BR112021012715A2 - Silenciamento de tgf-beta 1 e cox2 usando sirnas entregues em combinação com inibidores imune checkpoint para tratar câncer - Google Patents

Silenciamento de tgf-beta 1 e cox2 usando sirnas entregues em combinação com inibidores imune checkpoint para tratar câncer Download PDF

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Publication number
BR112021012715A2
BR112021012715A2 BR112021012715-1A BR112021012715A BR112021012715A2 BR 112021012715 A2 BR112021012715 A2 BR 112021012715A2 BR 112021012715 A BR112021012715 A BR 112021012715A BR 112021012715 A2 BR112021012715 A2 BR 112021012715A2
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sirna
beta
cancer
tgf
seq
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BR112021012715-1A
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English (en)
Portuguese (pt)
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David M. Evans
Patrick Y. Lu
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Sirnaomics, Inc.
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Publication of BR112021012715A2 publication Critical patent/BR112021012715A2/pt

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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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BR112021012715-1A 2018-12-27 2019-12-24 Silenciamento de tgf-beta 1 e cox2 usando sirnas entregues em combinação com inibidores imune checkpoint para tratar câncer BR112021012715A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862785647P 2018-12-27 2018-12-27
US62/785,647 2018-12-27
PCT/US2019/068499 WO2020139897A1 (en) 2018-12-27 2019-12-24 Silencing tgf-beta 1 and cox2 using sirnas delivered in combination with immune checkpoint inhibitors to treat cancer

Publications (1)

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BR112021012715A2 true BR112021012715A2 (pt) 2021-09-21

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BR112021012715-1A BR112021012715A2 (pt) 2018-12-27 2019-12-24 Silenciamento de tgf-beta 1 e cox2 usando sirnas entregues em combinação com inibidores imune checkpoint para tratar câncer

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US (1) US20210324384A1 (https=)
EP (1) EP3902817A4 (https=)
JP (1) JP7588074B2 (https=)
KR (1) KR20220030203A (https=)
CN (1) CN114144423B (https=)
AU (1) AU2019414427A1 (https=)
BR (1) BR112021012715A2 (https=)
CA (1) CA3125285A1 (https=)
IL (1) IL284412A (https=)
WO (1) WO2020139897A1 (https=)

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WO2021061437A1 (en) * 2019-09-12 2021-04-01 Sirnaomics, Inc. CO-DELIVERY OF TGF-β SIRNA AND PDL1 SIRNA TO TREAT CANCER
JP2024506240A (ja) * 2021-01-21 2024-02-13 サーナオミクス インコーポレイテッド 皮膚がんの治療のための組成物および方法
CN115463148A (zh) * 2021-06-11 2022-12-13 圣诺生物医药技术(苏州)有限公司 一种用于治疗皮肤肿瘤的小干扰核酸药物组合物及制剂
CN115919888A (zh) * 2021-07-16 2023-04-07 圣诺生物医药技术(苏州)有限公司 一种用于治疗多种肿瘤的核酸干扰药物组合物
CA3225925A1 (en) * 2021-07-16 2023-01-19 Sirnaomics, Inc. Sirna-copolymer compositions and methods of use for treatment of liver cancer
WO2023086386A1 (en) * 2021-11-09 2023-05-19 Sirnaomics, Inc. Treatment of 2019-ncov using sirnas against tgfb1 and cox2
EP4437107A4 (en) * 2021-11-22 2025-04-23 Sirnaomics, Inc. Method for inducing remodeling of adipose tissue using RNAi therapeutics
CN116421616B (zh) * 2022-03-17 2025-08-12 圣诺生物医药技术(苏州)有限公司 一种核酸干扰药物组合物及用于治疗结直肠癌、胃癌、前列腺癌的药物
CN116983322B (zh) * 2022-09-15 2026-04-07 圣诺生物医药技术(苏州)有限公司 用于治疗肺癌、胰腺癌、肝癌和结直肠癌的小核酸干扰药物
EP4673542A1 (en) * 2023-03-01 2026-01-07 Philipps-Universität Marburg Plac8 antisense molecules used as a medicament
WO2025171164A1 (en) * 2024-02-07 2025-08-14 Board Of Regents, The University Of Texas System Gene signatures predictive of cancer cell response to immunomodulatory therapy

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IL284412A (en) 2021-08-31
KR20220030203A (ko) 2022-03-10
CN114144423B (zh) 2025-04-04
AU2019414427A1 (en) 2021-07-22
JP2022515868A (ja) 2022-02-22
CN114144423A (zh) 2022-03-04
CA3125285A1 (en) 2020-07-02
JP7588074B2 (ja) 2024-11-21
EP3902817A4 (en) 2022-08-03
EP3902817A1 (en) 2021-11-03
WO2020139897A1 (en) 2020-07-02
US20210324384A1 (en) 2021-10-21

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