CN114112526A - Sample suction method, system, device and computer readable storage medium - Google Patents
Sample suction method, system, device and computer readable storage medium Download PDFInfo
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- CN114112526A CN114112526A CN202010896967.8A CN202010896967A CN114112526A CN 114112526 A CN114112526 A CN 114112526A CN 202010896967 A CN202010896967 A CN 202010896967A CN 114112526 A CN114112526 A CN 114112526A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/023—Cleaning the external surface
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/027—Cleaning the internal surfaces; Removal of blockages
- B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1418—Depression, aspiration
Abstract
The invention discloses a sample suction method, which is applied to a sample analyzer, wherein the sample analyzer comprises a sampling needle and a cleaning swab which can move up and down, the cleaning swab comprises two ports, one port is used as a liquid injection port of the cleaning swab and used for injecting cleaning liquid into the cleaning swab, and the other port is used as a liquid outlet of the cleaning swab and used for discharging the cleaning liquid in the cleaning swab; the sample sucking method comprises the following steps: driving the sampling needle to move downwards to extend below the liquid level of the sample to be detected, and extracting the sample to be detected; the invention can effectively improve the sampling efficiency and save the sampling resource by driving the sampling needle to move upwards until the part of the sampling needle extending into the liquid level of the sample to be detected is positioned below the liquid outlet of the cleaning swab.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a sample suction method, a sample analysis system, sample analysis equipment and a storage medium.
Background
In sample analyzers, a sample is typically aspirated and ejected by a sampling needle, and in order to avoid mutual contamination of the sampling needle when aspirating different samples, a cleaning swab is typically used to clean the sample adhering to the outer wall of the needle each time the sampling needle aspirates a sample and withdraws the needle from a sample container.
In actual use, the needle is usually inserted into the bottom of the sample container. The depth of the lower needle is set in the mode, the requirement on the sample size is high, and the lower needle cannot be used for testing when the samples are few, so that the blood sampling difficulty is indirectly increased, and the lower needle can hurt people such as children or other people with difficulty in blood sampling.
After the sampling needle stretches into the liquid level too much, the outer wall of the sampling needle has a long distance to contact with a sample, so that a lot of time and cleaning liquid are needed to clean the outer surface of the sampling needle tip in order to avoid cross contamination of the needle when different samples are sucked, and a lot of cleaning liquid can be wasted.
Disclosure of Invention
In view of the above, it is necessary to provide a sample aspirating method, a sample analyzing system, an apparatus and a storage medium for solving the above problems.
A sample sucking method applied to a sample analyzer including a sampling needle and a cleaning swab which are movable up and down, the cleaning swab including two ports, one of the ports serving as a liquid injection port of the cleaning swab for injecting a cleaning liquid into the cleaning swab, and the other port serving as a liquid outlet of the cleaning swab for discharging the cleaning liquid from the cleaning swab; the sample sucking method comprises the following steps: driving the sampling needle to move downwards to extend below the liquid level of a sample to be detected, and extracting the sample to be detected; and driving the sampling needle to move upwards, and when the sampling needle stops, the part of the sampling needle extending into the liquid level of the sample to be detected is positioned below the liquid outlet of the cleaning swab.
A sample draw management system, the sample draw management system comprising: the extraction module is used for driving the sampling needle to move downwards to extend below the liquid level of a sample to be detected and extracting the sample to be detected; and the driving module is used for driving the sampling needle to move upwards, and when the sampling needle stops, the part of the sampling needle extending into the liquid level of the sample to be detected is positioned below the liquid outlet of the cleaning swab.
A sample pick-up device comprising a memory and a processor, the memory storing a computer program which, when executed by the processor, causes the processor to perform the steps of the method as described above.
A computer-readable storage medium, storing a computer program which, when executed by a processor, causes the processor to perform the steps of the method as described above.
The embodiment of the invention has the following beneficial effects:
after the sample needle extracts the sample that awaits measuring, the part that the upward movement stretched into below the sample liquid level that awaits measuring to the sampling needle stops behind the liquid outlet below that is located clean swab to adnexed sample that awaits measuring can not pollute the notes liquid mouth of clean swab on the sampling needle, ensures that the liquid way system can not receive the pollution, and the in-process of sampling needle upward movement need not to wash, can promote the movement speed of sampling needle, thereby promotes the efficiency of sampling, resources are saved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Wherein:
FIG. 1 is a schematic block diagram of one embodiment of a sample analyzer provided by the present invention;
FIG. 2 is a schematic diagram of a sample analyzer and a container storing a sample to be tested according to the present invention;
FIG. 3 is a schematic flow chart of a first embodiment of a sample sucking method provided by the present invention;
FIG. 4 is a schematic flow chart of a second embodiment of the sample sucking method provided by the present invention;
FIG. 5 is a schematic flow chart of a third embodiment of the sample sucking method provided by the present invention;
FIG. 6 is a schematic flow chart of an embodiment of a sample aspirating system provided by the present invention;
FIG. 7 is a schematic structural diagram of an embodiment of a sample aspirating device provided in the present invention;
FIG. 8 is a schematic structural diagram of an embodiment of a computer-readable storage medium provided by the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the actual sampling process, the sampling needle can be inserted to the bottom of the sample container, so that the sample to be detected is required to be large in quantity, and the blood sampling difficulty is increased indirectly. In addition, the outer wall of the sampling needle is in contact with the sample for a long distance, so that a lot of time and cleaning liquid are needed to clean the outer surface of the sampling needle tip, and a lot of cleaning liquid is wasted.
In order to solve the problems, the invention provides a sample sucking method which can reduce the sampling demand, reduce the cleaning procedures and improve the sampling efficiency.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a sample analyzer according to an embodiment of the present invention. The sample analyzer 10 includes a sampling needle 11 that can move up and down. The sample analyzer 10 also includes a first syringe 12, and a control valve 13. Referring to fig. 2, fig. 2 is a schematic structural diagram of a sample analyzer and a container storing a sample to be tested according to the present invention.
When sampling is performed, the sampling needle 11 is driven to move downward until the sampling needle is inserted below the liquid level of the sample to be measured, so that the sampling needle 11 can extract the sample to be measured through the cooperation of the first syringe 12 and the control valve 13. When sampling is finished, the sampling needle 11 is driven to move upwards to be away from the sample to be measured, and the sampling needle 11 discharges the collected sample to be measured through the combined action of the first syringe 12 and the control valve 13.
The sample analyzer 10 further comprises a second syringe 14, a control valve 15, a washing swab 16 and a liquid pump 17, the washing swab 16 comprising two ports 161 and 162, the second syringe 14 and the control valve 13 and the control valve 15 injecting washing liquid from the washing swab port 161 and the liquid pump 17 withdrawing washing liquid from the washing swab 16 port 162 when the sampling needle 11 needs to be washed, such that the washing of the outer wall of the sampling needle 11 is completed during the upward movement of the sampling needle 11. Therefore, in this embodiment, the port 161 is a liquid inlet of the cleaning swab 16, and the port 162 is a liquid outlet of the cleaning swab 16.
The second syringe 14, the control valve 13 and the control valve 15 are also used to inject the washing liquid from the upper port of the sampling needle 11, the washing liquid flows out from the lower port of the sampling needle 11, and the liquid pump 17 draws the washing liquid from the port 162 of the washing swab 16, so that the sampling needle 11 completes the internal washing.
Referring to fig. 3, fig. 3 is a schematic flow chart of a sample sucking method according to a first embodiment of the present invention. The sample sucking method provided by the invention comprises the following steps:
s301: the sampling needle is driven to move downwards to extend below the liquid level of the sample to be detected, and the sample to be detected is extracted.
In a specific implementation scenario, when a sample to be detected needs to be collected for detection, the sampling needle is driven to move downwards and extend below the liquid level of the sample to be detected, the sample to be detected is extracted, and the amount of the extracted sample is set according to the detection requirement.
S302: the sampling needle is driven to move upwards, and when the sampling needle stops, the part of the sampling needle extending into the liquid level of the sample to be detected is positioned below the liquid outlet of the cleaning swab.
In a concrete implementation scenario, after the sample that awaits measuring is extracted and is finished, drive sampling needle upward movement, when the sampling needle stretches into the part that awaits measuring sample liquid level below be located the liquid outlet below of clean swab, sampling needle stop motion, the sample that awaits measuring that adheres to on the sampling needle like this will not pollute the notes liquid mouth of clean swab, owing to need not to wash the outer wall of sampling needle moreover, the speed of sampling needle upward movement can accelerate.
Further, when the part of the sampling needle extending into the liquid level of the sample to be detected is positioned below the liquid outlet of the cleaning swab, the sampling needle is driven to spit out the extracted sample to be detected after the sampling needle stops moving.
It can be known through the above-mentioned description, in this embodiment, after the sample to be measured is extracted to the sampling needle, the upward movement stops after stretching into the liquid outlet below that the part of the sample liquid level that awaits measuring under the sample to the sampling needle is located clean swab to the attached sample that awaits measuring can not pollute the notes liquid mouth of clean swab on the sampling needle, ensures that liquid way system can not receive the pollution, and the in-process of sampling needle upward movement need not to wash, can promote the movement speed of sampling needle, thereby promote the efficiency of sampling, resources are saved.
Referring to fig. 4, fig. 4 is a schematic flow chart of a sample sucking method according to a second embodiment of the present invention. The sample sucking method provided by the invention comprises the following steps:
s401: and acquiring sample information of the sample to be detected and project information of the project to be detected, and acquiring the minimum distance of the sampling needle extending below the liquid level of the sample to be detected according to the sample information and the project information.
In a specific implementation scenario, before the sampling needle is driven to move downward to a position below the liquid level of the sample to be measured to extract the sample to be measured, the minimum distance that the sampling needle extends below the liquid level of the sample to be measured is obtained, so that the surface of the sampling needle is in contact with the sample to be measured as little as possible, and the sample to be measured is contaminated less.
In this implementation scenario, the item information of the item to be tested that needs to be performed by the sample to be tested may be obtained according to the sample information of the sample to be tested and the item information of the item to be tested that needs to be performed by the sample to be tested. Specifically, the sample information to be measured includes a dimensional parameter of the container in which the sample to be measured is located, such as at least one of a bottom area, a depth, a diameter, a cross-sectional area, a cross-sectional shape, and a total volume of the sample to be measured of the container. The project information includes the sample suction amount of the sample to be tested required for completing the project to be tested. In actual detection, the sample size required by different detection items is different, and the sample sucking specification is usually 5 ul-100 ul. In this implementation scenario, the sample to be tested may only need to perform one test item, and the sample size required for the test item is obtained, for example, 10 ul. In other implementation scenarios, multiple detection items may need to be detected, and the sum of the required sample absorption amounts of the multiple detection items may be calculated.
Specifically, after the sample suction amount a and the size parameter B of the container obtained from the sample information are obtained from the item information of the item to be measured, if the size parameter B is the cross-sectional area of the container, the minimum distance H by which the sampling needle extends below the liquid level of the sample to be measured is a/B. Further, considering that the sample to be tested may be consumed during the transferring process, a preset distance may be added to H after the calculated H is calculated, as a final minimum distance, for example, five percent of the value of H is added, or a fixed value, for example, 1ul is added, so as to avoid the problem of insufficient sample suction.
S402: and driving the sampling needle to extend into the position below the liquid level of the sample to be detected for the minimum distance, and extracting the sample to be detected according to the project information.
In a specific implementation scenario, after the minimum distance is calculated, the sampling needle is driven to extend into the minimum distance below the liquid level of the sample to be measured. When the needle tip of the sampling needle is contacted with the liquid level of the sample to be measured, a contact signal is generated, and the sampling needle is driven to move downwards for a minimum distance from the contact of the contact signal. In other implementation scenarios, the distance between the initial state of the sampling needle and the liquid level of the sample to be detected can be obtained in advance, the distance is added to the minimum distance, the total distance that the sampling needle needs to move downwards is obtained, and the sampling needle is driven to move downwards by the total distance.
In this implementation scenario, after the sampling needle extends to a minimum distance below the liquid level of the sample to be measured, the sample to be measured may be extracted according to the item information, for example, the sample to be measured of a corresponding amount may be extracted according to the sample suction amount of the sample to be measured required for completing the item to be measured in the item information. In other implementation scenarios, the sample to be tested may be extracted after the sampling needle extends below the liquid level of the sample to be tested, and the downward movement of the sampling needle and the extraction of the sample to be tested are performed simultaneously until the sampling needle extends below the liquid level of the sample to be tested by a minimum distance and the sample to be tested satisfies the sample suction amount of the sample to be tested required by the item to be tested.
After the sampling needle extracts the sample to be detected, the sampling needle is driven to move upwards to leave the sample to be detected, the sampling needle can be driven to move to a preset position, and the sampling needle is driven to spit the sample to be detected which is sucked before, so that the sample to be detected can be used for executing the project to be detected.
S403: and determining the cleaning grade of the sampling needle according to the sample information and the item information, and selecting the type and the dosage of the cleaning liquid.
In a specific implementation scenario, the sample information further includes the variety and viscosity of the sample to be tested, the item information further includes the number of times of sample suction required by the item to be tested, and then the cleaning grade of the sampling needle is determined according to the sample information and the item information. For example, if the sample to be tested is a sample easy to clean or a sample with a viscosity greater than a preset viscosity threshold, the cleaning grade of the sampling needle is determined to be primary, and if the sample to be tested is a sample difficult to clean or a sample with a high viscosity, the cleaning grade of the sampling needle is determined to be high. For another example, if the amount of the sample to be measured is greater than the preset sample suction threshold, the cleaning level of the sampling needle is high, and if the amount of the sample to be measured is less than or equal to the preset sample suction threshold, the cleaning level of the sampling needle is low.
Further, the type and the amount of the cleaning liquid are selected according to the variety and the viscosity of the sample to be tested, and the sample sucking amount and the sample sucking times required by the item to be tested, if the variety of the sample to be tested is blood, the cleaning liquid capable of cleaning the blood is selected, and if the variety of the sample to be tested is serum, the cleaning liquid capable of cleaning the serum is selected. If the sample suction amount of the sample to be measured is large, the usage amount of the cleaning liquid is also large, and if the sample suction amount of the sample to be measured is small, the usage amount of the cleaning liquid is also small. And if the viscosity of the sample to be detected is high, selecting cleaning liquid with strong cleaning force, and if the viscosity of the sample to be detected is low, selecting cleaning liquid with weak cleaning force.
S404: and if the cleaning grade of the sampling needle is primary, driving the sampling needle to move upwards, and when the sampling needle stops, enabling the part of the sampling needle extending below the liquid level of the sample to be detected to be positioned below the liquid outlet of the cleaning swab.
In a specific implementation scenario, please refer to fig. 2 in combination, the sampling needle is driven to move upwards until the portion of the sampling needle extending below the liquid level of the sample to be detected is located below the liquid outlet of the cleaning swab, so that the sample to be detected with the contaminated outer wall of the sampling needle will not contaminate the cleaning swab, thereby effectively saving the cleaning time.
Specifically, assuming that the minimum distance calculated in step S301 is H, the distance by which the sampling needle extends below the liquid surface of the sample to be measured is also H, and when the sampling needle moves upward, a portion that is a distance H upward from the tip of the sampling needle is located below the two ports of the cleaning swab.
S405: and if the cleaning grade of the sampling needle is high, driving the sampling needle to move upwards, so that the part of the sampling needle extending below the liquid level of the sample to be detected penetrates through the cleaning swab, and driving the cleaning swab to clean the sampling needle by using the cleaning liquid.
In one specific implementation, referring to fig. 2 in combination, the sampling needle is driven to move upward so that the portion of the sampling needle extending below the liquid surface passes through the cleaning swab, the second syringe 14 and the control valve 13 and 15 inject the cleaning fluid from the port 161 of the cleaning swab, and the fluid pump 17 draws the cleaning fluid from the port 162 of the cleaning swab 16, thereby completing the cleaning of the outer wall of the sampling needle 11 during the upward movement of the sampling needle 11.
S406: and after the sampling needle is driven to spit out the extracted sample to be detected, the sampling needle is cleaned inside and outside.
In a specific implementation scenario, the sampling needle is driven to eject the extracted sample to be tested, and the ejected sample to be tested is used for testing the item to be tested. The sampling needle that spits the sample that awaits measuring carries out inside and outside cleanness, and it can be as above to carry out outside cleanness to the sampling needle, and the sampling needle after the cleanness can be used for sampling other samples. Because only a small part of the outer wall of the sampling needle contacts the sample to be measured, the part needing to be cleaned is small, the cleaning time is short, and the consumed cleaning resource is less.
According to the above description, in this embodiment, through obtaining the sample information of the sample to be tested and the project information of the project to be tested, the minimum distance that the sampling needle stretches into the sample liquid level of the sample to be tested is obtained according to the sample information and the project information, the minimum distance that the sampling needle stretches into the liquid level of the sample to be tested is driven, the sample to be tested is extracted according to the project information, the contact area between the sampling needle and the sample to be tested can be reduced, different cleaning methods are adopted according to different cleaning grades, and the resource utilization rate and the sampling efficiency can be effectively improved.
Referring to fig. 5, fig. 5 is a schematic flow chart of a sample sucking method according to a third embodiment of the present invention. The sample sucking method provided by the invention comprises the following steps:
s501: acquiring the last cleaning time and the current time of the sampling needle, calculating the time interval between the last cleaning time and the current time, and setting the initial cleaning times and time of the sampling needle according to the time interval.
In one particular implementation scenario, initial cleaning of the sampling needle is required before the sampling needle is used for sampling, which includes cleaning both the inner and outer walls of the sampling needle. An identification code may be configured for each sampling needle, and after the step of performing inside and outside cleaning in step S406 is performed after each time the sampling needle is used, the time for performing the inside and outside cleaning is recorded. When the sampling needle is used for sampling again, the longer the unused time is after the sampling needle is cleaned, the higher the probability that the sampling needle is polluted is, and the higher the requirement on cleaning the sampling needle is.
Specifically, the last cleaning time and the current time of the sampling needle may be acquired, the time interval between the last cleaning time and the current time may be calculated, and the number and time of initial cleaning of the sampling needle may be set according to the time interval. For example, if the time interval is less than or equal to a first time threshold, for example, less than or equal to 30 minutes, a first wash is performed on the sampling needle, and if the time interval is greater than the first time threshold and less than or equal to a second time threshold, for example, greater than 30 minutes and less than or equal to 60 minutes, a second wash is performed on the sampling needle, where the time and/or cleaning force of the first wash is less than that of the second wash. If the time interval is greater than the second time threshold, for example greater than 60 minutes, a third wash of the sampling needle is performed, the time and/or cleaning effort of the third wash being greater than the second wash. In one implementation scenario, the third purge includes two second purges, facilitating purging of air bubbles inside the sampling needle while purging the sampling needle.
Further, in order to save time effectively and improve efficiency, the sampling needle can be cleaned initially in the process of moving from the initial position to the position above the sample to be sampled.
S502: and acquiring sample information of the sample to be detected and project information of the project to be detected, and acquiring the minimum distance of the sampling needle extending below the liquid level of the sample to be detected according to the sample information and the project information.
S503: and driving the sampling needle to extend into the position below the liquid level of the sample to be detected for the minimum distance, and extracting the sample to be detected according to the project information.
In a specific implementation scenario, steps S502 to S503 are substantially the same as steps S401 to S402 in the second embodiment of the sample suction method provided by the present invention, and are not described herein again.
S504: and judging whether the current sample suction times are equal to the sample suction times required by the item to be detected.
In a specific implementation scenario, the number of times of the sample sucking for the item to be tested may be greater than one, that is, the item to be tested needs to perform multiple sample sucking on the same sample periodically or non-periodically. And acquiring the sample sucking times of the sampling needle in the sampling process through the project information.
When the number of times of sample suction is determined to be multiple times, obtaining the current number of times of sample suction, and determining whether the current number of times of sample suction is equal to the number of times of sample suction required by the item to be tested. Therefore, whether the current sample suction times are equal to the sample suction times required by the item to be detected or not can be judged.
S505: and if the current sample suction times are smaller than the sample suction times required by the item to be detected, the cleaning grade of the sampling needle is primary.
In a specific implementation scenario, if the current number of times of sample suction is less than the number of times of sample suction required by the item to be tested, the sampling needle needs to perform at least one sample suction, so that the cleaning grade of the sampling needle is determined as primary, that is, the outer wall of the sampling needle is not cleaned temporarily. The specific content is substantially the same as step S404 in the first embodiment of the sample suction method provided by the present invention, and details are not repeated here.
Further, referring to fig. 1 and fig. 2 in combination, after the sample is completely sucked by the sampling needle, the liquid pump is driven to pump off the sample to be detected attached to the surface of the sampling needle, so that the accuracy and reliability of the sample suction are effectively improved.
Furthermore, after the sample suction of the sampling needle is finished, the part of the sampling needle, which is contacted with the sample to be detected during the sample suction, is washed by the cleaning solution, so that the sample suction reliability is further improved.
S506: and if the current sample suction times are equal to the sample suction times required by the item to be tested, the cleaning grade of the sampling needle is high.
In a specific implementation scenario, if the current sample suction times are equal to the sample suction times required by the item to be tested, the current sampling is finished, the cleaning grade is set to high grade, and the outer wall of the sampling needle is cleaned. Furthermore, the sampling needle can be driven to move to a position where the part of the sampling needle extending below the liquid level of the sample to be detected is positioned below the cleaning swab, and the sampling needle is driven to continue to move upwards in the process of returning to the initial position from the upper part of the sample to be detected, so that the cleaning swab can clean the sampling needle.
According to the above description, in this embodiment, if need carry out a lot of in the sampling process and inhale the appearance, then only clean sampling needle outer wall after the sample is inhaled to last time and is accomplished, can effectively promote the work efficiency of sampling, save time.
Referring to fig. 6, fig. 6 is a schematic flow chart of a sample sucking system according to an embodiment of the present invention. The sample aspirating system 20 includes a draw module 21 and a drive module 22.
The extraction module 21 is used for driving the sampling needle to move downwards to extend below the liquid level of the sample to be detected, and extracting the sample to be detected. The driving module 22 is used for driving the sampling needle to move upwards, and when the sampling needle stops, the part of the sampling needle extending below the liquid level of the sample to be detected is positioned below the liquid outlet of the cleaning swab.
The extraction module 21 is further configured to obtain sample information of the sample to be detected and item information of the item to be detected, and obtain a minimum distance that the sampling needle extends below a liquid level of the sample to be detected according to the sample information and the item information; and driving the sampling needle to extend into the position below the liquid level of the sample to be detected for the minimum distance, and extracting the sample to be detected according to the project information.
The driving module 22 is also used for determining the cleaning grade of the sampling needle according to the sample information and the item information, and selecting the type and the dosage of the cleaning liquid; if the cleaning grade of the sampling needle is primary, driving the sampling needle to move upwards, and when the sampling needle stops, enabling the part of the sampling needle extending below the liquid level of the sample to be detected to be positioned below the liquid outlet of the cleaning swab; and if the cleaning grade of the sampling needle is high, driving the sampling needle to move upwards, so that the part of the sampling needle extending below the liquid level of the sample to be detected penetrates through the cleaning swab, and driving the cleaning swab to clean the sampling needle by using the cleaning liquid. The sample information comprises the size parameter of a container where the sample to be detected is located, the variety and the viscosity of the sample to be detected, and the project information comprises the sample suction amount of the sample to be detected required for completing the project to be detected and the sample suction times required for the project to be detected.
The driving module 22 is further configured to determine that the cleaning grade of the sampling needle is high if the viscosity of the sample to be tested is greater than the preset viscosity threshold; and/or if the sample suction amount of the sample to be detected is larger than a preset sample suction threshold value, the cleaning grade of the sampling needle is high.
The driving module 22 is further configured to determine whether the number of times of sample suction required by the item to be tested is greater than one, determine whether the current number of times of sample suction is equal to the number of times of sample suction required by the item to be tested, determine that the cleaning level of the sampling needle is high if the current number of times of sample suction is equal to the number of times of sample suction required by the item to be tested, and determine that the cleaning level of the sampling needle is low if the current number of times of sample suction is less than the number of times of sample suction required by the item to be tested.
The sample analyzer further comprises a liquid pump, and the driving module 22 is further configured to drive the liquid pump to pump off the sample to be measured attached to the surface of the sampling needle.
The drive module 22 is also used for internal cleaning of the interior of the sampling needle.
The extraction module 21 is further configured to obtain a last cleaning time and a current time of the sampling needle, and calculate a time interval between the last cleaning time and the current time; the number and time of initial cleaning of the sampling needle are set according to the time interval.
It can be known through the above description, inhale in this embodiment behind the sample system drive sampling needle extraction sample that awaits measuring, upward movement stops to the sampling needle stretches into behind the liquid outlet below that the part below the sample liquid level that awaits measuring is located clean swab to the sample needle, thereby the liquid way system is ensured not to receive the pollution to adnexed sample that awaits measuring can not pollute the notes liquid mouth of clean swab on the sampling needle, and the liquid way system need not to wash at the in-process of sampling needle upward movement, can promote the movement speed of sampling needle, thereby promote the efficiency of sampling, resources are saved.
Referring to fig. 7, fig. 7 is a schematic structural diagram of a sample sucking device according to an embodiment of the present invention. The sample suction device 30 comprises a processor 31 and a memory 32. The processor 31 is coupled to the memory 32. The memory 32 has stored therein a computer program which is executed by the processor 31 when in operation to implement the method as shown in fig. 3-5. The detailed methods can be referred to above and are not described herein.
It can be known through the above description, inhale appearance device drive sampling needle extraction sample back that awaits measuring in this embodiment, upward movement stops after the part that the sampling needle stretched into below the sample liquid level that awaits measuring is located the liquid outlet below of clean swab to the adnexed sample that awaits measuring can not pollute the notes liquid mouth of clean swab on the sampling needle, ensures that liquid way system can not receive the pollution, the in-process of sampling needle upward movement need not to wash, can promote the movement speed of sampling needle, thereby promote the efficiency of sampling, resources are saved.
Referring to fig. 8, fig. 8 is a schematic structural diagram of an embodiment of a computer-readable storage medium according to the present invention. The computer-readable storage medium 40 stores at least one computer program 41, and the computer program 41 is used for being executed by a processor to implement the method shown in fig. 3 to 5, and the detailed method can be referred to above and is not described herein again. In one embodiment, the computer readable storage medium 40 may be a memory chip in a terminal, a hard disk, or other readable and writable storage tool such as a removable hard disk, a flash disk, an optical disk, or the like, and may also be a server or the like.
It can be known from the above description that, in this embodiment, the computer program in the computer-readable storage medium can be used to drive the sampling needle to extract the sample to be tested, and move upward until the portion of the sampling needle below the liquid level of the sample to be tested is located below the liquid outlet of the cleaning swab, and then stop, so that the sample to be tested attached to the sampling needle does not contaminate the liquid injection port of the cleaning swab, and it is ensured that the liquid path system is not contaminated, and the sampling needle does not need to be cleaned during the upward movement process, and the movement speed of the sampling needle can be increased, thereby increasing the sampling efficiency and saving resources.
Different from the prior art, after the sampling needle extracts a sample to be detected, the part of the sampling needle, which extends into the liquid level of the sample to be detected, is positioned below the liquid outlet of the cleaning swab and then stops moving upwards, so that the sample to be detected attached to the sampling needle cannot pollute the liquid injection port of the cleaning swab, a liquid path system cannot be polluted, the sampling needle does not need to be cleaned in the upward movement process, the movement speed of the sampling needle can be increased, the sampling efficiency is improved, and resources are saved.
It will be understood by those skilled in the art that all or part of the processes of the methods of the embodiments described above can be implemented by hardware related to instructions of a computer program, and the program can be stored in a non-volatile computer readable storage medium, and when executed, can include the processes of the embodiments of the methods described above. Any reference to memory, storage, database, or other medium used in the embodiments provided herein may include non-volatile and/or volatile memory, among others. Non-volatile memory can include read-only memory (ROM), Programmable ROM (PROM), Electrically Programmable ROM (EPROM), Electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), Dynamic RAM (DRAM), Synchronous DRAM (SDRAM), Double Data Rate SDRAM (DDRSDRAM), Enhanced SDRAM (ESDRAM), Synchronous Link DRAM (SLDRAM), Rambus Direct RAM (RDRAM), direct bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).
The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above examples only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present application. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A sample sucking method, which is applied to a sample analyzer, wherein the sample analyzer comprises a sampling needle capable of moving up and down and a cleaning swab, and the cleaning swab comprises two ports, one of the two ports is used as a liquid injection port of the cleaning swab and used for injecting a cleaning liquid into the cleaning swab, and the other port is used as a liquid outlet of the cleaning swab and used for discharging the cleaning liquid in the cleaning swab;
the sample sucking method comprises the following steps:
driving the sampling needle to move downwards to extend below the liquid level of a sample to be detected, and extracting the sample to be detected;
and driving the sampling needle to move upwards, and when the sampling needle stops, the part of the sampling needle extending into the liquid level of the sample to be detected is positioned below the liquid outlet of the cleaning swab.
2. The method according to claim 1, wherein the step of driving the sampling needle to move downwards to extend below the liquid level of the sample to be tested to extract the sample to be tested comprises the following steps:
acquiring sample information of a sample to be detected and project information of a project to be detected, and acquiring the minimum distance of the sampling needle extending below the liquid level of the sample to be detected according to the sample information and the project information;
driving the sampling needle to extend into the position below the liquid level of the sample to be detected by the minimum distance, and extracting the sample to be detected according to the project information;
the step of driving the sampling needle to move upwards, and when the sampling needle stops, the part of the sampling needle extending into the liquid level of the sample to be detected is positioned below the liquid outlet of the cleaning swab, and the step of driving the sampling needle to move upwards comprises the following steps:
determining the cleaning grade of the sampling needle according to the sample information and the item information, and selecting the type and the dosage of cleaning liquid;
if the cleaning grade of the sampling needle is primary, driving the sampling needle to move upwards, and when the sampling needle stops, enabling the part of the sampling needle extending below the liquid level of the sample to be detected to be located below the liquid outlet of the cleaning swab;
if the cleaning grade of the sampling needle is high, driving the sampling needle to move upwards, enabling the part of the sampling needle extending below the liquid level of the sample to be detected to penetrate through the cleaning swab, and driving the cleaning swab to clean the sampling needle by using the cleaning liquid with the using amount;
the sample information comprises the size parameter of a container where the sample to be detected is located, the variety and the viscosity of the sample to be detected, and the project information comprises the sample suction amount of the sample to be detected required for completing the project to be detected and the sample suction times required for completing the project to be detected.
3. The method of claim 2, wherein the step of determining a cleaning level of the sampling needle based on the sample information and the item information comprises:
if the viscosity of the sample to be detected is greater than a preset viscosity threshold value, the cleaning grade of the sampling needle is high; and/or
And if the sample suction amount of the sample to be detected is larger than a preset sample suction threshold value, the cleaning grade of the sampling needle is high.
4. The method according to claim 2, wherein if the number of times of the sample sucking required for the item to be tested is more than one, the step of determining the cleaning grade of the sampling needle according to the sample information and the item information comprises:
judging whether the current sample suction times are equal to the sample suction times required by the item to be detected, if so, judging that the cleaning grade of the sampling needle is high grade, and if the current sample suction times are smaller than the sample suction times required by the item to be detected, judging that the cleaning grade of the sampling needle is low grade.
5. The method of claim 4, wherein the sample analyzer further comprises a liquid pump;
the current sample suction times are less than the sample suction times required by the item to be detected, the sampling needle is driven to move upwards, and when the sampling needle stops, the part of the sampling needle extending into the liquid level of the sample to be detected below the liquid outlet of the cleaning swab is positioned before the step of the liquid outlet below the liquid level of the cleaning swab, the method comprises the following steps:
and driving the liquid pump to dry the sample to be detected attached to the surface of the sampling needle.
6. The method according to claim 4, wherein the step of actuating the cleaning swab to clean the sampling needle with the amount of the cleaning liquid comprises:
internally cleaning the interior of the sampling needle.
7. The method according to claim 2, wherein the step of obtaining the sample information of the sample to be tested and the item information of the item to be tested is preceded by the steps of:
acquiring last cleaning time and current time of the sampling needle, and calculating time intervals of the last cleaning time and the current time;
setting the number and time of initial cleaning of the sampling needle according to the time interval.
8. A sample pipetting system, wherein the sample pipetting management system comprises:
the extraction module is used for driving the sampling needle to move downwards to extend below the liquid level of a sample to be detected and extracting the sample to be detected;
and the driving module is used for driving the sampling needle to move upwards, and when the sampling needle stops, the part of the sampling needle extending into the liquid level of the sample to be detected is positioned below the liquid outlet of the cleaning swab.
9. A sample pick-up device comprising a memory and a processor, the memory storing a computer program which, when executed by the processor, causes the processor to carry out the steps of the method according to any one of claims 1 to 7.
10. A computer-readable storage medium, in which a computer program is stored which, when being executed by a processor, causes the processor to carry out the steps of the method according to any one of claims 1 to 7.
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| CN202010896967.8A CN114112526A (en) | 2020-08-31 | 2020-08-31 | Sample suction method, system, device and computer readable storage medium |
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| CN202010896967.8A CN114112526A (en) | 2020-08-31 | 2020-08-31 | Sample suction method, system, device and computer readable storage medium |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102649121A (en) * | 2012-05-02 | 2012-08-29 | 深圳市国赛生物技术有限公司 | Sampling needle cleaner and sample analyzing device therewith inside |
| CN103433256A (en) * | 2013-09-04 | 2013-12-11 | 深圳市锦瑞电子有限公司 | Cleaning device and cleaning method for sampling needle of specific protein analysis meter |
| CN207036844U (en) * | 2017-06-30 | 2018-02-23 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyser |
| CN207742210U (en) * | 2017-08-03 | 2018-08-17 | 力合科技（湖南）股份有限公司 | A kind of sampler and the sampling device using the device, detecting system |
| CN209035024U (en) * | 2018-08-31 | 2019-06-28 | 深圳市帝迈生物技术有限公司 | A kind of blood cell analysis machine |
| CN110871202A (en) * | 2018-08-31 | 2020-03-10 | 深圳市帝迈生物技术有限公司 | Sampling needle cleaning method and blood cell analyzer |
-
2020
- 2020-08-31 CN CN202010896967.8A patent/CN114112526A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102649121A (en) * | 2012-05-02 | 2012-08-29 | 深圳市国赛生物技术有限公司 | Sampling needle cleaner and sample analyzing device therewith inside |
| CN103433256A (en) * | 2013-09-04 | 2013-12-11 | 深圳市锦瑞电子有限公司 | Cleaning device and cleaning method for sampling needle of specific protein analysis meter |
| CN207036844U (en) * | 2017-06-30 | 2018-02-23 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyser |
| CN207742210U (en) * | 2017-08-03 | 2018-08-17 | 力合科技（湖南）股份有限公司 | A kind of sampler and the sampling device using the device, detecting system |
| CN209035024U (en) * | 2018-08-31 | 2019-06-28 | 深圳市帝迈生物技术有限公司 | A kind of blood cell analysis machine |
| CN110871202A (en) * | 2018-08-31 | 2020-03-10 | 深圳市帝迈生物技术有限公司 | Sampling needle cleaning method and blood cell analyzer |
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