CN114127125B - 多特异性甲状腺素转运蛋白免疫球蛋白融合物 - Google Patents

多特异性甲状腺素转运蛋白免疫球蛋白融合物 Download PDF

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CN114127125B
CN114127125B CN202080049750.1A CN202080049750A CN114127125B CN 114127125 B CN114127125 B CN 114127125B CN 202080049750 A CN202080049750 A CN 202080049750A CN 114127125 B CN114127125 B CN 114127125B
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CN114127125A (zh
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K·W·沃克
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Amgen Inc
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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CN202080049750.1A 2019-07-08 2020-07-06 多特异性甲状腺素转运蛋白免疫球蛋白融合物 Active CN114127125B (zh)

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US201962871247P 2019-07-08 2019-07-08
US62/871,247 2019-07-08
PCT/US2020/040873 WO2021007150A1 (en) 2019-07-08 2020-07-06 Multispecific transthyretin immunoglobulin fusions

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CN114127125B true CN114127125B (zh) 2025-01-14

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US (1) US20220324924A1 (https=)
EP (1) EP3997112A1 (https=)
JP (1) JP7695925B2 (https=)
KR (1) KR20220032065A (https=)
CN (1) CN114127125B (https=)
AU (1) AU2020310851B2 (https=)
CA (1) CA3140208A1 (https=)
MX (1) MX2021015976A (https=)
SG (1) SG11202112762TA (https=)
WO (1) WO2021007150A1 (https=)

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Publication number Priority date Publication date Assignee Title
EP3692061A1 (en) 2017-10-04 2020-08-12 Amgen Inc. Transthyretin immunoglobulin fusions
EP4234695A1 (en) * 2022-02-24 2023-08-30 Sartorius BIA Separations d.o.o. Methods for the selective removal of contaminants during a process of purifying biologic agents

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WO2019070901A1 (en) * 2017-10-04 2019-04-11 Amgen Inc. IMMUNOGLOBULIN FUSIONS OF TRANSTHYRETIN

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SG11202112762TA (en) 2021-12-30
EP3997112A1 (en) 2022-05-18
CA3140208A1 (en) 2021-01-14
CN114127125A (zh) 2022-03-01
WO2021007150A1 (en) 2021-01-14
JP2022540089A (ja) 2022-09-14
US20220324924A1 (en) 2022-10-13
AU2020310851B2 (en) 2026-04-02
AU2020310851A1 (en) 2021-12-09
KR20220032065A (ko) 2022-03-15
MX2021015976A (es) 2022-02-10

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