CN114222739B - 磺酰脲衍生物及其用途 - Google Patents

磺酰脲衍生物及其用途 Download PDF

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Publication number
CN114222739B
CN114222739B CN202080057088.4A CN202080057088A CN114222739B CN 114222739 B CN114222739 B CN 114222739B CN 202080057088 A CN202080057088 A CN 202080057088A CN 114222739 B CN114222739 B CN 114222739B
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alkyl
optionally substituted
compound
disease
haloalkyl
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Chinese (zh)
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CN114222739A (zh
Inventor
M·G·波克
D·哈里森
J·E·斯坎伦
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Northera Ltd
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Northera Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
CN202080057088.4A 2019-06-12 2020-06-11 磺酰脲衍生物及其用途 Active CN114222739B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962860664P 2019-06-12 2019-06-12
US62/860664 2019-06-12
PCT/EP2020/066185 WO2020249664A1 (en) 2019-06-12 2020-06-11 Sulfonylurea derivatives and uses thereof

Publications (2)

Publication Number Publication Date
CN114222739A CN114222739A (zh) 2022-03-22
CN114222739B true CN114222739B (zh) 2025-02-11

Family

ID=71108562

Family Applications (1)

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CN202080057088.4A Active CN114222739B (zh) 2019-06-12 2020-06-11 磺酰脲衍生物及其用途

Country Status (6)

Country Link
US (1) US20230083495A1 (https=)
EP (1) EP3983407B1 (https=)
JP (1) JP7661248B2 (https=)
CN (1) CN114222739B (https=)
ES (1) ES3056339T3 (https=)
WO (1) WO2020249664A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201721185D0 (en) 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
PL3983387T3 (pl) 2019-06-12 2024-08-19 NodThera Limited Pochodne sulfonylomocznika i ich zastosowania
CN117279903A (zh) * 2021-02-10 2023-12-22 杭州英创医药科技有限公司 作为nlrp3抑制剂的化合物
EP4729514A1 (en) 2023-06-14 2026-04-22 Haisco Pharmaceutical Group Co., Ltd. Bicyclic derivative parp inhibitor and use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604178A (en) * 1993-10-15 1997-02-18 Kureha Kagaku Kogyo K.K. N-(substituted amino)pyrrole derivatives, and herbicidal compositions
US5610121A (en) * 1992-05-29 1997-03-11 Bayer Aktiengesellschaft Heterocyclically disubstituted sulphonylamino(thio)carbonyl compounds
CN109071454A (zh) * 2016-02-16 2018-12-21 昆士兰大学 磺酰脲和相关化合物及其用途
WO2019121691A1 (en) * 2017-12-18 2019-06-27 NodThera Limited Sulphonyl urea derivatives as nlrp3 inflammasome modulators
WO2020035464A1 (en) * 2018-08-15 2020-02-20 Inflazome Limited Novel sulfonamideurea compounds
WO2020035466A1 (en) * 2018-08-15 2020-02-20 Inflazome Limited Novel sulfoneurea compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JPS60214785A (ja) * 1984-03-27 1985-10-28 Nissan Chem Ind Ltd ピラゾ−ルスルホニルウレア誘導体、および植物生長調節剤または除草剤
DE4039734A1 (de) * 1990-12-13 1992-06-17 Basf Ag Substituierte 2-aminothiophene enthaltende herbizide mittel
JPH0827147A (ja) * 1994-07-20 1996-01-30 Kureha Chem Ind Co Ltd Ｎ−（置換アミノ）イミド誘導体、その製造方法及び除草剤
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
EP3272739A1 (en) * 2016-07-20 2018-01-24 NodThera Limited Sulfonyl urea derivatives and their use in the control of interleukin-1 activity

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610121A (en) * 1992-05-29 1997-03-11 Bayer Aktiengesellschaft Heterocyclically disubstituted sulphonylamino(thio)carbonyl compounds
US5604178A (en) * 1993-10-15 1997-02-18 Kureha Kagaku Kogyo K.K. N-(substituted amino)pyrrole derivatives, and herbicidal compositions
CN109071454A (zh) * 2016-02-16 2018-12-21 昆士兰大学 磺酰脲和相关化合物及其用途
WO2019121691A1 (en) * 2017-12-18 2019-06-27 NodThera Limited Sulphonyl urea derivatives as nlrp3 inflammasome modulators
WO2020035464A1 (en) * 2018-08-15 2020-02-20 Inflazome Limited Novel sulfonamideurea compounds
WO2020035466A1 (en) * 2018-08-15 2020-02-20 Inflazome Limited Novel sulfoneurea compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"RN:147000-89-3";ACS;STN registry数据库;19930415;第1页 *

Also Published As

Publication number Publication date
ES3056339T3 (en) 2026-02-19
US20230083495A1 (en) 2023-03-16
JP2022536160A (ja) 2022-08-12
JP7661248B2 (ja) 2025-04-14
EP3983407A1 (en) 2022-04-20
CN114222739A (zh) 2022-03-22
WO2020249664A1 (en) 2020-12-17
EP3983407C0 (en) 2025-11-12
EP3983407B1 (en) 2025-11-12

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