2023-11-16 2024-02-13 杭州荣谷生物科技有限公司 一种Claudin18.2纳米抗体的制备方法及其应用
CN117551199B (zh) * 2023-11-16 2024-04-19 杭州荣谷生物科技有限公司 一种Claudin18.2纳米抗体的制备方法及其应用

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