CN114145453A - 适用于早产儿和低出生体重儿的母乳营养补充剂 - Google Patents
适用于早产儿和低出生体重儿的母乳营养补充剂 Download PDFInfo
- Publication number
- CN114145453A CN114145453A CN202111525899.5A CN202111525899A CN114145453A CN 114145453 A CN114145453 A CN 114145453A CN 202111525899 A CN202111525899 A CN 202111525899A CN 114145453 A CN114145453 A CN 114145453A
- Authority
- CN
- China
- Prior art keywords
- percent
- locust bean
- bean gum
- breast milk
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000020256 human milk Nutrition 0.000 title claims abstract description 27
- 210000004251 human milk Anatomy 0.000 title claims abstract description 27
- 208000018773 low birth weight Diseases 0.000 title claims abstract description 15
- 231100000533 low birth weight Toxicity 0.000 title claims abstract description 15
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 13
- 230000002028 premature Effects 0.000 title claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 34
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 28
- 229920000161 Locust bean gum Polymers 0.000 claims abstract description 23
- 239000000711 locust bean gum Substances 0.000 claims abstract description 23
- 235000010420 locust bean gum Nutrition 0.000 claims abstract description 23
- 235000000346 sugar Nutrition 0.000 claims abstract description 23
- 229920002472 Starch Polymers 0.000 claims abstract description 22
- 239000008107 starch Substances 0.000 claims abstract description 22
- 235000019698 starch Nutrition 0.000 claims abstract description 22
- 150000001875 compounds Chemical class 0.000 claims abstract description 21
- 239000007787 solid Substances 0.000 claims abstract description 21
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 16
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 16
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 16
- 235000010755 mineral Nutrition 0.000 claims abstract description 16
- 239000011707 mineral Substances 0.000 claims abstract description 16
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 15
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 15
- 229940088594 vitamin Drugs 0.000 claims abstract description 15
- 229930003231 vitamin Natural products 0.000 claims abstract description 15
- 235000013343 vitamin Nutrition 0.000 claims abstract description 15
- 239000011782 vitamin Substances 0.000 claims abstract description 15
- 235000021119 whey protein Nutrition 0.000 claims abstract description 15
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 11
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 11
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 11
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims abstract description 9
- 229960005055 sodium ascorbate Drugs 0.000 claims abstract description 9
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 8
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims abstract description 8
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims abstract description 8
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims abstract description 8
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims abstract description 8
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 8
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960001231 choline Drugs 0.000 claims abstract description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 8
- 239000000194 fatty acid Substances 0.000 claims abstract description 8
- 229930195729 fatty acid Natural products 0.000 claims abstract description 8
- 229960000367 inositol Drugs 0.000 claims abstract description 8
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims abstract description 8
- 239000001103 potassium chloride Substances 0.000 claims abstract description 8
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 8
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000011780 sodium chloride Substances 0.000 claims abstract description 8
- 229960001295 tocopherol Drugs 0.000 claims abstract description 8
- 235000010384 tocopherol Nutrition 0.000 claims abstract description 8
- 239000011732 tocopherol Substances 0.000 claims abstract description 8
- 229930003799 tocopherol Natural products 0.000 claims abstract description 8
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 8
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000011575 calcium Substances 0.000 claims abstract description 7
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 7
- -1 compound vitamin Chemical class 0.000 claims abstract description 7
- 229960003563 calcium carbonate Drugs 0.000 claims abstract 2
- 229960002816 potassium chloride Drugs 0.000 claims abstract 2
- 239000013589 supplement Substances 0.000 claims description 25
- 238000004090 dissolution Methods 0.000 claims description 16
- 235000019871 vegetable fat Nutrition 0.000 claims description 15
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 6
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 6
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 6
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims description 6
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 3
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 3
- 235000000638 D-biotin Nutrition 0.000 claims description 3
- 239000011665 D-biotin Substances 0.000 claims description 3
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 claims description 3
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 3
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 3
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 3
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 3
- 229960000355 copper sulfate Drugs 0.000 claims description 3
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 3
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 3
- 239000011666 cyanocobalamin Substances 0.000 claims description 3
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 3
- 229960001781 ferrous sulfate Drugs 0.000 claims description 3
- 239000011790 ferrous sulphate Substances 0.000 claims description 3
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 3
- 229960000304 folic acid Drugs 0.000 claims description 3
- 235000019152 folic acid Nutrition 0.000 claims description 3
- 239000011724 folic acid Substances 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 3
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 3
- 229960003390 magnesium sulfate Drugs 0.000 claims description 3
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 3
- 229940099596 manganese sulfate Drugs 0.000 claims description 3
- 239000011702 manganese sulphate Substances 0.000 claims description 3
- 235000007079 manganese sulphate Nutrition 0.000 claims description 3
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 3
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 claims description 3
- 235000019175 phylloquinone Nutrition 0.000 claims description 3
- 239000011772 phylloquinone Substances 0.000 claims description 3
- 229960001898 phytomenadione Drugs 0.000 claims description 3
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims description 3
- 239000001230 potassium iodate Substances 0.000 claims description 3
- 235000006666 potassium iodate Nutrition 0.000 claims description 3
- 229940093930 potassium iodate Drugs 0.000 claims description 3
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 3
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims description 3
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 3
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 3
- 229960000342 retinol acetate Drugs 0.000 claims description 3
- 235000019173 retinyl acetate Nutrition 0.000 claims description 3
- 239000011770 retinyl acetate Substances 0.000 claims description 3
- 229960002477 riboflavin Drugs 0.000 claims description 3
- 235000019192 riboflavin Nutrition 0.000 claims description 3
- 239000002151 riboflavin Substances 0.000 claims description 3
- 239000011781 sodium selenite Substances 0.000 claims description 3
- 235000015921 sodium selenite Nutrition 0.000 claims description 3
- 229960001471 sodium selenite Drugs 0.000 claims description 3
- 229960000344 thiamine hydrochloride Drugs 0.000 claims description 3
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 3
- 235000019190 thiamine hydrochloride Nutrition 0.000 claims description 3
- 239000011747 thiamine hydrochloride Substances 0.000 claims description 3
- 229940042585 tocopherol acetate Drugs 0.000 claims description 3
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 3
- 235000005282 vitamin D3 Nutrition 0.000 claims description 3
- 239000011647 vitamin D3 Substances 0.000 claims description 3
- 229940021056 vitamin d3 Drugs 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 2
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 abstract description 5
- 230000035764 nutrition Effects 0.000 abstract description 5
- 239000002609 medium Substances 0.000 abstract description 3
- 229960002668 sodium chloride Drugs 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 21
- 235000013350 formula milk Nutrition 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000003715 nutritional status Nutrition 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 2
- 239000011755 sodium-L-ascorbate Substances 0.000 description 2
- 235000019187 sodium-L-ascorbate Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000001246 colloidal dispersion Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 229960002104 cyanocobalamin Drugs 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229960001518 levocarnitine Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000005305 organ development Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/238—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seeds, e.g. locust bean gum or guar gum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
- A23P10/47—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added using additives, e.g. emulsifiers, wetting agents or dust-binding agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Dispersion Chemistry (AREA)
- Pediatric Medicine (AREA)
- Mycology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
本申请提供了一种适用于早产儿/低出生体重儿的母乳营养补充剂，其包含固体淀粉糖、分离乳清蛋白粉、磷酸氢钙、复配维生素、氯化钾、胆碱、碳酸钙、复配矿物质、肌醇、左旋肉碱、氯化钠、麦芽糊精、中链甘油三酯、单、双甘油脂肪酸酯、磷脂、槐豆胶、L‑抗坏血酸钠、抗坏血酸棕榈酸酯、生育酚等成分；其营养配比合理，在母乳中溶解迅速，可以有效改善早产儿/低出生体重儿营养情况和使用便利性。
Description
技术领域
本申请属于婴幼儿奶粉/营养补充剂技术领域，具体地，本申请提供了一种适用于早产儿/低出生体重儿的母乳营养补充剂。
背景技术
我国每年现有早产儿/低出生体重儿百万以上，这些婴儿多数由于未能在母体中充分摄取营养而有组织器官发育、抵抗力等方面的问题，并且在出生后多有生长速率明显偏低的情况(生长抑制)，其护理和营养补充是产科、儿科以及家庭中的重要问题。
目前对于早产儿/低出生体重儿营养方式的选择在临床上有多种不同意见，母乳、配方奶粉和强化母乳各有其优点和适用情况。其中使用补充剂、特别是不需要稀释母乳的粉末状补充剂制备强化母乳，由于可以综合配方奶粉和母乳的优点，是一种被广泛接受的选择。
市售的多种补充剂产品均提供了在母乳中较好的溶解性能(98％以上)，但这种溶解性能一般要在摇动/搅拌3分钟以上，甚至5分钟才能实现。这在实际应用，特别是家庭应用中并不容易实现，根据我们的统计，即使有说明书的详细说明，家庭调配奶粉或补充剂时摇动时间90％以上的情况都不会大于1分钟，这样的情况下，补充剂往往不能充分溶解，虽然这种问题一般婴幼儿影响不大，但对早产儿/低出生体重儿的营养情况完全可能带来严重影响。因此，研制性能改进的早产儿用母乳补充剂对于改善早产儿/低出生体重儿营养状况有重要的意义。
发明内容
母乳和奶粉中含有大量糖、蛋白和脂分子，矿物离子以及其他小分子有机物等复杂的成分，调配此类产品时形成的溶解体系为多组分、多相的复杂溶解体系。这样的体系中存在胶体分散、乳化、缔合、络合等作用，其整体溶解性能不能以单独某种或某几种成分的溶解性来解释，在改进产品的溶解性，特别是溶解速度特性存在很大的困难。
为解决上述问题，申请人考虑从乳化剂入手，发现了适合比例的磷脂和增稠剂槐豆胶可以为补充剂产品提供有益的溶解性能，特别是在人乳中的短时间溶解性能。
一方面，本申请提供了一种适用于早产儿/低出生体重儿的母乳营养补充剂，其包含固体淀粉糖、分离乳清蛋白粉、植物脂肪粉、磷酸氢钙、复配维生素、氯化钾、胆碱、碳酸钙、复配矿物质、肌醇、左旋肉碱、氯化钠；其中植物脂肪粉包括：麦芽糊精、固体淀粉糖、中链甘油三酯、分离乳清蛋白粉、单、双甘油脂肪酸酯、磷脂、L-抗坏血酸钠、抗坏血酸棕榈酸酯、生育酚。
进一步地，所述补充剂配方为：固体淀粉糖30-45％、分离乳清蛋白粉20-30％、植物脂肪粉20-30％、磷酸氢钙3-5％、复配维生素1-3％、氯化钾0.2-1％、胆碱0.5-1％、碳酸钙0.5-1％、复配矿物质0.2-0.8％、肌醇0.1-0.4％、左旋肉碱0.05-0.02％、氯化钠0.01-0.1％；其中植物脂肪粉配方为：麦芽糊精40-50％、固体淀粉糖15-30％、中链甘油三酯15-25％、分离乳清蛋白粉5-15％、单、双甘油脂肪酸酯0.1-0.7％、磷脂0.1-0.5％、槐豆胶0.05-0.2％、L-抗坏血酸钠0.05-0.2％、抗坏血酸棕榈酸酯0.01-0.07％、生育酚0.02-0.07％；
优选固体淀粉糖39.5％、分离乳清蛋白粉25.8％、植物脂肪粉25％、磷酸氢钙4.3％、复配维生素2.2％、氯化钾0.75％、胆碱0.7％、碳酸钙0.7％、复配矿物质0.6％、肌醇0.28％、左旋肉碱0.12％、氯化钠0.05％；其中植物脂肪粉配方为：麦芽糊精48.3％、固体淀粉糖20.9％、中链甘油三酯19.9％、分离乳清蛋白粉9.9％、单、双甘油脂肪酸酯0.4％、磷脂0.2-0.4％、槐豆胶0.07-0.15％、L-抗坏血酸钠0.1％、抗坏血酸棕榈酸酯0.05％、生育酚0.05％。
进一步地，所述固体淀粉糖包括葡萄糖、麦芽糊精、低聚麦芽糖；所述复配维生素包括醋酸视黄酯、胆钙化醇、dl-α-醋酸生育酚、植物甲萘醌、盐酸硫胺素、核黄素、盐酸吡哆醇、氰钴胺、烟酰胺、叶酸、D-泛酸钙、L-抗坏血酸钠、D-生物素；所述复配矿物质包括硫酸铜、硫酸镁、硫酸亚铁、硫酸锌、硫酸锰、碘酸钾、亚硒酸钠。
进一步地，其中磷脂为0.3％、槐豆胶为0.1％。
另一方面，本申请提供了磷脂和槐豆胶在制备适用于适用于早产儿/低出生体重儿的母乳营养补充剂中的应用。
另一方面，本申请提供了在改进适用于早产儿/低出生体重儿的母乳营养补充剂在母乳中的溶解性能中的应用。
进一步地，磷脂和槐豆胶的重量比例为2-4:0.5-1.5。
进一步地，磷脂和槐豆胶的比例重量为3:1。
在基本成分种类不变的情况下，本申请中的淀粉糖、复配维生素、复配矿物质产品的具体组成可以根据产品的不同需要或者原料的情况而有所变化。
本申请中在母乳中的溶解性能优选是指在母乳中短时间溶解性能，特别是摇动3分钟以下，最优选1分钟以下时的溶解性能。
具体实施方式
实施例1材料和方法
食品用大豆浓缩磷脂：常规国产种类，含量>99.7％。
槐豆胶：常规国产种类，食品级。
其他补充剂用原料由申请人自制或取自申请人生产线中的现有原料。
实验中调配所用捐献母乳由申请人自行组织收集，按批次混合后冷冻保存，14天内使用，比较试验中尽量使用相同或相近批次的产品。
其他试剂或原料均为常规国产种类。
溶解性：
溶解性评价方法参考GB5413.29-2010设计：
测定温度为30摄氏度，测定之前将补充剂样品在30摄氏度下放置12小时，将母乳样品自然解冻后在30摄氏度下放置1小时。
取补充剂样品1g置于50ml离心管中，分多次加入母乳20mL，密封。
80rmp摇床振摇一定时间(30秒、1分钟、2分钟、3分钟、5分钟)后，置于离心机中，4000rmp离心10分钟。
倾倒上清，以棉棒擦净管壁，加入20mL纯净水，摇床振摇2分钟，置于离心机中，4000rmp离心10分钟。
倾倒上清，以棉棒擦净管壁，以少量水将沉淀物冲入称量皿中。
沸水浴中蒸干水分后100摄氏度烘箱中干燥至恒重。
按照公式溶解度(g/100g)＝100-干燥后沉淀克数×100/(1-样品每百克含水克数)×样品克数
实施例2不同乳化剂和增稠剂比例
产品1：磷脂0.4％；
产品2：磷脂0.2％，槐豆胶0.2％；
产品3：磷脂0.1％，槐豆胶0.3％；
产品4：磷脂0.3％，槐豆胶0.1％；
产品5：磷脂0.2％，卡拉胶0.2％；
产品6：磷脂0.3％，卡拉胶0.1％；
以上用量按照在植物脂肪粉中的重量百分比计算。
以上仅为大量筛选实验中的部分代表性方法，更多的种类、用量筛选方案由于篇幅原因未展示。
实施例3补充剂产品的制备
使用产品1-6和对照制备相应的补充剂1-6(即产品1对应补充剂1，产品2对应补充剂2……以此类推)。
补充剂的配方为：
固体淀粉糖39.5％、分离乳清蛋白粉25.8％、植物脂肪粉25％、磷酸氢钙4.3％、复配维生素2.2％、氯化钾0.75％、胆碱0.7％、碳酸钙0.7％、复配矿物质0.6％、肌醇0.28％、左旋肉碱0.12％、氯化钠0.05％。
其中植物脂肪粉配方为：
麦芽糊精48.3％、固体淀粉糖20.9％、中链甘油三酯19.9％、分离乳清蛋白粉9.9％、单、双甘油脂肪酸酯0.4％、磷脂和增稠剂依据产品而不同、L-抗坏血酸钠0.1％、抗坏血酸棕榈酸酯0.05％、生育酚0.05％。
固体淀粉糖包括葡萄糖、麦芽糊精、低聚麦芽糖；复配维生素包括醋酸视黄酯、胆钙化醇、dl-α-醋酸生育酚、植物甲萘醌、盐酸硫胺素、核黄素、盐酸吡哆醇、氰钴胺、烟酰胺、叶酸、D-泛酸钙、L-抗坏血酸钠、D-生物素；复配矿物质包括硫酸铜、硫酸镁、硫酸亚铁、硫酸锌、硫酸锰、碘酸钾、亚硒酸钠。
上述固体淀粉糖、复配维生素、复配矿物质同一批次比较试验中使用统一配方。后续也验证了磷脂和槐豆胶其对不同成分相同、含量不同的多种固体淀粉糖、复配维生素、复配矿物质的适应性，结果表明优选的磷脂和槐豆胶比例在成分相同、含量不同的多种固体淀粉糖、复配维生素、复配矿物质下都有明显的促溶作用。
其他各种复配原料和混合物为申请人生产中现有使用的种类。
实施例4补充剂溶解性能的测定
按照上述方法评价不同补充剂在不同振摇时间的溶解性能
结果表明各种营养补充剂在振摇3分钟后均能取得较好的溶解效果，但短时间振摇，特别是1分钟以下时(实际使用中最可能实际操作的时间)，各营养补充剂溶解效果差异显著，补充剂4的短时溶解性能明显超过其他产品。上述结果，说明产品4的特定比例槐豆胶和磷脂能有效提高相应补充剂产品的溶解性，其他增稠剂或比例的改善相比对照并不显著，某些种类和比例甚至对溶解性能会产生不利影响。
Claims (8)
1.一种适用于早产儿/低出生体重儿的母乳营养补充剂，其特征在于，其包含固体淀粉糖、分离乳清蛋白粉、植物脂肪粉、磷酸氢钙、复配维生素、氯化钾、胆碱、碳酸钙、复配矿物质、肌醇、左旋肉碱、氯化钠；其中植物脂肪粉包括：麦芽糊精、固体淀粉糖、中链甘油三酯、分离乳清蛋白粉、单、双甘油脂肪酸酯、磷脂、槐豆胶、L-抗坏血酸钠、抗坏血酸棕榈酸酯、生育酚。
2.根据权利要求所述的补充剂，其中所述补充剂配方为：固体淀粉糖30-45％、分离乳清蛋白粉20-30％、植物脂肪粉20-30％、磷酸氢钙3-5％、复配维生素1-3％、氯化钾0.2-1％、胆碱0.5-1％、碳酸钙0.5-1％、复配矿物质0.2-0.8％、肌醇0.1-0.4％、左旋肉碱0.05-0.02％、氯化钠0.01-0.1％；其中植物脂肪粉配方为：麦芽糊精40-50％、固体淀粉糖15-30％、中链甘油三酯15-25％、分离乳清蛋白粉5-15％、单、双甘油脂肪酸酯0.1-0.7％、磷脂0.1-0.5％、槐豆胶0.05-0.2％、L-抗坏血酸钠0.05-0.2％、抗坏血酸棕榈酸酯0.01-0.07％、生育酚0.02-0.07％；
优选固体淀粉糖39.5％、分离乳清蛋白粉25.8％、植物脂肪粉25％、磷酸氢钙4.3％、复配维生素2.2％、氯化钾0.75％、胆碱0.7％、碳酸钙0.7％、复配矿物质0.6％、肌醇0.28％、左旋肉碱0.12％、氯化钠0.05％；其中植物脂肪粉配方为：麦芽糊精48.3％、固体淀粉糖20.9％、中链甘油三酯19.9％、分离乳清蛋白粉9.9％、单、双甘油脂肪酸酯0.4％、磷脂0.2-0.4％、槐豆胶0.07-0.15％、L-抗坏血酸钠0.1％、抗坏血酸棕榈酸酯0.05％、生育酚0.05％。
3.根据权利要求1或2所述的补充剂，其中所述固体淀粉糖包括葡萄糖、麦芽糊精、低聚麦芽糖；所述复配维生素包括醋酸视黄酯、胆钙化醇、dl-α-醋酸生育酚、植物甲萘醌、盐酸硫胺素、核黄素、盐酸吡哆醇、氰钴胺、烟酰胺、叶酸、D-泛酸钙、L-抗坏血酸钠、D-生物素；所述复配矿物质包括硫酸铜、硫酸镁、硫酸亚铁、硫酸锌、硫酸锰、碘酸钾、亚硒酸钠。
4.根据权利要求1-3任一项所述的补充剂，其中磷脂为0.3％、槐豆胶为0.1％。
5.磷脂和槐豆胶在制备适用于早产儿/低出生体重儿的母乳营养补充剂中的应用。
6.磷脂和槐豆胶在改进适用于早产儿/低出生体重儿的母乳营养补充剂在母乳中的溶解性能中的应用。
7.根据权利要求5或6的应用，其中磷脂和槐豆胶的重量比例为2-4:0.5-1.5。
8.根据权利要求7所述的应用，其中磷脂和槐豆胶的比例重量为3:1。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111525899.5A CN114145453A (zh) | 2021-12-14 | 2021-12-14 | 适用于早产儿和低出生体重儿的母乳营养补充剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111525899.5A CN114145453A (zh) | 2021-12-14 | 2021-12-14 | 适用于早产儿和低出生体重儿的母乳营养补充剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114145453A true CN114145453A (zh) | 2022-03-08 |
Family
ID=80450968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111525899.5A Pending CN114145453A (zh) | 2021-12-14 | 2021-12-14 | 适用于早产儿和低出生体重儿的母乳营养补充剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114145453A (zh) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103636799A (zh) * | 2013-12-03 | 2014-03-19 | 内蒙古伊利实业集团股份有限公司 | 一种速溶营养奶粉冲调块及其制备方法 |
| CN107251949A (zh) * | 2017-08-03 | 2017-10-17 | 江西美庐乳业集团有限公司 | 一种保留羊奶脂肪酸的无膻味全脂羊乳粉的制备方法 |
| CN108968046A (zh) * | 2018-07-25 | 2018-12-11 | 哈尔滨拜仑斯特临床营养有限公司 | 一种特殊医学用途全营养配方食品及其制备方法 |
| CN110637888A (zh) * | 2019-11-11 | 2020-01-03 | 宁波特壹食品有限公司 | 早产/低出生体重婴儿配方粉及其制备方法 |
| CN112138169A (zh) * | 2020-09-14 | 2020-12-29 | 广东药科大学 | 天然多糖在增加难溶性药物溶解度中的应用 |
| CN113519626A (zh) * | 2021-07-15 | 2021-10-22 | 青岛圣桐营养食品有限公司 | 一种无乳糖奶粉及其制备方法 |
| CN113519686A (zh) * | 2021-07-22 | 2021-10-22 | 青岛圣桐营养食品有限公司 | 一种婴儿乳蛋白部分水解配方食品及其制备方法 |
-
2021
- 2021-12-14 CN CN202111525899.5A patent/CN114145453A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103636799A (zh) * | 2013-12-03 | 2014-03-19 | 内蒙古伊利实业集团股份有限公司 | 一种速溶营养奶粉冲调块及其制备方法 |
| CN107251949A (zh) * | 2017-08-03 | 2017-10-17 | 江西美庐乳业集团有限公司 | 一种保留羊奶脂肪酸的无膻味全脂羊乳粉的制备方法 |
| CN108968046A (zh) * | 2018-07-25 | 2018-12-11 | 哈尔滨拜仑斯特临床营养有限公司 | 一种特殊医学用途全营养配方食品及其制备方法 |
| CN110637888A (zh) * | 2019-11-11 | 2020-01-03 | 宁波特壹食品有限公司 | 早产/低出生体重婴儿配方粉及其制备方法 |
| CN112138169A (zh) * | 2020-09-14 | 2020-12-29 | 广东药科大学 | 天然多糖在增加难溶性药物溶解度中的应用 |
| CN113519626A (zh) * | 2021-07-15 | 2021-10-22 | 青岛圣桐营养食品有限公司 | 一种无乳糖奶粉及其制备方法 |
| CN113519686A (zh) * | 2021-07-22 | 2021-10-22 | 青岛圣桐营养食品有限公司 | 一种婴儿乳蛋白部分水解配方食品及其制备方法 |
Non-Patent Citations (5)
| Title |
|---|
| 于西延等: "《为了孩子的健康 做一个有准备的妈妈》", 31 March 2008, 人民军医出版社 * |
| 曹郁生等: "《食品添加剂手册》", 31 December 1987, 江西科学技术出版社 * |
| 科技部科技扶贫办公室•中国农村技术开发中心: "《贫困地区实用技术指南》", 31 December 2000, 知识出版社 * |
| 食品行业中心马超: "最新72款已获批特医食品标签说明书汇总", 《特医食品研发前沿动态》 * |
| 马同江等: "《新编食品添加剂手册》", 31 December 1989, 农村读物出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0034034B1 (en) | Nutrient composition | |
| CA2101274C (en) | Microbial oil mixtures and uses thereof | |
| CN101999558B (zh) | 一种适用于不同生理阶段的猪用复合预混料 | |
| CN111194912B (zh) | 一种稳定的医用液态肠内营养组合物及其制备方法 | |
| CA2400737C (en) | Nutritional formulation containing prebiotic substances | |
| AU2020294253B2 (en) | Nutritional Composition For Promoting Intestinal Health | |
| CN114223729B (zh) | 长双歧杆菌婴儿亚种与母乳低聚糖组合物在配方奶粉中的应用 | |
| CN114145454A (zh) | 特殊医学用途婴儿营养补充剂 | |
| Tao et al. | Production performance, egg quality, plasma biochemical constituents and lipid metabolites of aged laying hens supplemented with incomplete degradation products of galactomannan | |
| KR101397863B1 (ko) | 고농도의 나트륨을 함유한 액상 영양 조성물 및 그의 제조 방법 | |
| CN102511827A (zh) | 一种婴儿核桃米粉及其制备方法 | |
| CN103271166A (zh) | 一种大豆乳清复合粉及其配制方法 | |
| CN114145453A (zh) | 适用于早产儿和低出生体重儿的母乳营养补充剂 | |
| CN103859039A (zh) | 有益于提高儿童免疫力的液态奶组合物 | |
| CN105433033A (zh) | 含有刺梨提取物的肉鸡配合饲料及其制备方法 | |
| CN106360742A (zh) | 一种用于肥胖或减脂手术患者的营养食品组合物 | |
| JP7157496B1 (ja) | 経口組成物 | |
| EP3574770A1 (en) | Amino acid-containing composition | |
| CN103431235A (zh) | 一种含莲藕粉的生长猪预混料及其制备方法 | |
| CN107683974A (zh) | 一种促进雏鸡生长的保健型浓缩饮料及其制备方法 | |
| CN113729211A (zh) | 一种组合物及其制备方法、应用 | |
| CN106135752A (zh) | 一种诸氏鲻虾虎鱼生长配合饲料及其制备方法 | |
| WO2007092383A2 (en) | Mayonnaise-like food products | |
| CN112704216A (zh) | 一种适用于制备老年蔬菜类易食食品的助餐剂及其应用 | |
| CN114158736B (zh) | 适用于特殊医学用途全营养配方食品的复配维生素 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220308 |