CN114190379A - Universal high-stability monoperoxyacetic acid disinfectant and preparation method thereof - Google Patents
Universal high-stability monoperoxyacetic acid disinfectant and preparation method thereof Download PDFInfo
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- CN114190379A CN114190379A CN202111360183.4A CN202111360183A CN114190379A CN 114190379 A CN114190379 A CN 114190379A CN 202111360183 A CN202111360183 A CN 202111360183A CN 114190379 A CN114190379 A CN 114190379A
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- acid
- percent
- disinfectant
- stability
- monoperoxyacetic
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 32
- 239000002253 acid Substances 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims abstract description 48
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 40
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229960000583 acetic acid Drugs 0.000 claims abstract description 20
- 239000012362 glacial acetic acid Substances 0.000 claims abstract description 20
- 238000003756 stirring Methods 0.000 claims abstract description 18
- BAERPNBPLZWCES-UHFFFAOYSA-N (2-hydroxy-1-phosphonoethyl)phosphonic acid Chemical compound OCC(P(O)(O)=O)P(O)(O)=O BAERPNBPLZWCES-UHFFFAOYSA-N 0.000 claims abstract description 16
- CABMTIJINOIHOD-UHFFFAOYSA-N 2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]quinoline-3-carboxylic acid Chemical compound N1C(=O)C(C(C)C)(C)N=C1C1=NC2=CC=CC=C2C=C1C(O)=O CABMTIJINOIHOD-UHFFFAOYSA-N 0.000 claims abstract description 13
- WJJMNDUMQPNECX-UHFFFAOYSA-N Dipicolinic acid Natural products OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 11
- 230000032683 aging Effects 0.000 abstract description 4
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 239000003381 stabilizer Substances 0.000 abstract description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 230000009471 action Effects 0.000 description 6
- 244000063299 Bacillus subtilis Species 0.000 description 5
- 235000014469 Bacillus subtilis Nutrition 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a universal high-stability monoperoxyacetic acid disinfectant and a preparation method thereof, wherein the disinfectant comprises the following raw materials in percentage by weight: 32 to 50 percent of glacial acetic acid, 42 to 58 percent of hydrogen peroxide, 0.1 to 2 percent of hydroxyethylidene diphosphonic acid, 0.1 to 2 percent of 2, 6-pyridine dicarboxylic acid and the balance of water. The preparation method comprises the following steps: dissolving the 2, 6-pyridinedicarboxylic acid in water under stirring for 10-20min, adding hydroxyethylidene diphosphonic acid, stirring for dissolving, sequentially adding glacial acetic acid and hydrogen peroxide, stirring for 15min to obtain final solution, and aging at 25 deg.C for 2 days to obtain monoperoxyacetic acid disinfectant. The disinfectant of the invention uses the compound stabilizer of hydroxyethylidene diphosphonic acid and 2, 6-pyridine dicarboxylic acid, the concentration of peroxyacetic acid reaches more than 15 percent, the stability is good, the curing time is short, and the production is easy.
Description
Technical Field
The invention relates to the technical field of disinfectants, in particular to a universal high-stability monoperoxyacetic acid disinfectant and a preparation method thereof.
Background
Peroxyacetic acid is generally prepared by reacting glacial acetic acid with hydrogen peroxide under the catalysis of concentrated sulfuric acid. However, in the actual production process, concentrated sulfuric acid has strong corrosivity, and safety accidents are easy to happen during production, so that the concentrated sulfuric acid is avoided as much as possible during the actual production. If concentrated sulfuric acid is not used, the time for generating 15% peroxyacetic acid by the reaction of glacial acetic acid and hydrogen peroxide is long, and when the temperature is less than 15 ℃, the reaction time is required to exceed 14 days, so that the production progress is seriously influenced; secondly, peroxyacetic acid with concentrated sulfuric acid has poor stability. The invention can be cured for 2 days at the room temperature of 25 ℃ to reach more than 15 percent, the operation is safe and the curing time is short.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a general high-stability monoperoxyacetic acid disinfectant, and the formula has the advantages of short curing time, low temperature requirement, good stability, good safety and easy production.
The invention also aims to provide a preparation method of the monoperoxyacetic acid disinfectant.
In order to achieve the purpose, the invention adopts the following technical scheme:
a general type high-stability monoperoxyacetic acid disinfectant comprises the following raw materials in percentage by weight: 32 to 50 percent of glacial acetic acid, 42 to 58 percent of hydrogen peroxide, 0.1 to 2 percent of hydroxyethylidene diphosphonic acid, 0.1 to 2 percent of 2, 6-pyridine dicarboxylic acid and the balance of water.
The preparation method comprises the following steps:
adding water into the 2, 6-pyridinedicarboxylic acid, stirring and dissolving for 10-20min, then adding hydroxyethylidene diphosphonic acid, stirring and dissolving, sequentially adding glacial acetic acid and hydrogen peroxide, stirring for 15min, preparing a final solution, and finally curing the final solution at 25 ℃ for 2 days to obtain the unitary peroxyacetic acid disinfectant.
The technical requirements for preparing the raw materials of the invention are as follows: glacial acetic acid (industrial grade more than 99%), hydrogen peroxide (industrial grade more than 50%), hydroxyethylidene diphosphonic acid (industrial grade more than 99%), 2, 6-pyridinedicarboxylic acid (industrial grade more than 99%).
Advantageous effects
Compared with the prior art, the invention has the following beneficial effects:
1. the general high-stability unitary peracetic acid disinfectant accelerates for 14 days at 54 ℃, the degradation rate of peracetic acid is only 6.5%, the shelf life of the product reaches 1 year, and the stock solution has good stability. The disinfectant of the invention uses the compound stabilizer of hydroxyethylidene diphosphonic acid and 2, 6-pyridine dicarboxylic acid, the concentration of peroxyacetic acid reaches more than 15 percent, the stability is good, the curing time is short, and the production is easy.
2. The general high-stability unitary peracetic acid disinfectant can reach 15% only by curing for 2 days, and the peracetic acid has higher peracetic acid content and shortened production period under the condition that the addition contents of glacial acetic acid and hydrogen peroxide are the same; concentrated sulfuric acid is not used, so that the cost is saved, the production safety is improved, and safety accidents are avoided.
3. The concentration of the general high-stability monoperoxyacetic acid disinfectant is 1800ppm, the action temperature is 65 ℃, the action time is 18s, and the average killing logarithm value of the black variety ATCC9372 of the bacillus subtilis is more than 5.
Detailed Description
The present invention will be further described with reference to the following examples, which are not intended to limit the scope of the present invention, but are intended to cover modifications within the scope of the present invention.
Example 1:
a general type high-stability monoperoxyacetic acid disinfectant comprises the following raw materials in percentage by weight: 35% of glacial acetic acid, 55% of hydrogen peroxide, 0.5% of hydroxyethylidene diphosphonic acid, 0.5% of 2, 6-pyridinedicarboxylic acid and 9% of water.
The preparation method comprises the following steps: dissolving the 2.6-pyridinedicarboxylic acid in water under stirring for 20min, adding hydroxyethylidene diphosphonic acid, dissolving under stirring, sequentially adding glacial acetic acid and glacial acetic acid, stirring for 15min to obtain final solution, and aging at 25 deg.C for 2 days to obtain monoprotic peroxyacetic acid disinfectant.
Example 2:
a general type high-stability monoperoxyacetic acid disinfectant comprises the following raw materials in percentage by weight: glacial acetic acid 32%, hydrogen peroxide 53%, hydroxyethylidene diphosphonic acid 0.5%, 2, 6-pyridine dicarboxylic acid 1.0% and water 13.5%.
The preparation method comprises the following steps: dissolving the 2.6-pyridinedicarboxylic acid in water under stirring for 15min, adding hydroxyethylidene diphosphonic acid, dissolving under stirring, sequentially adding glacial acetic acid and glacial acetic acid, stirring for 15min to obtain final solution, and aging at 25 deg.C for 2 days to obtain monoprotic peroxyacetic acid disinfectant.
Example 3:
a general type high-stability monoperoxyacetic acid disinfectant comprises the following raw materials in percentage by weight: glacial acetic acid 42%, hydrogen peroxide 49%, hydroxyethylidene diphosphonic acid 0.2%, 2, 6-pyridine dicarboxylic acid 0.8% and water 8%.
The preparation method comprises the following steps: dissolving the 2.6-pyridinedicarboxylic acid in water under stirring for 10min, adding hydroxyethylidene diphosphonic acid, dissolving under stirring, sequentially adding glacial acetic acid and glacial acetic acid, stirring for 15min to obtain final solution, and aging at 25 deg.C for 2 days to obtain monoprotic peroxyacetic acid disinfectant.
The invention is further explained below by means of experimental tests:
(I) stock solution stability test
The general type high-stability unitary peracetic acid disinfectant is stored for 14 days at 54 ℃, and the change of the content of the peracetic acid is detected according to a method in disinfection technical specifications. The test was repeated twice and the results are shown in Table 1.
TABLE 1 stability of stock solutions of the invention
The result shows that the universal high-stability unitary peracetic acid disinfectant accelerates the 54 ℃ for 14 days, the degradation rate of the peracetic acid is only 6.5%, and the shelf life of the product reaches 1 year.
(II) curing time
The general high-stability unitary peroxyacetic acid disinfectant is cured at 20 ℃ and 25 ℃, the change of the content of peroxyacetic acid and the content of hydrogen peroxide are respectively measured, and the result is shown in table 2 according to the method in disinfection technical specification.
TABLE 2 curing time under different temperature conditions of the invention
The result shows that the general high-stability monoperoxyacetic acid disinfectant can be aged for 2 days at 25 ℃ to reach 15 percent, and can be aged for 3 days at 20 ℃ to reach 15 percent. The invention shortens the production period, saves the cost, does not use concentrated sulfuric acid, improves the production safety and avoids safety accidents.
(III) killing test on Bacillus subtilis var niger ATCC9372
The general type high-stability unitary peroxyacetic acid disinfectant disclosed by the invention is used for carrying out a killing test on the black variant of bacillus subtilis ATCC9372 under the conditions of the concentration of the peroxyacetic acid being 1800ppm, the action temperature being 65 ℃ and the action time being 18s, the killing test is carried out according to a method in 'disinfection technical Specification', and 3 times of tests are carried out in total, and the results are shown in Table 3.
TABLE 3 kill test of the invention against the black variety of Bacillus subtilis
The result shows that the concentration of the universal high-stability monoperoxyacetic acid disinfectant is 1800ppm, the action temperature is 65 ℃, and the action time is 18s, and the average killing logarithm value of the black variety ATCC9372 of the bacillus subtilis is more than 5.
Claims (3)
1. A general type high-stability unitary peroxyacetic acid disinfectant is characterized by comprising the following raw materials in percentage by weight: 32 to 50 percent of glacial acetic acid, 42 to 58 percent of hydrogen peroxide, 0.1 to 2 percent of hydroxyethylidene diphosphonic acid, 0.1 to 2 percent of 2, 6-pyridine dicarboxylic acid and the balance of water.
2. A preparation method of a universal high-stability monoperoxyacetic acid disinfectant is characterized by comprising the following steps: the preparation method comprises the following preparation processes: adding water into the 2, 6-pyridinedicarboxylic acid, stirring and dissolving for 10-20min, then adding hydroxyethylidene diphosphonic acid, stirring and dissolving, sequentially adding glacial acetic acid and hydrogen peroxide, stirring for 15min, preparing a final solution, and finally curing the final solution at 25 ℃ for 2 days to obtain the unitary peroxyacetic acid disinfectant.
3. The general-purpose high-stability monoperoxyacetic acid disinfectant as claimed in claim 1, wherein the raw material technical requirements are as follows:
glacial acetic acid: the industrial grade is more than 99 percent;
hydrogen peroxide: industrial grade is more than 50%;
hydroxyethylidene diphosphonic acid: the industrial grade is more than 99 percent;
2, 6-pyridinedicarboxylic acid: the industrial grade is more than 99 percent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111360183.4A CN114190379A (en) | 2021-11-17 | 2021-11-17 | Universal high-stability monoperoxyacetic acid disinfectant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111360183.4A CN114190379A (en) | 2021-11-17 | 2021-11-17 | Universal high-stability monoperoxyacetic acid disinfectant and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114190379A true CN114190379A (en) | 2022-03-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111360183.4A Pending CN114190379A (en) | 2021-11-17 | 2021-11-17 | Universal high-stability monoperoxyacetic acid disinfectant and preparation method thereof |
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| Country | Link |
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| CN (1) | CN114190379A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115418276A (en) * | 2022-09-16 | 2022-12-02 | 西安科曼多生物技术有限公司 | Strong decontamination CIP alkaline cleaning agent and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991007375A1 (en) * | 1989-11-10 | 1991-05-30 | Eka Nobel Ab | Peracetic acid composition |
| WO2001044176A1 (en) * | 1999-12-17 | 2001-06-21 | Degussa Ag | Method for producing peroxycarboxylic acid solutions, especially equilibrium peracetic acid and perpropionic acid |
| BE1020013A3 (en) * | 2011-07-11 | 2013-03-05 | Christeyns Nv | PRODUCTION OF MORE STABLE PERSONS. |
| CN104703926A (en) * | 2012-10-05 | 2015-06-10 | 艺康美国股份有限公司 | Stable percarboxylic acid compositions and uses thereof |
| CN110115271A (en) * | 2019-04-22 | 2019-08-13 | 肇庆大华农生物药品有限公司 | A kind of compound disinfectant with hydrogen peroxide dilution, purposes and the method for egg surface sterilization |
| CN110115266A (en) * | 2019-04-22 | 2019-08-13 | 肇庆大华农生物药品有限公司 | A kind of Compound Hydrogen Peroxide Disinfectant and preparation method thereof |
| CN112479963A (en) * | 2020-12-24 | 2021-03-12 | 武汉致远天合化工有限公司 | Method and device for preparing peroxyacetic acid |
| CN112956475A (en) * | 2021-01-25 | 2021-06-15 | 海韵一剑大卫生科技有限公司 | Foam type peroxyacetic acid disinfectant, and preparation method and use method thereof |
| CN113039260A (en) * | 2018-11-12 | 2021-06-25 | 三菱瓦斯化学株式会社 | Composition for sterilization and cleaning, method for producing same, and method for sterilization and cleaning using same |
-
2021
- 2021-11-17 CN CN202111360183.4A patent/CN114190379A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991007375A1 (en) * | 1989-11-10 | 1991-05-30 | Eka Nobel Ab | Peracetic acid composition |
| WO2001044176A1 (en) * | 1999-12-17 | 2001-06-21 | Degussa Ag | Method for producing peroxycarboxylic acid solutions, especially equilibrium peracetic acid and perpropionic acid |
| BE1020013A3 (en) * | 2011-07-11 | 2013-03-05 | Christeyns Nv | PRODUCTION OF MORE STABLE PERSONS. |
| CN104703926A (en) * | 2012-10-05 | 2015-06-10 | 艺康美国股份有限公司 | Stable percarboxylic acid compositions and uses thereof |
| CN113039260A (en) * | 2018-11-12 | 2021-06-25 | 三菱瓦斯化学株式会社 | Composition for sterilization and cleaning, method for producing same, and method for sterilization and cleaning using same |
| CN110115271A (en) * | 2019-04-22 | 2019-08-13 | 肇庆大华农生物药品有限公司 | A kind of compound disinfectant with hydrogen peroxide dilution, purposes and the method for egg surface sterilization |
| CN110115266A (en) * | 2019-04-22 | 2019-08-13 | 肇庆大华农生物药品有限公司 | A kind of Compound Hydrogen Peroxide Disinfectant and preparation method thereof |
| CN112479963A (en) * | 2020-12-24 | 2021-03-12 | 武汉致远天合化工有限公司 | Method and device for preparing peroxyacetic acid |
| CN112956475A (en) * | 2021-01-25 | 2021-06-15 | 海韵一剑大卫生科技有限公司 | Foam type peroxyacetic acid disinfectant, and preparation method and use method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115418276A (en) * | 2022-09-16 | 2022-12-02 | 西安科曼多生物技术有限公司 | Strong decontamination CIP alkaline cleaning agent and preparation method thereof |
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Application publication date: 20220318 |