CN114144423B - 使用与免疫检查点抑制剂组合递送的siRNA沉默TGF-BETA 1和COX2以治疗癌症 - Google Patents

使用与免疫检查点抑制剂组合递送的siRNA沉默TGF-BETA 1和COX2以治疗癌症 Download PDF

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CN114144423B
CN114144423B CN201980093031.7A CN201980093031A CN114144423B CN 114144423 B CN114144423 B CN 114144423B CN 201980093031 A CN201980093031 A CN 201980093031A CN 114144423 B CN114144423 B CN 114144423B
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sirna
cancer
beta
tgf
tumor
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CN114144423A (zh
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D·M·埃文斯
P·Y·陆
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Sirnaomics Inc
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CN201980093031.7A 2018-12-27 2019-12-24 使用与免疫检查点抑制剂组合递送的siRNA沉默TGF-BETA 1和COX2以治疗癌症 Active CN114144423B (zh)

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US201862785647P 2018-12-27 2018-12-27
US62/785,647 2018-12-27
PCT/US2019/068499 WO2020139897A1 (en) 2018-12-27 2019-12-24 Silencing tgf-beta 1 and cox2 using sirnas delivered in combination with immune checkpoint inhibitors to treat cancer

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CN114144423B true CN114144423B (zh) 2025-04-04

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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021061437A1 (en) * 2019-09-12 2021-04-01 Sirnaomics, Inc. CO-DELIVERY OF TGF-β SIRNA AND PDL1 SIRNA TO TREAT CANCER
JP2024506240A (ja) * 2021-01-21 2024-02-13 サーナオミクス インコーポレイテッド 皮膚がんの治療のための組成物および方法
CN115463148A (zh) * 2021-06-11 2022-12-13 圣诺生物医药技术(苏州)有限公司 一种用于治疗皮肤肿瘤的小干扰核酸药物组合物及制剂
CN115919888A (zh) * 2021-07-16 2023-04-07 圣诺生物医药技术(苏州)有限公司 一种用于治疗多种肿瘤的核酸干扰药物组合物
CA3225925A1 (en) * 2021-07-16 2023-01-19 Sirnaomics, Inc. Sirna-copolymer compositions and methods of use for treatment of liver cancer
WO2023086386A1 (en) * 2021-11-09 2023-05-19 Sirnaomics, Inc. Treatment of 2019-ncov using sirnas against tgfb1 and cox2
EP4437107A4 (en) * 2021-11-22 2025-04-23 Sirnaomics, Inc. Method for inducing remodeling of adipose tissue using RNAi therapeutics
CN116421616B (zh) * 2022-03-17 2025-08-12 圣诺生物医药技术(苏州)有限公司 一种核酸干扰药物组合物及用于治疗结直肠癌、胃癌、前列腺癌的药物
CN116983322B (zh) * 2022-09-15 2026-04-07 圣诺生物医药技术(苏州)有限公司 用于治疗肺癌、胰腺癌、肝癌和结直肠癌的小核酸干扰药物
EP4673542A1 (en) * 2023-03-01 2026-01-07 Philipps-Universität Marburg Plac8 antisense molecules used as a medicament
WO2025171164A1 (en) * 2024-02-07 2025-08-14 Board Of Regents, The University Of Texas System Gene signatures predictive of cancer cell response to immunomodulatory therapy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102985546A (zh) * 2010-05-04 2013-03-20 圣诺制药公司 TGF-beta和Cox-2抑制剂的联合及其治疗应用的方法
WO2018081726A2 (en) * 2016-10-30 2018-05-03 Sirnaomics, Inc. Pharmaceutical compositions and methods of use for activation of human fibroblast and myofibroblast apoptosis
WO2018089467A1 (en) * 2016-11-09 2018-05-17 Beth Israel Deaconess Medical Center, Inc. Methods for reducing recurrence of tumors
WO2018175323A1 (en) * 2017-03-19 2018-09-27 Suzhou Sirnaomics Biopharmaceuticals Co., Ltd. Gemcitabine derivatives for cancer therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
US7070807B2 (en) 1999-12-29 2006-07-04 Mixson A James Branched histidine copolymers and methods for using same
WO2001047496A1 (en) 1999-12-29 2001-07-05 Mixson A James Histidine copolymer and methods for using same
CA2429814C (en) 2000-12-01 2014-02-18 Thomas Tuschl Rna interference mediating small rna molecules
AU2005218759B2 (en) 2004-02-27 2009-07-16 Antisense Pharma Gmbh Pharmaceutical composition
CN101060849A (zh) 2004-11-17 2007-10-24 巴尔的摩马里兰大学 作为有效的siRNA载体的高分支HK肽
JP2011504170A (ja) 2007-11-06 2011-02-03 サーナオミクス、インク． 皮膚の中で平癒している瘢痕のない損傷のためのマルチ目標とされたＲＮＡｉ治療学
WO2009104051A2 (en) * 2007-12-31 2009-08-27 Lu Patrick Y Combinational therapeutics for treatment of prostate cancer using epoxy encapsulated magnetic particles and rnai medicine
WO2009151539A1 (en) * 2008-05-24 2009-12-17 Sirnaomics, Inc. COMPOSITIONS AND METHODS USING siRNA MOLECULES FOR TREATMENT OF GLIOMAS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102985546A (zh) * 2010-05-04 2013-03-20 圣诺制药公司 TGF-beta和Cox-2抑制剂的联合及其治疗应用的方法
WO2018081726A2 (en) * 2016-10-30 2018-05-03 Sirnaomics, Inc. Pharmaceutical compositions and methods of use for activation of human fibroblast and myofibroblast apoptosis
WO2018089467A1 (en) * 2016-11-09 2018-05-17 Beth Israel Deaconess Medical Center, Inc. Methods for reducing recurrence of tumors
WO2018175323A1 (en) * 2017-03-19 2018-09-27 Suzhou Sirnaomics Biopharmaceuticals Co., Ltd. Gemcitabine derivatives for cancer therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cancer stem cells in hepatocellular carcinoma: an overview and promising therapeutic strategies;Nuozhou Wang等;Therapeutic Advances in Medical Oncology;第10卷;第1页第1栏第1段，第10页第2蓝第2段 *
Targeting transforming growth factor-b signaling in liver metastasis of colon cancer;Bixiang Zhang等;Cancer Letters;第277卷(第1期);第114-115页 *

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JP2022515868A (ja) 2022-02-22
CN114144423A (zh) 2022-03-04
CA3125285A1 (en) 2020-07-02
JP7588074B2 (ja) 2024-11-21
EP3902817A4 (en) 2022-08-03
EP3902817A1 (en) 2021-11-03
WO2020139897A1 (en) 2020-07-02
US20210324384A1 (en) 2021-10-21

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