CN114099571A

CN114099571A - Composition for treating arthralgia and preparation method thereof

Info

Publication number: CN114099571A
Application number: CN202111486271.9A
Authority: CN
Inventors: 王斌; 杨继广
Original assignee: Beijing Chizhen Traditional Chinese Medicine Technology Development Co ltd
Current assignee: Beijing Chizhen Traditional Chinese Medicine Technology Development Co ltd
Priority date: 2021-12-07
Filing date: 2021-12-07
Publication date: 2022-03-01

Abstract

The invention belongs to the technical field of Chinese herbal medicines, and discloses a composition for treating arthralgia and a preparation method thereof. The external application is suitable for treating arthralgia caused by rheumatoid arthritis, is beneficial to curing the arthralgia caused by conventional causes and relieving the symptoms of the arthralgia caused by rheumatoid arthritis. Bitter taste and warm nature; the liver meridian and kidney meridian entered are the therapeutic criteria. The Chinese medicinal composition has the effects of promoting blood circulation to remove blood stasis, dispelling pathogenic wind and relieving pain after being combined with garden balsam stem, rhizoma drynariae, angelica tail, red paeony root, frankincense, myrrh, sapanwood, divaricate saposhnikovia root, Chinese arborvitae twig, spikemoss twig, raw ephedra, scorpion and centipede. Decocting to separate out effective components, adding yellow wine and Chinese liquor, standing, sterilizing, and promoting skin absorption. After the product is sprayed, a drug film is formed on the skin surface of a patient, water, white vinegar and glycerol are added, the white vinegar is beneficial to the dispersion of the glycerol, the glycerol has a lubricating effect, the water is used for harmonizing the drugs and is used as a carrier for driving the drugs to be attached to the skin surface of the patient when the product is sprayed subsequently.

Description

Composition for treating arthralgia and preparation method thereof

Technical Field

The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a composition for treating arthralgia and a preparation method thereof.

Background

Rheumatic arthralgia refers to a disease with muscle and joint pain caused by wind-cold-dampness pathogen, which can not only cause the joint pain of various parts of waist and legs, which is very intolerable for patients, and difficulty in walking of lower limbs, but also can cause paralysis and lifelong disability. The incidence rate of rheumatic arthralgia in people is high and tends to rise year by year, and many people are unconscious and asymptomatic when suffering from the rheumatic arthralgia, but the symptoms of the rheumatic arthralgia are more and more severe with the age.

The traditional Chinese medicine considers that the etiology and the pathology of the rheumatic-cold arthralgia have two aspects: 1. physically weak pathogen invasion: the deficiency of the body, loose striae and skin striae, insecurity of ying and defensive qi, retention of exogenous pathogenic factors in meridians, joints and muscles, blockage of qi and blood, and unsmooth circulation; 2. affection of exogenous wind-cold-dampness pathogen: for those with irregular climate change, alternating cold and hot conditions, or damp residence, wading of water and rain, the exogenous pathogenic factors directly enter the muscles, joints, tendons and vessels to cause arthralgia syndrome.

At present, most of the medicines adopted by western medicine for treating the disease are antibiotics, hormones and analgesics, and the physiotherapy is heat treatment, physiotherapy, acupuncture and massage. The traditional Chinese medicine is used for treating patients with a long disease period, but the long-term taking of the medicine not only can generate drug resistance, but also can generate adverse reactions such as gastrointestinal function damage, osteoporosis, endocrine disturbance, nervous system disorder, cortin hyperfunction and the like, and can not completely remove roots, and the traditional Chinese medicine is used for long-term persistence, can not be interrupted and can not be cured radically.

Disclosure of Invention

In order to solve the technical problems of poor administration effect and unsatisfactory treatment result of the joint pain caused by the rheumatoid arthritis in the prior art, the invention aims to provide a composition for treating the joint pain and a preparation method thereof.

The technical scheme adopted by the invention is as follows: the composition for treating arthralgia is mainly prepared from the following raw materials in parts by mass:

10-50 parts of garden balsam stem, 10-50 parts of rhizoma drynariae, 6-30 parts of angelica tail, 6-30 parts of red paeony root, 3-15 parts of frankincense, 3-15 parts of myrrh, 3-15 parts of sappan wood, 3-15 parts of divaricate saposhnikovia root, 10-50 parts of cacumen biotae twig, 10-50 parts of sabina chinensis, 6-30 parts of raw ephedra, 1-10 parts of scorpion and 1-10 parts of centipede.

Garden balsam stem, name of traditional Chinese medicine. Is whole plant of Speranskia turbinata (Bunge) Baill. The plant radix seu folium Broussonetiae is distributed in Liaoning, Jilin, inner Mongolia, Hebei, Henan, Shanxi, Gansu, Shandong, Jiangsu, Anhui, and Sichuan of China. Has the effects of dispelling pathogenic wind, removing dampness, relaxing muscles and tendons, promoting blood circulation, removing blood stasis, relieving swelling, removing toxic substance, and relieving pain. It can be used for treating rheumatic arthralgia, contracture of tendons and bones, cold-dampness, tinea pedis, lumbar sprain, paralysis, amenorrhea, eczema of scrotum, skin ulcer, furuncle, and pyogenic infections. Pungent flavor and warm nature. Enter liver and kidney meridians.

Drynaria rhizome, the name of traditional Chinese medicine. Is rhizome of Drynaria fortunei (Kunze) J.Sm. of Drynaria of Drynariaceae. Has effects of promoting blood circulation, promoting wound healing, invigorating kidney, and strengthening bone. Can be used for treating traumatic injury or wound, bone and muscle injury, blood stasis, swelling and pain, lumbago, asthenia, tinnitus, deafness, toothache, and chronic diarrhea. Bitter taste and warm nature; it enters liver and kidney meridians. Chemical components: contains naringin, rhizoma Drynariae dihydroflavonol glycoside, and garrulous bone acid supplementing agent. The pharmacological action is as follows: the water decoction and alcohol precipitation solution has effects of preventing increase of serum cholesterol and triglyceride, and preventing formation of atherosclerotic plaque; rhizoma Drynariae polysaccharide and rhizoma Drynariae dihydroflavoneglycoside have effects of reducing blood lipid and resisting arteriosclerosis. The bone fragment can promote the absorption of calcium by bones, improve the levels of blood calcium and blood phosphorus and facilitate the healing of fracture; improve cartilage cells and delay the degenerative change of bone cells. In addition, the rhizoma drynariae dihydroflavonol glycoside has obvious sedative and analgesic effects.

The surface of the angelica root, i.e. the tail of Dang Gui, is yellowish-brown to tan, with longitudinal wrinkles and transverse long skin pores. The root and head (return to the head) has a diameter of 1.5-4 cm, has ring veins, has a round and blunt upper end, and can activate blood circulation to remove blood stasis, and treat amenorrhea and blood stasis accumulation and swelling pain.

Red peony root, name of Chinese traditional medicine. Is dried root of Paeonia lactiflora pall or Paeonia veitchii Lynch of Paeonia of Paeoniaceae. Has the effects of clearing heat, cooling blood, promoting blood circulation and removing blood stasis. It can be used for treating macula due to toxic heat, hematemesis, epistaxis, conjunctival congestion, swelling and pain, carbuncle, swelling, sore, ulcer, stagnation of liver-qi, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal mass, abdominal pain, and traumatic injury. Bitter taste and slightly cold nature; it enters liver meridian. Chemical components: the product contains paeoniflorin, albiflorin, oxypaeoniflorin, benzoylpaeoniflorin, peonidine, peoniflorin, gallotannin, benzoic acid, volatile oil, fatty oil, resin, etc. The pharmacological action is as follows: the product has effects in dilating coronary artery and increasing coronary blood flow; the water extract of radix Paeoniae Rubra, paeoniflorin, radix Paeoniae Rubra and its derivatives have platelet aggregation inhibiting effect; the water decoction can prolong the time of in vitro thrombosis and reduce the dry weight of the thrombus. The paeoniflorin has tranquilizing, antiinflammatory and analgesic effects. Radix Paeoniae fluid extract and paeoniflorin have anticonvulsive effect. Radix Paeoniae Rubra and paeoniflorin have spasmolytic effect; the red peony root has obvious enhancement effect on the synthesis of hepatocyte DNA and stronger inhibition effect on various pathogenic microorganisms.

Frankincense, name of traditional Chinese medicine. Is resin exuded from bark of Boswellia carterii Birdw of Boswellia of Burseraceae and plants of the same genus. Has effects of promoting blood circulation, activating qi-flowing, relieving pain, eliminating swelling and promoting granulation. The traditional Chinese medicine is mainly used for activating blood and promoting qi circulation to relieve pain, reducing swelling and promoting granulation, and relieving pain due to qi stagnation and blood stasis. Pungent and bitter taste, warm nature; it enters heart, liver and spleen meridians. Chemical components: mainly contains resin, gum and volatile oil. The main components of the resin are free alpha, beta-boswellic acid, combined boswellic acid and boswellic resin hydrocarbon; the gum comprises calcium and magnesium salt of arabonic acid, and tragacanth as main ingredient; the volatile oil contains pinene, alpha-phellandrene, beta-phellandrene, etc. The pharmacological action is as follows: olibanum has effects of relieving pain, diminishing inflammation, increasing leukocyte, accelerating excretion of inflammatory exudation, and promoting wound healing; pinene contained in the extract has the effect of eliminating phlegm; the frankincense can obviously relieve gastric mucosa injury and stress mucosa injury caused by aspirin, phenylbutazone and reserpine, and reduce pyloric ligation ulcer index and gastric juice free acidity.

Myrrh, name of traditional Chinese medicine. Is oleoresin exuded from bark of Commiphora myrrha Engl. or other plants of the same genus of Commiphora of Burseraceae. Has effects of promoting blood circulation, relieving pain, eliminating swelling, and promoting granulation. Can be used for treating traumatic injury, swelling and pain due to blood stasis, carbuncle, cellulitis, swelling and pain, unhealed skin ulcer, chest pain, hypochondriac pain, cardialgia, dysmenorrhea, puerperal abdominal pain, rheumatalgia, and abdominal mass. Pungent, bitter and neutral in flavor; it enters heart, liver and spleen meridians. Chemical components: comprises Myrrha resin, volatile oil (eugenol, etc.), gum, small amount of bitter substances, and also comprises bisabolol, formic acid, acetic acid, oxidase, etc. The pharmacological action is as follows: 1. effects on the metabolic system: has effects in reducing blood lipid and preventing formation of atherosclerotic plaque. 2. Effects on uterus: the myrrh firstly shows transient excitation to the isolated uterus, so that the uterine tension is improved, the contraction frequency is increased, and then the inhibition phenomenon is shown. 3. The function of resisting pathogenic microorganisms: the water-soaking agent has inhibitory effect on various pathogenic fungi such as Trichophyton violaceum, Trichophyton concentricum, Trichophyton schoenleini, etc., and the volatile oil can slightly inhibit mould. 4. In addition, Mo Yao has local stimulation and can stimulate the peristalsis of intestine.

Lignum sappan, name of Chinese traditional medicine. Is dried heartwood of Caesalpinia sappan L. of Rutaceae of Leguminosae. Has effects of promoting blood circulation, healing wound, removing blood stasis, and dredging channels. Can be used for treating traumatic injury, fracture, injury of tendons and bones, blood stasis, swelling and pain, amenorrhea due to blood stasis, puerperal abdominal pain due to blood stasis, dysmenorrhea, pain of heart and abdomen, carbuncle, swelling, and sore. Sweet, salty, pungent and neutral in nature; it enters heart and liver meridians. Chemical components: contains brazilein, volatile oil (mainly phellandrene and ocimene) and tannin. The pharmacological action is as follows: 1. influence on the circulation system: the lignum sappan decoction can enhance the contraction of in vitro frog heart, and the water decoction can increase coronary blood flow and promote microcirculation. 2. Effects on the blood system: brazilin and hematoxylin can inhibit platelet aggregation induced by ADP and promote blood coagulation. 3. Effects on the nervous system: the lignum sappan decoction has sedative and hypnotic effects, and can resist central excitation of strychnine and cocaine. 4. The function of resisting pathogenic microorganisms: the lignum sappan decoction and decoction have effect in inhibiting Bacillus leukotrichiae, Staphylococcus aureus, and Salmonella typhi. 5. In addition, lignum sappan has anticancer, antiinflammatory, and immunosuppressive effects.

Ledebouriella root, name of Chinese medicine. Is root of Saposhnikovia divaricata (Turcz.) Schischk. of Saposhnikovia of Umbelliferae. Has the effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm. It can be used for treating exterior syndrome due to exogenous pathogenic factors, rubella pruritus, rheumatalgia, and tetanus. Pungent and sweet in flavor and slightly warm in nature; it enters bladder and liver meridians. Chemical components: the product contains volatile oil, mannitol, beta-sitosterol, picroside, phenols, polysaccharides, organic acids, etc. The pharmacological action is as follows: the product has antipyretic, antiinflammatory, tranquilizing, analgesic, anticonvulsive, and antiallergic effects. The divaricate saposhnikovia root fresh juice has a certain antibacterial effect on pseudomonas aeruginosa and staphylococcus aureus, the decoction has different degrees of inhibition effects on dysentery bacillus, hemolytic streptococcus and the like, and the decoction has the effect of enhancing the phagocytic function of abdominal cavity macrophages of mice.

Cacumen biotae, named as traditional Chinese medicine. Is the tender branch of the Chinese arborvitae twig of Myricaria paniculata P.Y.Zhang et Y.J.Zhang of Tamaricaceae. Has the effects of relieving exterior syndrome, promoting eruption, dispelling pathogenic wind and relieving itching. Can be used for treating measles, fever, cough, rheumatalgia, rubella, pruritus, and tinea. Pungent and sweet in flavor and warm in nature; it enters lung and liver meridians.

Sabina vulgaris, name of Chinese medicine. Is root, root bark or branch and leaf of Juniperus formosana Hayata of Juniperus of Cupressaceae. The plant Juniperus Rigida is distributed in southwest, Shaanxi, Gansu, Qinghai, Jiangsu, Anhui, Zhejiang, Fujian, Taiwan, Jiangxi, Hubei, Hunan, Tibet and other places in China. Has the effects of clearing away heat and toxic materials, eliminating dampness and relieving itching. It can be used for treating measles, hyperpyrexia, eczema, tinea, and sore. Bitter taste and cold nature. Enter liver meridian.

Raw Ma Huang is pungent and warm in nature and flavor. Has effects of inducing sweat, relieving exterior syndrome, dispersing lung qi, relieving asthma, and inducing diuresis to alleviate edema. Can be used for treating headache, nasal obstruction, rhinorrhea, sneeze, etc. caused by common cold due to wind-cold. In addition, the ephedra herb has the functions of ventilating the lung and relieving asthma, and can be used for treating cough, asthma and other diseases caused by wind-cold restraining the lung. According to clinical pharmacology, the ephedra has the functions of strengthening heart, promoting urination and expanding blood vessels, and can relieve contracted bronchus, so that the ephedra can be used for treating diseases such as chronic bronchitis, bronchopneumonia, pulmonary heart disease, emphysema and the like.

Scorpio, named as Chinese medicine. Is dried body of Buthus martensii Karsch belonging to Buthus of Buthidae. Has effects of calming endogenous wind, relieving spasm, removing toxic substances, resolving hard mass, dredging collaterals, and relieving pain. Can be used for treating convulsion, spasm and convulsion due to various reasons; sores and ulcers, swelling, scrofula, tuberculosis, gangrene, breast abscess and swelling; stubborn arthralgia due to wind-damp evils, spasm of tendons and vessels; intractable migraine; and can be used for treating various tumors. Pungent taste and mild nature; it enters liver meridian. Chemical components: the product contains scorpion venom, a protein similar to snake venom neurotoxin. And comprises trimethylamine, betaine, taurine, palmitic acid, cholesterol, lecithin, ammonium salt and the like. And trace elements such as sodium, potassium, calcium, magnesium, iron, copper, zinc, manganese and the like. Most researches are carried out on scorpion toxin III and antiepileptic peptide (AEP) with the strongest analgesic activity. The pharmacological action is as follows: 1. action on the central nervous system: has analgesic, anticonvulsive, and antiepileptic effects. 2. Effect on the cardiovascular system: the scorpion venom of Buthus martensii Karsch has the effects of enhancing myocardial contractility and remarkably improving the contraction function of the left ventricle. Scorpion venom can raise blood pressure obviously. The compound scorpion oral liquid has the functions of resisting thrombosis, reducing the adhesion rate of blood platelets and delaying blood coagulation for healthy rabbits. 3. Immunological activity: the scorpion venom contains protein as main component and thus has certain antigenicity. 4. Other functions are as follows: scorpion venom can promote the release of acetylcholine, increase the levels of adrenaline and noradrenaline in blood plasma, affect the permeability of nerve membranes, and produce uterine contractions, resulting in early abortion. Also has antibacterial and antitumor effects.

Centipede, name of traditional Chinese medicine. Is dried product of Scolopendra subspinipes mutilans L.Koch of Scolopendra family. Has effects of calming endogenous wind, relieving spasm, removing toxic substances, resolving hard mass, dredging collaterals, and relieving pain. Mainly treats spasm and convulsion caused by various reasons; sores and ulcers, swelling, scrofula and tuberculosis; stubborn rheumatism and arthralgia; intractable migraine; bite by poisonous snake. Pungent taste and warm nature; it enters liver meridian. Chemical components: the product contains two components similar to bee venom, namely histamine-like substance and hemolytic protein. Contains fatty oil, cholesterol, formic acid, histidine, arginine, leucine, and other amino acids. It also contains saccharide, protein, and multiple trace elements such as Fe, Zn, Mn, Ca, Mg, etc. The pharmacological action is as follows: 1. effect on the cardiovascular system: the centipede water-soluble deproteinized extracting solution has the function of strengthening myocardial contraction force within a certain dosage range, and the myocardial contraction force is weakened by a large dosage. And has effects in lowering blood pressure and dilating blood vessel. 2. Anticonvulsant action: scolopendra and Scorpio have antagonistic effect on mice convulsion caused by half amount of convulsion of strychnine, Kadizao, and pure nicotine, and Scolopendra has stronger effect than Scorpio. 3. Impact on immune function: the Scolopendra granule has immunity enhancing effect. The high and low dose groups have the function of improving phagocytic ability of macrophages in abdominal cavities of mice. The centipede with proper amount has the function of inhibiting the humoral immunity function of mice when orally taken. 4. Anti-inflammatory action: centipede has a strong inhibition effect on acute and chronic inflammation. 5. Antifungal action: the Scolopendra soaking agent (1: 4) has effect in inhibiting dermatophytes such as Trichophyton violaceum, Trichophyton schoenleinii, Microsporum donovani, Epidermophyton grometns, Epidermophyton rubrum, and Trichophyton coloratum in test tube. 6. In addition, Scolopendra has analgesic and antitumor effects.

Preferably, the composition is mainly prepared from the following raw materials in parts by mass:

20-40 parts of garden balsam stem, 20-40 parts of rhizoma drynariae, 12-24 parts of angelica tail, 12-24 parts of red paeony root, 6-12 parts of frankincense, 6-12 parts of myrrh, 6-12 parts of sappan wood, 6-12 parts of divaricate saposhnikovia root, 20-40 parts of cacumen biotae twig, 20-40 parts of sabia amurensis, 12-24 parts of raw ephedra, 4-8 parts of scorpion and 4-8 parts of centipede.

30 parts of garden balsam stem, 30 parts of rhizoma drynariae, 20 parts of angelica tail, 20 parts of red paeony root, 10 parts of frankincense, 10 parts of myrrh, 10 parts of sappan wood, 10 parts of divaricate saposhnikovia root, 30 parts of cacumen biotae, 30 parts of sabina japonica, 20 parts of raw ephedra, 6 parts of scorpion and 6 parts of centipede.

A method for preparing a composition for treating joint pain, the method comprising the steps of:

s1, selecting herba speranskiae tuberculatae, rhizoma Drynariae, radix Angelicae sinensis, radix Paeoniae Rubra, Olibanum, Myrrha, lignum sappan, radix Saposhnikoviae, cacumen Myricariae Germanicae, cortex et radix junci, herba Ephedrae, Scorpio and Scolopendra according to corresponding proportion, mixing, decocting, adding medicated wine after decocting, stirring, standing, filtering to obtain filtrate;

s2, drying and grinding the filtrate, adding water, white vinegar and glycerol, and mixing uniformly to obtain the finished product.

Preferably, in the step S1, the cooking temperature is 80-100 ℃.

Preferably, in the step S1, the cooking time is 2-3 hours.

Preferably, in step S1, the wine agent includes a mixture of yellow wine and white wine;

the volume ratio of the yellow wine to the white spirit is as follows: 2-3: 1;

the ratio of the volume of the medicated wine to the total mass of the garden balsam stem, the rhizoma drynariae, the angelica tail, the red paeony root, the frankincense, the myrrh, the sappan wood, the divaricate saposhnikovia root, the Chinese arborvitae twig, the sabina vulgaris, the raw ephedra, the scorpion and the centipede is as follows: 30-80 mL: 1.

preferably, in the step S1, the standing time is 1-2 hours.

Preferably, in the step S2, the particle size of the powder obtained after grinding is 10 to 50 nm.

Preferably, in step S2, the ratio of the weight of the ground powder, the volume of water, the volume of white vinegar and the volume of glycerin is: 10-20 g: 30-40 mL: 5-15mL and 10-20 mL.

The invention has the beneficial effects that:

the composition is applied in an external application mode, and the spray is suitable for treating the arthralgia caused by the rheumatoid arthritis, is beneficial to curing the arthralgia caused by the conventional causes, and is beneficial to relieving symptoms such as the arthralgia caused by the rheumatoid arthritis.

The composition provided by the invention is bitter in taste and warm in nature; the liver meridian and kidney meridian entered are the therapeutic criteria. Wherein, the garden balsam stem has the efficacies of dispelling wind and eliminating dampness, relaxing muscles and tendons and promoting blood circulation, eliminating stasis and swelling, and detoxifying and relieving pain; rhizoma Drynariae has effects of promoting blood circulation, tonifying kidney, and strengthening bone; the angelica tail can promote blood circulation to remove blood stasis, and treat the diseases of amenorrhea and blood stasis and swelling and pain; radix Paeoniae Rubra has effects of clearing heat, cooling blood, promoting blood circulation and removing blood stasis; the frankincense has the effects of activating blood circulation, promoting qi circulation, relieving pain, reducing swelling and promoting tissue regeneration; myrrh with the functions of promoting blood circulation, relieving pain, eliminating swelling and promoting granulation; lignum sappan with effects of promoting blood circulation, healing wound, removing blood stasis, and dredging channels; radix Saposhnikoviae has effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm; cacumen biotae branches and twigs have the effects of relieving exterior syndrome, promoting eruption, dispelling wind and arresting itching; the sabina vulgaris has the effects of clearing away heat and toxic materials, eliminating dampness and relieving itching; raw ephedra has the efficacies of sweating, relieving exterior syndrome, freeing lung, relieving asthma, inducing diuresis and reducing edema; scorpio has effects of calming endogenous wind, relieving spasm, removing toxic substances, resolving hard mass, dredging collaterals, and relieving pain; scolopendra has effects of calming endogenous wind, relieving spasm, counteracting toxic substances, resolving hard mass, dredging collaterals, and relieving pain.

The formula (III) has the effects of promoting blood circulation to remove blood stasis, dispelling wind and relieving pain after the raw materials are compatible, and achieves the purpose of treating arthralgia.

The preparation method of the formula comprises the steps of firstly separating out the active ingredients of the raw materials by boiling, then adding the yellow wine and the white wine and standing, and is used for further promoting the mixing of the active ingredients of the raw materials and the wine agent, providing the effects of disinfection and sterilization for subsequent use and promoting the absorption rate of skin. After the product is sprayed, in order to form a drug film on the skin surface of a patient, water, white vinegar and glycerol are added after the liquid is dried and ground, the white vinegar is beneficial to the dispersion of the glycerol, the glycerol has a lubricating effect, the water is used for harmonizing the drugs and is used as a carrier for driving the drugs to be attached to the skin surface of the patient during subsequent spraying.

Detailed Description

The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. The reagents used are all conventional products which are commercially available.

Example 1:

a method for preparing a composition for treating joint pain, comprising the steps of:

s1, selecting 100 g of garden balsam stem, 100 g of drynaria rhizome, 60 g of angelica tail, 60 g of red peony root, 30 g of frankincense, 30 g of myrrh, 30 g of sappan wood, 30 g of divaricate saposhnikovia root, 100 g of cacumen biotae, 100 g of juniper, 60 g of raw ephedra, 10 g of scorpion and 10 g of centipede according to a corresponding proportion, mixing, decocting at 80 ℃ for 2 hours, adding a wine agent (yellow wine: white wine: 2:1, V/V) after the decoction is finished, stirring uniformly, standing for 1 hour, and filtering to obtain a filtrate;

s2, drying and grinding the filtrate to obtain powder with a particle size of 10nm, and adding water, white vinegar and glycerol to mix uniformly to obtain the finished product.

Example 2:

s1, selecting 500 g of garden balsam stem, 500 g of drynaria rhizome, 300 g of angelica tail, 300 g of red peony root, 150 g of frankincense, 150 g of myrrh, 150 g of sappan wood, 150 g of divaricate saposhnikovia root, 500 g of cacumen biotae, 500 g of juniper, 300 g of raw ephedra, 100 g of scorpion and 100 g of centipede according to a corresponding proportion, mixing, decocting at 100 ℃ for 3 hours, adding a wine agent (yellow wine: white wine: 2:1, V/V) after the decoction is finished, stirring uniformly, standing for 2 hours, filtering, and obtaining a filtrate;

s2, drying and grinding the filtrate to obtain powder with a particle size of 50nm, and adding water, white vinegar and glycerol to mix uniformly to obtain the finished product.

Example 3:

s1, selecting 200 g of garden balsam stem, 200 g of drynaria rhizome, 120 g of angelica tail, 120 g of red peony root, 60 g of frankincense, 60 g of myrrh, 60 g of sappan wood, 60 g of divaricate saposhnikovia root, 200 g of cacumen biotae, 200 g of juniper, 120 g of raw ephedra, 40 g of scorpion and 40 g of centipede according to a corresponding proportion, mixing, decocting at 80 ℃ for 3 hours, adding a wine agent (yellow wine: white wine ═ 3:1, V/V) after the decoction is finished, stirring uniformly, standing for 1 hour, and filtering to obtain a filtrate;

Example 4:

s1, selecting 400 g of garden balsam stem, 400 g of drynaria rhizome, 240 g of angelica tail, 240 g of red peony root, 120 g of frankincense, 120 g of myrrh, 120 g of sappan wood, 120 g of divaricate saposhnikovia root, 400 g of cacumen biotae, 400 g of juniper, 240 g of raw ephedra, 80 g of scorpion and 80 g of centipede according to a corresponding proportion, mixing, decocting at 100 ℃ for 2 hours, adding a wine agent (yellow wine: white wine ═ 3:1, V/V) after the decoction is finished, stirring uniformly, standing for 2 hours, and filtering to obtain a filtrate;

Example 5:

s1, selecting 300 g of garden balsam stem, 300 g of drynaria rhizome, 200 g of angelica tail, 200 g of red peony root, 100 g of frankincense, 100 g of myrrh, 100 g of sappan wood, 100 g of divaricate saposhnikovia root, 300 g of cacumen biotae, 300 g of juniper, 200 g of raw ephedra, 60 g of scorpion and 60 g of centipede according to a corresponding proportion, mixing, decocting at 100 ℃ for 2 hours, adding a wine agent (yellow wine: white wine: 2:1, V/V) after the decoction is finished, stirring uniformly, standing for 1 hour, filtering, and obtaining a filtrate;

The using method comprises the following steps: a spray for external use. 3-5 times per day, and in the first and second treatment courses, spraying at 6-hour intervals; the third course of treatment begins, spraying once every 12 hours. Each treatment period was 7 days.

The present invention is not limited to the above alternative embodiments, and any other products in various forms can be obtained by the present invention, and the present invention is within the protection scope of the present invention. The above embodiments should not be construed as limiting the scope of the present invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the above embodiments, or equivalent substitutions may be made to some or all of the technical features thereof, without departing from the scope of the present invention, and at the same time, such modifications or substitutions may not make the essence of the corresponding technical solutions depart from the scope of the embodiments of the present invention.

Claims

1. The composition for treating arthralgia is characterized by being prepared from the following raw materials in parts by mass:

2. The composition for treating arthralgia according to claim 1, wherein the composition is prepared from the following raw materials in parts by mass:

3. The composition for treating arthralgia according to claim 2, wherein the composition is prepared from the following raw materials in parts by mass:

4. A method for preparing a composition for treating joint pain according to any one of claims 1 to 3, comprising the steps of:

5. The method for preparing a composition for treating arthralgia according to claim 4, wherein the cooking temperature in step S1 is 80-100 ℃.

6. The method for preparing a composition for treating arthralgia according to claim 5, wherein the cooking time of step S1 is 2-3 hours.

7. The method for preparing a composition for treating arthralgia according to claim 4, wherein in said step S1, the wine comprises a mixture of yellow wine and white wine;

the volume ratio of the yellow wine to the white spirit is as follows: 2-3: 1;

8. the method for preparing a composition for treating arthralgia according to claim 4, wherein said step S1 is performed by standing for 1-2 hours.

9. The method for preparing a composition for treating arthralgia according to claim 4, wherein the powder obtained after grinding in step S2 has a particle size of 10-50 nm.

10. The method for preparing a composition for treating arthralgia according to claim 4, wherein the ratio of the weight of the ground powder, the volume of water, the volume of white vinegar, and the volume of glycerin in step S2 is: 10-20 g: 30-40 mL: 5-15mL and 10-20 mL.