CN114174337B - 针对犬ctla-4的犬源化抗体 - Google Patents

针对犬ctla-4的犬源化抗体 Download PDF

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Publication number
CN114174337B
CN114174337B CN202080050841.7A CN202080050841A CN114174337B CN 114174337 B CN114174337 B CN 114174337B CN 202080050841 A CN202080050841 A CN 202080050841A CN 114174337 B CN114174337 B CN 114174337B
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seq
amino acid
acid sequence
canine
sequence
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Chinese (zh)
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CN114174337A (zh
Inventor
M·莫尔塞耶
张远征
I·塔佩
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Intervet International BV
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Intervet International BV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080050841.7A 2019-07-15 2020-07-15 针对犬ctla-4的犬源化抗体 Active CN114174337B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411406750.9A CN119241706A (zh) 2019-07-15 2020-07-15 针对犬ctla-4的犬源化抗体

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962874287P 2019-07-15 2019-07-15
US62/874287 2019-07-15
US201962926047P 2019-10-25 2019-10-25
US62/926047 2019-10-25
US202063048873P 2020-07-07 2020-07-07
US63/048873 2020-07-07
PCT/EP2020/069923 WO2021009187A1 (en) 2019-07-15 2020-07-15 Caninized antibodies against canine ctla-4

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202411406750.9A Division CN119241706A (zh) 2019-07-15 2020-07-15 针对犬ctla-4的犬源化抗体

Publications (2)

Publication Number Publication Date
CN114174337A CN114174337A (zh) 2022-03-11
CN114174337B true CN114174337B (zh) 2024-10-25

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Family Applications (2)

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CN202080050841.7A Active CN114174337B (zh) 2019-07-15 2020-07-15 针对犬ctla-4的犬源化抗体
CN202411406750.9A Pending CN119241706A (zh) 2019-07-15 2020-07-15 针对犬ctla-4的犬源化抗体

Family Applications After (1)

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CN202411406750.9A Pending CN119241706A (zh) 2019-07-15 2020-07-15 针对犬ctla-4的犬源化抗体

Country Status (8)

Country Link
US (1) US12435143B2 (https=)
EP (1) EP3999538A1 (https=)
JP (2) JP7757271B2 (https=)
CN (2) CN114174337B (https=)
AU (1) AU2020312686A1 (https=)
BR (1) BR112022000721A2 (https=)
CA (1) CA3145345A1 (https=)
WO (1) WO2021009187A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022226102A1 (en) * 2021-04-21 2022-10-27 The Trustees Of The University Of Pennsylvania Canine monoclonal antibodies against canine cytotoxic t lymphocyte associated protein 4 (ctla-4)
US12263232B1 (en) * 2024-06-10 2025-04-01 Wyvern Pharmaceuticals Inc. Composition for regulating production of proteins

Citations (1)

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CN107074952A (zh) * 2014-09-30 2017-08-18 英特维特国际股份有限公司 结合犬pd‑l1的pd‑l1抗体

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Also Published As

Publication number Publication date
BR112022000721A2 (pt) 2022-03-08
AU2020312686A1 (en) 2022-02-03
EP3999538A1 (en) 2022-05-25
JP7757271B2 (ja) 2025-10-21
US12435143B2 (en) 2025-10-07
CA3145345A1 (en) 2021-01-21
WO2021009187A1 (en) 2021-01-21
US20220251208A1 (en) 2022-08-11
JP2025159730A (ja) 2025-10-21
CN114174337A (zh) 2022-03-11
CN119241706A (zh) 2025-01-03
JP2022542808A (ja) 2022-10-07

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