CN114177240A - Sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation and preparation method thereof - Google Patents
Sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation and preparation method thereof Download PDFInfo
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Abstract
The invention provides a sugar-coated tablet for relaxing muscles and tendons and activating blood circulation and a preparation method thereof, wherein safflower, lycopodium clavatum, Chinese starjasmine stem and calcined native copper are decocted by adding water for 3 times, each time is 1.5 hours, the precipitation is 24 hours, the filtration is carried out, the filtrate is concentrated into water decoction, the concentration and the precipitation are 24 hours for standby, mistletoe, scalded cibotium rhizome, cortex periplocae, herba lycopi, mistletoe and caulis spatholobi are extracted by refluxing with 70% ethanol for three times, each time is 1 hour, the filtration is carried out, the ethanol is recovered, the filtrate is concentrated into ethanol extract for standby, the ethanol extract and the water decoction are combined, the mixture is concentrated into thick paste, the thick paste is concentrated into 18 DEG Be (75 ℃), and the spray drying is carried out to obtain extract powder. Mixing the extract powder, sucrose and magnesium stearate, granulating with fluidized bed, mixing, tabletting, coating, and packaging. The prepared sugar-coated tablet for relaxing muscles and tendons and activating blood circulation has stable quality, accurate medicine content and convenient and quick taking, and is used for relaxing muscles and tendons and activating collaterals, activating blood and removing blood stasis, and is used for treating arthralgia and myalgia, limb spasm, waist and back ache and traumatic injury.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation and a preparation method thereof.
Background
The waist sprain and contusion is a common waist tendon injury disease which is mostly seen in young and young, rheumatism is a disease encountered by most of middle-aged and old people, the key reason is caused by overstrain in young, and the blood-activating tablet has a good curative effect as a Chinese patent medicine for relaxing tendons and activating collaterals and promoting blood circulation and removing blood stasis.
The direct use of water extraction, alcohol extraction and oil extraction or grinding of traditional Chinese medicines is the routine choice of the technicians in the field
Disclosure of Invention
The invention aims to overcome the defects that part of medicinal materials are directly crushed and part of medicinal materials are extracted by alcohol, and medicinal components cannot be effectively extracted in the prior art, and provides the sugar-coated tablet for relaxing muscles and tendons and activating blood circulation and the preparation method thereof.
In order to solve the problems of the prior art, the invention adopts the technical scheme that:
a sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation comprises the following raw materials in parts by weight: 15-20 parts of safflower, 70-80 parts of vinegar-processed rhizoma cyperi, 95-105 parts of scalded rhizoma cibotii, 45-55 parts of cortex periplocae, 70-80 parts of Chinese starjasmine stem, 70-80 parts of lycopodium clavatum, 70-80 parts of herba lycopi, 95-105 parts of mistletoe, 70-80 parts of caulis spatholobi, 5-10 parts of calcined native copper and 3105 parts of magnesium stearate 3115.
Preferably, the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation comprises the following raw materials in parts by weight: 19 parts of safflower, 77 parts of vinegar-processed rhizoma cyperi, 103 parts of scalded rhizoma cibotii, 50 parts of cortex periplocae, 77 parts of Chinese starjasmine stem, 77 parts of lycopodium clavatum, 77 parts of herba lycopi, 103 parts of mistletoe, 77 parts of caulis spatholobi, 11 parts of calcined pyrite and 3110 parts of magnesium stearate.
The application also discloses a preparation method of the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation, which comprises the following steps:
step 1: decocting Carthami flos, herba Lycopodii, caulis Trachelospermi, and Pyritum preparata for three times (2 hr each time), filtering, concentrating to obtain 6 ° Be (75 deg.C), precipitating for 24 hr, and decocting with water;
step 2: extracting rhizoma Cyperi (processed with vinegar), rhizoma Cibotii, cortex Periplocae Radicis, herba Lycopi, herba Visci, and caulis Spatholobi with ethanol under reflux for three times (each for 1.5 hr), filtering, and concentrating the ethanol extractive solution;
and step 3: combining the water decoction obtained in the step 1 and the alcohol extract obtained in the step 2, concentrating under reduced pressure until the concentration is 15-20 degrees Be (75 ℃), obtaining clear paste in a D-grade clean area, and performing spray drying to obtain clear paste powder for later use;
and 4, step 4: mixing the clear paste powder and magnesium stearate in a D-level clean area, granulating, totally mixing, tabletting, coating, subpackaging and packaging to obtain the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation.
Preferably, the decocting temperature in the step 1 is 100 ℃.
Preferably, the ethanol concentration in the step 2 is 70%.
In the raw materials, safflower: pungent flavor and warm nature. Promoting blood circulation, dredging channels, removing blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, thoracic and hypochondriac pain, traumatic injury, and pain and swelling of skin and external diseases;
in the raw materials, the vinegar rhizoma cyperi: pungent, slightly bitter, slightly sweet and neutral in nature. To soothe the liver, relieve depression, regulate qi, relieve epigastric distention, regulate menstruation and alleviate pain. Can be used for treating stagnation of qi due to depression of the liver, distending pain in chest and hypochondrium, hernia pain, breast pain, stagnation of qi in spleen and stomach, abdominal distention, fullness and pain, menoxenia, amenorrhea and dysmenorrhea;
among raw materials, scalding rhizoma cibotii: bitter and sweet in taste and warm in nature. Dispel wind, tonify liver and kidney. Can be used for treating rheumatalgia, soreness of waist and knees, and weakness of lower limbs;
in the raw materials, cortex periplocae: pungent and bitter in flavor, warm in nature, and toxic. Induce diuresis to alleviate edema, dispel wind-damp, strengthen tendons and bones. Can be used for treating edema of lower limbs, palpitation, short breath, arthralgia due to wind-cold-dampness, and soreness of waist and knees;
in the raw materials, Chinese starjasmine stem: bitter in taste and slightly cold in nature. Dispel wind, dredge collaterals, cool blood and relieve swelling. Can be used for treating rheumatism, pyretic arthralgia, muscular spasm, soreness of waist and knees, pharyngitis, carbuncle, swelling, and traumatic injury;
among the raw materials, lycopodium clavatum: slightly bitter and pungent taste, warm nature. Dispel wind and dampness, relax tendons and activate collaterals. Can be used for treating joint pain and difficulty in flexion and extension;
in the raw materials, herba lycopi: bitter and pungent in flavor, slightly warm in nature. Promote blood circulation to regulate menstruation, dispel stasis to cure abscess, induce diuresis to alleviate edema. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, puerperal blood stasis and abdominal pain, skin ulcer, carbuncle, toxic swelling, edema, and ascites;
in the raw materials, mistletoe: bitter taste and mild nature. Dispel wind-damp, tonify liver and kidney, strengthen tendons and bones, and prevent abortion. Can be used for treating rheumatalgia, soreness of waist and knees, weakness of bones and muscles, metrorrhagia, metrostaxis, pregnant hemorrhage, threatened abortion, and dizziness;
in the raw materials, caulis spatholobi: bitter and sweet in taste and warm in nature. Promoting blood circulation, tonifying blood, regulating menstruation, relieving pain, relaxing muscles and tendons, and activating collateral flow. Can be used for treating menoxenia, dysmenorrhea, amenorrhea, rheumatalgia, numbness, paralysis, phlegm, and blood deficiency sallow complexion;
in the raw materials, calcined pyrite: pungent flavor and mild property. Disperse blood stasis and alleviate pain, reunion of fractured tendons and bones. Can be used for treating traumatic injury, fracture, swelling and pain.
The sugar-coated tablet for relaxing muscles and stimulating blood circulation, prepared by the invention, has the following specifications: 0.33 g/tablet, the quality of the formula is controlled by the content of cortex Periplocae Radicis, and each tablet contains 4-methoxysalicylaldehyde (C)8H8O3) It is not less than 67. mu.g.
Has the advantages that:
compared with the prior art, the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation and the preparation method thereof have the following advantages:
the shape, appearance, identification, weight difference, disintegration time limit and microorganism limit of the invention all meet the requirements;
one part of the medicinal materials is subjected to water extraction, and the other part of the medicinal materials is subjected to alcohol extraction, so that the components in the medicinal materials can be extracted more effectively, and the content can be higher;
each tablet contains cortex Periplocae Radicis and 4-methoxysalicylaldehyde (C)8H8O3) The content is 66-71 μ g, the content is accurate, and the dosage can be accurately controlled;
after standing for 36 months, each tablet contains cortex Periplocae Radicis and 4-methoxysalicylaldehyde (C)8H8O3) The measured quantity is not less than 67 mu g, and the quality is stable;
the adopted preparation form is a tablet (sugar-coated tablet), can cover the unpleasant smell of the medicine, is easy to swallow and is convenient to store and transport.
Drawings
Fig. 1 is a flow chart of the present application.
Detailed Description
The present invention will be described in further detail below with reference to specific examples, but is not limited thereto.
Example 1
A sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation comprises the following raw materials in parts by weight: 17 parts of safflower, 77 parts of vinegar-processed rhizoma cyperi, 100 parts of scalded rhizoma cibotii, 51 parts of cortex periplocae, 77 parts of Chinese starjasmine stem, 77 parts of lycopodium clavatum, 76 parts of herba lycopi, 101 parts of mistletoe, 76 parts of caulis spatholobi, 10 parts of calcined pyrite and 3110 parts of magnesium stearate.
The preparation method of the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation comprises the following steps:
step 1: decocting Carthami flos, herba Lycopodii, caulis Trachelospermi, and Pyritum preparata for three times (2 hr each time), filtering, concentrating, precipitating for 24 hr, and collecting water decoction;
step 2: extracting rhizoma Cyperi (processed with vinegar), rhizoma Cibotii, cortex Periplocae Radicis, herba Lycopi, herba Visci, and caulis Spatholobi with ethanol under reflux for three times (each for 1.5 hr), filtering, and concentrating the ethanol extractive solution;
and step 3: combining the water decoction obtained in the step 1 and the ethanol extract obtained in the step 2, concentrating under reduced pressure until the concentration is 16-degree Be (75 ℃), obtaining clear paste in a D-level clean area, and performing spray drying to obtain clear paste powder for later use;
and 4, step 4: mixing the clear paste powder and magnesium stearate in a D-level clean area, granulating, totally mixing, tabletting, coating, subpackaging and packaging to obtain the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation.
The product detection of the embodiment: each tablet contains cortex Periplocae Radicis and 4-methoxysalicylaldehyde (C)8H8O3) The weight was 69. mu.g.
Example 2
A sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation comprises the following raw materials in parts by weight: 18 parts of safflower, 77 parts of vinegar-processed rhizoma cyperi, 102 parts of scalded rhizoma cibotii, 50 parts of cortex periplocae, 77 parts of Chinese starjasmine stem, 75 parts of lycopodium clavatum, 77 parts of herba lycopi, 102 parts of mistletoe, 77 parts of caulis spatholobi, 11 parts of calcined pyrite and 3110 parts of magnesium stearate.
The preparation method of the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation comprises the following steps:
step 1: decocting Carthami flos, herba Lycopodii, caulis Trachelospermi, and Pyritum preparata for three times (2 hr each time), filtering, concentrating, precipitating for 24 hr, and collecting water decoction;
step 2: extracting rhizoma Cyperi (processed with vinegar), rhizoma Cibotii, cortex Periplocae Radicis, herba Lycopi, herba Visci, and caulis Spatholobi with ethanol under reflux for three times (each for 1.5 hr), filtering, and concentrating the ethanol extractive solution;
and step 3: combining the water decoction obtained in the step 1 and the ethanol extract obtained in the step 2, concentrating under reduced pressure until the concentration is 17-degree Be (75 ℃), obtaining clear paste in a D-level clean area, and performing spray drying to obtain clear paste powder for later use;
and 4, step 4: mixing the clear paste powder and magnesium stearate in a D-level clean area, granulating, totally mixing, tabletting, coating, subpackaging and packaging to obtain the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation.
The product detection of the embodiment: each tablet contains cortex Periplocae Radicis and 4-methoxysalicylaldehyde (C)8H8O3) Calculated as 68 μ g.
Example 3
A sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation comprises the following raw materials in parts by weight: 19 parts of safflower, 77 parts of vinegar-processed rhizoma cyperi, 103 parts of scalded rhizoma cibotii, 50 parts of cortex periplocae, 77 parts of Chinese starjasmine stem, 77 parts of lycopodium clavatum, 77 parts of herba lycopi, 103 parts of mistletoe, 77 parts of caulis spatholobi, 11 parts of calcined pyrite and 3110 parts of magnesium stearate.
The preparation method of the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation comprises the following steps:
step 1: decocting Carthami flos, herba Lycopodii, caulis Trachelospermi, and Pyritum preparata for three times (2 hr each time), filtering, concentrating, precipitating for 24 hr, and collecting water decoction;
step 2: extracting rhizoma Cyperi (processed with vinegar), rhizoma Cibotii, cortex Periplocae Radicis, herba Lycopi, herba Visci, and caulis Spatholobi with ethanol under reflux for three times (each for 1.5 hr), filtering, and concentrating the ethanol extractive solution;
and step 3: combining the water decoction obtained in the step 1 and the ethanol extract obtained in the step 2, concentrating under reduced pressure until the concentration is 18-degree Be (75 ℃), obtaining clear paste in a D-level clean area, and performing spray drying to obtain clear paste powder for later use;
and 4, step 4: mixing the clear paste powder and magnesium stearate in a D-level clean area, granulating, totally mixing, tabletting, coating, subpackaging and packaging to obtain the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation.
The product detection of the embodiment: each tablet contains cortex Periplocae Radicis and 4-methoxysalicylaldehyde (C)8H8O3) Calculated as 68 μ g.
The products of examples 1-3 were subjected to stability tests, the results of which are shown in tables 1-3:
table 1 shows the results of the product stability test of example 1
Table 1:
table 2 shows the results of the product stability test of example 2
Table 2:
table 3 shows the results of the product stability test of example 3
Table 3:
as can be seen from tables 1-3, the sugar-coated tablets for relaxing muscles and tendons and promoting blood circulation prepared by the invention have the following advantages:
(1) the shape, appearance, identification, weight difference, disintegration time limit and microorganism limit all meet the requirements;
(2) each tablet contains cortex Periplocae Radicis and 4-methoxysalicylaldehyde (C)8H8O3) The content is 66-71 μ g, the content is accurate, and the dosage can be accurately controlled;
after standing for 36 months, each tablet contains cortex Periplocae Radicis and 4-methoxysalicylaldehyde (C)8H8O3) The measured amount is not less than 67 mu g, and the quality is stable.
Claims (5)
1. A sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation is characterized in that: the composite material comprises the following raw materials in parts by weight: 15-20 parts of safflower, 70-80 parts of vinegar-processed rhizoma cyperi, 95-105 parts of scalded rhizoma cibotii, 45-55 parts of cortex periplocae, 70-80 parts of Chinese starjasmine stem, 70-80 parts of lycopodium clavatum, 70-80 parts of herba lycopi, 95-105 parts of mistletoe, 70-80 parts of caulis spatholobi, 5-10 parts of calcined native copper and 3105 parts of magnesium stearate 3115.
2. The sugar-coated tablet for relaxing muscles and stimulating blood circulation according to claim 1, wherein: the sugar-coated tablet for relaxing muscles and stimulating blood circulation comprises the following raw materials in parts by weight: 19 parts of safflower, 77 parts of vinegar-processed rhizoma cyperi, 103 parts of scalded rhizoma cibotii, 50 parts of cortex periplocae, 77 parts of Chinese starjasmine stem, 77 parts of lycopodium clavatum, 77 parts of herba lycopi, 103 parts of mistletoe, 77 parts of caulis spatholobi, 11 parts of calcined pyrite and 3110 parts of magnesium stearate.
3. A method for preparing a sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation according to claim 1 or 2, wherein: the method comprises the following steps:
step 1: decocting Carthami flos, herba Lycopodii, caulis Trachelospermi, and Pyritum preparata for three times (2 hr each time), filtering, concentrating to obtain 6 ° Be (75 deg.C), precipitating for 24 hr, and decocting with water;
step 2: extracting rhizoma Cyperi (processed with vinegar), rhizoma Cibotii, cortex Periplocae Radicis, herba Lycopi, herba Visci, and caulis Spatholobi with ethanol under reflux for three times (each for 1.5 hr), filtering, and concentrating the ethanol extractive solution;
and step 3: combining the water decoction obtained in the step 1 and the alcohol extract obtained in the step 2, concentrating under reduced pressure until the concentration is 15-20 degrees Be (75 ℃), obtaining clear paste in a D-grade clean area, and performing spray drying to obtain clear paste powder for later use;
and 4, step 4: mixing the clear paste powder and magnesium stearate in a D-level clean area, granulating, totally mixing, tabletting, coating, subpackaging and packaging to obtain the sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation.
4. The method for preparing a sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation according to claim 3, wherein: the decocting temperature in the step 1 is 100 ℃.
5. The method for preparing a sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation according to claim 3, wherein: the ethanol concentration in the step 2 is 70%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111598672.3A CN114177240A (en) | 2021-12-24 | 2021-12-24 | Sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111598672.3A CN114177240A (en) | 2021-12-24 | 2021-12-24 | Sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN114177240A true CN114177240A (en) | 2022-03-15 |
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| CN202111598672.3A Withdrawn CN114177240A (en) | 2021-12-24 | 2021-12-24 | Sugar-coated tablet for relaxing muscles and tendons and promoting blood circulation and preparation method thereof |
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| Country | Link |
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| CN (1) | CN114177240A (en) |
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