CN114146165A - 一种聚合血红蛋白在制备防治呼吸衰竭药物中的应用 - Google Patents
一种聚合血红蛋白在制备防治呼吸衰竭药物中的应用 Download PDFInfo
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- CN114146165A CN114146165A CN202111462838.9A CN202111462838A CN114146165A CN 114146165 A CN114146165 A CN 114146165A CN 202111462838 A CN202111462838 A CN 202111462838A CN 114146165 A CN114146165 A CN 114146165A
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- sodium
- polymerized hemoglobin
- medicament
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- hemoglobin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 受试药物 | 剂量 |
模型组 | 生理盐水 | 12.31ml/kg |
药物组 | 聚合血红蛋白药物 | 800mg/kg |
正常组 | 生理盐水 | 12.31ml/kg |
分组 | NS组 | LPS组 | HBOC组 |
致伤后6h平均体重 | 229g | 221g | 227g |
MMP-9 | MMP-12 | Caspase-12 | CHOP | |
正常组 | 6.31 | 6.08 | 1557.66 | 1217.82 |
模型组 | 145.46 | 123.74 | 10418.63 | 10271.29 |
阳性对照组 | 60.07 | 50.58 | 7295.39 | 7208.45 |
药物组 | 53.12 | 42.21 | 6223.67 | 6226.35 |
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111462838.9A CN114146165B (zh) | 2021-12-02 | 2021-12-02 | 一种聚合血红蛋白在制备防治呼吸衰竭药物中的应用 |
PCT/CN2021/135696 WO2023097706A1 (zh) | 2021-12-02 | 2021-12-06 | 一种聚合血红蛋白在制备防治呼吸衰竭药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN202111462838.9A CN114146165B (zh) | 2021-12-02 | 2021-12-02 | 一种聚合血红蛋白在制备防治呼吸衰竭药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN114146165A true CN114146165A (zh) | 2022-03-08 |
CN114146165B CN114146165B (zh) | 2022-08-12 |
Family
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Family Applications (1)
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CN202111462838.9A Active CN114146165B (zh) | 2021-12-02 | 2021-12-02 | 一种聚合血红蛋白在制备防治呼吸衰竭药物中的应用 |
Country Status (2)
Country | Link |
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CN (1) | CN114146165B (zh) |
WO (1) | WO2023097706A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115120580A (zh) * | 2022-07-14 | 2022-09-30 | 中国人民解放军军事科学院军事医学研究院 | 姜黄素在制备血红蛋白供氧效能调节剂中的应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4826811A (en) * | 1986-06-20 | 1989-05-02 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
CN102026654A (zh) * | 2008-03-18 | 2011-04-20 | 麦德佰欧法姆有限公司俄罗斯联邦 | 具有氧气转运功能的血液代用品,药物组合物(任选项) |
CN104379160A (zh) * | 2012-03-29 | 2015-02-25 | 桑加特公司 | 双阿司匹林交联聚乙二醇化血红蛋白 |
CN107625954A (zh) * | 2016-07-19 | 2018-01-26 | 上海本素医药科技有限公司 | 含一氧化碳的血红蛋白制剂及其在抗炎症中的应用 |
CN110522904A (zh) * | 2019-09-09 | 2019-12-03 | 润方(北京)生物医药研究院有限公司 | 一种抑制血压升高的聚合血红蛋白 |
CN110563836A (zh) * | 2019-09-09 | 2019-12-13 | 润方(北京)生物医药研究院有限公司 | 交联血红蛋白的制备方法及包含该血红蛋白的器官灌注液 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2026824A2 (en) * | 2006-05-09 | 2009-02-25 | The United States Of America As Represented By the Sectretary of the Navy | Multifunctional blood substitute |
DE102013014651A1 (de) * | 2013-09-03 | 2015-03-05 | Sanguibiotech Gmbh | Zubereitungen zur verbesserten Gewebe-Oxygenierung durch peritoneale Beatmung |
WO2016022554A1 (en) * | 2014-08-04 | 2016-02-11 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
-
2021
- 2021-12-02 CN CN202111462838.9A patent/CN114146165B/zh active Active
- 2021-12-06 WO PCT/CN2021/135696 patent/WO2023097706A1/zh unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4826811A (en) * | 1986-06-20 | 1989-05-02 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
CN102026654A (zh) * | 2008-03-18 | 2011-04-20 | 麦德佰欧法姆有限公司俄罗斯联邦 | 具有氧气转运功能的血液代用品,药物组合物(任选项) |
CN104379160A (zh) * | 2012-03-29 | 2015-02-25 | 桑加特公司 | 双阿司匹林交联聚乙二醇化血红蛋白 |
CN107625954A (zh) * | 2016-07-19 | 2018-01-26 | 上海本素医药科技有限公司 | 含一氧化碳的血红蛋白制剂及其在抗炎症中的应用 |
CN110522904A (zh) * | 2019-09-09 | 2019-12-03 | 润方(北京)生物医药研究院有限公司 | 一种抑制血压升高的聚合血红蛋白 |
CN110563836A (zh) * | 2019-09-09 | 2019-12-13 | 润方(北京)生物医药研究院有限公司 | 交联血红蛋白的制备方法及包含该血红蛋白的器官灌注液 |
Non-Patent Citations (2)
Title |
---|
SOPHIE LANZKRON等: "Polymerized human Hb use in acute chest syndrome: a case report", 《TRANSFUSION PRACTICE》, vol. 42, 30 November 2002 (2002-11-30), pages 1422 - 1427 * |
李红英: "聚合人脐带血红蛋白对复苏失血性休克大鼠肺组织的影响", 《中国优秀博硕士学位论文全文数据库(硕士) 医药卫生科技辑》, no. 2, 15 February 2020 (2020-02-15), pages 060 - 395 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115120580A (zh) * | 2022-07-14 | 2022-09-30 | 中国人民解放军军事科学院军事医学研究院 | 姜黄素在制备血红蛋白供氧效能调节剂中的应用 |
Also Published As
Publication number | Publication date |
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CN114146165B (zh) | 2022-08-12 |
WO2023097706A1 (zh) | 2023-06-08 |
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Effective date of registration: 20230426 Address after: 102600 room 402, 4 / F, building 19, No. 99, Kechuang 14th Street, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee after: REDPHARM (BEIJING) BIOMEDICAL RESEARCH INSTITUTE Co.,Ltd. Patentee after: Runfang (Changchun) Biotechnology Co.,Ltd. Patentee after: Runfang (Beijing) Biotechnology Co.,Ltd. Patentee after: You Kewei Address before: 102600 room 402, 4 / F, building 19, No. 99, Kechuang 14th Street, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee before: REDPHARM (BEIJING) BIOMEDICAL RESEARCH INSTITUTE Co.,Ltd. Patentee before: Runfang (Beijing) Biotechnology Co.,Ltd. Patentee before: You Kewei |
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Effective date of registration: 20230628 Address after: 101149 building 19, No. 99, Kechuang 14th Street, economic and Technological Development Zone, Daxing District, Beijing Patentee after: REDPHARM (BEIJING) BIOMEDICAL RESEARCH INSTITUTE Co.,Ltd. Patentee after: Runfang (Changchun) Biotechnology Co.,Ltd. Patentee after: Runfang (Beijing) Biotechnology Co.,Ltd. Address before: 102600 room 402, 4 / F, building 19, No. 99, Kechuang 14th Street, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee before: REDPHARM (BEIJING) BIOMEDICAL RESEARCH INSTITUTE Co.,Ltd. Patentee before: Runfang (Changchun) Biotechnology Co.,Ltd. Patentee before: Runfang (Beijing) Biotechnology Co.,Ltd. Patentee before: You Kewei |