CN114129566A - 用于治疗肺腺癌的met、vegfr和ret的抑制剂 - Google Patents

用于治疗肺腺癌的met、vegfr和ret的抑制剂 Download PDF

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CN114129566A
CN114129566A CN202111124139.3A CN202111124139A CN114129566A CN 114129566 A CN114129566 A CN 114129566A CN 202111124139 A CN202111124139 A CN 202111124139A CN 114129566 A CN114129566 A CN 114129566A
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ret
compound
kif5b
fusion
gene
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D.T.阿夫塔布
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Exelixis Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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CN202111124139.3A 2012-09-07 2013-09-09 用于治疗肺腺癌的met、vegfr和ret的抑制剂 Pending CN114129566A (zh)

Applications Claiming Priority (3)

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US201261698143P 2012-09-07 2012-09-07
US61/698143 2012-09-07
CN201380052164.2A CN104703600A (zh) 2012-09-07 2013-09-09 用于治疗肺腺癌的met、vegfr和ret的抑制剂

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US (2) US20140121239A1 (https=)
EP (1) EP2892532B1 (https=)
JP (2) JP6513567B2 (https=)
CN (2) CN114129566A (https=)
ES (1) ES2726605T3 (https=)
WO (1) WO2014039971A1 (https=)

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CN104703600A (zh) 2015-06-10
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JP6513567B2 (ja) 2019-05-15
JP2015530389A (ja) 2015-10-15
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