CN114159421B - 包含反丁烯二酸二甲酯的药物组合物 - Google Patents
包含反丁烯二酸二甲酯的药物组合物 Download PDFInfo
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- CN114159421B CN114159421B CN202111543717.7A CN202111543717A CN114159421B CN 114159421 B CN114159421 B CN 114159421B CN 202111543717 A CN202111543717 A CN 202111543717A CN 114159421 B CN114159421 B CN 114159421B
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- dimethyl fumarate
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 80
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 title claims abstract description 67
- 229960004419 dimethyl fumarate Drugs 0.000 title claims abstract description 64
- 239000000203 mixture Substances 0.000 claims abstract description 59
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- 229920002785 Croscarmellose sodium Polymers 0.000 claims abstract description 26
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 26
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims abstract description 26
- 238000011282 treatment Methods 0.000 claims abstract description 26
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- 239000003085 diluting agent Substances 0.000 claims abstract description 22
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- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 8
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 8
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
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- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 6
- 239000001095 magnesium carbonate Substances 0.000 claims description 6
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 6
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 5
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| EP13382504.2 | 2013-12-12 | ||
| PCT/EP2014/076767 WO2015086467A1 (en) | 2013-12-12 | 2014-12-05 | Pharmaceutical compositions comprising dimethyl fumarate |
| CN201480066692.8A CN105813634A (zh) | 2013-12-12 | 2014-12-05 | 包含反丁烯二酸二甲酯的药物组合物 |
| CN202111543717.7A CN114159421B (zh) | 2013-12-12 | 2014-12-05 | 包含反丁烯二酸二甲酯的药物组合物 |
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| CN201480066692.8A Pending CN105813634A (zh) | 2013-12-12 | 2014-12-05 | 包含反丁烯二酸二甲酯的药物组合物 |
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| CN (2) | CN114159421B (https=) |
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| WO (1) | WO2015086467A1 (https=) |
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| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| ES2713157T3 (es) | 2014-02-28 | 2019-05-20 | Banner Life Sciences Llc | Cápsulas blandas entéricas de liberación controlada de ésteres de fumarato |
| WO2016194004A1 (en) * | 2015-06-01 | 2016-12-08 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical compositions of dimethyl fumarate |
| CA2990230A1 (en) | 2015-06-19 | 2016-12-22 | University Of Southern California | Compositions and methods for modified nutrient delivery |
| US10744070B2 (en) | 2015-06-19 | 2020-08-18 | University Of Southern California | Enteral fast access tract platform system |
| WO2017040272A1 (en) * | 2015-08-31 | 2017-03-09 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| EP3397247B1 (en) * | 2015-12-31 | 2023-06-07 | Zaklady Farmaceutyczne Polpharma SA | Process for preparation of an enteric coated granulate comprising dimethyl fumarate |
| PL3407873T3 (pl) * | 2016-01-28 | 2025-01-13 | Zakłady Farmaceutyczne POLPHARMA S.A. | Sposób otrzymywania granulatu zawierającego fumaran dimetylu |
| JP2019510743A (ja) * | 2016-02-12 | 2019-04-18 | ウニヴェルズィテート チューリッヒ | 痛風、ざ瘡及び糖尿病の予防又は治療のためのジメチルフマレート（ｄｍｆ） |
| WO2017145036A1 (en) * | 2016-02-25 | 2017-08-31 | Aurobindo Pharma Ltd | Pharmaceutical compositions comprising dimethyl fumarate |
| KR20200018458A (ko) | 2017-06-23 | 2020-02-19 | 알미랄, 에스.에이. | 디메틸 푸마레이트를 포함하는 약학 조성물 |
| JP7000148B2 (ja) * | 2017-12-27 | 2022-01-19 | 日本化薬株式会社 | ダサチニブを有効成分とする医薬組成物 |
| WO2020053218A1 (en) | 2018-09-13 | 2020-03-19 | Almirall, S.A. | Treatment of psoriasis |
| WO2020053219A1 (en) | 2018-09-13 | 2020-03-19 | Almirall, S.A. | Treatment of psoriasis |
| AU2020283238B2 (en) * | 2019-05-31 | 2022-07-07 | Curacle Co., Ltd. | Enteric tablet containing dimethyl fumarate |
| JP6744518B1 (ja) * | 2019-11-07 | 2020-08-19 | 旭化成株式会社 | セルロース組成物及び錠剤 |
| US11903918B2 (en) | 2020-01-10 | 2024-02-20 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
| US12138351B2 (en) * | 2020-04-14 | 2024-11-12 | Janssen Biotech, Inc. | Pharmaceutical composition for oral administration comprising aminopyrimidine derivative or pharmaceutically acceptable salt, hydrate, or solvate thereof |
| WO2022203432A1 (ko) * | 2021-03-25 | 2022-09-29 | 주식회사 큐라클 | 특정 약동학적 매개변수를 나타내는 디메틸푸마레이트를 유효성분으로 함유한 약학적 조성물 |
| EP4313023A1 (en) * | 2021-04-02 | 2024-02-07 | Biogen MA Inc. | Combination treatment methods of multiple sclerosis |
| WO2024232931A1 (en) * | 2023-05-11 | 2024-11-14 | Yon Doo Ough | Apparatus and method for contact free delivery and administration of magnesium as a drug |
| WO2025235457A1 (en) | 2024-05-09 | 2025-11-13 | Alsteni Medical, Inc. | Intraoral gastrointestinal access device and related methods |
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