CN114126599A - 改变衰老相关分泌表型的方法和组合物 - Google Patents

改变衰老相关分泌表型的方法和组合物 Download PDF

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Publication number
CN114126599A
CN114126599A CN202080052117.8A CN202080052117A CN114126599A CN 114126599 A CN114126599 A CN 114126599A CN 202080052117 A CN202080052117 A CN 202080052117A CN 114126599 A CN114126599 A CN 114126599A
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China
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composition
akg
subject
vitamin
composition comprises
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CN202080052117.8A
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English (en)
Chinese (zh)
Inventor
B·肯尼迪
G·利思高
A·沙米尔扎迪
C·威利
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Buck Institute for Research on Aging
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Buck Institute for Research on Aging
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202080052117.8A 2019-06-10 2020-06-10 改变衰老相关分泌表型的方法和组合物 Pending CN114126599A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962859623P 2019-06-10 2019-06-10
US62/859,623 2019-06-10
PCT/US2020/036974 WO2020252005A1 (en) 2019-06-10 2020-06-10 Methods and compositions for altering senescence associated secretory phenotype

Publications (1)

Publication Number Publication Date
CN114126599A true CN114126599A (zh) 2022-03-01

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Family Applications (1)

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CN202080052117.8A Pending CN114126599A (zh) 2019-06-10 2020-06-10 改变衰老相关分泌表型的方法和组合物

Country Status (7)

Country Link
US (1) US20220241229A1 (https=)
EP (1) EP3980000A4 (https=)
JP (1) JP2022536653A (https=)
CN (1) CN114126599A (https=)
AU (1) AU2020293094A1 (https=)
CA (1) CA3142781A1 (https=)
WO (1) WO2020252005A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115813784A (zh) * 2022-11-28 2023-03-21 麦吉丽生物科技有限公司 α-酮戊二酸、含有α-酮戊二酸的米发酵液在制备皮肤炎症抑制剂中的用途

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102833111B1 (ko) 2018-09-25 2025-07-10 폰세 드 리온 헬스 데지그네이티드 액티비티 컴퍼니 칼슘 알파-케토글루타레이트의 제조 방법
DE102021111719A1 (de) * 2021-05-05 2022-11-10 Henkel Ag & Co. Kgaa Erhalt der Haarstruktur gegenüber Umwelteinflüssen umfassend ein Phenol und multivalente Ionen
US20250376678A1 (en) * 2022-04-01 2025-12-11 Japanese Foundation For Cancer Research Therapeutic agent for cancer, testing assistance method, and screening method for therapeutic agent
EP4561696A1 (en) * 2022-06-30 2025-06-04 Mechanobiologics, Inc. Reversal of cellular senescence by treatment with low frequency ultrasound
WO2024123738A1 (en) * 2022-12-06 2024-06-13 Ponce De Leon Health Designated Activity Company Compositions and methods for treating diseases responsive to akg-vitamin b coadministration

Citations (9)

* Cited by examiner, † Cited by third party
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US5198465A (en) * 1991-06-19 1993-03-30 Dioguardi Francesco S Compositions based on amino acids for preventing and treating precursor deficiencies in the synthesis of collagen
US20040072160A1 (en) * 2001-05-22 2004-04-15 Donna Mendrick Molecular toxicology modeling
US20090069429A1 (en) * 2006-04-21 2009-03-12 Sgp & Sons Ab Compositions Comprising Alpha-Ketoglutarate and Their Use for Modulating Muscle Performance
WO2012143405A1 (en) * 2011-04-18 2012-10-26 Nestec S.A. Nutritional compositions having alpha-hica and alpha-ketoglutarate
US20150328176A1 (en) * 2013-01-25 2015-11-19 Winning The Fight Inc. Composition for treatment of neurodegenerative disease
CN106163557A (zh) * 2014-01-28 2016-11-23 巴克老龄化研究所 用于杀死衰老细胞和用于治疗衰老相关疾病和病症的方法和组合物
CN106963749A (zh) * 2017-03-23 2017-07-21 华南农业大学 α‑酮戊二酸（盐）在抗疲劳和提高肌肉运动力量方面的应用
WO2018200736A2 (en) * 2017-04-25 2018-11-01 The Buck Institute For Research On Aging Formulations for extending lifespan and healthspan
CN108774203A (zh) * 2018-06-25 2018-11-09 北京未蓝时代科技有限公司 一种延缓哺乳动物细胞和机体衰老的化合物及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1824470T3 (da) * 2004-12-17 2014-08-18 Cash Alan Brian Fremgangsmåde til forlængelse af levetiden og forsinke starttidspunktet for alders-relateret sygdom
WO2007053943A1 (en) * 2005-11-08 2007-05-18 Multi Formulations Ltd. The use of compositions comprising ketoacids and amino acids for increasing muscle mass and muscle performance
MX2009013937A (es) * 2007-07-02 2010-04-30 Entress Ab Nuevo uso de compuestos quimicos farmacologicamente activos conocidos.
DE102009016119A1 (de) * 2009-04-03 2010-10-14 Evonik Degussa Gmbh Nahrungsergänzungsmittel enthaltend alpha-Ketosäuren zur Unterstützung der Diabetestherapie
KR20160111529A (ko) * 2014-02-12 2016-09-26 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 노화 및 연령 관련 질환 및 증상의 치료를 위한 조성물 및 방법
WO2020086733A1 (en) * 2018-10-24 2020-04-30 Ponce De Leon Health Designated Activity Company Nicotinamide riboside compositions for healthspan extension

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198465A (en) * 1991-06-19 1993-03-30 Dioguardi Francesco S Compositions based on amino acids for preventing and treating precursor deficiencies in the synthesis of collagen
US20040072160A1 (en) * 2001-05-22 2004-04-15 Donna Mendrick Molecular toxicology modeling
US20090069429A1 (en) * 2006-04-21 2009-03-12 Sgp & Sons Ab Compositions Comprising Alpha-Ketoglutarate and Their Use for Modulating Muscle Performance
WO2012143405A1 (en) * 2011-04-18 2012-10-26 Nestec S.A. Nutritional compositions having alpha-hica and alpha-ketoglutarate
US20150328176A1 (en) * 2013-01-25 2015-11-19 Winning The Fight Inc. Composition for treatment of neurodegenerative disease
CN106163557A (zh) * 2014-01-28 2016-11-23 巴克老龄化研究所 用于杀死衰老细胞和用于治疗衰老相关疾病和病症的方法和组合物
CN106963749A (zh) * 2017-03-23 2017-07-21 华南农业大学 α‑酮戊二酸（盐）在抗疲劳和提高肌肉运动力量方面的应用
WO2018200736A2 (en) * 2017-04-25 2018-11-01 The Buck Institute For Research On Aging Formulations for extending lifespan and healthspan
CN108774203A (zh) * 2018-06-25 2018-11-09 北京未蓝时代科技有限公司 一种延缓哺乳动物细胞和机体衰老的化合物及其应用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115813784A (zh) * 2022-11-28 2023-03-21 麦吉丽生物科技有限公司 α-酮戊二酸、含有α-酮戊二酸的米发酵液在制备皮肤炎症抑制剂中的用途

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Publication number Publication date
WO2020252005A1 (en) 2020-12-17
EP3980000A4 (en) 2023-06-21
CA3142781A1 (en) 2020-12-17
AU2020293094A1 (en) 2022-01-06
US20220241229A1 (en) 2022-08-04
EP3980000A1 (en) 2022-04-13
JP2022536653A (ja) 2022-08-18

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